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List of works by Bart De Spiegeleer

123/125I-labelled 2-iodo-L: -phenylalanine and 2-iodo-D: -phenylalanine: comparative uptake in various tumour types and biodistribution in mice.

scientific article published on 30 March 2006

5-HT2A receptors in the feline brain: 123I-5-I-R91150 kinetics and the influence of ketamine measured with micro-SPECT.

scientific article published on 2 July 2013

A novel bending point criterion for dissolution profile interpretation

scientific article published in September 2001

A rapid stability-indicating, fused-core HPLC method for simultaneous determination of β-artemether and lumefantrine in anti-malarial fixed dose combination products

scientific article published on 30 April 2013

Adsorption of peptides at the sample drying step: influence of solvent evaporation technique, vial material and solution additive

scientific article published on 11 December 2008

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides.

scientific article

An analytical quality by design (aQbD) approach for a L-asparaginase activity method

scientific article published on 3 September 2015

An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: Proof-of-concept in the treatment of psoriasis

scientific article

An integrated view on how the management of the dry period length of lactating cows could affect mammary biology and defence.

scientific article published on 09 June 2010

Analysis of iodinated peptides by LC-DAD/ESI ion trap mass spectrometry

scientific article

Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides

scientific article published on 27 March 2010

Analytical characterization of NOTA-modified somatropins

scientific article published on 20 March 2014

Analytical quality-by-design approach for sample treatment of BSA-containing solutions.

scientific article published on 26 June 2014

Analytical, biopharmaceutical and regulatory evaluation of topical testosterone preparations

scientific article published on 6 November 2008

Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils

scientific article published in January 2011

Assessment of Efficacy and Quality of Two Albendazole Brands Commonly Used against Soil-Transmitted Helminth Infections in School Children in Jimma Town, Ethiopia

scientific article

Assessment of the solid-state composition of an active salicylanilide compound by FT-Raman spectroscopy

scientific article

Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold.

scientific article

Blood-brain barrier transport kinetics of the cyclic depsipeptide mycotoxins beauvericin and enniatins

scientific article published on 24 June 2016

Blood-brain barrier transport kinetics of the neuromedin peptides NMU, NMN, NMB and NT.

scientific article published on 31 March 2016

Blood-brain barrier transport of short proline-rich antimicrobial peptides

scientific article published in April 2014

Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

scientific article published on 4 November 2014

Bovine blood neutrophil acyloxyacyl hydrolase (AOAH) activity during endotoxin and coliform mastitis

scientific article published on 23 June 2007

Brainpeps: the blood-brain barrier peptide database

scientific article

Cell-Penetrating Peptides Selectively Cross the Blood-Brain Barrier In Vivo

scientific article published on 14 October 2015

Central administration of obestatin fails to show inhibitory effects on food and water intake in mice.

scientific article published on 5 May 2009

Characterization data on the topical carrier DDC642.

scientific article

Characterization of FDG PET Images Using Texture Analysis in Tumors of the Gastro-Intestinal Tract: A Review

scientific article published on 24 August 2020

Chemical-functional diversity in cell-penetrating peptides

scientific article (publication date: 2013)

Chiral nickel(II) complexes in the preparation of 11C- and 18F-labelled enantiomerically pure α-amino acids.

scientific article published on 08 December 2011

Comparative biodistribution study of the new tumor tracer [123I]-2-iodo-L-phenylalanine with [123I]-2-iodo-L-tyrosine

scientific article published on January 2006

Crosstalk between the microbiome and cancer cells by quorum sensing peptides

scientific article

Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria

scientific article published on 6 May 2016

Derringer desirability and kinetic plot LC-column comparison approach for MS-compatible lipopeptide analysis

scientific article

Determination of the relative amounts of three crystal forms of a benzimidazole drug in complex finished formulations by FT-Raman spectroscopy

scientific article published on 14 April 2005

Development of peptide and protein based radiopharmaceuticals.

scientific article published on January 2014

Development of peptide receptor binding assays: methods to avoid false negatives

scientific article published on 23 August 2009

Differential gene expression of the toll-like receptor-4 cascade and neutrophil function in early- and mid-lactating dairy cows

scientific article published in March 2011

Differential microRNA expression analysis in blastocysts by whole mount in situ hybridization and reverse transcription quantitative polymerase chain reaction on laser capture microdissection samples.

scientific article

Direct assay for phosphotransacetylase and acetyl-coenzyme A carboxylase by high-performance liquid chromatography

scientific article published on 01 October 1986

Dry heat forced degradation of buserelin peptide: kinetics and degradant profiling

scientific article

Dry heat stress stability evaluation of casein peptide mixture

scientific article published on 5 March 2011

Enniatin-containing solutions for oromucosal use: Quality-by-design ex-vivo transmucosal risk assessment of composition variability

scientific article published on 23 June 2015

Evaluation of dissolution profiles using principal component analysis

scientific article published on 01 January 2001

Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain.

scientific article published in August 2008

Exploring the chemical space of quorum sensing peptides

scientific article published on 6 April 2015

Fish Hydrolysates: A Regulatory Perspective of Bioactive Peptides.

scientific article published on 2 November 2016

Flatworm models in pharmacological research: the importance of compound stability testing

scientific article published on 3 July 2014

Gas chromatographic method for the determination of lumefantrine in antimalarial finished pharmaceutical products

scientific article published on 20 May 2015

Growth factor/peptide receptor imaging for the development of targeted therapy in oncology.

scientific article published on January 2008

Half-fraction and full factorial designs versus central composite design for retention modelling in reversed-phase ion-pair liquid chromatography

scientific article published in March 1996

High performance liquid chromatography stability study of malonyl-coenzyme A, using statistical experimental designs

scientific article published in September 1989

Human skin penetration of selected model mycotoxins

scientific article

Human skin permeation of emerging mycotoxins (beauvericin and enniatins).

scientific article

Hydrophilic interaction LC of peptides: columns comparison and clustering

scientific article published in March 2010

Identification of a microscopically selected microorganism in milk samples

scientific article

Implementation of a single quad MS detector in high-throughput transdermal research of plant extracts.

scientific article published on 18 August 2015

Implementation of a single quad MS detector in routine QC analysis of peptide drugs.

scientific article published on 26 September 2015

Improved positive electrospray ionization of patulin by adduct formation: usefulness in liquid chromatography-tandem mass spectrometry multi-mycotoxin analysis.

scientific article published on 3 November 2012

Impurity profiling quality control testing of synthetic peptides using liquid chromatography-photodiode array-fluorescence and liquid chromatography-electrospray ionization-mass spectrometry: the obestatin case

scientific article published on 23 February 2008

In Vitro Functional Quality Characterization of NOTA-Modified Somatropins.

scientific article published on 31 January 2017

In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops

scientific article published in November 2010

In vitro metabolic stability of iodinated obestatin peptides

scientific article published on 27 December 2011

In vitro metabolic stability of obestatin: kinetics and identification of cleavage products

scientific article published on 3 July 2008

In vivo imaging of apoptosis in oncology: an update.

scientific article published on 26 April 2011

Increase of the transdermal penetration of testosterone by miconazole nitrate.

scientific article published on 21 December 2012

Influence of sedation and data acquisition method on tracer uptake in animal models: [123I]-2-iodo-L-phenylalanine in pentobarbital-sedated tumor-bearing athymic mice.

scientific article

Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules

scientific article published on 25 March 2014

Ion mobility spectrometry as a high-throughput technique for in vitro transdermal Franz diffusion cell experiments of ibuprofen

scientific article

LC-MS Compatible Antiadsorption Diluent for Peptide Analysis

scientific article published on 07 January 2020

LC-MS N-alkylamide Profiling of an Ethanolic Anacyclus pyrethrum Root Extract ⬇️

scientific article published on October 9, 2012

LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol. ⬇️

scientific article

LC-UV/MS characterization and DOE optimization of the iodinated peptide obestatin

scientific article published on 13 October 2007

LC-UV/MS quality analytics of paediatric artemether formulations.

scientific article

Laser capture microdissection of intestinal tissue from sea bass larvae using an optimized RNA integrity assay and validated reference genes

scientific article published on 17 February 2016

Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism-blocking agent

scientific article published on 12 January 2011

Metabolic and morphological measurements of subcutaneous and visceral fat and their relationship with disease stage and overall survival in newly diagnosed pancreatic adenocarcinoma : Metabolic and morphological fat measurements in pancreatic adenoc

scientific article

Metabolic fate of lactoferricin-based antimicrobial peptides: effect of truncation and incorporation of amino acid analogs on the in vitro metabolic stability

scientific article published in December 2009

Mucosal and blood-brain barrier transport kinetics of the plant N-alkylamide spilanthol using in vitro and in vivo models.

scientific article

Neuro-imaging the serotonin 2A receptor as a valid biomarker for canine behavioural disorders

scientific article published on 3 November 2010

Normal regional distribution of cerebral blood flow in dogs: comparison between (99m) Tc-ethylcysteinate dimer and (99m) Tc- hexamethylpropylene amine oxime single photon emission computed tomography

scientific article published on 18 March 2013

Nuclear medicine and large animal studies in the pharmacological development of psychotropics

scientific article published in March 2008

Optimization by experimental design of precursor synthesis and radiolabeling of 2-iodo-L-phenylalanine, a novel amino acid for tumor imaging

scientific article published in June 2006

Peptide profiling of Internet-obtained Cerebrolysin using high performance liquid chromatography - electrospray ionization ion trap and ultra high performance liquid chromatography - ion mobility - quadrupole time of flight mass spectrometry

scientific article

Pharmaceutical Regulatory Framework in Ethiopia: A Critical Evaluation of Its Legal Basis and Implementation

scientific article

Quality analysis of salmon calcitonin in a polymeric bioadhesive pharmaceutical formulation: sample preparation optimization by DOE.

scientific article published on 3 July 2010

Quality control of cationic cell-penetrating peptides

scientific article published on 12 September 2015

Quality evaluation of synthetic quorum sensing peptides used in R&D.

scientific article published on 31 January 2015

Quality of medicines commonly used in the treatment of soil transmitted helminths and giardia in ethiopia: a nationwide survey

scientific article (publication date: December 2014)

Quality specifications for peptide drugs: a regulatory-pharmaceutical approach

scientific article

Quantitative In Vitro and In Vivo Evaluation of Intestinal and Blood-Brain Barrier Transport Kinetics of the Plant N-Alkylamide Pellitorine

scientific article published on 4 July 2016

Quantitative analysis of cis-dichlorodiammineplatinum(II) by high-performance thin-layer chromatography

scientific article published on 01 December 1984

Quantitative p retreatment VOI analysis of liver metastases. (99m)Tc-MAA SPECT/CT and FDG PET/CT in relation with treatment response to SIRT.

scientific article published on 29 January 2013

Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract

scientific article published on 11 November 2014

Quorum Sensing Peptides Selectively Penetrate the Blood-Brain Barrier

scientific article

Quorumpeps database: chemical space, microbial origin and functionality of quorum sensing peptides

scientific article

Raman model development for the protein conformational state classification in different freeze-dried formulations.

scientific article published on 26 March 2014

Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations.

scientific article

Rapid determination of malonic acid by ion-pair reversed-phase high-performance liquid chromatography

scientific article published in January 1986

Reactive oxygen species generation by bovine blood neutrophils with different CXCR1 (IL8RA) genotype following Interleukin-8 incubation

scientific article published on 6 May 2015

Recognition of anatomical predilection sites in canine elbow pathology on bone scans using micro-single photon emission tomography

scientific article published on 26 March 2010

Regulatory development of geriatric medicines: To GIP or not to GIP?

scientific article published on 17 February 2016

Related impurities in peptide medicines.

scientific article

Reversed-phase fused-core HPLC modeling of peptides.

scientific article published on 30 November 2012

SIRT of liver metastases: physiological and pathophysiological considerations ⬇️

scientific article published on July 17, 2012

Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder

scientific article

Single photon emission computed tomography (SPECT) imaging of the dopamine transporter in healthy dogs.

scientific article published on 16 June 2010

Skin penetration enhancing properties of the plant N-alkylamide spilanthol.

scientific article published on 9 April 2013

Spilanthes acmella ethanolic flower extract: LC–MS alkylamide profiling and its effects on sexual behavior in male rats ⬇️

scientific article published on July 16, 2011

Stability of extemporaneously prepared cytarabine, methotrexate sodium, and methylprednisolone sodium succinate

scientific article published in February 2012

Stability-indicating HPLC-DAD/UV-ESI/MS impurity profiling of the anti-malarial drug lumefantrine

scientific article published on 28 February 2011

Targeting the S1 and S3 subsite of trypsin with unnatural cationic amino acids generates antimicrobial peptides with potential for oral administration

scientific article published on 11 July 2012

The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs

scientific article

The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with (123)I-R91150 SPECT.

scientific article published on 26 March 2014

The effects of ARBs, ACEIs and statins on clinical outcomes of COVID-19 infection among nursing home residents

scientific article published on 15 May 2020

The importance of the cosolvent propylene glycol on the antimicrobial preservative efficacy of a pharmaceutical formulation by DOE-ruggedness testing

scientific article published in January 2006

The influence of morphine on cerebral 5-HT2A availability in dogs: a SPECT study

scientific article published on 22 October 2012

The influence of peptide impurity profiles on functional tissue-organ bath response: the 11-mer peptide INSL6[151-161] case

scientific article published on 6 October 2011

The influence of the acyl chain on the transdermal penetration-enhancing effect of synthetic phytoceramides.

scientific article published on 16 December 2014

The mycotoxin definition reconsidered towards fungal cyclic depsipeptides

scientific article published on 10 March 2016

The potential role of quorum-sensing peptides in oncology.

scientific article

The quorum sensing peptides PhrG, CSP and EDF promote angiogenesis and invasion of breast cancer cells in vitro

scientific article

The tissue distribution in rats of [195mPt]carboplatin following intravenous, intraperitoneal and oral administration

scientific article published on January 1990

The use of [123I]-2-iodo-L-phenylalanine as an early radiotherapy evaluation tool: in vitro R1M rabdomyosarcoma cell and in vivo mouse experiments

scientific article published in April 2008

The use of the HiSPECT bone scan in canine flexor enthesopathy and coronoid pathology

scientific article published on 31 January 2013

Thermal sensitivity as a quality control attribute for biotherapeutics: The L-asparaginase case

scientific article published on 12 September 2019

Topical distribution of acyclovir in normal equine skin and equine sarcoids: An in vitro study.

scientific article published on 2 April 2016

Transdermal behaviour of the N-alkylamide spilanthol (affinin) from Spilanthes acmella (Compositae) extracts.

scientific article

Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds

scientific article published on 22 August 2007

Transsplenic portal scintigraphy using 99mTc-pertechnetate for the diagnosis of portosystemic shunts in cats: a retrospective review of 12 patients ⬇️

scientific article published on May 15, 2013

UHPLC-MS/MS method for the determination of the cyclic depsipeptide mycotoxins beauvericin and enniatins in in vitro transdermal experiments

scientific article

Use of [123I]-2-iodo-L-phenylalanine as a tumor imaging agent in two dogs with synovial cell sarcoma.

scientific article published in September 2007

Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers

scientific article published on 9 September 2010

Variation of inflammatory dynamics and mediators in primiparous cows after intramammary challenge with Escherichia coli.

scientific article

Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution

scientific article published on 12 November 2012

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