List of works - Peter D Arkwright

A Rapid Shift from Chronic Hyperoxia to Normoxia Induces Systemic Anaphylaxis via Transient Receptor Potential Ankyrin 1 Channels on Mast Cells

scientific article published on 23 October 2020

Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome

scientific article

Adrenal and sympathetic nervous activity in subjects with "low' and "high' normal blood pressure

scientific article published on 01 June 1983

Age-related prevalence and antibiotic resistance of pathogenic staphylococci and streptococci in children with infected atopic dermatitis at a single-specialty center

scientific article published in July 2002

Alcohol, personality and predisposition to essential hypertension

article

Allergy testing in predicting outcome of open food challenge to peanut

scientific article published on 16 June 2017

Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).

scientific article

Anatomic and anthropometric determinants of intramuscular versus subcutaneous administration in children with epinephrine autoinjectors.

scientific article

Anatomical and Anthropometric Determinants of Intramuscular Versus Subcutaneous Administration in Children with Epinephrine Auto-Injectors

Anti-CD20 or anti-IgE therapy for severe chronic autoimmune urticaria

scientific article published in February 2009

Association between hypoparathyroidism and defective T cell immunity in 22q11.2 deletion syndrome

scientific article published in February 2010

Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis

article

Astute Clinician Report: A Novel 10 bp Frameshift Deletion in Exon 2 of ICOS Causes a Combined Immunodeficiency Associated with an Enteritis and Hepatitis

scientific article

Atopic dermatitis in children

scientific article published on 18 April 2014

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

scientific article

Autoantibodies against Type I Interferons as an Additional Diagnostic Criterion for Autoimmune Polyendocrine Syndrome Type I

scientific article published on 26 August 2008

Autoimmune lymphoproliferative syndrome with somatic Fas mutations

scientific article

Autoimmunity and recurrent infections in partial complement C3 immunodeficiency

scientific article published on 04 January 2010

Autoimmunity in human primary immunodeficiency diseases

scientific article

Automatic epinephrine device use in children with food allergies

scientific article

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

scientific article

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

scientific article published on 19 July 2018

Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis

scientific article published on 01 March 2007

Bronchiectasis and deteriorating lung function in agammaglobulinaemia despite immunoglobulin replacement therapy

scientific article

C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes

scientific article

CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

article

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

scientific article

Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD5- B lymphocytes without an increase in disease severity

scientific article published on 01 August 2001

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

scientific article

Clinical features that identify children with primary immunodeficiency diseases

scientific article published on 11 April 2011

Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation

scientific article published on 14 November 2012

Clinical variability and characteristic autoantibody profile in primary C1q complement deficiency

scientific article published on 01 October 2007

Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss

article

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

scientific article

DOCK8 is critical for the survival and function of NKT cells

scientific article published on 08 August 2013

Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients

scientific article published on March 2011

Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension

scientific article published on 08 October 2019

Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled, severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study

scientific article published on 24 September 2020

Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages

scientific article published on 01 November 2003

Effect of Mycobacterium vaccae on cytokine responses in children with atopic dermatitis.

scientific article published in April 2005

Effect of childhood eczema and asthma on parental sleep and well-being: a prospective comparative study.

scientific article

Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses

scientific article published on 4 February 2010

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

scientific article published on 17 October 2016

End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms.

scientific article

FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function

scientific article

Factors determining the ability of parents to effectively administer intramuscular adrenaline to food allergic children

scientific article

Factors determining the effectiveness of oral ciclosporin in the treatment of severe childhood atopic dermatitis

scientific article published on 12 April 2012

Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center

article

Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes

scientific article published on 22 September 2009

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

scientific article

G6PC3 mutations cause non-syndromic severe congenital neutropenia

scientific article

Glycoprotein glycosylation and the immunosuppressive effects of human pregnancy serum.

scientific article published in January 1992

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

scientific article published on 16 March 2006

Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils

scientific article published on 7 June 2005

Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo

scientific article published on April 2006

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

scientific article published on December 2002

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

scientific article published on 24 October 2013

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

scientific article

IgE sensitization to the nonspecific lipid-transfer protein Ara h 9 and peanut-associated bronchospasm

scientific article published on 12 September 2013

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

scientific article published on 19 July 2010

Impaired TH17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy

article

Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED.

scientific article published in December 2008

Infantile nephrotic syndrome and atopy

scientific article published on 01 August 1996

Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation

scientific article published on February 2006

Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease

article published in 2001

Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomized, double-blind, placebo-controlled trial

scientific article published on 01 September 2006

Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations

scientific article published on 01 October 1999

Marked variability in clinical presentation and outcome of patients with C1q immunodeficiency

scientific article

Mast Cell Disorders: from Infancy to Maturity

scientific article published on 28 November 2018

Memory switched B cell percentage and not serum immunoglobulin concentration is associated with clinical complications in children and adults with specific antibody deficiency and common variable immunodeficiency

scientific article

Mevalonic aciduria cured by bone marrow transplantation

scientific article published in September 2007

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

scientific article published on 07 July 2015

Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency

scientific article

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

scientific article

Mycobacterium vaccae reduces scratching behavior but not the rash in NC mice with eczema: a randomized, blinded, placebo-controlled trial

scientific article

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

scientific article

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease

scientific article published in August 2006

Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation

scientific article

Past mortality from infectious diseases and current burden of allergic diseases in England and Wales

scientific article

Pattern recognition receptor expression is not impaired in patients with chronic mucocutanous candidiasis with or without autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

scientific article published on 22 January 2009

Plasma calcium and cortisol as predisposing factors to alcohol related blood pressure elevation

scientific article published on 01 August 1984

Polymorphisms of the Bcl-2 family member bfl-1 in children with atopic dermatitis

article

Prevalence, outcome and pre-hospital management of anaphylaxis by first aiders and paramedical ambulance staff in Manchester, UK.

scientific article published in March 2010

Recently identified factors predisposing children to infectious diseases

scientific article published on June 2008

Recurrent hemiplegia associated with cerebral vasculopathy following third trimester maternal herpes zoster infection

scientific article

STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis

scientific article

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

scientific article published on 4 May 2015

Severe vernal keratoconjunctivitis successfully treated with subcutaneous omalizumab

scientific article published on 19 April 2013

Severity and threshold of peanut reactivity during hospital-based open oral food challenges: An international multicenter survey

scientific article published on 17 September 2018

Side by side comparison of 0.03% tacrolimus ointment (Protopic) versus usual topical steroid treatment in children with atopic dermatitis

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

scientific article published on 04 July 2013

Skin pH Is the Master Switch of Kallikrein 5-Mediated Skin Barrier Destruction in a Murine Atopic Dermatitis Model

scientific article published on January 2016

Spectrum and management of complement immunodeficiencies (excluding hereditary angioedema) across Europe

scientific article published on 8 February 2015

Successful cure of C1q deficiency in human subjects treated with hematopoietic stem cell transplantation

scientific article published on 12 September 2013

Suppression of allogeneic reactivity in vitro by the syncytiotrophoblast membrane glycocalyx of the human term placenta is carbohydrate dependent.

scientific article published on February 1994

Syncytiotrophoblast membrane protein glycosylation patterns in normal human pregnancy and changes with gestational age and parturition

scientific article published on 01 November 1991

TGF-beta(1) genotype and accelerated decline in lung function of patients with cystic fibrosis

scientific article published on June 2000

The United Kingdom Primary Immune Deficiency (UKPID) registry 2012 to 2017

scientific article published on 01 June 2018

The deep fascia of the thigh forms an impenetrable barrier to fluid injected subcutaneously by autoinjectors

scientific article published on 26 January 2015

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

scientific article

The pressor effect of moderate alcohol consumption in man: a search for mechanisms

scientific article published in September 1982

The use of adrenaline autoinjectors by children and teenagers

article

Treatment of Epstein-Barr-virus-associated primary CNS B cell lymphoma with allogeneic T-cell immunotherapy and stem-cell transplantation

scientific article

Ultra-pure soft water ameliorates atopic skin disease by preventing metallic soap deposition in NC/Tnd mice and reduces skin dryness in humans

scientific article

V(D)J recombination defects in lymphocytes due to RAG mutations: severe immunodeficiency with a spectrum of clinical presentations

scientific article published on 01 January 2001

X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease

scientific article

List of works by Peter D Arkwright

A Rapid Shift from Chronic Hyperoxia to Normoxia Induces Systemic Anaphylaxis via Transient Receptor Potential Ankyrin 1 Channels on Mast Cells

Abnormal tumor necrosis factor receptor I cell surface expression and NF-kappaB activation in tumor necrosis factor receptor-associated periodic syndrome

Adrenal and sympathetic nervous activity in subjects with "low' and "high' normal blood pressure

Age-related prevalence and antibiotic resistance of pathogenic staphylococci and streptococci in children with infected atopic dermatitis at a single-specialty center

Alcohol, personality and predisposition to essential hypertension

Allergy testing in predicting outcome of open food challenge to peanut

Alu-repeat-induced deletions within the NCF2 gene causing p67-phox-deficient chronic granulomatous disease (CGD).

Anatomic and anthropometric determinants of intramuscular versus subcutaneous administration in children with epinephrine autoinjectors.

Anatomical and Anthropometric Determinants of Intramuscular Versus Subcutaneous Administration in Children with Epinephrine Auto-Injectors

Anti-CD20 or anti-IgE therapy for severe chronic autoimmune urticaria

Association between hypoparathyroidism and defective T cell immunity in 22q11.2 deletion syndrome

Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis

Astute Clinician Report: A Novel 10 bp Frameshift Deletion in Exon 2 of ICOS Causes a Combined Immunodeficiency Associated with an Enteritis and Hepatitis

Atopic dermatitis in children

Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I

Autoantibodies against Type I Interferons as an Additional Diagnostic Criterion for Autoimmune Polyendocrine Syndrome Type I

Autoimmune lymphoproliferative syndrome with somatic Fas mutations

Autoimmunity and recurrent infections in partial complement C3 immunodeficiency

Autoimmunity in human primary immunodeficiency diseases

Automatic epinephrine device use in children with food allergies

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

Biallelic RIPK1 mutations in humans cause severe immunodeficiency, arthritis, and intestinal inflammation

Blinded side-to-side comparison of topical corticosteroid and tacrolimus ointment in children with moderate to severe atopic dermatitis

Bronchiectasis and deteriorating lung function in agammaglobulinaemia despite immunoglobulin replacement therapy

C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes

CD4+CD25+ T-regulatory cells are decreased in patients with autoimmune polyendocrinopathy candidiasis ectodermal dystrophy

CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation

Children with atopic dermatitis who carry toxin-positive Staphylococcus aureus strains have an expansion of blood CD5- B lymphocytes without an increase in disease severity

Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency

Clinical features that identify children with primary immunodeficiency diseases

Clinical outcome in IL-10- and IL-10 receptor-deficient patients with or without hematopoietic stem cell transplantation

Clinical variability and characteristic autoantibody profile in primary C1q complement deficiency

Cytokine promoter gene polymorphisms and idiopathic recurrent pregnancy loss

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

DOCK8 is critical for the survival and function of NKT cells

Differential cytokine secretion results from p65 and c-Rel NF-κB subunit signaling in peripheral blood mononuclear cells of TNF receptor-associated periodic syndrome patients

Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension

Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled, severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study

Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages

Effect of Mycobacterium vaccae on cytokine responses in children with atopic dermatitis.

Effect of childhood eczema and asthma on parental sleep and well-being: a prospective comparative study.

Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

End-organ dysfunction in cystic fibrosis: association with angiotensin I converting enzyme and cytokine gene polymorphisms.

FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function

Factors determining the ability of parents to effectively administer intramuscular adrenaline to food allergic children

Factors determining the effectiveness of oral ciclosporin in the treatment of severe childhood atopic dermatitis

Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center

Fas stimulation of T lymphocytes promotes rapid intercellular exchange of death signals via membrane nanotubes

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

G6PC3 mutations cause non-syndromic severe congenital neutropenia

Glycoprotein glycosylation and the immunosuppressive effects of human pregnancy serum.

Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation.

Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils

Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo

Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept

IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

IgE sensitization to the nonspecific lipid-transfer protein Ara h 9 and peanut-associated bronchospasm

Impaired Epstein-Barr virus-specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family-positive B-cell targets

Impaired TH17 responses in patients with chronic mucocutaneous candidiasis with and without autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy

Impaired dendritic cell maturation and cytokine production in patients with chronic mucocutanous candidiasis with or without APECED.

Infantile nephrotic syndrome and atopy

Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation

Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease

Killed Mycobacterium vaccae suspension in children with moderate-to-severe atopic dermatitis: a randomized, double-blind, placebo-controlled trial

Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations

Marked variability in clinical presentation and outcome of patients with C1q immunodeficiency

Mast Cell Disorders: from Infancy to Maturity

Memory switched B cell percentage and not serum immunoglobulin concentration is associated with clinical complications in children and adults with specific antibody deficiency and common variable immunodeficiency

Mevalonic aciduria cured by bone marrow transplantation

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency

Mutations in STAT3 and diagnostic guidelines for hyper-IgE syndrome

Mycobacterium vaccae reduces scratching behavior but not the rash in NC mice with eczema: a randomized, blinded, placebo-controlled trial

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease

Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation

Past mortality from infectious diseases and current burden of allergic diseases in England and Wales