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List of works by Alex Strongin

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia.

scientific article published in July 2005

A humanized leucine zipper-TRAIL hybrid induces apoptosis of tumors both in vitro and in vivo

scientific article

A monoclonal antibody interferes with TIMP-2 binding and incapacitates the MMP-2-activating function of multifunctional, pro-tumorigenic MMP-14/MT1-MMP.

scientific article published on 02 December 2013

A myelin basic protein fragment induces sexually dimorphic transcriptome signatures of neuropathic pain in mice

scientific article published on 12 June 2020

A new chromogenic substrate for subtilisin

scientific article published in December 1974

A novel monoclonal antibody, L1A3, is directed to the functional site of the alpha v integrin subunit

scientific article published on August 1996

A reliable technique for large-scale DNA separation

scientific article

A sensitive and selective ELISA methodology quantifies a demyelination marker in experimental and clinical samples.

scientific article published on 8 February 2018

A simple method for phage or plasmid DNA's isolation suitable as a "screening test" after molecular cloning

scientific article published in May 1978

A suitable method for construction and cloning hybrid plasmids containing EcoRI-fragments of E. coli genome

scientific article published on January 1977

A unique substrate binding mode discriminates membrane type-1 matrix metalloproteinase from other matrix metalloproteinases

scientific article published on 16 April 2002

Aberrant, persistent inclusion into lipid rafts limits the tumorigenic function of membrane type-1 matrix metalloproteinase in malignant cells

scientific article published on February 2004

Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase.

scientific article published in April 1992

An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinase

scientific article published on 10 December 2001

Anthrax lethal factor protease inhibitors: synthesis, SAR, and structure-based 3D QSAR studies.

scientific article published on January 2006

Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site

scientific article

Bacillusamyloliquefaciens α -amylase signal sequence fused in frame with human proinsulin is properly processed by Bacillussubtilis cells

scientific article published on 01 May 1990

Basis for substrate recognition and distinction by matrix metalloproteinases

scientific article

Biochemical characterization of the cellular glycosylphosphatidylinositol-linked membrane type-6 matrix metalloproteinase

scientific article

Biochemical evidence of the interactions of membrane type-1 matrix metalloproteinase (MT1-MMP) with adenine nucleotide translocator (ANT): potential implications linking proteolysis with energy metabolism in cancer cells

scientific article published on 28 April 2009

Both PA63 and PA83 are endocytosed within an anthrax protective antigen mixed heptamer: a putative mechanism to overcome a furin deficiency

scientific article published on 7 December 2005

Cell-surface-associated tissue transglutaminase is a target of MMP-2 proteolysis

scientific article published on September 2004

Cellular membrane type-1 matrix metalloproteinase (MT1-MMP) cleaves C3b, an essential component of the complement system

scientific article published on 14 September 2004

Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis.

scientific article

Chemical modification of the recombinant human alpha A- and beta-interferons.

scientific article

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

scientific article (publication date: 15 January 2006)

Cloning of Clostridium thermocellum endoglucanase genes in Escherichia coli.

scientific article

Comparative study of the multiplicity of exoenzymes produced by different strains of Bacillus subtilis

scientific article

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

scientific article (publication date: 20 January 2003)

Construction and molecular cloning of hybrid plasmids containing specific fragments of Escherichia coli DNA

scientific article published on January 1978

Convergent evolution as a mechanism for pathogenic adaptation

scientific article

Crystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut Case

scientific article

Defining the roles of T cell membrane proteinase and CD44 in type 1 diabetes.

scientific article published on January 2007

Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat

scientific article published on 11 August 2008

Determination of matrix metalloproteinase activity using biotinylated gelatin.

scientific article

Direct Comparison of the Subtilisin-Like Intracellular Protease of Bacillus licheniformis with the Homologous Enzymes of Bacillus subtilis ⬇️

scientific article published on February 1, 1979

Distinct interactions with cellular E-cadherin of the two virulent metalloproteinases encoded by a Bacteroides fragilis pathogenicity island

scientific article

Distribution of DNA sequences recognized by specific endonucleases

scientific article

Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.

scientific article published on 11 March 2014

Dynamic interdomain interactions contribute to the inhibition of matrix metalloproteinases by tissue inhibitors of metalloproteinases.

scientific article

Effect of Bacillus subtilis A-50 "streptomycin" mutations on the formation of molecular forms of subtilisin, an extracellular alkaline proteinase

scientific article published on November 1, 1978

Effects of mutations in Bacillus subtilis genome decreasing the protease activity on the formation of subtilisin molecular forms

scientific article

Efficient synthetic inhibitors of anthrax lethal factor

scientific article

Electron microscopic study of Bacillus subtilis mutants differing in the serine proteinase activity and spectrum

scientific article published on July 1, 1978

Epigenetic control of the invasion-promoting MT1-MMP/MMP-2/TIMP-2 axis in cancer cells

scientific article published on 13 March 2009

Epigenetic regulation of matrix metalloproteinases and their collagen substrates in cancer ⬇️

scientific article published on June 1, 2011

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B–NS3 junction region

scientific article

Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinase

scientific article published on 01 April 2000

Furin regulates the intracellular activation and the uptake rate of cell surface-associated MT1-MMP.

scientific article published on 24 April 2006

Gelatin zymography and substrate cleavage assays of matrix metalloproteinase-2 in breast carcinoma cells overexpressing membrane type-1 matrix metalloproteinase.

scientific article

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

scientific article

High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome

scientific article

Human 92kDa type IV collagenase: Functional analysis of fibronectin and carboxyl-end domains

article

Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies

scientific article published on April 2009

Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival

scientific article

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain.

scientific article

Inflammatory proprotein convertase-matrix metalloproteinase proteolytic pathway in antigen-presenting cells as a step to autoimmune multiple sclerosis.

scientific article published on 02 September 2009

Inhibition of membrane type-1 matrix metalloproteinase by cancer drugs interferes with the homing of diabetogenic T cells into the pancreas.

scientific article

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

scientific article

Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7)

scientific article

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin ⬇️

scientific article published on March 5, 1992

Interaction of hepatitis B viral oncoprotein with cellular target HBXIP dysregulates centrosome dynamics and mitotic spindle formation.

scientific article

Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice

scientific article

Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.

scientific article

Intracellular proteinase of Bacillus subtilis

scientific article published on January 1, 1977

Intracellular serine protease from Bacillus subtilis. Structural comparison with extracellular serine proteases-subtilisins

scientific article

Intracellular serine protease of Bacillus subtilis: sequence homology with extracellular subtilisins ⬇️

scientific article published on March 1, 1978

Intracellular serine proteinase of Bacillus subtilis strain Marburg 168. Comparison with the homologous enzyme from Bacillus subtilis strain A-50 ⬇️

scientific article published on May 1, 1979

Intradomain cleavage of inhibitory prodomain is essential to protumorigenic function of membrane type-1 matrix metalloproteinase (MT1-MMP) in vivo.

scientific article

Isoelectric focusing of plasma membrane proteins from Strongylocentrotus intermedius sea urchin embryo cells

scientific article published on 01 September 1976

Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus

scientific article

Isolation and properties of leucine aminopeptidase from Aspergillus oryzae

scientific article published on May 1, 1977

Isolation of proteinase I from E. coli cells using affinty chromatography on bacitracin-Sepharose

scientific article published on April 1980

MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors

scientific article

MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells

scientific article published in February 2001

Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients

scientific article published on March 2006

Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis ⬇️

scientific article published on August 8, 2011

Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury

scientific article

Matrix metalloproteinase-2 activation modulates glioma cell migration.

scientific article published in October 1997

Matrix metalloproteinases, T cell homing and beta-cell mass in type 1 diabetes.

scientific article

Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.

scientific article published on 2 March 2001

Mechanistic insights into targeting T cell membrane proteinase to promote islet β-cell rejuvenation in type 1 diabetes

scientific article published on 01 September 2006

Membrane type-1 matrix metalloproteinase (MT1-MMP) exhibits an important intracellular cleavage function and causes chromosome instability

scientific article

Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells

scientific article published on November 2003

Membrane type-1 matrix metalloproteinase (MT1-MMP) protects malignant cells from tumoricidal activity of re-engineered anthrax lethal toxin

scientific article published on January 2005

Membrane type-1 matrix metalloproteinase functions as a proprotein self-convertase. Expression of the latent zymogen in Pichia pastoris, autolytic activation, and the peptide sequence of the cleavage forms

scientific article

Membrane type-1 matrix metalloproteinase stimulates tumour cell-induced platelet aggregation: role of receptor glycoproteins

scientific article published on 22 December 2003

Membrane-type-1 matrix metalloproteinase confers tumorigenicity on nonmalignant epithelial cells.

scientific article

Methylation of MGMT and ADAMTS14 in normal colon mucosa: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

scientific article published on February 2015

Mislocalization and unconventional functions of cellular MMPs in cancer.

scientific article

Molecular organization and pigment composition of R-phycoerythrin from the red alga Callithamnion rubosum

scientific article published in March 1984

Multiple forms of Bacillus subtilis subtilisin and effects of mutations on the distribution of its molecular forms

scientific article

Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in brea

scientific article

Mycoplasma CG- and GATC-specific DNA methyltransferases selectively and efficiently methylate the host genome and alter the epigenetic landscape in human cells

scientific article

NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus

scientific article published on 27 May 2009

New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay

scientific article

Nicotinic acetylcholine receptor-mediated stimulation of endothelial cells results in the arrest of haematopoietic progenitor cells on endothelium

scientific article published in April 2005

Non-proteolytic, receptor/ligand interactions associate cellular membrane type-1 matrix metalloproteinase with the complement component C1q.

scientific article published on 16 September 2004

Novel MT1-MMP Small-Molecule Inhibitors Based on Insights into Hemopexin Domain Function in Tumor Growth ⬇️

scientific article published on March 9, 2012

O-glycosylation regulates autolysis of cellular membrane type-1 matrix metalloproteinase (MT1-MMP).

scientific article published on 20 April 2006

Peptide Sequence Region That is Essential for the Interactions of the Enterotoxigenic Bacteroides fragilis Metalloproteinase II with E-cadherin.

scientific article

Potential Relation of Aberrant Proteolysis of Human Protein Tyrosine Kinase 7 (PTK7) chuzhoi by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) to Congenital Defects ⬇️

scientific article published on April 25, 2011

Prinomastat, a hydroxamate inhibitor of matrix metalloproteinases, has a complex effect on migration of breast carcinoma cells

scientific article published in May 2003

Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinase

scientific article

Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase

scientific article published on 27 November 2001

Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells

scientific article published on August 2004

Prostaglandin FP agonists alter metalloproteinase gene expression in sclera

scientific article published in December 2004

Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis

scientific article

Proteolysis of the membrane type-1 matrix metalloproteinase prodomain: implications for a two-step proteolytic processing and activation.

scientific article

Proteolysis-driven oncogenesis

scientific article

Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy

scientific article published on 04 May 2009

Purification and properties of serine protease from Halobacterium halobium ⬇️

scientific article published on August 1, 1983

Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells

scientific article

Reconstruction of an epitope capable of binding murine monoclonal antibodies NK2 within the sequence of human leukocyte interferon αF by site-directed mutagenesis ⬇️

scientific article published on June 29, 1990

Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2.

scientific article published in August 1998

Retracted: A Femtomol Range FRET Biosensor Reports Exceedingly Low Levels of Cell Surface Furin: Implications for the Processing of Anthrax Protective Antigen

retracted article

Rhodanine derivatives as selective protease inhibitors against bacterial toxins

scientific article published on 19 January 2008

Selective and potent furin inhibitors protect cells from anthrax without significant toxicity

scientific article

Sequence regions of Bacilli metalloproteinases that can affect enzyme thermostability

scientific article published on December 1, 1991

Simultaneous visualization of protumorigenic Src and MT1-MMP activities with fluorescence resonance energy transfer.

scientific article published on 2 March 2010

Specific Inhibition of Autoimmune T Cell Transmigration Contributes to β Cell Functionality and Insulin Synthesis in Non-obese Diabetic (NOD) Mice

scientific article published in Journal of Biological Chemistry

Structural and functional diversity of metalloproteinases encoded by theBacteroides fragilispathogenicity island

scientific article

Structural and functional parameters of the flaviviral protease: a promising antiviral drug target

scientific article

Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold

scientific article

Structure-based mutagenesis identifies important novel determinants of the NS2B cofactor of the West Nile virus two-component NS2B-NS3 proteinase

scientific article published in March 2008

Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

scientific article

Substrate cleavage analysis of furin and related proprotein convertases. A comparative study

scientific article published on 27 May 2008

Substrate cleavage profiling suggests a distinct function of Bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer interface

scientific article

Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens

scientific article

Targeting metalloproteins by fragment-based lead discovery

scientific article

Temperature-dependent activation of Bacillus brevis metalloprotease expressed in mesophilic Bacillus subtilis

scientific article published on 01 September 1990

The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration

scientific article

The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.

scientific article

The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase.

scientific article

The calcium-binding proteins S100A8 and S100A9 initiate the early inflammatory program in injured peripheral nerves

scientific article published on 19 March 2015

The cytoplasmic tail peptide sequence of membrane type-1 matrix metalloproteinase (MT1-MMP) directly binds to gC1qR, a compartment-specific chaperone-like regulatory protein

scientific article published in September 2002

The distribution of melanin in the developing optic cup and stalk and its relation to cellular degeneration

scientific article published on 01 November 1981

The effect of synthetic proteinase inhibitors of the level of human recombinant proinsulin production, secreted by a genetically engineered strain of Bacillus subtilis

scientific article published in July 1989

The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qR

scientific article (publication date: 15 March 2002)

The intrinsic fluorescence of the recombinant human leukocyte interferon-alpha A and fibroblast interferon-beta 1.

scientific article published in May 1990

The isolation and properties of collagenolytic proteases from crab hepatopancreas.

scientific article

The specificity of the Bacillus amyloliquefaciens intracellular serine protease: A comparison with the specificity of secretory subtilisins

scientific article published on 01 January 1981

The structure and regulation of the human and mouse matrix metalloproteinase-21 gene and protein

scientific article

The study of Escherichia coli proteases. Intracellular serine protease of E. coli-an analogue of bacillus proteases

scientific article published on February 1979

The transmembrane domain is essential for the microtubular trafficking of membrane type-1 matrix metalloproteinase (MT1-MMP).

scientific article published on 11 October 2005

Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2.

scientific article published in September 1997

Two related structural genes coding two homologous serine proteases in the Bacillus subtilis genome

scientific article published on February 1978

Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis.

scientific article published on January 2002

Virtual ligand screening of the National Cancer Institute (NCI) compound library leads to the allosteric inhibitory scaffolds of the West Nile Virus NS3 proteinase

scientific article

Visualization of leucineaminopeptidase activity after acrylamide gel electrophoresis

scientific article published on 01 August 1976

[Bacillus subtilis mutant strains, producers of alkaline proteinases]

scientific article published on 01 January 1974

[Immunologic comparison of intracellular and extracellular serine proteases from Bacillus amyloliquefaciens and some other proteases]

scientific article published on 01 July 1981

[Intercellular serine proteinases from spore-forming bacilli]

scientific article published on 01 August 1981

[Isoelectric focusing in a stable pH gradient of 1-3. The isoelectric point of swine pepsin]

scientific article

[Specific features of intracellular serine proteinase of Bacillus amyloliquefaciens on native and denatured protein substrates]

scientific article

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