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List of works by Martha Wadleigh

A Multicenter Phase II Study Using a Dose Intensified Pegylated-Asparaginase Pediatric Regimen in Adults with Untreated Acute Lymphoblastic Leukemia: A DFCI ALL Consortium Trial ⬇️

scholarly article

A Phase 1/2 Study of NS-018, an Oral JAK2 Inhibitor, in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (pPV MF), or Post-Essential Thrombocythemia Myelofibrosis (pET MF) ⬇️

scholarly article

A Phase I Study of Asciminib (ABL001) in Combination with Dasatinib and Prednisone for Untreated BCR-ABL1-Positive ALL in Older Adults ⬇️

scholarly article

A Phase II Trial of Panobinostat, an Orally Available Deacetylase Inhibitor (DACi), in Patients with Primary Myelofibrosis (PMF), Post Essential Thrombocythemia (ET), and Post Polycythemia Vera (PV) Myelofibrosis ⬇️

scholarly article

A Randomized Phase II Trial of Dasatinib 100 Mg Vs Imatinib 400 Mg In Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP): The S0325 Intergroup Trial ⬇️

scholarly article

A genome-wide aberrant RNA splicing in patients with acute myeloid leukemia identifies novel potential disease markers and therapeutic targets

scientific article published on 27 November 2013

A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms

scientific article

A phase I study of lenalidomide plus chemotherapy with mitoxantrone, etoposide, and cytarabine for the reinduction of patients with acute myeloid leukemia.

scientific article published on 9 November 2017

A phase II study of the EGFR inhibitor gefitinib in patients with acute myeloid leukemia

scientific article

A randomized trial of dasatinib 100 mg versus imatinib 400 mg in newly diagnosed chronic-phase chronic myeloid leukemia

scientific article

A randomized, double-blind study of zinpentraxin alfa in patients with myelofibrosis who were previously treated with or ineligible for ruxolitinib: Stage 2 of a phase II trial

scholarly article

Aberrant Splicing In Patients With AML Is Associated With Over- Expression Of Specific Splicing Factors ⬇️

scholarly article

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia

scientific article published in July 2015

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

scientific article

After chronic myelogenous leukemia: tyrosine kinase inhibitors in other hematologic malignancies

scientific article published on 9 September 2004

Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials

scientific article

Allogeneic transplantation is not superior to chemotherapy in most patients over 40 years of age with Philadelphia-negative acute lymphoblastic leukemia in first remission

scientific article

An Expanded Multicenter Phase I/II Study of CYT387, a JAK- 1/2 Inhibitor for the Treatment of Myelofibrosis, ⬇️

scholarly article

Assessment of Outcomes After Stopping Tyrosine Kinase Inhibitors Among Patients With Chronic Myeloid Leukemia: A Nonrandomized Clinical Trial

scientific article published on 12 November 2020

Bortezomib added to daunorubicin and cytarabine during induction therapy and to intermediate-dose cytarabine for consolidation in patients with previously untreated acute myeloid leukemia age 60 to 75 years: CALGB (Alliance) study 10502.

scientific article published on 5 November 2012

Classification and diagnosis of myeloproliferative neoplasms according to the 2008 World Health Organization criteria

scientific article published on 27 February 2010

Clinical Outcomes of Acute Promyelocytic Leukemia (APL) Patients According to FLT3 Mutation Status ⬇️

scholarly article

Clinical outcome of patients with acute promyelocytic leukemia and FLT3 mutations ⬇️

scientific article published on December 1, 2010

Comparison of autologous stem cell transplantation versus consolidation chemotherapy for patients with cytogenetically normal acute myeloid leukemia (CN‐AML) and FLT3ITD ⬇️

scientific article published on July 1, 2011

Considerations for Use of Hematopoietic Growth Factors in Patients With Cancer Related to the COVID-19 Pandemic

scientific article published on 01 September 2020

Derivation and validation of the SEER-Medicare myelodysplastic syndromes risk score (SMMRS).

scientific article

Derivative (1)t(1;19)(p13;p13) in the setting of myelofibrosis with JAK2 V617F.

scientific article published in June 2009

Design and rationale for the life after stopping tyrosine kinase inhibitors (LAST) study, a prospective, single-group longitudinal study in patients with chronic myeloid leukemia.

scientific article published on 2 April 2018

Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.

scientific article published on October 2012

ENESTnext Final Results: Deep Molecular Response (MR) with Nilotinib (NIL) in Patients (pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP) ⬇️

scholarly article

FLT3 Splice Variant (FLT3Va) As a Potential Immunotherapeutic Target in Patients with Acute Myeloid Leukemia (AML) ⬇️

scholarly article

Fit older adults with advanced myelodysplastic syndromes: who is most likely to benefit from transplant?

scientific article published on 17 November 2020

Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia

scientific article

Gemtuzumab ozogamicin-associated sinusoidal obstructive syndrome (SOS): an overview from the research on adverse drug events and reports (RADAR) project

scientific article published on 07 September 2006

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

scientific article

Geriatric Assessment Variables Add Prognostic Value to the International Prognostic Scoring System ⬇️

scholarly article

Geriatric assessment in older patients with acute myeloid leukemia: a retrospective study of associated treatment and outcomes

scientific article published on 06 June 2013

Haematopoietic cell transplantation with and without sorafenib maintenance for patients with FLT3-ITD acute myeloid leukaemia in first complete remission

scientific article published on 19 July 2016

Health care utilization and end-of-life care for older patients with acute myeloid leukemia

scientific article published on 29 April 2015

Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment ⬇️

scientific article published on November 1, 2003

HighNPM1-mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML

article

Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms

scientific article published on April 2015

IDH1 Splicing Alterations in Patients with AML and Their Relationship to Blood 2HG Levels ⬇️

scholarly article

Imatinib 800 mg daily induces deeper molecular responses than imatinib 400 mg daily: results of SWOG S0325, an intergroup randomized PHASE II trial in newly diagnosed chronic phase chronic myeloid leukaemia

scientific article

Inclusion and response criteria for clinical trials in relapsed/refractory acute lymphoblastic leukemia and usefulness of historical control trials

scientific article published in March 2017

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

scientific article published in April 2018

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis

scientific article

Intensified Chemotherapy for Older Patients with Acute Lymphoblastic Leukemia (ALL): A Phase II Study from the Dana Farber Cancer Institute (DFCI) ALL Consortium ⬇️

scholarly article

International Working Group (IWG) consensus criteria for treatment response in myelofibrosis with myeloid metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT).

scientific article

International reference analysis of outcomes in adults with B-precursor Ph-negative relapsed/refractory acute lymphoblastic leukemia

scientific article

JAK2 mutation in essential thrombocythaemia: clinical associations and long-term prognostic relevance

scientific article published on October 2005

Loss-Of-Function Mutations In The Splicing Factor ZRSR2 Are Common In Blastic Plasmacytoid Dendritic Cell Neoplasm and Have Male Predominance ⬇️

scholarly article

Low Efficacy and High Mortality Associated with Clofarabine Treatment of Patients with Acute Myeloid Leukemia and Higher-Risk Myelodysplastic Syndromes ⬇️

scholarly article

Low efficacy and high mortality associated with clofarabine treatment of relapsed/refractory acute myeloid leukemia and myelodysplastic syndromes

scientific article published on 12 December 2014

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients

scientific article published on 25 July 2006

MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia

scientific article

Myeloid Growth Factors, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

scientific article published in December 2017

Myeloid/Lymphoid Neoplasms with Eosinophilia and TK Fusion Genes, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology

scientific article published on 01 September 2020

Myeloproliferative Neoplasms, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology

scientific article

NCCN Guidelines Insights: Hematopoietic Growth Factors, Version 1.2020

scientific article published on 01 January 2020

NCCN Guidelines Insights: Myeloproliferative Neoplasms, Version 2.2018.

scientific article

NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML

scientific article

Non-hematologic predictors of mortality improve the prognostic value of the international prognostic scoring system for MDS in older adults

scientific article published on 11 June 2015

Outcome of older adults with cytogenetically normal AML (CN-AML) and FLT3 mutations ⬇️

scientific article published on June 21, 2011

Outcomes for Older Patients with Acute Myeloid Leukemia Admitted to the Intensive Care Unit ⬇️

scholarly article

Outcomes for older adults with acute myeloid leukemia after an intensive care unit admission

scientific article published on 12 July 2019

Ovarian reserve in women treated for acute lymphocytic leukemia or acute myeloid leukemia with chemotherapy, but not stem cell transplantation

scientific article

PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

scientific article

Patient-Clinician Discordance in Perceptions of Treatment Risks and Benefits in Older Patients with Acute Myeloid Leukemia

scientific article published on 23 August 2018

Patient-Reported Outcomes Associated with Different Treatments for Myelodysplastic Syndromes ⬇️

scholarly article

Patients over Age 40 with Ph-Negative Acute Lymphoblastic Leukemia Do Not Benefit from Allogeneic Transplant in First Remission. Retrospective Analysis from a Large Tertiary Center ⬇️

scholarly article

Patients' Perspectives on the Definition of Cure in Chronic Myeloid Leukemia: A US Based Survey ⬇️

scholarly article

Patients' perspectives on the definition of cure in chronic myeloid leukemia

scientific article published on 28 March 2019

Phase 1/2 Study of NS-018, an Oral JAK2 Inhibitor, in Patients with Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (postPV MF), or Post-Essential Thrombocythemia Myelofibrosis (postET MF) ⬇️

scholarly article

Phase 2 study of intensified chemotherapy and allogeneic hematopoietic stem cell transplantation for older patients with acute lymphoblastic leukemia

scientific article published on 12 May 2016

Phase I and pharmacokinetic study of bortezomib in combination with idarubicin and cytarabine in patients with acute myelogenous leukemia

scientific article published in March 2008

Phase I dose escalation study of bortezomib in combination with lenalidomide in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML).

scientific article published on 15 June 2013

Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor

scientific article published on 11 December 2013

Phase II trial of panobinostat, an oral pan‐deacetylase inhibitor in patients with primary myelofibrosis, post–essential thrombocythaemia, and post–polycythaemia vera myelofibrosis ⬇️

scientific article published on May 23, 2013

Post-transplant hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment.

scientific article published in June 2004

Potentially Avoidable Hospitalizations in Older Patients with Acute Myeloid Leukemia (AML) ⬇️

scholarly article

Potentially avoidable hospital admissions in older patients with acute myeloid leukaemia in the USA: a retrospective analysis

scientific article published on 18 May 2016

Preclinical and clinical activity of ATP mimetic JAK2 inhibitors

scientific article published on August 1, 2010

Predictive factors for all-trans retinoic acid-related differentiation syndrome in patients with acute promyelocytic leukemia ⬇️

scientific article published on 01 May 2013

Primary myelofibrosis (PMF), post polycythemia vera myelofibrosis (post-PV MF), post essential thrombocythemia myelofibrosis (post-ET MF), blast phase PMF (PMF-BP): Consensus on terminology by the international working group for myelofibrosis resear

scientific article published on 8 January 2007

Prior gemtuzumab ozogamicin exposure significantly increases the risk of veno-occlusive disease in patients who undergo myeloablative allogeneic stem cell transplantation ⬇️

scientific article (publication date: September 2003)

Prospective Cohort Study of Geriatric Assessment in Older Patients with Acute Myeloid Leukemia ⬇️

scholarly article

Quality of Life and Psychological Distress in Patients with Acute Myeloid Leukemia (AML) ⬇️

scholarly article

Quality of life and mood of older patients with acute myeloid leukemia (AML) receiving intensive and non-intensive chemotherapy

scientific article published on 28 March 2019

Rates of deep molecular response by digital and conventional PCR with frontline nilotinib in newly diagnosed chronic myeloid leukemia: a landmark analysis

scientific article published on 26 March 2019

Real-World Outcomes of Adult B-Cell Acute Lymphocytic Leukemia Patients Treated With Inotuzumab Ozogamicin

scientific article published on 19 March 2020

Real-World Outcomes of Ruxolitinib Treatment for Polycythemia Vera

scientific article published on 29 May 2020

Real-world outcomes of adult B-cell acute lymphocytic leukemia patients treated with blinatumomab

scientific article published on 01 May 2020

Relationship between physician and patient assessment of performance status and survival in a large cohort of patients with haematologic malignancies

scientific article published on 23 August 2016

Results from Ongoing Phase 2 Trial of SL-401 in Patients with Advanced, High-Risk Myeloproliferative Neoplasms Including Chronic Myelomonocytic Leukemia ⬇️

scholarly article

Results of a Phase 2 Study of Pacritinib (SB1518), a Novel Oral JAK2 Inhibitor, In Patients with Primary, Post-Polycythemia Vera, and Post-Essential Thrombocythemia Myelofibrosis ⬇️

scholarly article

Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis

scientific article

Self-reported sleep disturbance and survival in myelodysplastic syndromes

scientific article

Sequencing of novel agents in relapsed/refractory B-cell acute lymphoblastic leukemia: Blinatumomab and inotuzumab ozogamicin may have comparable efficacy as first or second novel agent therapy in relapsed/refractory acute lymphoblastic leukemia

scientific article published on 01 December 2020

Sleep Disturbance Among Patients with Myelodysplastic Syndromes and Acute Leukemia ⬇️

scholarly article

Survival after Hematopoietic Stem Cell Transplantation in an Older, Fit Cohort of Patients with Advanced Myelodysplastic Syndromes: The MDS-TAO Study ⬇️

scholarly article

Survival following allogeneic transplant in patients with myelofibrosis

scientific article published on 01 May 2020

Systemic Mastocytosis, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology

scientific article published on 01 December 2018

Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical, Clinical, and Correlative Studies ⬇️

scholarly article

Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2.

scientific article published on 16 January 2014

Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.

scientific article published in October 2005

The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates

scientific article

The JAK2(V617F) tyrosine kinase mutation in myeloproliferative disorders: Summary of published literature and a perspective

scientific article published on June 2006

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on April 2016

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

scientific article published on 11 July 2016

The burden of fatigue and quality of life in myeloproliferative disorders (MPDs): an international Internet-based survey of 1179 MPD patients.

scientific article published on January 2007

The clinical phenotype of wild-type, heterozygous, and homozygous JAK2V617F in polycythemia vera

scientific article published on February 2006

The role of myeloid growth factors in acute leukemia

scientific article published on January 2009

Thrombosis in Myeloproliferative Neoplasms Is Linked to Increased Neutrophil Extracellular Trap (NET) Formation ⬇️

scholarly article

Update On The Long-Term Efficacy and Safety Of Momelotinib, a JAK1 and JAK2 Inhibitor, For The Treatment Of Myelofibrosis ⬇️

scholarly article

Vemurafenib Has Potent Antitumor Activity in Patients with Relapsed/Refractory BRAF Mutant Hairy Cell Leukemia ⬇️

scholarly article

X-inactivation-based clonality analysis and quantitative JAK2V617F assessment reveal a strong association between clonality and JAK2V617F in PV but not ET/MMM, and identifies a subset of JAK2V617F-negative ET and MMM patients with clonal hematopoies

scientific article published on 24 January 2006

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