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List of works by Ulrich Schweizer

3,5-Diiodo-L-thyronine (3,5-t2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese mice.

scientific article

Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.

scientific article

Authentic Bosutinib Inhibits Triiodothyronine Transport by Monocarboxylate Transporter 8

scholarly article by Doreen Braun & Ulrich Schweizer published May 2014 in Thyroid

Bag1 is essential for differentiation and survival of hematopoietic and neuronal cells

scientific article

Biosynthesis of 3-Iodothyronamine From T4 in Murine Intestinal Tissue

scientific article published on 8 September 2015

CHAPTER 2. Biochemistry and Molecular Biology of Selenoproteins

scholarly article

CHAPTER 27. Selenoproteins in Brain

Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons

scientific article published on 06 March 2014

Chemie und Biologie der Schilddrüsenhormon-Biosynthese und -Wirkung

Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones

scientific article published on 25 May 2016

Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease

scientific article

Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals

scientific article published on 21 November 2007

Conditional gene ablation of Stat3 reveals differential signaling requirements for survival of motoneurons during development and after nerve injury in the adult

scientific article published on 21 January 2002

Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis

scientific article published on 6 February 2013

Cover Picture: Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones (Angew. Chem. Int. Ed. 27/2016)

scholarly article by Santanu Mondal et al published 25 May 2016 in Angewandte Chemie International Edition

Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism

scientific article

Development of a serum-free supplement for primary neuron culture reveals the interplay of selenium and vitamin E in neuronal survival

scientific article published on 2 February 2010

Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells

scientific article published on 29 December 2010

Disorders of selenium metabolism and selenoprotein function

scientific article published on August 2011

Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis?

scientific article published on 28 October 2011

Down-regulation of the hepatic selenoprotein biosynthesis machinery impairs selenium metabolism during the acute phase response in mice

scientific article published on 9 January 2009

Effect of age on sexually dimorphic selenoprotein expression in mice

scientific article published in October 2007

Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones

scientific article published on 14 September 2015

Efficient selenium transfer from mother to offspring in selenoprotein-P-deficient mice enables dose-dependent rescue of phenotypes associated with selenium deficiency

scientific journal article

Endocrine side-effects of anti-cancer drugs: thyroid effects of tyrosine kinase inhibitors

scientific article published on 15 May 2014

Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8.

scientific article published on 13 July 2010

Expression of Selenoproteins Is Maintained in Mice Carrying Mutations in SECp43, the tRNA Selenocysteine 1 Associated Protein (Trnau1ap).

scientific article published on 4 June 2015

Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8.

scientific article published in September 2005

Few Amino Acid Exchanges Expand the Substrate Spectrum of Monocarboxylate Transporter 10

scientific article published on 31 May 2016

Function of Cathepsin K in the Central Nervous System of Male Mice is Independent of Its Role in the Thyroid Gland

scientific article published on 05 December 2019

Function of thyroid hormone transporters in the central nervous system ⬇️

scientific article published on 07 August 2012

Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues

scientific article published on March 2003

Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

scientific article published on 26 May 2016

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death

scientific article

Hepatic deiodinase activity is dispensable for the maintenance of normal circulating thyroid hormone levels in mice

scientific article

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination in Sepp-knockout mice

scientific article published in February 2008

Hepatically derived selenoprotein P is a key factor for kidney but not for brain selenium supply

scientific article published on March 2005

Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium

scientific article published on 25 March 2009

High T3, Low T4 Serum Levels in Mct8 Deficiency Are Not Caused by Increased Hepatic Conversion through Type I Deiodinase

scientific article published on 23 May 2015

Histidines in potential substrate recognition sites affect thyroid hormone transport by monocarboxylate transporter 8 (MCT8).

scientific article published on 16 April 2013

Homozygous mutation in TXNRD1 is associated with genetic generalized epilepsy

scientific article

Hormone des Hypothalamus und der Hypophyse

Impaired selenoprotein expression in brain triggers striatal neuronal loss leading to co-ordination defects in mice

scientific article

Insights into molecular properties of the human monocarboxylate transporter 8 by combining functional with structural information

scientific article

Insights into the Mechanism of Human Deiodinase 1

scientific article published on 11 May 2022

Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland

scientific article

Mammalian Trit1 is a tRNA([Ser]Sec)-isopentenyl transferase required for full selenoprotein expression

scientific article published on March 2013

Membrane-traversing mechanism of thyroid hormone transport by monocarboxylate transporter 8.

scientific article

Monocarboxylate transporter 8 deficiency: altered thyroid morphology and persistent high triiodothyronine/thyroxine ratio after thyroidectomy

scientific article published on 3 August 2011

Mouse Models that Target Individual Selenoproteins

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain

scientific article published on October 2010

Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. ⬇️

scientific article published in July 2009

Neuronal and ependymal expression of selenoprotein P in the human brain

scientific article published on 25 January 2007

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

scientific journal article

New insights into the physiological actions of selenoproteins from genetically modified mice

scientific article

New insights into the structure and mechanism of iodothyronine deiodinases

scientific article

Peroxides and peroxide-degrading enzymes in the thyroid

scientific article published on September 2008

Photocrosslinking locates a binding site for the large subunit of human replication protein A to the damaged strand of cisplatin-modified DNA

scientific article

Post-transcriptional control of selenoprotein biosynthesis

scientific article published on June 2012

Ribosome profiling of selenoproteins in vivo reveals consequences of pathogenic Secisbp2 missense mutations

scientific article published on 26 July 2019

Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice

scientific article

Schilddrüsenhormone – Zentrale Regulatoren von Entwicklung, Wachstum, Grundumsatz, Stoffwechsel und Zelldifferenzierung

Secisbp2 is essential for embryonic development and enhances selenoprotein expression

scientific journal article

Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34.

scientific article published on 11 September 2007

Selenium Transport in Mammals: Selenoprotein P and Its Receptors

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis.

scientific article published on 16 December 2017

Selenium and Iodothyronine Deiodinases

Selenium and brain function: a poorly recognized liaison

article

Selenium and goiter prevalence in borderline iodine sufficiency

scientific article published in December 2006

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα

scientific article

Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic

scientific article published in August 2004

Selenium levels, selenoenzyme activities and oxidant/antioxidant parameters in H1N1-infected children.

scientific article

Selenium, selenoproteins and brain function

article

Selenium-dependent pre- and posttranscriptional mechanisms are responsible for sexual dimorphic expression of selenoproteins in murine tissues

scientific article published on 7 September 2006

Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing

scientific article published in January 2018

Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals

scientific article published on 16 May 2016

Selenoprotein Gene Nomenclature

scientific article published on 19 September 2016

Selenoprotein P

Selenoprotein P and Selenium Distribution in Mammals

Selenoprotein P is the essential selenium transporter for bones

scientific article published in May 2014

Selenoproteins in Nervous System Development, Function and Degeneration

article

Selenoproteins in Nervous System Development, Function, and Degeneration

article

Selenoproteins in brain development and function

scientific article published in 2022

Silychristin, a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8.

scientific article

Steroidhormone – Produkte von Nebennierenrinde und Keimdrüsen

Structural aspects of thyroid hormone binding to proteins and competitive interactions with natural and synthetic compounds

scientific article published on 25 January 2017

Structure and function of thyroid hormone plasma membrane transporters

scientific article published on 10 September 2014

Supplementieren oder nicht? Das Spurenelement Selen

Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent

scientific article

Synthesis and metabolism of thyroid hormones is preferentially maintained in selenium-deficient transgenic mice

scientific article published in December 2005

TNF-alpha pretreatment prevents subsequent activation of cultured brain cells with TNF-alpha and hypoxia via ceramide.

scientific article

Targeted deletion of Secisbp2 reduces, but does not abrogate, selenoprotein expression and leads to striatal interneuron loss

scientific article published in October 2014

The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome

scientific article published on 15 December 2016

The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism

scientific article published on 28 October 2011

The Ins and Outs of Steroid Hormone Transport Across the Plasma Membrane: Insight From an Insect

scientific article published on 01 February 2019

The Protein Translocation Defect of MCT8L291R Is Rescued by Sodium Phenylbutyrate

scientific article published on 08 July 2020

The RNA-binding protein Secisbp2 differentially modulates UGA codon reassignment and RNA decay.

scientific article

The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity

scientific article

The modified base isopentenyladenosine and its derivatives in tRNA.

scientific article published on 17 February 2017

The role of thioredoxin reductases in brain development

scientific article

The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice

scientific article published on February 2009

The tricyclic antidepressant desipramine inhibits T3 import into primary neurons

scientific article published on 6 May 2010

Think globally: act locally. New insights into the local regulation of thyroid hormone availability challenge long accepted dogmas.

scientific article

Thyroid Hormone Transport and Transporters

scientific article

Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia

scientific article published on 7 October 2010

Thyroid function is maintained despite increased oxidative stress in mice lacking selenoprotein biosynthesis in thyroid epithelial cells

scientific article published on 18 April 2012

Thyroid hormone transporters in the brain.

scientific article published on January 2010

Thyroid hormones-From Crystal Packing to Activity to Reactivity

scholarly article by Ulrich Schweizer & Clemens Steegborn published 11 September 2015 in Angewandte Chemie International Edition

Transport of thyroid hormone in brain

scientific article

Triterpenoid saponins from Zygophyllum decumbens

Tyrosine kinase inhibitors noncompetitively inhibit MCT8-mediated iodothyronine transport

scientific article published on 26 October 2011

Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies

scientific article published on April 2010

Wachstumshormon und Prolactin

article

Why 21? The significance of selenoproteins for human health revealed by inborn errors of metabolism.

scientific article

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