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List of works by Carmen Méndez

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis

scientific article

A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. ⬇️

scientific article

A simple method to study colony development in Streptomyces

article

ABC transporters in antibiotic-producing actinomycetes

scientific article published in 1998

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus

scientific article published on 10 June 2011

An ABC transporter is essential for resistance to the antitumor agent mithramycin in the producer Streptomyces argillaceus

scientific article published on July 1996

An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57. ⬇️

scientific article

Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis

scientific article published on 27 February 2009

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

scientific article

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate ⬇️

scientific article

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation

scientific article

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

scientific article published on 11 May 2006

Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives

scientific article

Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells

scientific article published on 4 December 2009

Chapter 11. Sugar biosynthesis and modification

scientific article published in January 2009

Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus ⬇️

scientific article

Cloning and disruption of a fragment of Streptomyces halstedii DNA involved in the biosynthesis of a spore pigment

scientific article published on March 1, 1992

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

scientific article

Combinatorial biosynthesis of antitumor indolocarbazole compounds

scientific article

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

scientific article

DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis

scientific article published on 16 November 2010

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives

scientific article published in October 2009

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

scientific article published on February 2006

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

scientific article

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity ⬇️

scientific article

Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern

scientific article published in January 2008

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships

scientific article

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

scientific article

Discovery of cryptic largimycins in Streptomyces reveals novel biosynthetic avenues enriching the structural diversity of the leinamycin family

scientific article published on 20 April 2020

Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity ⬇️

scientific article published on January 2009

Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

scientific article published in April 2005

Engineered Biosynthesis of Gilvocarcin Analogues with Altered Deoxyhexopyranose Moieties ⬇️

scientific article published on November 12, 2010

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

scientific article

Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives

scientific article

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

scientific article

Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase

scientific article published in March 2002

Engineering the glycosylation of natural products in actinomycetes

scientific article published on 6 April 2007

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences

scientific article published on 16 March 2007

Functional analysis of OleY L-oleandrosyl 3-O-methyltransferase of the oleandomycin biosynthetic pathway in Streptomyces antibioticus ⬇️

scientific article

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis

scientific article published on September 2008

Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus

scientific article published on April 2004

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

scientific article

Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.

scientific article published in September 2004

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

scientific article published on March 2008

Glycosyltransferases, important tools for drug design

scientific article published on January 2008

Heterologous reconstitution of the biosynthesis pathway for 4-demethyl-premithramycinone, the aglycon of antitumor polyketide mithramycin

scientific article published on 24 May 2020

Hybridization and DNA sequence analyses suggest an early evolutionary divergence of related biosynthetic gene sets encoding polyketide antibiotics and spore pigments in Streptomyces spp.

scientific article published on August 1993

Identification and expression of genes involved in biosynthesis of L-oleandrose and its intermediate L-olivose in the oleandomycin producer Streptomyces antibioticus

scientific article

Identification of a growth phase-dependent promoter in the rplJL operon of Streptomyces coelicolor A3(2)

scientific article published on 01 January 2001

Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycin ⬇️

scientific article

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

scientific article published in August 2008

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

scientific article published on 15 July 2008

Indolocarbazole antitumour compounds by combinatorial biosynthesis

scientific article published on 27 February 2009

Indolocarbazole natural products: occurrence, biosynthesis, and biological activity

scientific article

Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes

scientific article

Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis

scientific article published on 01 September 2007

Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis ⬇️

scientific article published on 22 February 2010

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

scientific article

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov ⬇️

scientific article published on February 2002

Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

scientific article published on 4 August 2006

Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells

scientific article

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis ⬇️

scientific article published on May 14, 2003

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity ⬇️

scientific article published on 15 January 2008

Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis

scientific article published on 20 February 2009

Molecular insights on the biosynthesis of antitumour compounds by actinomycetes

scientific article

Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya ⬇️

scientific article published on 24 January 2011

Novel Hybrid Tetracenomycins through Combinatorial Biosynthesis Using a Glycosyltransferase Encoded by theelmGenes in Cosmid 16F4 and Which Shows a Broad Sugar Substrate Specificity

article

Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin ⬇️

scientific article

Parallel pathways for oxidation of 14-membered polyketide macrolactones in Saccharopolyspora erythraea

scientific article published in May 2002

Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus ⬇️

scientific article published on 22 June 2012

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

scientific article published on April 2010

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways

scientific article published in May 2002

Reactome array: forging a link between metabolome and genome

scientific article published on October 2009

Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.

scientific article

Separation of anti-angiogenic and cytotoxic activities of borrelidin by modification at the C17 side chain

scientific article published on 8 September 2006

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus ⬇️

scientific article published in August 2004

The Biosynthesis of Aureolic Acid Group Antibiotics

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya ⬇️

scientific article (publication date: April 2003)

The Structure of Mithramycin Reinvestigated

scientific article (publication date: 1999)

The Volatile Organic Compounds of Streptomyces spp.: An In-Depth Analysis of Their Antifungal Properties

scientific article published in 2023

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives

scientific article published on 30 September 2006

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

scientific article published in April 2002

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

scientific article published on 18 November 2010

The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

scientific article published in February 2001

Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.

scientific article

Topological studies of the membrane component of the OleC ABC transporter involved in oleandomycin resistance in Streptomyces antibioticus.

scientific article

Transcriptional organization of ThnI-regulated thienamycin biosynthetic genes in Streptomyces cattleya.

scientific article published on 22 January 2010

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches. ⬇️

scientific article

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