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List of works by Alfredo F. Braña

A Novel Mithramycin Analogue with High Antitumor Activity and Less Toxicity Generated by Combinatorial Biosynthesis ⬇️

scientific article published on June 7, 2012

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus

scientific article published on 10 June 2011

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster

scientific article

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate ⬇️

scientific article

Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation

scientific article

Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues

scientific article published on 11 May 2006

Characterization of Two Polyketide Methyltransferases Involved in the Biosynthesis of the Antitumor Drug Mithramycin by Streptomyces argillaceus ⬇️

scientific article published in Journal of Biological Chemistry

Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus ⬇️

scientific article

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses

scientific article

Combinatorial biosynthesis of antitumor indolocarbazole compounds

scientific article

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins

scientific article

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives

scientific article published in October 2009

Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species

scientific article published on February 2006

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase

scientific article

Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity ⬇️

scientific article

Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp ⬇️

scientific article published on 12 February 2019

Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT.

scientific article

Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity ⬇️

scientific article published on January 2009

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

scientific article

Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds

scientific article

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis

scientific article published on September 2008

Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus

scientific article published on April 2004

Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles

scientific article

Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.

scientific article published in September 2004

Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity

scientific article published on March 2008

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

scientific article published in August 2008

Independent and interactive association of blood antioxidants and oxidative damage in elderly people.

scientific article published in August 2002

Insights in the glycosylation steps during biosynthesis of the antitumor anthracycline cosmomycin: characterization of two glycosyltransferase genes

scientific article

Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin

scientific article

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal nov ⬇️

scientific article published on February 2002

Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activity ⬇️

scientific article published on May 11, 2012

Mithramycin SK, A Novel Antitumor Drug with Improved Therapeutic Index, Mithramycin SA, and Demycarosyl-mithramycin SK: Three New Products Generated in the Mithramycin Producer Streptomyces argillaceus through Combinatorial Biosynthesis ⬇️

scientific article published on May 14, 2003

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity ⬇️

scientific article published on 15 January 2008

Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis

scientific article published on 20 February 2009

Mutational Analysis of the Thienamycin Biosynthetic Gene Cluster from Streptomyces cattleya ⬇️

scientific article published on January 24, 2011

Novel Hybrid Tetracenomycins through Combinatorial Biosynthesis Using a Glycosyltransferase Encoded by theelmGenes in Cosmid 16F4 and Which Shows a Broad Sugar Substrate Specificity

article

Oxidative cleavage of premithramycin B is one of the last steps in the biosynthesis of the antitumor drug mithramycin

scientific article published in January 1999

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways

scientific article published in May 2002

Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis.

scientific article

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus ⬇️

scientific article published in August 2004

The Biosynthetic Gene Cluster for the β-Lactam Carbapenem Thienamycin in Streptomyces cattleya ⬇️

scientific article (publication date: April 2003)

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives

scientific article published in April 2002

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin

scientific article published on 18 November 2010

The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties

scientific article published in February 2001

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