List of works - Wataru Araki

A family of membrane proteins associated with presenilin expression and γ-secretase function

A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein

scientific article published on 4 January 2007

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis

scientific article

Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein

scientific article published on 19 March 2005

Altered localization of amyloid precursor protein under endoplasmic reticulum stress

scientific article published on 5 April 2006

Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

scientific article

Amyloid beta peptide binds a novel death-inducing protein, AB-DIP.

scientific article

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons

scientific article

Autoreactive‐Aβ antibodies promote APP β‐secretase processing ⬇️

scientific article published on January 23, 2012

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif

scientific article published on January 2006

Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice

scientific article

Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth.

scientific article published on October 1997

Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line

scientific article published on February 1994

ER-stress-inducible Herp, facilitates the degradation of immature nicastrin

scientific journal article

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

scientific article published on March 2007

Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.

scientific article published on January 2004

Expression of reticulon 3 in Alzheimer's disease brain.

scientific article

Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.

scientific article

Extracellular release of BACE1 holoproteins from human neuronal cells

scientific article published on 13 October 2005

Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene

scientific article published in July 2001

Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease

scientific article published in June 2005

How is membrane phospholipid biosynthesis controlled in neural tissues?

scientific article published on March 1998

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex

scientific article

IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.

scientific article

Identification and characterization of a novel human APH-1b splice variant lacking exon 4

scientific article published on 01 May 2005

Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells

scientific article published in May 1998

LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).

scientific article

Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.

scientific article published on 13 March 2017

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.

scientific article published in February 2000

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

scientific article

Neuronal β‐amyloid generation is independent of lipid raft association of β‐secretase BACE1: analysis with a palmitoylation‐deficient mutant ⬇️

scientific article published on May 1, 2012

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

scientific article

Post-translational regulation of the β-secretase BACE1.

scientific article published on 13 April 2016

Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease

scientific article published in August 1991

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

scientific article

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

scientific article published on 30 April 2009

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders

scientific article published on 22 September 2017

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex

scientific article published in January 2006

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

scientific article published on 8 September 2006

Secretion kinetics of Alzheimer's amyloid beta-protein differs from secreted beta-amyloid precursor protein

scientific article

Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons

scientific article published on 28 December 2012

TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons

scientific article published on 21 January 2019

The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line

scientific article published on November 1994

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.

scientific article published on 31 January 2017

The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1.

scientific article published on October 2009

Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture

scientific article published on November 1991

List of works by Wataru Araki

A family of membrane proteins associated with presenilin expression and γ-secretase function

A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis

Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein

Altered localization of amyloid precursor protein under endoplasmic reticulum stress

Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain.

Amyloid beta peptide binds a novel death-inducing protein, AB-DIP.

Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons

Autoreactive‐Aβ antibodies promote APP β‐secretase processing ⬇️

Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif

Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice

Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth.

Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line

ER-stress-inducible Herp, facilitates the degradation of immature nicastrin

Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides.

Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.

Expression of reticulon 3 in Alzheimer's disease brain.

Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes.

Extracellular release of BACE1 holoproteins from human neuronal cells

Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene

Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease

How is membrane phospholipid biosynthesis controlled in neural tissues?

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex

IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.

Identification and characterization of a novel human APH-1b splice variant lacking exon 4

Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells

LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3).

Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein.

Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function.

Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model

Neuronal β‐amyloid generation is independent of lipid raft association of β‐secretase BACE1: analysis with a palmitoylation‐deficient mutant ⬇️

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells.

Post-translational regulation of the β-secretase BACE1.

Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease

Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons

Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor.

Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders

Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex

Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.

Secretion kinetics of Alzheimer's amyloid beta-protein differs from secreted beta-amyloid precursor protein

Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons

TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons

The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line

The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model.

The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1.

Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture