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List of works by Bryan Maloney

A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling.

scientific article

Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

scientific article published on January 2008

BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation

scientific article published on January 2006

Challenges in creating a vaccine to prevent hepatitis E.

scientific article published in March 2005

Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease.

scientific article published on 9 February 2005

Characterization of the human beta-secretase 2 (BACE2) 5'-flanking region: identification of a 268-bp region as the basal BACE2 promoter

scientific article

Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease

scientific article published on 22 December 2004

Construction of recombinant avian infectious laryngotracheitis virus expressing the beta-galactosidase gene and DNA sequencing of the insertion region

scientific article published on August 1994

Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

scientific article published on 25 February 2004

Correction: Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease

scientific article published on 02 March 2020

Development and validation of the high-quality 'rapid method for swab' to genotype the HTTLPR serotonin transporter (SLC6A4) promoter polymorphism

scientific article

Do epigenetic pathways initiate late onset Alzheimer disease (LOAD): towards a new paradigm.

scientific article published on June 2012

Early-emerging cognitive vulnerability to depression and the serotonin transporter promoter region polymorphism

scientific article published on 04 September 2007

Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model.

scientific article published on 31 July 2008

Epigenetics of dementia: understanding the disease as a transformation rather than a state.

scientific article published on 9 May 2016

Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain

scientific article published on 16 February 2006

Functional activity of the novel Alzheimer's amyloid β-peptide interacting domain (AβID) in the APP and BACE1 promoter sequences and implications in activating apoptotic genes and in amyloidogenesis

scientific article

Functional characterization of the 5' flanking region of the BACE gene: identification of a 91 bp fragment involved in basal level of BACE promoter expression

scientific article published on April 2004

Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions

scientific article

Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells

scientific article published on January 2006

Gene structure and organization of the human beta-secretase (BACE) promoter.

scientific article published on April 2004

Gene × environment interaction by a longitudinal epigenome-wide association study (LEWAS) overcomes limitations of genome-wide association study (GWAS)

scientific article

Genes are not our destiny: the somatic epitype bridges between the genotype and the phenotype

article

How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD.

scientific article published on April 2007

How autism and Alzheimer's disease are TrAPPed

scientific article published on 12 November 2020

Important differences between human and mouse APOE gene promoters: limitation of mouse APOE model in studying Alzheimer's disease.

scientific article published on 8 September 2007

Late-onset Alzheimer's disease, heating up and foxed by several proteins: pathomolecular effects of the aging process.

scientific article

Latent consequences of early-life lead (Pb) exposure and the future: Addressing the Pb crisis

scientific article published on 05 July 2018

Lessons from a BACE1 inhibitor trial: off-site but not off base.

scientific article

Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice

scientific article published on January 2009

Lithium alters expression of RNAs in a type-specific manner in differentiated human neuroblastoma neuronal cultures, including specific genes involved in Alzheimer's disease

scientific article published on 04 December 2019

M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera

scientific article published on 30 September 2019

Mechanism of promoter activity of the beta-amyloid precursor protein gene in different cell lines: identification of a specific 30 bp fragment in the proximal promoter region

scientific article published on September 2004

MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties

scientific article published on 15 January 2020

NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells

scientific article

Novel roles of amyloid-beta precursor protein metabolites in fragile X syndrome and autism.

scientific article published on 30 August 2016

Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease

scientific article published on 23 November 2018

Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease

scientific article

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

scientific article (publication date: 31 January 2013)

Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease

scientific article published on 03 February 2020

Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants.

scientific article published on 4 January 2011

Structural and functional characterization of H2 haplotype MAPT promoter: unique neurospecific domains and a hypoxia-inducible element would enhance rationally targeted tauopathy research for Alzheimer's disease.

scientific article

Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors

scientific article published on December 2006

Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study

scientific article published in June 2007

The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps

scientific article

The "LEARn" (latent early-life associated regulation) model: an epigenetic pathway linking metabolic and cognitive disorders

scientific article published on January 1, 2012

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif

scientific article

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases

scientific article published in November 2009

The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.

scientific article published on 26 September 2006

Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing

scientific article published on March 2008

Transgenerational latent early-life associated regulation unites environment and genetics across generations

scientific article published on 7 March 2016

Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses

scientific article

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