List of works - Cristine Alves da Costa

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

scientific article published on 7 February 2006

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

scientific article

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

scientific article published on 22 October 2002

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

scientific article published on November 1998

Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism? ⬇️

scientific article published on October 20, 2010

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

scientific article published on March 2006

Direct α-synuclein promoter transactivation by the tumor suppressor p53.

scientific article published on 2 February 2016

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

scientific article published on 27 February 2013

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

scientific article published on 06 May 2013

Interplay between parkin and p53 governs a physiological homeostasis that is disrupted in Parkinson's disease and cerebral cancer.

scientific article published on 04 September 2013

JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway

scientific article

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

scientific article published on November 2003

Neprilysin activity and expression are controlled by nicastrin

scientific article

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

scientific article published on May 2001

Nuclear TP53: An unraveled function as transcriptional repressor of PINK1

scientific article published on 11 May 2018

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

scientific article

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies

scientific article published on December 2002

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.

scientific article

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

scientific article

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

scientific article published on June 2006

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

scientific journal article

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells

scientific article

Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases

scientific article published on 15 September 2017

Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels

scientific article published on 21 October 2003

Recent advances on alpha-synuclein cell biology: functions and dysfunctions.

scientific article

Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554

article

Role of the proteasome in Alzheimer’s disease

Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

scientific article

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

scientific article

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

scientific article

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology

scientific article published on 17 November 2020

The Transcription Factor Function of Parkin: Breaking the Dogma

scientific article published on 01 January 2018

The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells

scientific article

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

scientific article published on September 2007

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity

scientific article published on 2 February 2007

p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex

scientific article

p53-dependent control of transactivation of the Pen2 promoter by presenilins

scientific article

α-synuclein and p53 functional interplay in physiopathological contexts.

scientific article published on 30 December 2016

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

scientific article published on 3 May 2017

List of works by Cristine Alves da Costa

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism? ⬇️

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins

Direct α-synuclein promoter transactivation by the tumor suppressor p53.

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

Glioma tumor grade correlates with parkin depletion in mutant p53-linked tumors and results from loss of function of p53 transcriptional activity.

Interplay between parkin and p53 governs a physiological homeostasis that is disrupted in Parkinson's disease and cerebral cancer.

JLK inhibitors: isocoumarin compounds as putative probes to selectively target the gamma-secretase pathway

JLK isocoumarin inhibitors: selective gamma-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

Neprilysin activity and expression are controlled by nicastrin

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

Nuclear TP53: An unraveled function as transcriptional repressor of PINK1

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti-PrP antibodies

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.

Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells

Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases

Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels

Recent advances on alpha-synuclein cell biology: functions and dysfunctions.

Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554

Role of the proteasome in Alzheimer’s disease

Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology

The Transcription Factor Function of Parkin: Breaking the Dogma

The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity

p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex

p53-dependent control of transactivation of the Pen2 promoter by presenilins

α-synuclein and p53 functional interplay in physiopathological contexts.

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models