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List of works by Emmanuel Mikros

(1)H NMR metabonomic analysis in renal cell carcinoma: a possible diagnostic tool

scientific article published in August 2010

(1)H NMR-based metabonomic investigation of the effect of two different exercise sessions on the metabolic fingerprint of human urine

scientific article published on 2 November 2010

1-Ethyl-1H-3-nitrobenzopyrano[4,3,2-cd]isoindole: a novel heterocyclic ring system bearing an unusually labile deuterium-exchangeable aromatic proton

1H NMR Study on the Short- and Long-Term Impact of Two Training Programs of Sprint Running on the Metabolic Fingerprint of Human Serum

scientific article published on 11 December 2012

1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics

scientific article published on 31 January 2007

1H NMR-MS-based heterocovariance as a drug discovery tool for fishing bioactive compounds out of a complex mixture of structural analogues

scientific article published on 31 July 2019

1H NMR-based metabonomics approach in a rat model of acute liver injury and regeneration induced by CCl4 administration

scientific article

1H NMR-based metabonomics for the classification of Greek wines according to variety, region, and vintage. Comparison with HPLC data

scientific article

1H NMR-based metabonomics for the diagnosis of inborn errors of metabolism in urine

1H and13C NMR spectral assignments of some phenothiazine derivatives

1H-NMR Spectroscopic Elucidation of Stereochemical Effects of Substituted Cerium Porphyrin Double-Deckers

6-Br-5methylindirubin-3'oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: exploitation of GSK-3 for treating leishmaniasis

scientific article published on 13 May 2009

A Novel Quantitative Method for the Detection of Lipofuscin, the Main By-Product of Cellular Senescence, in Fluids

scientific article published on 01 January 2019

A facile consensus ranking approach enhances virtual screening robustness and identifies a cell-active DYRK1α inhibitor

scientific article published on 16 October 2018

A new class of phytoestrogens; evaluation of the estrogenic activity of deoxybenzoins.

scientific article published on March 2004

A new process for the management of olive oil mill waste water and recovery of natural antioxidants

scientific article

A pilot case-control study of urine metabolomics in preterm neonates with necrotizing enterocolitis

scientific article published on 08 April 2019

A substrate translocation trajectory in a cytoplasm-facing topological model of the monocarboxylate/H⁺ symporter Jen1p

scientific article

Acute liver acetaminophen toxicity in rabbits and the use of antidotes: a metabonomic approach in serum

scientific article

Alteration in the liver metabolome of rats with metabolic syndrome after treatment with Hydroxytyrosol. A Mass Spectrometry And Nuclear Magnetic Resonance - based metabolomics study

scientific article

An Integrated Computational Approach to the Phenomenon of Potent and Selective Inhibition of Aurora Kinases B and C by a Series of 7-Substituted Indirubins

scientific article published on 01 August 2007

An Overview of Metabolic Phenotyping in Blood Pressure Research

scientific article published on 10 July 2018

An inhibitor-driven study for enhancing the selectivity of indirubin derivatives towards leishmanial Glycogen Synthase Kinase-3 over leishmanial cdc2-related protein kinase 3

scientific article

Analysis of PPAR-α/γ Activity by Combining 2-D QSAR and Molecular Simulation

scientific article published on 15 April 2013

Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.

scientific article published on 20 July 2015

Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood. ⬇️

scientific article

Application of NMR-based metabonomics in the investigation of myocardial ischemia-reperfusion, ischemic preconditioning and antioxidant intervention in rabbits

scientific article published on 02 December 2006

Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats

scientific article

Application of nuclear magnetic resonance spectroscopy combined with principal component analysis in detecting inborn errors of metabolism using blood spots: a metabonomic approach

Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?

Combination of FCPC and NMR for the activity-guided isolation of skin whitening natural agents

Combined Virtual and Experimental Screening for CK1 Inhibitors Identifies a Modulator of p53 and Reveals Important Aspects of in Silico Screening Performance

scientific article published on 6 October 2017

Computer simulation of histo-blood group oligosaccharides: energy maps of all constituting disaccharides and potential energy surfaces of 14 ABH and Lewis carbohydrate antigens

scientific article published on 01 June 1995

Conformational Analysis of Ochratoxin A by NMR Spectroscopy and Computational Molecular Modeling

scientific article published on 01 September 2005

Conformational Analysis of Poly(N-vinylcarbazole) by NMR Spectroscopy and Molecular Modeling

Conformational Analysis of a Complex BetweenDolichos biflorusLectin and the Forssman Pentasaccharide Using Transferred NOE Build-Up Curves

article published in 1998

Conformational Analysis ofC-Disaccharides using Molecular Mechanics Calculations

article published in 2000

Conformational Analysis ofC‐Trehaloses Using Molecular Mechanics Calculations

Conformational analysis of asperlin by NMR spectroscopy and molecular modeling

Conformational analysis of peptide analogues of silkmoth chorion protein segments using CD, NMR and molecular modelling

scientific article

Conformational properties of the macrocyclic trichothecene mycotoxin verrucarin A in solution

scientific article published in December 2008

Could multivariate statistics exploit HPTLC and NMR data to reveal bioactive compounds? The case of Paeonia mascula

Cryptic purine transporters in Aspergillus nidulans reveal the role of specific residues in the evolution of specificity in the NCS1 family

scientific article

Cytosolic N- and C-Termini of the Aspergillus nidulans FurE Transporter Contain Distinct Elements that Regulate by Long-Range Effects Function and Specificity

scientific article published on 12 July 2019

Deoxybenzoins are novel potent selective estrogen receptor modulators.

scientific article

Design and synthesis of new C-nucleosides as potential adenosine deaminase inhibitors

article published in 2010

Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter

scientific article published on 22 September 2016

Design, synthesis and biological evaluation of novel substituted purine isosters as EGFR kinase inhibitors, with promising pharmacokinetic profile and in vivo efficacy

scientific article published on 08 May 2019

Design, synthesis and molecular simulation studies of dihydrostilbene derivatives as potent tyrosinase inhibitors

scientific article published on 14 July 2012

Detection of interactions of the beta-amyloid peptide with small molecules employing transferred NOEs.

scientific article published in June 2009

Differential estrogen receptor subtype modulators: assessment of estrogen receptor subtype-binding selectivity and transcription-regulating properties of new cycloalkyl pyrazoles

scientific article published on 20 September 2009

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

scientific article

Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme

scientific article published on 07 December 2016

Discovery of the glycogen phosphorylase-modulating activity of a resveratrol glucoside by using a virtual screening protocol optimized for solvation effects

scientific article published on 15 April 2015

Effects of the olive tree leaf constituents on myocardial oxidative damage and atherosclerosis

scientific article published on 27 May 2015

Erratum to ‘Exploring and exploiting the systemic effects of deregulated replication licensing’ [Seminars in Cancer Biology 37–38C, (2016) 3–15]

scientific article published on 21 February 2017

Erythroidine alkaloids: a novel class of phytoestrogens.

scientific article published on July 2014

Estrogenic activity of isoflavonoids from Onobrychis ebenoides.

scientific article published on May 2006

Estrogenic activity of isoflavonoids from the stem bark of the tropical tree Amphimas pterocarpoides, a source of traditional medicines.

scientific article published on 16 December 2015

Exploring and exploiting the systemic effects of deregulated replication licensing

scientific article published on 17 December 2015

From bench to bedside, via desktop. Recent advances in the application of cutting-edge in silico tools in the research of drugs targeting bromodomain modules

scientific article published in 2019

Glycyrrhiza glabra-Enhanced Extract and Adriamycin Antiproliferative Effect on PC-3 Prostate Cancer Cells

scientific article published on 05 July 2019

Heterocovariance Based Metabolomics as a Powerful Tool Accelerating Bioactive Natural Product Identification

High-Resolution NMR Spectroscopy of the beta-Amyloid(1-28) Fibril Typical for Alzheimer's Disease

scientific article published on 01 October 2001

How do antibodies and lectins recognize histo-blood group antigens? A 3D-QSAR study by comparative molecular field analysis (CoMFA).

scientific article

Hydroxytyrosol (HT) Analogs Act as Potent Antifungals by Direct Disruption of the Fungal Cell Membrane

scientific article published in 2018

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

scientific article published on 10 December 2018

Identification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) family

scientific article

In Silico Screening of Compound Libraries Using a Consensus of Orthogonal Methodologies

scientific article published on 01 January 2018

Indirubin Analogues Inhibit Trypanosoma brucei Glycogen Synthase Kinase 3 Short and T. brucei Growth

scientific article published on 24 May 2019

Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli.

scientific article published on 13 February 2018

Interactions of a series of novel spiropyranocoumarin derivatives with reactive oxygen species

scientific article published in July 2003

Interactions of water-soluble zinc porphyrin with amino acids

Investigating the Effect of Antioxidant Treatment on the Protective Effect of Preconditioning in Anesthetized Rabbits

scientific article published on 01 December 2011

LiSIs: An Online Scientific Workflow System for Virtual Screening

scientific article published on January 2015

Losartan's molecular basis of interaction with membranes and AT1 receptor.

scientific article published in September 2003

Megistosarcimine and megistosarconine, two alkaloids from Sarcomelicope megistophylla

scientific article published on 01 December 1999

Melatonin does not prevent the protection of ischemic preconditioning in vivo despite its antioxidant effect against oxidative stress

scientific article published in August 2004

Metabonomic identification of novel biomarkers in doxorubicin cardiotoxicity and protective effect of the natural antioxidant oleuropein

scientific article published in July 2009

Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter

scientific article published on 11 September 2012

Modelling, substrate docking and mutational analysis identify residues essential for function and specificity of the major fungal purine transporter AzgA

scientific article published in 2014

Mutational Analysis and Modeling Reveal Functionally Critical Residues in Transmembrane Segments 1 and 3 of the UapA Transporter

article

NMR Studies of Inborn Errors of Metabolism

NMR study of 5-substituted pyrazolo[3,4-c]pyridine derivatives

NMR-Based Metabolic Profiling Procedures for Biofluids and Cell and Tissue Extracts.

scientific article published in January 2018

NMR-Based Metabolomic Study on Isatis tinctoria: Comparison of Different Accessions, Harvesting Dates, and the Effect of Repeated Harvesting

scientific article published on 6 May 2015

Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.

scientific article published on 11 October 2016

NmeA, a novel efflux transporter specific for nucleobases and nucleosides, contributes to metal resistance in Aspergillus nidulans

scientific article published on 16 May 2017

Novel Carbonyl Analogs of Tamoxifen: Design, Synthesis, and Biological Evaluation

scientific article

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases

scientific article published on November 2012

Novel indole–flutimide heterocycles with activity against influenza PA endonuclease and hepatitis C virus

Oleuropein prevents doxorubicin-induced cardiomyopathy interfering with signaling molecules and cardiomyocyte metabolism

scientific article published on 28 January 2014

Origin, diversification and substrate specificity in the family of NCS1/FUR transporters

scientific article published on 7 April 2015

Prevezols A and B: new brominated diterpenes from the red alga Laurencia obtusa

article by Nikos Mihopoulos et al published May 2001 in Tetrahedron Letters

Quantitative treatment of the rotational dynamics of flexible-chain molecules.13C NMR relaxation study of hydrocarbon chains attached to the fluorene anchor

Recent advances and new strategies in the NMR-based identification of natural products

scientific article published on 04 September 2013

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

scientific article

Sample preparation issues in NMR-based plant metabolomics: optimisation for Vitis wood samples

scientific article

Scaffold hybridization strategy towards potent hydroxamate-based inhibitors of Flaviviridae viruses and Trypanosoma species

scientific article published on 16 May 2019

Screening of Heteroaromatic Scaffolds against Cystathionine Beta-Synthase Enables Identification of Substituted Pyrazolo[3,4-c]Pyridines as Potent and Selective Orthosteric Inhibitors

scientific article published on 16 August 2020

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of

scientific article published on 10 August 2016

Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights

scientific article published in March 2018

Silymarin Enriched Extract (Silybum marianum) Additive Effect on Doxorubicin-Mediated Cytotoxicity in PC-3 Prostate Cancer Cells

scientific article published on 09 July 2019

Small molecules discovery from marine organisms and microorganisms: A new pipeline combing LC-HRMS and NMR metabolomics

Soluble 3',6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period

scientific article published on 25 September 2008

Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease

scientific article published on 23 August 2006

Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity

scientific article

Structural Study by NMR of an Oxorhenium−RGD Decapeptide Complex for Application in Radiotherapy

scientific article published on 01 September 2004

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

scientific article published in February 2004

Structural characteristics of some mercaptoacetic acid hydrazides

Structural studies of metalloporphyrins. Part XIa: Complexes of water-soluble zinc(II) porphyrins with amino acids: influence of ligand-ligand interactions on the stability of the complexes

scientific article

Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.

scientific article published on 18 April 2016

Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analogues

scientific article published on 18 June 2018

Structure-activity relationships of alphaIIb 313-320 derived peptide inhibitors of human platelet aggregation

scientific article published in November 2008

Synthesis and characterization of homo- and heteroporphyrin dimers involving a rhodium-indium bond

scholarly article by A.G. Coutsolelos et al published February 1996 in Polyhedron

Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines

Synthesis of 1,2-annulated adamantane heterocycles: structural determination studies of a bioactive cyclic sulfite

Synthesis, Docking Study and Kinase Inhibitory Activity of a Number of New Substituted Pyrazolo[3,4-c]pyridines

scientific article published on January 2017

Synthesis, conformational analysis and free radical scavenging activity of some new spiropyranoquinolinones

scientific article published in May 2003

Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones

scientific article

Tales of tails in transporters

scientific article published on 19 June 2019

Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation.

scientific article

The Ac-RGD-NH2 peptide as a probe of slow conformational exchange of short linear peptides in DMSO.

scientific article

The Aspergillus nidulans proline permease as a model for understanding the factors determining substrate binding and specificity of fungal amino acid transporters

scientific article

The Indirubin Derivative 6-Bromoindirubin-3'-Oxime Activates Proteostatic Modules, Reprograms Cellular Bioenergetic Pathways, and Exerts Antiaging Effects

scientific article

The Synthesis of a Novel C-Nucleoside Designed as Guanosine Analogue

The Use of Oleuropein on Myocardium

The estrogen receptor and polyphenols: molecular simulation studies of their interactions, a review

article

The natural olive constituent oleuropein induces nutritional cardioprotection in normal and cholesterol-fed rabbits: comparison with preconditioning

scientific article published on 4 December 2014

The olive constituent oleuropein exhibits anti-ischemic, antioxidative, and hypolipidemic effects in anesthetized rabbits.

scientific article

The olive constituent oleuropein, as a PPARα agonist, markedly reduces serum triglycerides

scientific article published on 05 June 2018

Urine metabolomics in neonates with late-onset sepsis in a case-control study

scientific article published on 04 April 2017

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