List of works - Boris Schmidt

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease

scientific article

3-[2,6-Bis(diethylcarbamoyl)pyridin-4-yl]-N-(tert-butoxycarbonyl)alanine methyl ester: a chiral tridentate ligand that causes a diastereomeric excess of its lanthanide complexes in solution.

scientific article

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

scientific article

A frame shifted disulfide bridged analogue of angiotensin II

scientific article published on 01 March 2003

Amyloid plaque formation precedes dendritic spine loss ⬇️

scientific article published on September 21, 2012

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

scientific article published in May 2012

Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

scientific article

Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

scientific article published in April 2002

Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release

scientific article published on 04 April 2007

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

scientific article

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models

scientific article published on 31 August 2012

Cell-Based Optimization of Covalent Reversible Ketoamide Inhibitors Bridging the Unprimed to the Primed Site of the Proteasome β5 Subunit

scientific article published on 12 November 2019

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells

scientific article published on August 2006

Complexation of copper(II)-Chelidamate: A multifrequency-pulsed electron paramagnetic resonance and electron nuclear double resonance analysis

scientific article published on 01 October 2006

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors.

scientific article published on 2 September 2014

Computer-guided design, synthesis, and biological evaluation of quinoxalinebisarylureas as FLT3 inhibitors

scientific article published on 10 February 2015

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor

scientific article published on 6 August 2007

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

scientific article

Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms

scientific article published on 09 September 2009

Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism.

scientific article published on January 2007

Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

scientific article published in January 2008

DOCKTITE-a highly versatile step-by-step workflow for covalent docking and virtual screening in the molecular operating environment

scientific article published on 16 January 2015

Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.

scientific article published on 16 April 2013

Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers

scientific article published in January 2008

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

scientific article (publication date: 2013)

Development of tau aggregation inhibitors for Alzheimer's disease

scientific article

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.

scientific article published on 29 November 2017

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.

scientific article published on 9 February 2018

Drug development and PET-diagnostics for Alzheimer's disease.

scientific article

Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model.

scientific article published on 10 September 2016

EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis

scientific article published on 8 March 2007

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome's β5 Catalytic Subunit

scientific article

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

scientific article published on January 10, 2011

Ensemble-Docking Approach on BACE-1: Pharmacophore Perception and Guidelines for Drug Design

scholarly article by Vittorio Limongelli et al published 11 June 2007 in ChemMedChem

Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design

scientific article published in May 2007

Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa

scientific article published on 12 November 2018

Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.

scientific article published on 27 June 2013

Fmoc protected peptide mimetic based on a cyclohexane framework and incorporation into angiotensin II

Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions

scientific article published on 15 October 2012

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

scientific article published on May 2012

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model

scientific article

Improved synthesis of ADAM10 inhibitor GI254023X.

scientific article

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.

scientific article

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

scientific article published on 4 March 2010

Inhibitors and modulators of beta- and gamma-secretase

scientific article

Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease

scientific article published on 07 September 2018

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice

scientific article

Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation

scientific article published on 24 October 2013

Membrane anchoring γ-secretase modulators with terpene-derived moieties

scientific article

Memory trace interference impairs recall in a mouse model of Alzheimer's disease

scientific article published on 08 June 2020

Methyltrioxorhenium - from oxidation and cyclopropanation to metathesis

Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3.

scientific article

Modulators and inhibitors of gamma- and beta-secretases.

scientific article published on January 2006

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

scientific article published on 30 October 2019

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

scientific article published in January 2011

NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.

scientific article published on 13 October 2009

NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.

scientific article

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

scientific article published on 8 August 2007

Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites

scientific article published on 19 December 2005

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

scientific article

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.

scientific article

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

scientific article

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

scientific article

Structure-based optimization of oxadiazole-based GSK-3 inhibitors.

scientific article

Substrate-targeting gamma-secretase modulators

scientific article published on June 2008

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

scientific article

Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.

scientific article published on 25 September 2013

Synthesis of tetramic and tetronic acids as beta-secretase inhibitors

scientific article published in July 2006

Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade

scientific article

Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations

scientific article published on 25 February 2019

List of works by Boris Schmidt

2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease

3-[2,6-Bis(diethylcarbamoyl)pyridin-4-yl]-N-(tert-butoxycarbonyl)alanine methyl ester: a chiral tridentate ligand that causes a diastereomeric excess of its lanthanide complexes in solution.

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

A frame shifted disulfide bridged analogue of angiotensin II

Amyloid plaque formation precedes dendritic spine loss ⬇️

An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.

Angiotensin receptor type 1 blockade in astroglia decreases hypoxia-induced cell damage and TNF alpha release

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models

Cell-Based Optimization of Covalent Reversible Ketoamide Inhibitors Bridging the Unprimed to the Primed Site of the Proteasome β5 Subunit

Combined effect of proteasome and calpain inhibition on cisplatin-resistant human melanoma cells

Complexation of copper(II)-Chelidamate: A multifrequency-pulsed electron paramagnetic resonance and electron nuclear double resonance analysis

Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors.

Computer-guided design, synthesis, and biological evaluation of quinoxalinebisarylureas as FLT3 inhibitors

Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor

Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain

Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms

Curcumin derivatives inhibit or modulate beta-amyloid precursor protein metabolism.

Curcumin-derived pyrazoles and isoxazoles: Swiss army knives or blunt tools for Alzheimer's disease?

DOCKTITE-a highly versatile step-by-step workflow for covalent docking and virtual screening in the molecular operating environment

Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium.

Determinants of steady-state torasemide pharmacokinetics: impact of pharmacogenetic factors, gender and angiotensin II receptor blockers

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

Development of tau aggregation inhibitors for Alzheimer's disease

Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.

Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors.

Drug development and PET-diagnostics for Alzheimer's disease.

Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model.

EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome's β5 Catalytic Subunit

Elucidation of the α‐Keto‐Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition ⬇️

Ensemble-Docking Approach on BACE-1: Pharmacophore Perception and Guidelines for Drug Design

Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design

Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer's disease from bioptic olfactory mucosa

Fluorescent rhodanine-3-acetic acids visualize neurofibrillary tangles in Alzheimer's disease brains.

Fmoc protected peptide mimetic based on a cyclohexane framework and incorporation into angiotensin II

Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions

Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-3α.

Immunotherapy alleviates amyloid-associated synaptic pathology in an Alzheimer's disease mouse model

Improved synthesis of ADAM10 inhibitor GI254023X.

In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques.

Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.

Inhibitors and modulators of beta- and gamma-secretase

Lipid bilayer position and orientation of novel carprofens, modulators of γ-secretase in Alzheimer's disease

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice

Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation

Membrane anchoring γ-secretase modulators with terpene-derived moieties

Memory trace interference impairs recall in a mouse model of Alzheimer's disease

Methyltrioxorhenium - from oxidation and cyclopropanation to metathesis

Modification of a promiscuous inhibitor shifts the inhibition from γ-secretase to FLT-3.

Modulators and inhibitors of gamma- and beta-secretases.

Mutation-specific dual potentiators maximize rescue of CFTR gating mutants

N'-benzylidene-benzohydrazides as novel and selective tau-PHF ligands

NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.

NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.

Phenylthiazolyl-hydrazide and its derivatives are potent inhibitors of tau aggregation and toxicity in vitro and in cells

Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites

Screening for inhibitors of tau protein aggregation into Alzheimer paired helical filaments: a ligand based approach results in successful scaffold hopping

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models

Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

Structure-based optimization of oxadiazole-based GSK-3 inhibitors.

Substrate-targeting gamma-secretase modulators

Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: an fast and atom efficient access to 1-aryl-3-benzylureas.

Synthesis of methoxy-X04 derivatives and their evaluation in Alzheimer's disease pathology.

Synthesis of tetramic and tetronic acids as beta-secretase inhibitors

Therapeutic effects of angiotensin (AT1) receptor antagonists: potential contribution of mechanisms other than AT1 receptor blockade

Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations