List of works - Mikko Kettunen

(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

scientific article

(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

scientific article

13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine

scientific article

A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment

scientific article published on June 2009

A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging.

scientific article published on 6 April 2007

Acute cerebral ischemia in rats studied by Carr-Purcell spin-echo magnetic resonance imaging: assessment of blood oxygenation level-dependent and tissue effects on the transverse relaxation

scientific article published in June 2004

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

scientific article published on 19 February 2018

Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

scientific article published on 25 February 2013

Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

scientific article published on 21 December 2019

B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo

scientific article

Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome

scientific article

Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation

scientific article

Blood NMR relaxation in the rotating frame: mechanistic implications

scientific article published in September 2002

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors

scientific article

Cyclodextrin-Based Organic Radical Contrast Agents for in vivo Imaging of Gliomas

scientific article published on 01 June 2020

Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate

scientific article

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

scientific article

Detection of apoptosis using the C2A domain of synaptotagmin I.

scientific article published on September 2004

Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.

scientific article published on 09 January 2008

Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate

scientific article published on 07 January 2020

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

scientific article

Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy

scientific article

Development of Timd2 as a reporter gene for MRI

scientific article published on 15 May 2015

Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning

scientific journal article

Direct Enhancement of Nuclear Singlet Order by Dynamic Nuclear Polarization

scientific article published on 25 April 2012

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

scientific article

Dual-modality gene reporter for in vivo imaging

scientific article

Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho

scientific article published on 01 October 2000

Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

scientific article published on 16 June 2016

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

scientific article

Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration

scientific article published on April 2002

Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model

scientific article published on 15 November 2002

Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

scientific article

Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry

scientific article published on 17 August 2011

Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo

scientific article published on 8 July 2011

Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells

scientific article published on 17 December 2014

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

scientific article

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

scientific article published on 3 December 2015

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

scientific article

Imaging pH with hyperpolarized 13C.

scientific article published on 03 August 2011

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents.

scientific article

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

scientific article

Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.

scientific article published on 19 May 2011

Long-term protective effect of atorvastatin in permanent focal cerebral ischemia

scientific article

Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma

scientific article

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model

scientific article

Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.

scientific article published on 25 January 2006

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

scientific article published on 28 May 2008

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

scientific article published on 08 December 2013

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis

scientific article

Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma

scientific article published in April 2010

Metabolic consequences of p300 gene deletion in human colon cancer cells

scientific article published on August 2006

Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.

scientific article

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

scientific article

Monitoring the CNS pathology in aspartylglucosaminuria mice

scientific article published in December 1998

Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors

scientific article

Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy

scientific article

Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions

scientific article published in December 2001

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons

scientific article

Quantitative T(1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat.

scientific article

Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

scientific article

Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study

scientific article published in March 2006

Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS

scientific article published on 01 November 2004

The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice

scientific article published in November 2002

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform

scientific article

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

scientific article published on 09 June 2011

Tumour gene therapy monitoring using magnetic resonance imaging and spectroscopy.

scientific article

Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: correlation with cell density.

scientific article

List of works by Mikko Kettunen

(13) C magnetic resonance spectroscopic imaging of hyperpolarized [1-(13) C, U-(2) H5 ] ethanol oxidation can be used to assess aldehyde dehydrogenase activity in vivo.

(13) C magnetic resonance spectroscopy measurements with hyperpolarized [1-(13) C] pyruvate can be used to detect the expression of transgenic pyruvate decarboxylase activity in vivo

13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine

A comparison between radiolabeled fluorodeoxyglucose uptake and hyperpolarized (13)C-labeled pyruvate utilization as methods for detecting tumor response to treatment

A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging.

Acute cerebral ischemia in rats studied by Carr-Purcell spin-echo magnetic resonance imaging: assessment of blood oxygenation level-dependent and tissue effects on the transverse relaxation

Analysis of 13 C and 14 C labeling in pyruvate and lactate in tumor and blood of lymphoma-bearing mice injected with 13 C- and 14 C-labeled pyruvate.

Analysis of image heterogeneity using 2D Minkowski functionals detects tumor responses to treatment.

Assessment of the Relaxation-Enhancing Properties of a Nitroxide-Based Contrast Agent TEEPO-Glc with In Vivo Magnetic Resonance Imaging

B0 dependence of the on-resonance longitudinal relaxation time in the rotating frame (T1rho) in protein phantoms and rat brain in vivo

Behavioral and stereological characterization of Hdc KO mice: Relation to Tourette syndrome

Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation

Blood NMR relaxation in the rotating frame: mechanistic implications

Carbonic Anhydrase Activity Monitored In Vivo by Hyperpolarized 13C-Magnetic Resonance Spectroscopy Demonstrates Its Importance for pH Regulation in Tumors

Cyclodextrin-Based Organic Radical Contrast Agents for in vivo Imaging of Gliomas

Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy.

Detection of apoptosis using the C2A domain of synaptotagmin I.

Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.

Detection of lentiviral suicide gene therapy in C6 rat glioma using hyperpolarised [1-13 C]pyruvate

Detection of transgene expression using hyperpolarized 13C urea and diffusion-weighted magnetic resonance spectroscopy.

Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy

Development of Timd2 as a reporter gene for MRI

Diazepam binding inhibitor overexpression in mice causes hydrocephalus, decreases plasticity in excitatory synapses and impairs hippocampus-dependent learning

Direct Enhancement of Nuclear Singlet Order by Dynamic Nuclear Polarization

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia

Dual-modality gene reporter for in vivo imaging

Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho

Effects of fasting on serial measurements of hyperpolarized [1-(13) C]pyruvate metabolism in tumors.

Enhanced polyamine catabolism alters homeostatic control of white adipose tissue mass, energy expenditure, and glucose metabolism

Expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 (KDR/Flk-1) in ischemic skeletal muscle and its regeneration

Fibroblast growth factor 4 induces vascular permeability, angiogenesis and arteriogenesis in a rabbit hindlimb ischemia model

Hyperpolarized (13)C spectroscopy detects early changes in tumor vasculature and metabolism after VEGF neutralization.

Hyperpolarized 13C MRI and PET: in vivo tumor biochemistry

Hyperpolarized [1-13C]-ascorbic and dehydroascorbic acid: vitamin C as a probe for imaging redox status in vivo

Hyperpolarized [U-(2) H, U-(13) C]Glucose reports on glycolytic and pentose phosphate pathway activity in EL4 tumors and glycolytic activity in yeast cells

Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse.

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging

Imaging Glycosylation In Vivo by Metabolic Labeling and Magnetic Resonance Imaging.

Imaging pH with hyperpolarized 13C.

Implantable RF-coil with multiple electrodes for long-term EEG-fMRI monitoring in rodents.

In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells.

Long-term protective effect of atorvastatin in permanent focal cerebral ischemia

Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma

MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model

Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres.

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

Magnetic resonance imaging of tumor glycolysis using hyperpolarized 13C-labeled glucose.

Magnetic resonance imaging with hyperpolarized [1,4-(13)C2]fumarate allows detection of early renal acute tubular necrosis

Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma

Metabolic consequences of p300 gene deletion in human colon cancer cells

Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro.

Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient mice

Monitoring the CNS pathology in aspartylglucosaminuria mice

Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors

Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy

Proton exchange as a relaxation mechanism for T1 in the rotating frame in native and immobilized protein solutions

Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons

Quantitative T(1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat.

Spin echo measurements of the extravasation and tumor cell uptake of hyperpolarized [1-(13) C]lactate and [1-(13) C]pyruvate.

Status epilepticus in 12-day-old rats leads to temporal lobe neurodegeneration and volume reduction: a histologic and MRI study

Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS

The combination of HSV-tk and endostatin gene therapy eradicates orthotopic human renal cell carcinomas in nude mice

The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform

Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy

Tumour gene therapy monitoring using magnetic resonance imaging and spectroscopy.

Water diffusion in a rat glioma during ganciclovir-thymidine kinase gene therapy-induced programmed cell death in vivo: correlation with cell density.