List of works by Rafael Franco

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

scientific article published on 23 August 2016

A computer program for enzyme kinetics that combines model discrimination, parameter refinement and sequential experimental design.

scientific article

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

scientific article

A method for binding parameters estimation of A1 adenosine receptor subtype: a practical approach

scientific article published on January 1990

A model for adenosine transport and metabolism

scientific article published on October 1992

A model of the pentose phosphate pathway in rat liver cells.

scientific article published in January 1995

A new strategy for the evaluation of force parameters from quantum mechanical computations

A program for the numerical integration of enzyme kinetic equations using small computers.

scientific article published in November 1984

A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase.

scientific article published on February 1990

A role for interleukin-12 in the regulation of T cell plasma membrane compartmentation

scientific article published on 3 April 2003

A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

scientific article published on October 2003

A1 adenosine receptors can occur manifesting two kinetic components of 8-cyclopentyl-1,3-[3H]dipropylxanthine ([3H]DPCPX) binding

scientific article published in May 1994

A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes.

scientific article published on 10 May 2013

A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector

scientific article published on 05 October 2019

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

scientific article published in May 2011

A2A and A2B adenosine receptors: The extracellular loop 2 determines high (A2A) or low affinity (A2B) for adenosine

scientific article published on 18 November 2019

ATP-sensitive K(+) channels regulate the concentrative adenosine transporter CNT2 following activation by A(1) adenosine receptors

scientific journal article

Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease

scientific article published on 14 September 2006

Abnormal calcium handling in atrial fibrillation is linked to up-regulation of adenosine A2A receptors.

scientific article

Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor

scientific article

Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes

scientific article published on 01 October 1993

Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM)

scientific article published on 01 August 1991

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function

scientific article

Adenosine A1 Receptor in Cultured Neurons from Rat Cerebral Cortex

scientific article published on 01 August 2000

Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease

scientific article published on 26 April 2020

Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling

scientific article published on 17 July 2020

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

scientific article

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

scientific article

Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia

scientific article published on 10 August 2005

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers

scientific article published in September 2009

Adenosine A2A receptors are expressed in human atrial myocytes and modulate spontaneous sarcoplasmic reticulum calcium release.

scientific article

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on 21 August 2003

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

scientific article published on July 2004

Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells

scientific article (publication date: 2001)

Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors

scientific article published on 01 February 1996

Adenosine deaminase and A1 adenosine receptors internalize together following agonist-induced receptor desensitization

scientific article published on July 1998

Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles

scientific article

Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV.

scientific article published on 11 August 2009

Adenosine deaminase enhances the immunogenicity of human dendritic cells from healthy and HIV-infected individuals

scientific article

Adenosine deaminase interacts with A1 adenosine receptors in pig brain cortical membranes

scientific article published in April 1996

Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells.

scientific article published on 19 October 2010

Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1.

scientific article published on 26 August 2015

Adenosine metabolism in kidney slices under normoxic conditions.

scientific article

Adenosine receptor heteromers and their integrative role in striatal function

scientific article

Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function.

scientific article

Adenosine receptor-mediated modulation of dopamine release in the nucleus accumbens depends on glutamate neurotransmission and N-methyl-D-aspartate receptor stimulation

scientific article published in November 2004

Adenosine receptors in myelin fractions and subfractions: the effect of the agonist (R)-phenylisopropyladenosine on myelin membrane microviscosity

scientific article published in November 1991

Adenosine-cannabinoid receptor interactions. Implications for striatal function

scientific article

Adenosine-glutamate receptor-receptor interactions in the central nervous system

Adenosine/dopamine receptor-receptor interactions in the central nervous system

scholarly article by Rafael Franco et al published January 2001 in Drug Development Research

Adreno-melatonin receptor complexes control ion homeostasis and intraocular pressure - their disruption contributes to hypertensive glaucoma

scientific article published on 04 January 2020

Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease.

scientific article

Allosteric modulation of dopamine D2 receptors by homocysteine

scientific article

Alternatively activated microglia and macrophages in the central nervous system.

scientific article published on 08 June 2015

Ammonium toxicity in different cell lines

article

An improved method for the preparation of rat brain microsomes

scientific article published in April 1986

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV.

scientific article

Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis

scientific article

Antioxidant Defense Mechanisms in Erythrocytes and in the Central Nervous System

scientific article published on 18 February 2019

Antioxidants versus Food Antioxidant Additives and Food Preservatives

scientific article published on 11 November 2019

Aspects of the general biology of adenosine A2A signaling.

scientific article published on August 2007

Association of adenosine deaminase with erythrocyte and platelet plasma membrane: an immunological study using light and electron microscopy

scientific article published on 01 May 1990

Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

scientific article

Basic concepts in G-protein-coupled receptor homo- and heterodimerization.

scientific article published on 2 November 2007

Biochemical systems theory: increasing predictive power by using second-order derivatives measurements.

scientific article published in April 1991

Bridging the gap

Building a new conceptual framework for receptor heteromers

scientific article

CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum

scientific article published on 23 June 2014

CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients

scientific article published on 2 July 2012

CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface

scientific article

CD26 and Adenosine Deaminase Interaction: Its Role in the Fusion Between Horse Membrane Vesicles and Spermatozoa1

scientific article published on 01 September 1999

CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse.

scientific article

Calcium mobilization in Jurkat cells via A2b adenosine receptors

scientific article published on November 1997

Calcium-mediated modulation of the quaternary structure and function of adenosine A2A-dopamine D2 receptor heteromers

scientific article

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

scientific article published on 24 April 2012

Cell surface adenosine deaminase: much more than an ectoenzyme.

scientific article

Challenges in the development of heteromer-GPCR-based drugs

scientific article published on January 2013

Characterization of adenosine receptors in brush-border membranes from pig kidney

scientific article published on November 1992

Characterization of the GTP/GDP binding site in the murine CD3-zeta polypeptide chain.

scientific article published on December 1994

Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration

scientific article

Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis

scientific article published on 16 June 2016

Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice

scientific article published in January 2012

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.

scientific article published on 14 January 2011

Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland

scientific article

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

scientific article (publication date: 17 May 2002)

Cocaine Blocks Effects of Hunger Hormone, Ghrelin, Via Interaction with Neuronal Sigma-1 Receptors

scientific article published on 07 June 2018

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers

scientific article

Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer

scientific article

Cocaine self-administration markedly increases dopamine D2 receptor negative cooperativity for dopamine binding: A receptor dimer-based analysis

scientific article published in July 2010

Coffee and cancer

scientific article published in November 2008

Coffee and mental health

scientific article published on 10 September 2009

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

scientific article published on September 2004

Comodulation of CXCR4 and CD26 in human lymphocytes

scientific article (publication date: June 2001)

Computer simulation of purine metabolism ⬇️

scientific article published on October 15, 1984

Computer-based learning of cooperativity and allostery.

scientific article published in September 1985

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease

scientific article

Control analysis of systems having two steps catalyzed by the same protein molecule in unbranched chains

scientific article published in September 1990

Control analysis of transition times. Extension of analysis and matrix method.

scientific article published in February 1991

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.

scientific article published on 28 February 2018

Cytokines regulate membrane adenosine deaminase on human activated lymphocytes

scientific article published in December 2001

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

scientific article published in June 2015

Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.

scientific article published on January 2011

Degradation of adenosine by extracellular adenosine deaminase in the rat duodenum.

scientific article published in January 1988

Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism

scientific article published on 28 June 2014

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

scientific article

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

scientific article

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology

scientific article published in January 2013

Determination of the characteristics, properties and homogeneity of rat brain microsomes. Binding of lactate dehydrogenase, malate dehydrogenase and 5' nucleotidase to microsomal membranes

scientific article

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine

scientific article

Dimer-based model for heptaspanning membrane receptors

scientific article published on 01 July 2005

Dipropylcyclopentylxanthine triggers apoptosis in Jurkat T cells by a receptor-independent mechanism

scientific article published on October 1997

Dipropylcyclopentylxanthine triggers apoptosis in cells from patients with myeloid leukaemia

scientific article published on 01 January 1998

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

scientific article

Disruption of a dopamine receptor complex amplifies the actions of cocaine

scientific article published on 29 July 2016

Distribution of A1-adenosine receptors, adenosine deaminase and 5'-nucleotidase in brain and other tissues of the pig.

scientific article published in August 1990

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway

scientific article

Dopamine D2 and angiotensin II type 1 receptors form functional heteromers in rat striatum.

scientific article published on 16 May 2015

Dopamine receptor heteromeric complexes and their emerging functions

scientific article published on January 2014

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

scientific article

Dynamic Regulation of CXCR1 and CXCR2 Homo- and Heterodimers

scientific article published on 04 November 2009

Ecto-ADA in the development of theimmune system

article

Effect of Endogenous Phospholipids on the [3H]R-Pia Binding to A1Adenosine Receptors from PIG Cerebral Cortex

Effect of phospholipases and proteases on the [3H]N6-(R)-phenylisopropyladenosine ([3H]R-PIA) binding to A1 adenosine receptors from pig cerebral cortex

scientific article published in November 1991

Energy gradients for VT-signal migration in the CNS: studies on melanocortin receptors, mitochondrial uncoupling proteins and food intake.

scientific article published in January 2004

Enhancing cognition before clinical symptoms of dementia.

scientific article

Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function.

scientific article published on January 2007

Enzymatic and extraenzymatic role of ecto-adenosine deaminase in lymphocytes

scientific article published on February 1998

Enzyme kinetic studies from progress curves.

scientific article

Enzymes of the purine metabolism in rat brain microsomes

scientific article published in March 1986

Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line.

scientific article published on January 1999

Epigenetic drugs in Alzheimer's disease

scientific article

Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation

scientific article

Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates

scientific article published on 20 July 2020

Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension

scientific article published on 08 January 2020

Expression of cannabinoid CB1 R-GPR55 heteromers in neuronal subtypes of the Macaca fascicularis striatum

scientific article published on 27 June 2020

Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule

scientific article

Expression of the mRNA coding the cannabinoid receptor 2 in the pallidal complex of Macaca fascicularis

scientific article published on 20 May 2010

Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease.

scientific article published on 15 June 2016

Fitting integrated enzyme rate equations to progress curves with the use of a weighting matrix

scientific article published on March 1991

Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue

scientific article published on 16 December 2020

Functional relevance of neurotransmitter receptor heteromers in the central nervous system.

scientific article published on 10 August 2007

Further characterization of adenosine transport in renal brush-border membranes

scientific article published on 01 May 1990

G protein-coupled receptor heteromers as new targets for drug development

scientific article published on January 2010

G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system.

scientific article published on 09 May 2014

G-protein-coupled receptor heteromers: function and ligand pharmacology

scientific article

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

scientific article published on 05 August 2009

GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells

scientific article published on 27 February 2014

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

scientific article published on 13 May 2010

Glutamate Released by Dendritic Cells as a Novel Modulator of T Cell Activation

scientific article published on 01 November 2006

Graphical analysis of data from pharmacology experiments

scientific article

Health benefits of methylxanthines in cacao and chocolate

scientific article

Health benefits of methylxanthines in neurodegenerative diseases

scientific article published on 11 January 2017

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function

scientific article

Heterodimeric adenosine receptors: a device to regulate neurotransmitter release.

scientific article published in November 2006

Heterogeneity of the gradients performed by the freeze-thaw method

scientific article published on 01 May 1989

Heterogeneous localization of some purine enzymes in subcellular fractions of rat brain and cerebellum.

scientific article published in March 1986

Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release.

scientific article published on 17 May 2006

Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling

scientific article

Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease

scientific article

Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum.

scientific article

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on February 2004

Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals

scientific article published on 04 September 2019

How calmodulin interacts with the adenosine A(2A) and the dopamine D(2) receptors

scientific article

Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.

scientific article

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus

scientific article

IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation

scientific article published on 01 March 1999

Identification and rejection of outliers in enzyme kinetics.

scientific article published in October 1988

Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D2 and D3 Dopamine Receptors

scholarly article by Irene Reyes-Resina et al published 14 December 2018 in ACS Omega

Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum

scientific article

Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment

scientific article published on 4 August 2009

Immunolocalization of A1 Adenosine Receptors in Mammalian Spermatozoa

scientific article published on 01 September 2000

Immunological dysfunction in HIV-1-infected individuals caused by impairment of adenosine deaminase-induced costimulation of T-cell activation.

scientific article published in November 2009

Immunological identification of A1adenosine receptors in brain cortex

scientific article published on 01 December 1995

Increase in A2A receptors in the nucleus accumbens after extended cocaine self-administration and its disappearance after cocaine withdrawal

scientific article

Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression

scientific article

Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation.

scientific article published on 18 March 2016

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

scientific article published in September 2009

Interaction of trans-acting factors with the proximal promoter of the mouse alpha-fetoprotein gene

scientific article published on December 1992

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

scientific article

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

scientific article (publication date: August 2008)

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

scientific article

Interdependence between cooperativity and control coefficients.

scientific article published in January 1989

Intramembrane receptor-receptor interactions: a novel principle in molecular medicine.

scientific article published on 27 October 2006

Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine

scientific article published on 6 March 2006

Involvement of caveolin in ligand-induced recruitment and internalization of A(1) adenosine receptor and adenosine deaminase in an epithelial cell line

scientific article published on May 2001

Is adenosine deaminase involved in adenosine transport?

scientific article published on December 1990

Kinetics of the 5'-nucleotidase and the adenosine deaminase in subcellular fractions of rat brain

scientific article published in April 1986

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

scientific article published on 9 January 2014

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus

scientific article

Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson's and Alzheimer's Diseases

scientific article published on 04 July 2019

Ligand-Induced Phosphorylation, Clustering, and Desensitization of A1Adenosine Receptors

scientific article published on 01 November 1997

Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling

scientific article published on April 2003

Light resonance energy transfer-based methods in the study of G protein-coupled receptor oligomerization

scientific article published on January 2008

Loss of parvalbumin-positive neurons from the globus pallidus in animal models of Parkinson disease

scientific article

MECHANISMS OF CD26/DIPEPTIDYL PEPTIDASE IV CYTOKINE-DEPENDENT REGULATION ON HUMAN ACTIVATED LYMPHOCYTES

scientific article published on 01 July 2000

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

scientific article

Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors.

scientific article

Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.

scientific article published on 13 February 2001

Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions

scientific article published in August 2003

Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration.

scientific article

Modulation of GABA transport by adenosine A1R-A2AR heteromers, which are coupled to both Gs- and G(i/o)-proteins

scientific article published on 01 November 2011

Modulation of adenosine agonist [3H]N6-(R)-phenylisopropyladenosine binding to pig brain cortical membranes by changes of membrane fluidity and of medium physicochemical characteristics.

scientific article

Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons.

scientific article

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

scientific article

Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model

scientific article published on 28 May 2014

Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity

scientific article published on October 2004

N-Methyl-D-aspartate (NMDA) and cannabinoid CB<sub>2</sub> receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

scientific article published on 08 November 2021

N-ethylmaleimide affects agonist binding to A1 adenosine receptors differently in the presence than in the absence of ligand

scientific article published in November 1991

Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors

scientific article published on 30 October 2020

Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation

scientific article published on 9 September 2016

Neuroprotective Effect of JZL184 in MPP(+)-Treated SH-SY5Y Cells Through CB2 Receptors

scientific article published on 15 May 2015

Neuroprotective effect of L-DOPA co-administered with the adenosine A2A receptor agonist CGS 21680 in an animal model of Parkinson's disease

scientific article published on August 2004

Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.

scientific article published in May 2014

Neurotransmitter receptor heteromers and their integrative role in 'local modules': the striatal spine module.

scientific article

Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity.

scientific article published on 11 November 2008

Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.

scientific article published in November 1997

New methods to evaluate colocalization of fluorophores in immunocytochemical preparations as exemplified by a study on A2A and D2 receptors in Chinese hamster ovary cells

scientific article

New possibilities in the therapy of immunodeficiency diseases

scientific article published on 01 August 1991

Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia

scientific article published on 20 January 2021

Novel ergopeptides as dual ligands for adenosine and dopamine receptors

scientific article

Novel pharmacological targets based on receptor heteromers

scientific article

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

scientific article published on 14 June 2007

On the molecular basis of the receptor mosaic hypothesis of the engram

scientific article published in August 2004

Optimal association-saturation procedure for estimating association and dissociation rate parameters in receptor studies. Application to solubilized A1 adenosine receptors.

scientific article published on January 1992

Partners for adenosine A1 receptors

scientific article

Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease.

scientific article

Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

scientific article published on 7 December 2015

Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease

scientific article published on 28 September 2016

Phenyl acyl acids attenuate the unfolded protein response in tunicamycin-treated neuroblastoma cells

scientific article

Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model

scientific article

Phosphodiesterase inhibition in cognitive decline

scientific article

Phosphorylation of adenosine in renal brush-border membrane vesicles by an exchange reaction catalysed by adenosine kinase

scientific article published on February 1994

Plasma membrane diffusion of G protein-coupled receptor oligomers

scientific article published on 21 July 2008

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

scientific article published on April 2010

Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia.

scientific article

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease

scientific article published on 9 February 2017

Potential of caveolae in the therapy of cardiovascular and neurological diseases

scientific article published on 30 September 2014

Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists

scientific article published on 19 August 2019

Preparative purification of adenosine deaminase from human erythrocytes by affinity chromatography

Presence of adenosine deaminase on the surface of mononuclear blood cells: immunochemical localization using light and electron microscopy

scientific article

Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.

scientific article published on 19 January 2016

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

scientific article

Purification and partial characterization of brain adenosine deaminase: inhibition by purine compounds and by drugs

scientific article

Purification of Adenosine Deaminase from Chicken-Egg Yolk by Affinity Column Chromatography

scientific article published on 01 January 1990

Purinergic signaling in Parkinson's disease. Relevance for treatment

scientific article published on 23 July 2015

Quantum Chemical Study of the Electronic and Conformational Characteristics of Adenosine and 8-Substituted Derivatives: Functional Implications in the Mechanism of Reaction of Adenosine Deaminase

scientific article published on 01 February 1990

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

scientific article

Real-time G-protein-coupled receptor imaging to understand and quantify receptor dynamics.

scientific article

Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins.

scientific article published on 6 October 2006

Regulation of L-type calcium channels in GH4 cells via A1 adenosine receptors

scientific article

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction

scientific article

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

scientific article published on 01 May 2003

Regulation of nitrobenzylthioninosine-sensitive adenosine uptake by cultured kidney cells.

scientific article published on November 1994

Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist

scientific article

Release of adenosine deaminase from rat intestinal mucosa

scientific article published on 01 August 1990

Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action

article

Role of adenosine in the control of homosynaptic plasticity in striatal excitatory synapses.

scientific article

Role of electrostatic interaction in receptor-receptor heteromerization

scientific article published in January 2005

Role of glutamate on T-cell mediated immunity.

scientific article published on 14 February 2007

Role of histidine residues in agonist and antagonist binding sites of A1 adenosine receptor.

scientific article published in April 1993

SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production

scientific article published on 17 July 2020

SIMCODE: A program for simulating point mutations in genomic DNA

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.

scientific article published on December 2011

Simulation of the purine nucleotide cycle as an anaplerotic process in skeletal muscle.

scientific article published on April 1987

Slight differences between adenosine deaminases from different species an immunochemical study

scientific article published on December 1990

Solubilization and molecular characterization of the nitrobenzylthioinosine binding sites from pig kidney brush-border membranes

scientific article published on April 1994

Solubilization of A1adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high- and low-affinity states

scientific article published on 01 August 1990

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

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Striatal plasticity at the network level. Focus on adenosine A2A and D2 interactions in models of Parkinson's Disease

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Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists

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Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia

scientific article published on 26 October 2014

Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins

scientific article published in October 2015

Studies on homocysteine plasma levels in Alzheimer's patients. Relevance for neurodegeneration

scientific article published on 12 May 2004

Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?

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Suggesting a Way to Understand the Actual Potential of Anti-Alzheimer's Disease Drugs That Show Promise in Transgenic Mouse Models

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Surface adenosine deaminase. A novel B-cell marker in chronic lymphocytic leukemia

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Surface expression of adenosine deaminase in mitogen-stimulated lymphocytes

scientific article published on 01 August 1993

Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.

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Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice

scientific article published on 6 December 2013

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

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Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders

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The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression

scientific article (publication date: 14 July 2000)

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin

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The adenosine receptors present on the plasma membrane of chromaffin cells are of the A2b subtype

scientific article published in August 1992

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function

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The binding of [3H]R-PIA to A1 adenosine receptors produces a conversion of the high- to the low-affinity state.

scientific article published in July 1991

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

scientific article published on 27 November 2012

The cluster-arranged cooperative model: a model that accounts for the kinetics of binding to A1 adenosine receptors

scientific article

The emergence of neurotransmitters as immune modulators.

scientific article published on 6 August 2007

The heat shock cognate protein hsc73 assembles with A(1) adenosine receptors to form functional modules in the cell membrane

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The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor

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The potential of methylxanthine-based therapies in pediatric respiratory tract diseases

scientific article published on February 2016

The relevance of theobromine for the beneficial effects of cocoa consumption

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The two-state dimer receptor model: a general model for receptor dimers

scientific article published on 24 February 2006

Theoretical Approximation to the Reaction Mechanism of Adenosine Deaminase

Theoretical study about the variability of the genome of foot-and-mouth disease viruses

scientific article published on 01 February 1992

Theoretical study of the acidic strength of amino acid side chains

Theoretical study of the protonation and tautomerization of adenosine, formycin, and their 2-NH2 and 2-F derivatives: functional implications in the mechanism of reaction of adenosine deaminase.

scientific article published in February 1989

Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors

scientific article published on 01 September 1993

Trafficking of adenosine A2A and dopamine D2 receptors

scientific article published in January 2005

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression

scientific article published on 7 August 2012

Two Affinity Sites of the Cannabinoid Subtype 2 Receptor Identified by a Novel Homogeneous Binding Assay.

scientific article published on 29 June 2016

Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes

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Understanding the added value of g-protein-coupled receptor heteromers.

scientific article published on 22 April 2014

Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB).

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Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

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Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

scientific article published on 28 July 2009

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

scientific article published on 7 July 2006

[Purine catabolism in rat brain (author's transl)]

scientific article published on 01 September 1981

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