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List of works by Ana García-Osta

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

scientific article published on 23 August 2016

A critical role for IGF-II in memory consolidation and enhancement.

scientific article

Advanced Assay Monitoring APP-Carboxyl-Terminal Fragments as Markers of APP Processing in Alzheimer Disease Mouse Models

scientific article published on 01 January 2016

Amyloid beta mediates memory formation

scientific article published on 24 March 2009

BDNF mediates the neuroprotective effect of PACAP-38 on rat cortical neurons

scientific article published in April 2001

Chronic Mild Stress Assay Leading to Early Onset and Propagation of Alzheimer's Disease Phenotype in Mouse Models

scientific article published in January 2016

Chronic mild stress accelerates the onset and progression of the Alzheimer's disease phenotype in Tg2576 mice

scientific article published in January 2012

Chronic mild stress in mice promotes cognitive impairment and CDK5-dependent tau hyperphosphorylation.

scientific article published on 14 January 2011

Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease

scientific article

Current animal models of Alzheimer's disease: challenges in translational research

scientific article published on 29 September 2014

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease

scientific article published in June 2015

Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease.

scientific article published on January 2011

Design, Synthesis, and Biological Evaluation of First-in-Class Dual Acting Histone Deacetylases (HDACs) and Phosphodiesterase 5 (PDE5) Inhibitors for the Treatment of Alzheimer's Disease.

scientific article published on 8 September 2016

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease

scientific article published on 14 March 2018

Differential regulation by methylenedioxymethamphetamine of 5-hydroxytryptamine1A receptor density and mRNA expression in rat hippocampus, frontal cortex, and brainstem: the role of corticosteroids

scientific article

Discovery of in Vivo Chemical Probes for Treating Alzheimer's Disease: Dual Phosphodiesterase 5 (PDE5) and Class I Histone Deacetylase Selective Inhibitors

scientific article published on 21 December 2018

Disrupting the memory of places induced by drugs of abuse weakens motivational withdrawal in a context-dependent manner

scientific article

Effect of p-Chloroamphetamine on 5-HT1A and 5-HT7 Serotonin Receptor Expression in Rat Brain

scientific article published on 01 May 2000

Epigenetic drugs in Alzheimer's disease

scientific article

Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT(1A) receptors

scientific article published in December 1999

GLUT12 Expression in Brain of Mouse Models of Alzheimer's Disease

scientific article published on 31 August 2019

Immunomodulatory Properties of Carvone Inhalation and Its Effects on Contextual Fear Memory in Mice.

scientific article published on 25 January 2018

Impact of Neurodegenerative Diseases on Drug Binding to Brain Tissues: From Animal Models to Human Samples

scientific article published on 19 April 2018

Impact of Scaffold Exploration on Novel Dual-Acting Histone Deacetylases and Phosphodiesterase 5 Inhibitors for the Treatment of Alzheimer's Disease

scientific article

Implanted BDNF-producing fibroblasts prevent neurotoxin-induced serotonergic denervation in the rat striatum.

scientific article

Increased CRE-binding activity and tryptophan hydroxylase mRNA expression induced by 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") in the rat frontal cortex but not in the hippocampus

scientific article published in July 2004

Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

scientific article

Long-term phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Abeta

scientific article published in June 2011

MuSK expressed in the brain mediates cholinergic responses, synaptic plasticity, and memory formation

scientific journal article

Multitarget Approach for the Treatment of Alzheimer's Disease: Inhibition of Phosphodiesterase 9 (PDE9) and Histone Deacetylases (HDACs) Covering Diverse Selectivity Profiles

scientific article published on 04 September 2019

Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels

scientific article published on 7 December 2015

Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model

scientific article published on 14 January 2009

Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model

scientific article

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

scientific article published on 10 November 2010

Phosphodiesterase inhibition in cognitive decline

scientific article

Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition

scientific article

Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone

scientific article

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology

scientific article published on 24 March 2010

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

scientific article published on 25 January 2010

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease.

scientific article published on December 2011

Synthesis and evaluation of (13)N-labelled azo compounds for β-amyloid imaging in mice

scientific article published on 6 December 2013

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

scientific article

Taking Advantage of the Selectivity of Histone Deacetylases and Phosphodiesterase Inhibitors to Design Better Therapeutic Strategies to Treat Alzheimer's Disease

scientific article published on 21 June 2019

Targeting RNA-Mediated Toxicity in C9orf72 ALS and/or FTD by RNAi-Based Gene Therapy

article

The aberrant splicing of BAF45d links splicing regulation and transcription in glioblastoma.

scientific article

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