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List of works by Wiep Scheper

A new PERKspective on neurodegeneration.

scientific article

Abeta 1-42 induces mild endoplasmic reticulum stress in an aggregation state-dependent manner.

scientific article published on December 2007

Activation of the unfolded protein response and granulovacuolar degeneration are not common features of human prion pathology

scientific article published on 28 October 2016

Activation of the unfolded protein response is an early event in Alzheimer's and Parkinson's disease.

scientific article published on February 2012

Adult neurogenesis and the unfolded protein response; new cellular and molecular avenues in sleep research

scientific article published on 3 April 2009

Alpha-synuclein induces the unfolded protein response in Parkinson's disease SNCA triplication iPSC-derived neurons

scientific article

Alternative splicing in the N-terminus of Alzheimer's presenilin 1.

scientific article published on 5 October 2004

Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment

scientific article published on 12 June 2013

BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.

scientific article

Branched KLVFF tetramers strongly potentiate inhibition of beta-amyloid aggregation.

scientific article published in October 2007

Coordination of N-glycosylation and protein translocation across the endoplasmic reticulum membrane by Sss1 protein.

scientific article

Effects of Fat and Sugar, Either Consumed or Infused toward the Brain, on Hypothalamic ER Stress Markers.

scientific article published on 15 May 2017

Endolysosome and Autolysosome Dysfunction in Alzheimer's Disease: Where Intracellular and Extracellular Meet

scientific article published on 01 July 2019

Endoplasmic reticulum protein quality control in neurodegenerative disease: the good, the bad and the therapy

scientific article published on January 2009

Endoplasmic reticulum: the unfolded protein response is tangled in neurodegeneration.

scientific article published on 04 May 2012

From alpha to omega with Abeta: targeting the multiple molecular appearances of the pathogenic peptide in Alzheimer's disease.

scientific article published on January 2010

Granulovacuolar degeneration bodies are neuron-selective lysosomal structures induced by intracellular tau pathology

scientific article published on 27 August 2019

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

IRE1 signaling exacerbates Alzheimer's disease pathogenesis

scientific article published on 24 March 2017

Inhibition of endoplasmic reticulum associated degradation reduces endoplasmic reticulum stress and alters lysosomal morphology and distribution.

scientific article published on 18 March 2013

Insulin deficiency results in reversible protein kinase A activation and tau phosphorylation

scientific article published on 8 April 2017

Intracellular accumulation of aggregated pyroglutamate amyloid beta: convergence of aging and Aβ pathology at the lysosome ⬇️

scientific article published on April 4, 2012

Liposomes bi-functionalized with phosphatidic acid and an ApoE-derived peptide affect Aβ aggregation features and cross the blood-brain-barrier: implications for therapy of Alzheimer disease.

scientific article published on 10 December 2013

Long-range RNA interaction of two sequence elements required for endonucleolytic cleavage of human insulin-like growth factor II mRNAs.

scientific article published on January 1995

Neuroinflammation is not a Prerequisite for Diabetes-induced Tau Phosphorylation

scientific article published on 9 November 2015

New method based on capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) to monitor interaction between nanoparticles and the amyloid-β peptide

scientific article

No evidence for cell-to-cell transmission of the unfolded protein response in cell culture

scientific article published on 21 October 2019

Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake

scientific article

PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.

scientific article published on 19 June 2012

Pin1 levels are downregulated during ER stress in human neuroblastoma cells.

scientific article published on 14 September 2006

Pontocerebellar hypoplasia type 2: a neuropathological update.

scientific article

Proteasome Activation by Small Molecules.

scientific article

Protein translocation across the endoplasmic reticulum membrane in cold-adapted organisms.

scientific article published on 27 May 2003

Rab6 is a modulator of the unfolded protein response: implications for Alzheimer's disease.

scientific article published in January 2012

Rab6 membrane association is dependent of Presenilin 1 and cellular phosphorylation events

scientific article published in March 2004

Removing Protein Aggregates: The Role of Proteolysis in Neurodegeneration ⬇️

scientific article published on January 1, 2011

STOX1A induces phosphorylation of tau proteins at epitopes hyperphosphorylated in Alzheimer's disease

scientific article

Site-specific cleavage of IGF-II mRNAs requires sequence elements from two distinct regions of the IGF-II gene ⬇️

scientific article published on October 11, 1992

Targeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain.

scientific article published on 7 October 2016

The UPR in Neurodegenerative Disease: Not Just an Inside Job

scientific article published on 22 July 2020

The UPR reduces glucose metabolism via IRE1 signaling.

scientific article published on 13 January 2017

The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease

scientific article

The significance of neuroinflammation in understanding Alzheimer's disease.

scientific article

The unfolded protein response affects neuronal cell cycle protein expression: implications for Alzheimer's disease pathogenesis

scientific article published on 27 March 2006

The unfolded protein response and proteostasis in Alzheimer disease: preferential activation of autophagy by endoplasmic reticulum stress.

scientific article published on August 2011

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

scientific article (publication date: September 2015)

The unfolded protein response is activated in Alzheimer's disease.

scientific article published on 23 June 2005

The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies ⬇️

scientific article published on February 17, 2012

The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress

scientific article published on 28 August 2014

Ubiquilin 2 is not associated with tau pathology

scientific article

Ubiquitin proteasome system as a pharmacological target in neurodegeneration.

scientific article published on September 2006

Unconventional secretion factor GRASP55 is increased by pharmacological unfolded protein response inducers in neurons

scientific article published in Scientific Reports

Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation.

scientific article published on 14 February 2013

Untangling the origin and function of granulovacuolar degeneration bodies in neurodegenerative proteinopathies

scientific article published on 03 September 2020

Versatile and efficient targeting using a single nanoparticulate platform: application to cancer and Alzheimer's disease.

scientific article

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