List of works - Amadeu Gavaldà

4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships

scientific article published on 5 March 2018

Abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, has a fast association rate and long residence time at receptor

scientific article published on 25 November 2017

Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.

scientific article published on 20 January 2010

Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile

scientific article published on 22 December 2011

Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways

scientific article published on 04 June 2010

Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition.

scientific article published on 27 September 2012

Aclidinium inhibits human lung fibroblast to myofibroblast transition.

scientific article

Acute stress attenuates but does not abolish circadian rhythmicity of serum thyrotrophin and growth hormone in the rat

scientific article published on 01 December 1996

Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships

scientific article published on 17 November 2016

Blockade of opioid receptors with naltrexone inhibits thyrotropin increase after noise stress but does not prevent the decrease caused by immobilization

scientific article

Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.

scientific article

Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.

scientific article published on 12 June 2017

Chronic but not acute exposure to stress is associated with hypothalamic vasoactive intestinal polypeptide (VIP) release into median eminence

scientific article published in August 1993

Chronic stress affects in vivo hypothalamic somatostatin release but not in vitro GH responsiveness to somatostatin in rats

scientific article published on 01 September 1993

Chronic stress induced changes in LH secretion: The contribution of anorexia associated to stress

scientific article published on 01 January 1993

Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats.

scientific article published in January 1995

Direct evidence for chronic stress-induced facilitation of the adrenocorticotropin response to a novel acute stressor

scientific article published in July 1994

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thien

scientific article published in August 2009

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists

scientific article published on 05 March 2015

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

scientific article published on 3 April 2011

Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists ⬇️

scientific article published on January 6, 2011

Effect of regularity of exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal hormones, growth hormone, and thyroid stimulating hormone in the adult male rat

scientific article published on 01 January 1993

Effects of Changing to Individually Ventilated Caging on Guinea Pigs (Cavia porcellus).

scientific article published on May 2015

Effects of aclidinium bromide in a cigarette smoke-exposed Guinea pig model of chronic obstructive pulmonary disease

scientific article published in February 2014

Effects of chronic immobilization stress on GH and TSH secretion in the rat: response to hypothalamic regulatory factors

scientific article published in January 1993

Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat.

scientific article published in January 1993

Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate

scientific article published in December 1988

In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol

scientific article published on 4 December 2015

Inhaled muscarinic antagonists for respiratory diseases: a review of patents and current developments (2006 - 2010).

scientific article published on 25 June 2011

Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors

scientific article published on 01 April 1997

Negative feedback of corticosterone on the pituitary-adrenal axis is maintained after inhibition of serotonin synthesis with parachlorophenylalanine

scientific article published in June 1992

New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors

scientific article published on 01 May 2005

Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.

scientific article published on 8 November 2016

Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction

scientific article published on 01 August 2006

Pharmacological characterization of abediterol, a novel inhaled β(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models

scientific article published on 15 May 2012

Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi.

scientific article published on 22 October 2014

Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule.

scientific article published on 17 July 2017

Phosphodiesterase-4 inhibitors: a review of current developments (2010 - 2012).

scientific article published on 04 May 2013

Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands ⬇️

scientific article published on September 22, 2010

Role of somatostatin in the acute immobilization stress-induced GH decrease in rat.

scientific article published in January 1993

Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice.

scientific article published on 8 November 2016

Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors

scientific article published on 05 August 2011

Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors

scientific article

Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents

scientific article published in August 2002

The effect of acute and chronic acth administration on pituitary-adrenal response to acute immobilization stress. Relationship to changes in corticosteroid-binding globulin

article

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D.

scientific article

The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide

scientific article published on 10 June 2014

List of works by Amadeu Gavaldà

4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships

Abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, has a fast association rate and long residence time at receptor

Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.

Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile

Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways

Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition.

Aclidinium inhibits human lung fibroblast to myofibroblast transition.

Acute stress attenuates but does not abolish circadian rhythmicity of serum thyrotrophin and growth hormone in the rat

Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships

Blockade of opioid receptors with naltrexone inhibits thyrotropin increase after noise stress but does not prevent the decrease caused by immobilization

Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.

Characterization of the chloroquine-induced mouse model of pruritus using an automated behavioural system.

Chronic but not acute exposure to stress is associated with hypothalamic vasoactive intestinal polypeptide (VIP) release into median eminence

Chronic stress affects in vivo hypothalamic somatostatin release but not in vitro GH responsiveness to somatostatin in rats

Chronic stress induced changes in LH secretion: The contribution of anorexia associated to stress

Comparison of the behavioural and endocrine response to forced swimming stress in five inbred strains of rats.

Direct evidence for chronic stress-induced facilitation of the adrenocorticotropin response to a novel acute stressor

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thien

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists

Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists

Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists ⬇️

Effect of regularity of exposure to chronic immobilization stress on the circadian pattern of pituitary adrenal hormones, growth hormone, and thyroid stimulating hormone in the adult male rat

Effects of Changing to Individually Ventilated Caging on Guinea Pigs (Cavia porcellus).

Effects of aclidinium bromide in a cigarette smoke-exposed Guinea pig model of chronic obstructive pulmonary disease

Effects of chronic immobilization stress on GH and TSH secretion in the rat: response to hypothalamic regulatory factors

Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat.

Forced swimming test in rats: effect of desipramine administration and the period of exposure to the test on struggling behavior, swimming, immobility and defecation rate

In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol

Inhaled muscarinic antagonists for respiratory diseases: a review of patents and current developments (2006 - 2010).

Inhibition of corticosteroid-binding globulin caused by a severe stressor is apparently mediated by the adrenal but not by glucocorticoid receptors

Negative feedback of corticosterone on the pituitary-adrenal axis is maintained after inhibition of serotonin synthesis with parachlorophenylalanine

New pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors

Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.

Novel pyrazolopyrimidopyridazinones with potent and selective phosphodiesterase 5 (PDE5) inhibitory activity as potential agents for treatment of erectile dysfunction

Pharmacological characterization of abediterol, a novel inhaled β(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models

Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi.

Pharmacological preclinical characterization of LAS190792, a novel inhaled bifunctional muscarinic receptor antagonist /β2-adrenoceptor agonist (MABA) molecule.

Phosphodiesterase-4 inhibitors: a review of current developments (2010 - 2012).

Pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A1 adenosine receptor ligands ⬇️

Role of somatostatin in the acute immobilization stress-induced GH decrease in rat.

Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice.

Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors

Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors

Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents

The effect of acute and chronic acth administration on pituitary-adrenal response to acute immobilization stress. Relationship to changes in corticosteroid-binding globulin

The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D.

The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide