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List of works by Peter W. Swaan

ATP-binding cassette transporter expression in human placenta as a function of pregnancy condition.

scientific article

Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development

scientific article published on 16 February 2007

Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.

scientific article published on 12 May 2008

Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity.

scientific article published on 12 October 2006

Cellular Entry of G3.5 Poly (amido amine) Dendrimers by Clathrin- and Dynamin-Dependent Endocytosis Promotes Tight Junctional Opening in Intestinal Epithelia

scientific article published on 22 April 2010

Comparative pharmacophore modeling of organic anion transporting polypeptides: a meta-analysis of rat Oatp1a1 and human OATP1B1.

scientific article

Computational approaches to modeling drug transporters.

scientific article

Computational modeling to accelerate the identification of substrates and inhibitors for transporters that affect drug disposition

scientific article

Computational models to assign biopharmaceutics drug disposition classification from molecular structure

scientific article published on 11 September 2007

Conserved aspartic acid residues lining the extracellular loop 1 of sodium-coupled bile acid transporter ASBT Interact with Na+ and 7alpha-OH moieties on the ligand cholestane skeleton.

scientific article published on 28 May 2008

Current perspectives on the cellular uptake and trafficking of riboflavin

scientific article published on November 2003

Cytoskeletal scaffolds regulate riboflavin endocytosis and recycling in placental trophoblasts

scientific article published on 24 March 2006

Cytosolic half of transmembrane domain IV of the human bile acid transporter hASBT (SLC10A2) forms part of the substrate translocation pathway

scientific article published in March 2008

Design of high-affinity peptide conjugates with optimized fluorescence quantum yield as markers for small peptide transporter PEPT1 (SLC15A1).

scientific article published on 20 March 2008

Design of novel synthetic MTS conjugates of bile acids for site-directed sulfhydryl labeling of cysteine residues in bile acid binding and transporting proteins

scientific article published on 4 January 2006

Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells

scientific article

Determination of membrane protein glycation in diabetic tissue

scientific article published on January 1999

Determination of transport rates for arginine and acetaminophen in rabbit intestinal tissues in vitro

scientific article published on 01 February 1994

Downregulation of topoisomerase I in differentiating human intestinal epithelial cells

scientific article

Dynamin 2 Regulates Riboflavin Endocytosis in Human Placental Trophoblasts

scientific article published on 12 June 2007

Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1.

scientific article

Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3).

scientific article published on 30 January 2006

Electrostatic and potential cation-pi forces may guide the interaction of extracellular loop III with Na+ and bile acids for human apical Na+-dependent bile acid transporter

scientific article published in March 2008

Endocytosis and Interaction of Poly (Amidoamine) Dendrimers with Caco-2 Cells

scientific article published on 15 August 2007

Endocytosis inhibitors prevent poly(amidoamine) dendrimer internalization and permeability across Caco-2 cells

scientific article published on 4 January 2008

Enhanced transepithelial transport of peptides by conjugation to cholic acid

scientific article published on July 1997

Evaluation of the effect of ethanol's toxic metabolite acetaldehyde on the gastrointestinal oligopeptide transporter, PEPT1: in vitro and in vivo studies

scientific article published on 20 November 2007

Future directions for drug transporter modelling.

scientific article published on October 2007

G3.5 PAMAM dendrimers enhance transepithelial transport of SN38 while minimizing gastrointestinal toxicity.

scientific article published on 27 November 2010

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites

scientific article

ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

scientific article

Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening

scientific article

Identification of Key Amino Acids that Impact Organic Solute Transporter <i>α</i>/<i>β</i> (OSTα/β)

scientific article published on 01 October 2021

Identification of Novel Breast Cancer Resistance Protein (BCRP) Inhibitors by Virtual Screening ⬇️

scientific article published on March 21, 2013

Identification of interactive gene networks: a novel approach in gene array profiling of myometrial events during guinea pig pregnancy

scientific article published on June 2006

In silico strategies for modeling membrane transporter function.

scientific article

In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors

scientific article

Intracellular Ca2+ release mediates cationic but not anionic poly(amidoamine) (PAMAM) dendrimer-induced tight junction modulation

scientific article published on 20 March 2014

Intracellular processing of riboflavin in human breast cancer cells.

scientific article

Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin.

scientific article

Machine learning methods and docking for predicting human pregnane X receptor activation

scientific article published on 12 June 2008

Membrane transporters in drug development

scientific article (publication date: March 2010)

Microfabricated porous silicon particles enhance paracellular delivery of insulin across intestinal Caco-2 cell monolayers

scientific article published in January 2003

Microfluidic preparation of liposomes to determine particle size influence on cellular uptake mechanisms

scientific article published on 3 October 2013

Modeling of active transport systems

scientific article published on March 2002

Molecular Determinants of Recognition for the Intestinal Peptide Carrier

scientific article published on 01 May 1997

Molecular analysis and structure-activity relationship modeling of the substrate/inhibitor interaction site of plasma membrane monoamine transporter.

scientific article

Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration

scientific article

Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2.

scientific article published on 3 January 2005

Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1.

scientific article published in March 2004

Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination

scientific article published on 3 January 2008

Pharmaceutical Research—Looking Ahead

scientific article published on 22 January 2009

Pharmacophore-based discovery of ligands for drug transporters

scientific article published on 26 September 2006

Potential oral delivery of 7-ethyl-10-hydroxy-camptothecin (SN-38) using poly(amidoamine) dendrimers

scientific article published on 26 April 2008

Pregnancy and estradiol modulate myometrial G-protein pathways in the guinea pig

scientific article published on 08 May 2006

Rapid Identification of P-glycoprotein Substrates and Inhibitors

scientific article published on 22 September 2006

Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways

scientific article published on June 1, 1998

Recognition, co-internalization, and recycling of an avian riboflavin carrier protein in human placental trophoblasts

scientific article published on 6 January 2006

Reengineering the pharmaceutical industry by crash-testing molecules

scientific article

Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2).

scientific article published on April 2014

Riboflavin-targeted polymer conjugates for breast tumor delivery.

scientific article published on 9 April 2013

Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4.

scientific article published on 23 October 2013

Science Beyond Impact Factors

scientific article published on 18 February 2009

Sequential processing of human ProIL-1beta by caspase-1 and subsequent folding determined by a combined in vitro and in silico approach

scientific article

Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)

scientific article

Straight-Chain Naltrexone Ester Prodrugs: Diffusion and Concurrent Esterase Biotransformation in Human Skin

scientific article published on 01 December 2002

Structural biology and function of solute transporters: implications for identifying and designing substrates

scientific article

Structural determinants of P-glycoprotein-mediated transport of glucocorticoids

scientific article published on November 2003

Structural requirements of the ASBT by 3D-QSAR analysis using aminopyridine conjugates of chenodeoxycholic acid

scientific article published on 22 October 2010

Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members

scientific article published on 5 June 2007

Targeting Drug Transporters – Combining In Silico and In Vitro Approaches to Predict In Vivo

scientific article published on 01 January 2010

The cytosolic half of helix III forms the substrate exit route during permeation events of the sodium/bile acid cotransporter ASBT.

scientific article

The ethanol metabolite acetaldehyde increases paracellular drug permeability in vitro and oral bioavailability in vivo

scientific article published on 9 October 2009

Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)

scientific article

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

scientific article

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

article

Transepithelial transport of PEGylated anionic poly(amidoamine) dendrimers: implications for oral drug delivery

scientific article published on 22 April 2009

Transmembrane Domain VII of the Human Apical Sodium-Dependent Bile Acid Transporter ASBT (SLC10A2) Lines the Substrate Translocation Pathway

scientific article published on 09 August 2006

Transmembrane domain II of the human bile acid transporter SLC10A2 coordinates sodium translocation

scientific article published on 17 September 2013

Transmembrane domain V plays a stabilizing role in the function of human bile acid transporter SLC10A2.

scientific article published on 16 July 2013

Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2.

scientific article

Transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers: Influence of size, charge and fluorescent labeling

scientific article

Tyrosine Phosphorylation Regulates Plasma Membrane Expression and Stability of the Human Bile Acid Transporter ASBT (SLC10A2)

scientific article published on 08 July 2019

Use of the intestinal bile acid transporter for the uptake of cholic acid conjugates with HIV-1 protease inhibitory activity

scientific article published on February 1997

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