List of works - Kathryn J Else

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

scientific article published on 11 July 2018

A Cellular Automata Model for Helper T Cell Subset Polarization in Chronic and Acute Infection

article

A classification of tasks for the systematic study of immune response using functional genomics data.

scientific article

A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis

article

A comparison of local and peripheral parasite-specific antibody production in different strains of mice infected with Trichuris muris.

scientific article

A novel copro-diagnostic molecular method for qualitative detection and identification of parasitic nematodes in amphibians and reptiles

scientific article published on 21 September 2017

Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection.

scientific article

Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase

scientific article published on 12 March 2020

Accumulation of eosinophils in intestine‐draining mesenteric lymph nodes occurs after Trichuris muris infection ⬇️

scientific article published on January 1, 2011

Altered antibody responses in mannose-binding lectin-A deficient mice do not affect Trichuris muris or Schistosoma mansoni infections

scientific article published in February 2009

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

scientific article

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

scientific article published on 2 December 2017

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Anthelmintic drug discovery: target identification, screening methods and the role of open science

scientific article published on 02 June 2020

Antibody isotype responses to Trichuris infection in humanized SCID mice

article

Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris

scientific article

Antigen selection for future anti-Trichuris vaccines: a comparison of cytokine and antibody responses to larval and adult antigen in a primary infection.

scientific article

Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis

scientific article published in May 1988

Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.

scientific article published on July 2011

CD4+ T-cell localization to the large intestinal mucosa during Trichuris muris infection is mediated by G alpha i-coupled receptors but is CCR6- and CXCR3-independent.

scientific article published on 9 September 2009

Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection.

scientific article published on 12 June 2019

Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection

scientific article published in April 1991

Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice

scientific article

Characterisation of cuticular inflation development and ultrastructure in Trichuris muris using correlative X-ray computed tomography and electron microscopy

scientific article published on 03 April 2020

Characterisation of the protective immune response following subcutaneous vaccination of susceptible mice against Trichuris muris

scientific article

Chemokines and leucocyte migration in parasitic disease

scientific article

Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation

scientific article published on 11 May 2017

Correction: A novel copro-diagnostic molecular method for qualitative detection and identification of parasitic nematodes in amphibians and reptiles.

scientific article published on 7 June 2018

Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris

scientific article

Cytokine and chemokine responses underlying acute and chronic Trichuris muris infection

scientific article

Cytokine production in BALB/c mice immunized with radiation attenuated third stage larvae of the filarial nematode, Brugia pahangi.

scientific article

Cytokine response profiles predict species-specific infection patterns in human GI nematodes

article

Cytokine-mediated regulation of chronic intestinal helminth infection

scientific article

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

scientific article

Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation

scientific article

Dynamical and critical behavior of a simple discrete model of the cellular immune system

article

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

scientific article published on 17 March 2017

Eosinophils may play regionally disparate roles in influencing IgA(+) plasma cell numbers during large and small intestinal inflammation

scientific article

Evaluating the IgMi mouse as a novel tool to study B cell biology

article

Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris

scientific article published on February 1995

Experimental steering of electron microscopy studies using prior X-ray computed tomography.

scientific article published on 20 March 2019

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell

scientific article

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

scientific article published on 3 October 2005

Genetic influences upon eosinophilia and resistance in mice infected with Trichinella spiralis

scientific article published on 01 August 1992

Genetic variation in the humoral immune responses of mice to the nematode Trichuris muris

article

Genetically-determined influences on the ability of poor responder mice to respond to immunization against Trichuris muris

scientific article published on 01 June 1990

Have gastrointestinal nematodes outwitted the immune system?

scientific article

Helper T-cell subsets in mouse trichuriasis

scientific article

Heterogeneity across the murine small and large intestine

scientific article

Host predisposition to trichuriasis: the mouse--T. muris model.

scientific article

Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes

scientific article published on October 1991

Human Trichuris-specific antibody responses in vaccinated hu-PBL-SCID mice

article

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

scientific article published on 15 December 2023

Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite

scientific article

Immunity to Trichuris muris in the laboratory mouse

scientific article published on 01 June 2003

Immunity to coccidiosis: genetic influences on lymphocyte and cytokine responses to infection with Eimeria vermiformis in inbred mice.

scientific article

Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms

scientific article published on 01 July 1993

Immunological relationships during primary infection with Heligmosomoides polygyrus: Th2 cytokines and primary response phenotype

scientific article published on 01 May 1994

Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.

scientific article

In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection

scientific article published on 23 March 2020

In vitro antigen presenting cell-derived IL-10 and IL-6 correlate with Trichuris muris isolate-specific survival

scientific article published on March 2009

Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice

scientific article published on February 2014

Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5 CD11c cells

scientific article published on 01 August 2018

Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8 T Cell Responses

article

Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness

scientific article published in April 2008

Interactions of helminths with macrophages: therapeutic potential for inflammatory intestinal disease

scientific article published on 16 August 2018

Interleukin-12 promotes a chronic intestinal nematode infection

scientific article published on 01 April 1997

Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation

scientific article published on 15 May 2017

Intestinal epithelial suppressor of cytokine signaling 3 enhances microbial-induced inflammatory tumor necrosis factor-α, contributing to epithelial barrier dysfunction

scientific article

Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection.

scientific article published in September 2006

Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse

scientific article published on 10 August 2020

Invited review Intestinal nematode parasites, cytokines and effector mechanisms

article

Isolates of Trichuris muris elicit different adaptive immune responses in their murine host.

scientific article

Leucocyte recruitment during enteric nematode infection

scientific article

Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response

scientific article published on 01 December 1994

MHC-restricted antibody responses to Trichuris muris excretory/secretory (E/S) antigen

scientific article published in September 1990

Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris.

scientific article

Mechanisms of leucocyte recruitment to the inflamed large intestine: redundancy in integrin and addressin usage

scientific article published in March 2008

Modulation of cytokine production and response phenotypes in murine trichuriasis.

scientific article

P2X7 receptor-dependent tuning of gut epithelial responses to infection

scientific article

Peripheral cytokine responses to Trichuris muris reflect those occurring locally at the site of infection

scientific article

Possible substitutes for nitrite for pigment formation in cured meat products.

scientific article

Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection

scientific article

Regulation of colonic epithelial cell turnover by IDO contributes to the innate susceptibility of SCID mice to Trichuris muris infection

scientific article published on April 2011

Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival

scientific article published on February 2009

Retinoic acid signalling in gastrointestinal parasite infections: lessons from mouse models.

scientific article

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation

scientific article

T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans.

scientific article

Th2 Cytokines Are Associated with Reduced Worm Burdens in a Human Intestinal Helminth Infection

scientific article published on 14 November 2003

The Characterization of Intraepithelial Lymphocytes, Lamina Propria Leukocytes, and Isolated Lymphoid Follicles in the Large Intestine of Mice Infected with the Intestinal Nematode Parasite Trichuris muris

scientific article published on 01 November 2005

The Essential Role Played by B Cells in Supporting Protective Immunity Against Trichuris muris Infection Is by Controlling the Th1/Th2 Balance in the Mesenteric Lymph Nodes and Depends on Host Genetic Background

scientific article published on 10 December 2019

The Gut-Associated Lymphoid Tissues in the Small Intestine, Not the Large Intestine, Play a Major Role in Oral Prion Disease Pathogenesis

scientific article published on 8 July 2015

The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock.

scientific article

The effect of challenge and trickle Trichuris muris infections on the polarisation of the immune response

scientific article published on 01 December 2001

The effects of H-2 and non-H-2 genes on the expulsion of the nematode Trichuris muris from inbred and congenic mice

scientific article published in June 1988

The essential role played by B cells in supporting protective immunity against Trichuris muris infection is dependent on host genetic background and is independent of antibody

The goblet cell is the cellular source of the anti-microbial angiogenin 4 in the large intestine post Trichuris muris infection

scientific article

The in vivo role of stem cell factor (c-kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice

scientific article published on 01 January 1993

The influence of genes mapping within the major histocompatibility complex on resistance to Trichuris muris infections in mice

scientific article

The innate immune responses of colonic epithelial cells to Trichuris muris are similar in mouse strains that develop a type 1 or type 2 adaptive immune response

scientific article published on November 2006

The mannose receptor binds Trichuris muris excretory/secretory proteins but is not essential for protective immunity

scientific article published on 27 June 2008

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines.

scientific article published on 19 December 2011

The retinoic acid receptor agonist Am80 increases mucosal inflammation in an IL-6 dependent manner during Trichuris muris infection

scientific article published on 15 September 2013

The retinoic acid-producing capacity of gut dendritic cells and macrophages is reduced during persistent T. muris infection

scientific article published on July 2013

The role of CD4 cells in protective immunity to Brugia pahangi.

scientific article published in July 1994

The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection

scientific article published in July 2006

Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages

scientific article published on 30 July 2021

Trichuris muris research revisited: a journey through time

scientific article published on September 2013

Trichuris muris: CD4+ T cell-mediated protection in reconstituted SCID mice

Trichuris muris: antigen recognition and transfer of immunity in mice by IgA monoclonal antibodies

scientific article published in January 1991

Trichuris muris: host intestinal epithelial cell hyperproliferation during chronic infection is regulated by interferon-gamma.

scientific article

Whipworm and roundworm infections

scientific article published on 28 May 2020

X-ray micro-computed tomography (μCT): an emerging opportunity in parasite imaging

scientific article published on 28 November 2017

β7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection

scientific article published on 01 June 2000

List of works by Kathryn J Else

2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm

A Cellular Automata Model for Helper T Cell Subset Polarization in Chronic and Acute Infection

A classification of tasks for the systematic study of immune response using functional genomics data.

A comparison of cellular and humoral immune responses to trichuroid derived antigens in human trichuriasis

A comparison of local and peripheral parasite-specific antibody production in different strains of mice infected with Trichuris muris.

A novel copro-diagnostic molecular method for qualitative detection and identification of parasitic nematodes in amphibians and reptiles

Absence of CC chemokine ligand 2 results in an altered Th1/Th2 cytokine balance and failure to expel Trichuris muris infection.

Accelerated onset of CNS prion disease in mice co-infected with a gastrointestinal helminth pathogen during the preclinical phase

Accumulation of eosinophils in intestine‐draining mesenteric lymph nodes occurs after Trichuris muris infection ⬇️

Altered antibody responses in mannose-binding lectin-A deficient mice do not affect Trichuris muris or Schistosoma mansoni infections

An antagonist of the retinoid X receptor reduces the viability of Trichuris muris in vitro

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes

Anthelmintic drug discovery: target identification, screening methods and the role of open science

Antibody isotype responses to Trichuris infection in humanized SCID mice

Antibody-independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris

Antigen selection for future anti-Trichuris vaccines: a comparison of cytokine and antibody responses to larval and adult antigen in a primary infection.

Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis

Arginase-1-expressing macrophages are dispensable for resistance to infection with the gastrointestinal helminth Trichuris muris.

CD4+ T-cell localization to the large intestinal mucosa during Trichuris muris infection is mediated by G alpha i-coupled receptors but is CCR6- and CXCR3-independent.

Caveolin1 interacts with the glucocorticoid receptor in the lung but is dispensable for its anti-inflammatory actions in lung inflammation and Trichuris Muris infection.

Cellular immune responses to the murine nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection

Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of TH-cell subsets in resistant versus susceptible mice

Characterisation of cuticular inflation development and ultrastructure in Trichuris muris using correlative X-ray computed tomography and electron microscopy

Characterisation of the protective immune response following subcutaneous vaccination of susceptible mice against Trichuris muris

Chemokines and leucocyte migration in parasitic disease

Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation

Correction: A novel copro-diagnostic molecular method for qualitative detection and identification of parasitic nematodes in amphibians and reptiles.

Correlations between worm burden and markers of Th1 and Th2 cell subset induction in an inbred strain of mouse infected with Trichuris muris

Cytokine and chemokine responses underlying acute and chronic Trichuris muris infection

Cytokine production in BALB/c mice immunized with radiation attenuated third stage larvae of the filarial nematode, Brugia pahangi.

Cytokine response profiles predict species-specific infection patterns in human GI nematodes

Cytokine-mediated regulation of chronic intestinal helminth infection

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation

Dynamical and critical behavior of a simple discrete model of the cellular immune system

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Eosinophils may play regionally disparate roles in influencing IgA(+) plasma cell numbers during large and small intestinal inflammation

Evaluating the IgMi mouse as a novel tool to study B cell biology

Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris

Experimental steering of electron microscopy studies using prior X-ray computed tomography.

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell

Gastrointestinal nematode infection is associated with variation in innate immune responsiveness

Genetic influences upon eosinophilia and resistance in mice infected with Trichinella spiralis

Genetic variation in the humoral immune responses of mice to the nematode Trichuris muris

Genetically-determined influences on the ability of poor responder mice to respond to immunization against Trichuris muris

Have gastrointestinal nematodes outwitted the immune system?

Helper T-cell subsets in mouse trichuriasis

Heterogeneity across the murine small and large intestine

Host predisposition to trichuriasis: the mouse--T. muris model.

Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes

Human Trichuris-specific antibody responses in vaccinated hu-PBL-SCID mice

Human serous cavity macrophages and dendritic cells possess counterparts in the mouse with a distinct distribution between species

Identification of novel genes in intestinal tissue that are regulated after infection with an intestinal nematode parasite

Immunity to Trichuris muris in the laboratory mouse

Immunity to coccidiosis: genetic influences on lymphocyte and cytokine responses to infection with Eimeria vermiformis in inbred mice.

Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): downregulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms

Immunological relationships during primary infection with Heligmosomoides polygyrus: Th2 cytokines and primary response phenotype

Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.

In silico design of a T-cell epitope vaccine candidate for parasitic helminth infection

In vitro antigen presenting cell-derived IL-10 and IL-6 correlate with Trichuris muris isolate-specific survival

Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice

Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5 CD11c cells

Infection-Induced Resistance to Experimental Cerebral Malaria Is Dependent Upon Secreted Antibody-Mediated Inhibition of Pathogenic CD8 T Cell Responses

Intensity of intestinal infection with multiple worm species is related to regulatory cytokine output and immune hyporesponsiveness

Interactions of helminths with macrophages: therapeutic potential for inflammatory intestinal disease

Interleukin-12 promotes a chronic intestinal nematode infection

Intestinal epithelial suppressor of cytokine signaling 3 (SOCS3) impacts on mucosal homeostasis in a model of chronic inflammation

Intestinal epithelial suppressor of cytokine signaling 3 enhances microbial-induced inflammatory tumor necrosis factor-α, contributing to epithelial barrier dysfunction

Intraepithelial gammadelta+ lymphocytes maintain the integrity of intestinal epithelial tight junctions in response to infection.

Investigating the importance of B cells and antibodies during Trichuris muris infection using the IgMi mouse

Invited review Intestinal nematode parasites, cytokines and effector mechanisms

Isolates of Trichuris muris elicit different adaptive immune responses in their murine host.

Leucocyte recruitment during enteric nematode infection

Low-level infection with Trichuris muris significantly affects the polarization of the CD4 response

MHC-restricted antibody responses to Trichuris muris excretory/secretory (E/S) antigen

Mast cells, eosinophils and antibody-mediated cellular cytotoxicity are not critical in resistance to Trichuris muris.

Mechanisms of leucocyte recruitment to the inflamed large intestine: redundancy in integrin and addressin usage

Modulation of cytokine production and response phenotypes in murine trichuriasis.