List of works - Roger J. Daly

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

scientific article (publication date: 13 June 2003)

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer.

scientific article published on 25 July 2017

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

scientific article

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

scientific article published on 17 July 2020

Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib

scientific article published in October 2007

Ablation of Grb10 specifically in muscle impacts on muscle size and glucose metabolism in mice

scientific article published on 23 January 2018

Adapter protein connections: the MRL and Grb7 protein families

scientific article

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

scientific article

Annexin A6 is a scaffold for PKCα to promote EGFR inactivation ⬇️

scientific article published on July 16, 2012

Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

scientific article published in September 2005

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

scientific article (publication date: 17 December 1992)

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

scientific article published on 10 October 2017

Author Correction: Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.

scientific article published on 5 December 2017

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

scientific article published on 26 January 2021

Cell graph neural networks enable the precise prediction of patient survival in gastric cancer

scientific article published in 2022

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

scientific article published on 20 March 2019

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

scientific article published in Nature Communications

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

scientific article published on 25 June 2013

Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer

scientific article

Cloning and characterization of GRB14, a novel member of the GRB7 gene family

scientific journal article

Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells.

scientific article

Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer.

scientific article

Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells

scientific article published on 24 August 2015

Distinction at the leading edge of the cell

scientific article published on 01 April 2005

Docking proteins.

scientific article published on 30 September 2010

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

scientific article published on 18 June 2009

Effect of FAK inhibitor VS-6063 (defactinib) on docetaxel efficacy in prostate cancer.

scientific article

Enduring epigenetic landmarks define the cancer microenvironment

scientific article published on 12 April 2018

Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models

scientific article published on 03 August 2021

Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines

scientific article published on November 1996

FAK signaling in human cancer as a target for therapeutics

scientific article

FGFR3 signaling and function in triple negative breast cancer

scientific article published on 27 January 2020

Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by heat shock protein 90 inhibition

scientific article published on 15 July 2020

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein

scientific article published on 15 May 2006

Functional characterization of cancer-associated Gab1 mutations.

scientific article

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.

scientific article published on 12 November 2007

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation

scientific article

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

scientific article

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

scientific article

Global characterization of signalling networks associated with tamoxifen resistance in breast cancer.

scientific article

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells

scientific article published on 19 April 2022

Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation

scientific article published on November 2014

Grb10 regulates the development of fiber number in skeletal muscle

article

Grb7-based molecular therapeutics in cancer ⬇️

scientific article published on May 10, 2003

Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel

scientific article

Helicobacter pylori Type IV Secretion System and Its Adhesin Subunit, CagL, Mediate Potent Inflammatory Responses in Primary Human Endothelial Cells

scientific article published on 6 February 2018

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases

scientific article published on 16 August 2016

Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells.

scientific article

How to Grb2 a Gab.

scientific article

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

scientific article published on 25 May 2021

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

scientific article (publication date: 22 October 1999)

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

scientific article

Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.

scientific article

Identification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants

scientific article published on 9 April 2018

Impact of the anti-cancer drug NT157 on tyrosine kinase signalling networks

scientific article published on 12 February 2018

Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells

scientific article

Interaction of growth factors during progression towards steroid independence in T-47-D human breast cancer cells

scientific article published on July 1990

Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway

scientific article published on February 2013

KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling

scientific article

Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status.

scientific article

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

scientific article

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer.

scientific article

Nedd4 controls animal growth by regulating IGF-1 signaling

scientific article

Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial α5 integrin

scientific article published on 20 May 2013

New insights into signalling networks regulating breast cancer stem cells.

scientific article

Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development

article

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

scientific article published on March 2010

PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.

scientific article published in April 2010

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2 ⬇️

scientific article published on January 15, 2002

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.

scientific article published on 12 February 2016

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

scientific article

PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection

scientific article

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes

scientific article

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

scientific article published on 22 August 2013

Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer

scientific article published on 5 November 2013

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

scientific article

Professor Robert Sutherland FAA, AO (1947-2012).

scientific article published in December 2013

Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

scientific article

Progression to steroid autonomy is accompanied by altered sensitivity to growth factors in S115 mouse mammary tumour cells

scientific article

Protein kinase Cdelta and calmodulin regulate epidermal growth factor receptor recycling from early endosomes through Arp2/3 complex and cortactin

scientific journal article

Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment

scientific article published on 06 May 2019

Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia.

scientific article published on 9 March 2016

Quokka: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome

scientific article published on 01 December 2018

RON is not a prognostic marker for resectable pancreatic cancer ⬇️

scientific article published on September 7, 2012

Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling

scientific article published on 3 June 2016

SH2 domain-containing signaling proteins in human breast cancer

scientific article published on April 1995

Signalling through the grapevine ⬇️

scientific article published on March 1, 2012

Signalome-wide assessment of host cell response to hepatitis C virus

scientific article published on 8 May 2017

Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain

scientific article

Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2

scientific article

Special Issue - Signalling. Introduction: Frontiers in cell signalling

scientific article published in 2013

Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association

scientific article published on 27 October 2017

TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.

scientific article published on 19 November 2012

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

scientific article

The Grb7 Family of Signalling Proteins

scientific article published on 01 October 1998

The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells.

scientific article

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

scientific article published on August 7, 1992

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

scientific article published on August 2002

The docking protein and proto-oncogene product Gab2 is regulated via a novel negative feedback mechanism mediated by 14-3-3 binding.

scientific article

The kinome 'at large' in cancer

scientific article published on January 2016

The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling

scientific article published on 29 July 2015

The pseudokinases SgK269 and SgK223: A novel oncogenic alliance in human cancer.

scientific article

The ras signaling pathway in mammary tumorigenesis and metastasis.

scientific article

The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.

scientific article

Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.

scientific article published on 5 October 2017

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

scientific article published on 21 September 2010

Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation with GRB2 expression

scientific article

iFeature: a python package and web server for features extraction and selection from protein and peptide sequences.

scientific article published on 8 March 2018

iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data

scientific article published on 24 April 2019

iLearnPlus: a comprehensive and automated machine-learning platform for nucleic acid and protein sequence analysis, prediction and visualization

scientific article published on 01 June 2021

List of works by Roger J. Daly

A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib

Ablation of Grb10 specifically in muscle impacts on muscle size and glucose metabolism in mice

Adapter protein connections: the MRL and Grb7 protein families

Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3

Annexin A6 is a scaffold for PKCα to promote EGFR inactivation ⬇️

Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

Aurora Kinase B, a novel regulator of TERF1 binding and telomeric integrity

Author Correction: Tyrosine dephosphorylated cortactin downregulates contractility at the epithelial zonula adherens through SRGAP1.

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies

Cell graph neural networks enable the precise prediction of patient survival in gastric cancer

Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target

Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Circulating microRNAs are associated with docetaxel chemotherapy outcome in castration-resistant prostate cancer

Cloning and characterization of GRB14, a novel member of the GRB7 gene family

Cortactin modulates RhoA activation and expression of Cip/Kip cyclin-dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells.

Cytokine profiling of docetaxel-resistant castration-resistant prostate cancer.

Dataset from the global phosphoproteomic mapping of early mitotic exit in human cells

Distinction at the leading edge of the cell

Docking proteins.

Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis

Effect of FAK inhibitor VS-6063 (defactinib) on docetaxel efficacy in prostate cancer.

Enduring epigenetic landmarks define the cancer microenvironment

Evaluation of FGFR targeting in breast cancer through interrogation of patient-derived models

Expression and tyrosine phosphorylation of EMS1 in human breast cancer cell lines

FAK signaling in human cancer as a target for therapeutics

FGFR3 signaling and function in triple negative breast cancer

Fatty acid oxidation is an adaptive survival pathway induced in prostate tumors by heat shock protein 90 inhibition

Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein

Functional characterization of cancer-associated Gab1 mutations.

Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis.

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors.

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

Global characterization of signalling networks associated with tamoxifen resistance in breast cancer.

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells

Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation

Grb10 regulates the development of fiber number in skeletal muscle

Grb7-based molecular therapeutics in cancer ⬇️

Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel

Helicobacter pylori Type IV Secretion System and Its Adhesin Subunit, CagL, Mediate Potent Inflammatory Responses in Primary Human Endothelial Cells

Homo- and Heterotypic Association Regulates Signaling by the SgK269/PEAK1 and SgK223 Pseudokinases

Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells.

How to Grb2 a Gab.

INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer

Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration

Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14

Identification of novel non-phosphorylated ligands, which bind selectively to the SH2 domain of Grb7.

Identification of novel response and predictive biomarkers to Hsp90 inhibitors through mass spectrometry-based proteomic profiling of patient-derived prostate tumor explants

Impact of the anti-cancer drug NT157 on tyrosine kinase signalling networks

Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells

Interaction of growth factors during progression towards steroid independence in T-47-D human breast cancer cells

Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway

KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling

Loss of STARD10 expression identifies a group of poor prognosis breast cancers independent of HER2/Neu and triple negative status.

Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer.

Nedd4 controls animal growth by regulating IGF-1 signaling

Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial α5 integrin

New insights into signalling networks regulating breast cancer stem cells.

Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development

PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2 ⬇️

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells.

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

PhosphoPredict: A bioinformatics tool for prediction of human kinase-specific phosphorylation substrates and sites by integrating heterogeneous feature selection

Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein

Professor Robert Sutherland FAA, AO (1947-2012).

Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

Progression to steroid autonomy is accompanied by altered sensitivity to growth factors in S115 mouse mammary tumour cells