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List of works by Scott D Gray-Owen

A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii

scientific article published on 01 November 2021

A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the outer membrane protein P5-homologous adhesin

scientific article published on 15 October 2007

A comparative, cross-species investigation of the properties and roles of transferrin- and lactoferrin-binding protein B from pathogenic bacteria

scientific article published on 19 August 2016

A native outer membrane vesicle vaccine confers protection against meningococcal colonization in human CEACAM1 transgenic mice

scientific article

Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease

scientific article published in September 2011

Adherent-invasive Escherichia coli blocks interferon-γ-induced signal transducer and activator of transcription (STAT)-1 in human intestinal epithelial cells

scientific article

Adherent-invasive Escherichia coli target the epithelial barrier

scientific article published on 5 January 2010

Adherent-invasive Escherichia coli, strain LF82 disrupts apical junctional complexes in polarized epithelia

scientific article

Alternate synthesis to d-glycero-β-d-manno-heptose 1,7-biphosphate.

scientific article published on 24 August 2017

Arrested maturation of Neisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2.

scientific article published on 15 May 2007

Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response

scientific article

Bacterial transferrin and lactoferrin receptors

scientific article

Bcl10 synergistically links CEACAM3 and TLR-dependent inflammatory signalling

scientific article published on 8 September 2017

CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes ⬇️

scientific article published on June 16, 1997

CEACAM1 (CD66a) promotes human monocyte survival via a phosphatidylinositol 3-kinase- and AKT-dependent pathway.

scientific article published on 27 October 2006

CEACAM1 as a multi-purpose target for cancer immunotherapy

scientific article

Carcinoembryonic antigen (CEA) inhibits NK killing via interaction with CEA-related cell adhesion molecule 1.

scientific article

Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells.

scientific article published on June 2000

Characterization of aferric-binding proteinmutant inHaemophilus influenzae

scientific article published on 01 September 1997

Characterization of the Moraxella catarrhalis opa-like protein, OlpA, reveals a phylogenetically conserved family of outer membrane proteins

scientific article

Characterization of transferrin binding proteins 1 and 2 in invasive type b and nontypeable strains of Haemophilus influenzae.

scientific article

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment.

scientific article

Defining the roles of human carcinoembryonic antigen-related cellular adhesion molecules during neutrophil responses to Neisseria gonorrhoeae.

scientific article

Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity

scientific article

Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae

article

Differential response of primary and immortalized CD4+ T cells to Neisseria gonorrhoeae-induced cytokines determines the effect on HIV-1 replication.

scientific article

Discordant Effects of Licensed Meningococcal Serogroup B Vaccination on Invasive Disease and Nasal Colonization in a Humanized Mouse Model

scientific article published on 27 March 2017

Endometrial epithelial cell responses to coinfecting viral and bacterial pathogens in the genital tract can activate the HIV-1 LTR in an NF{kappa}B-and AP-1-dependent manner

scientific article published in July 2011

Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors.

scientific article

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation

scientific article

Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis

scientific article published on 29 May 2007

Genome-based Definition of an Inflammatory Bowel Disease-associated Adherent-Invasive Escherichia coli Pathovar

scientific article published on 5 October 2015

Global analysis of neutrophil responses to Neisseria gonorrhoeae reveals a self-propagating inflammatory program

scientific article (publication date: September 2014)

Helicobacter pylori induces but survives the extracellular release of oxygen radicals from professional phagocytes using its catalase activity

article

Helicobacter pylori inhibits phagocytosis by professional phagocytes involving type IV secretion components

scientific article published on September 2000

Heptose Sounds the Alarm: Innate Sensing of a Bacterial Sugar Stimulates Immunity

scientific article

High Density or Urban Sprawl: What Works Best in Biology?

scientific article

High-Throughput Screening Identifies Genes Required for Induction of Macrophage Pyroptosis

article

Host cell invasion by pathogenic Neisseriae.

scientific article

INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity.

scientific article published on June 2015

Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor.

scientific article

In vivo adaptation and persistence of Neisseria meningitidis within the nasopharyngeal mucosa.

scientific article

Induction of antigen-specific TH 9 immunity accompanied by mast cell activation blocks tumor cell engraftment

scientific article

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.

scientific article published on May 2017

Inside-out signaling promotes dynamic changes in the carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) oligomeric state to control its cell adhesion properties.

scientific article published on 04 September 2013

Interaction of ruminant transferrins with transferrin receptors in bovine isolates of Pasteurella haemolytica and Haemophilus somnus ⬇️

scientific article published on July 1, 1992

Invasive potential of nonencapsulated disease isolates of Neisseria meningitidis.

scientific article

Metagenomics-Based, Strain-Level Analysis of Escherichia coli From a Time-Series of Microbiome Samples From a Crohn's Disease Patient

scientific article published on 30 October 2018

Modeling Neisseria meningitidis Infection in Mice: Methods and Logistical Considerations for Nasal Colonization and Invasive Disease

scientific article published on 01 January 2019

Modular arrangement of allelic variants explains the divergence in Moraxella catarrhalis UspA protein function.

scientific article published on 4 August 2008

Moraxella catarrhalis binding to host cellular receptors is mediated by sequence-specific determinants not conserved among all UspA1 protein variants

scientific article published on 4 August 2008

Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses

scientific article

Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers

scientific article published on 16 June 2021

Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae

scientific article

Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

article

Neisseria gonorrhoeae co-infection exacerbates vaginal HIV shedding without affecting systemic viral loads in human CD34+ engrafted mice

scientific article published on 23 January 2018

Neisseria gonorrhoeae effectively blocks HIV-1 replication by eliciting a potent TLR9-dependent interferon-α response from plasmacytoid dendritic cells

article

Neisseria gonorrhoeae infects the heterogeneous epithelia of the human cervix using distinct mechanisms

scientific article published on 02 December 2019

Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms.

scientific article published on 22 February 2012

Neisseria gonorrhoeae-derived heptose elicits an innate immune response and drives HIV-1 expression

scientific article published on 03 June 2013

Neisserial Opa proteins: impact on colonization, dissemination and immunity.

scientific article published on January 2003

Neisserial binding to CEACAM1 arrests the activation and proliferation of CD4+ T lymphocytes

scientific article published on 19 February 2002

Neisserial outer membrane vesicles bind the coinhibitory receptor carcinoembryonic antigen-related cellular adhesion molecule 1 and suppress CD4+ T lymphocyte function.

scientific article published on 9 July 2007

Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers.

scientific article

Opa proteins and CEACAMs: pathways of immune engagement for pathogenic Neisseria

scientific article published on 17 January 2011

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

scientific article published on 01 October 2020

Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae.

scientific article

Progress Toward a Gonococcal Vaccine: The Way Forward

scientific article published on 15 October 2019

Redefined nomenclature for members of the carcinoembryonic antigen family

scientific article

Reverse vaccinology-based identification of a novel surface lipoprotein that is an effective vaccine antigen against bovine infections caused by Pasteurella multocida ⬇️

scientific article published on 24 March 2023

Selection for a CEACAM receptor-specific binding phenotype during Neisseria gonorrhoeae infection of the human genital tract.

scientific article

Shikimate Induced Transcriptional Activation of Protocatechuate Biosynthesis Genes by QuiR, a LysR-Type Transcriptional Regulator, in Listeria monocytogenes

scientific article published on 9 March 2018

Slam is an outer membrane protein that is required for the surface display of lipidated virulence factors in Neisseria

scientific article published on 29 February 2016

Specific binding to differentially-expressed human CEACAMs determines the outcome of Neisseria gonorrhoeae infections along the female reproductive tract.

scientific article

Sterilizing immunity elicited by Neisseria meningitidis carriage shows broader protection than predicted by serum antibody cross-reactivity in CEACAM1-humanized mice.

scientific article

Summary and Recommendations from the National Institute of Allergy and Infectious Diseases (NIAID) Workshop "Gonorrhea Vaccines: the Way Forward".

scientific article published on 22 June 2016

TIFA Signaling in Gastric Epithelial Cells Initiates the cag Type 4 Secretion System-Dependent Innate Immune Response to Helicobacter pylori Infection

scientific article published on 15 August 2017

The HopQ-CEACAM Interaction Controls CagA Translocation, Phosphorylation, and Phagocytosis of Helicobacter pylori in Neutrophils

scientific article published on 04 February 2020

The bacterial virulence factor InlC perturbs apical cell junctions and promotes cell-to-cell spread of Listeria.

scientific article

The global roadmap for advancing development of vaccines against sexually transmitted infections: Update and next steps.

scientific article published on 19 April 2016

The heme-regulated inhibitor is a cytosolic sensor of protein misfolding that controls innate immune signaling

scientific article

The interaction of primate transferrins with receptors on bacteria pathogenic to humans

scientific article published in May 1993

The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD.

scientific article

The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.

scientific article published on 23 December 2015

The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway

scientific article published on 15 May 2007

The structural basis of CEACAM-receptor targeting by neisserial Opa proteins.

scientific article

Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis.

scientific article

Utility of Hybrid Transferrin Binding Protein Antigens for Protection Against Pathogenic Neisseria Species

scientific article published on 19 February 2019

Vigorous response of human innate functioning IgM memory B cells upon infection by Neisseria gonorrhoeae

scientific article

Whole-Genome Sequencing Reveals the Origin and Rapid Evolution of an Emerging Outbreak Strain of Streptococcus pneumoniae 12F.

scientific article

d-Glycero-β-d-Manno-Heptose 1-Phosphate and d-Glycero-β-d-Manno-Heptose 1,7-Biphosphate Are Both Innate Immune Agonists

scholarly article by Itunuoluwa A Adekoya et al published 15 October 2018 in Journal of Immunology

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