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List of works by Trevor M Penning

3 alpha-hydroxysteroid dehydrogenase: three dimensional structure and gene regulation

article

5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1).

scientific article published on 08 February 2014

A bioactive metabolite of benzo[a]pyrene, benzo[a]pyrene-7,8-dione, selectively alters microsomal Ca2+ transport and ryanodine receptor function.

scientific article

A nomenclature system for the aldo-keto reductase superfamily

scientific article published in January 1997

AKR1B10: a new diagnostic marker of non-small cell lung carcinoma in smokers

scientific article

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer

scientific article

AKR1C3 (type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase): Roles in malignancy and endocrine disorders

scientific article published on 19 September 2018

AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells

scientific article published on 11 June 2018

AKR1D1 knockout mice develop a sex-dependent metabolic phenotype

scientific article published in 2022

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

scientific article published on 12 February 2019

Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells

scientific article

Affinity labeling of 3 alpha-hydroxysteroid dehydrogenase with 3 alpha-bromoacetoxyandrosterone and 11 alpha-bromoacetoxyprogesterone. Isolation and sequence of active site peptides containing reactive cysteines; sequence confirmation using nucleoti

scientific article published on 01 May 1991

Affinity-labelling of the anti-inflammatory drug and prostaglandin-binding site of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol with 17 beta- and 21-bromoacetoxysteroids

scientific article published on July 1987

Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step

scientific article

Aldo-Keto Reductase Regulation by the Nrf2 System: Implications for Stress Response, Chemotherapy Drug Resistance, and Carcinogenesis

scientific article published on 3 November 2016

Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors

scientific article published on 18 January 2006

Aldo-keto reductase (AKR) superfamily: genomics and annotation.

scientific article published on July 2009

Aldo-keto reductase family 1 member C3 (AKR1C3) is expressed in adenocarcinoma and squamous cell carcinoma but not small cell carcinoma.

scientific article

Aldo-keto reductase- and cytochrome P450-dependent formation of benzo[a]pyrene-derived DNA adducts in human bronchoalveolar cells

scientific article published on 13 February 2007

Aldo-keto reductases and bioactivation/detoxication.

scientific article published on January 2007

Aldo-keto reductases and formation of polycyclic aromatic hydrocarbon o-quinones.

scientific article published on January 2004

Aldo-keto reductases in which the conserved catalytic histidine is substituted

scientific article published on 5 November 2008

Alternative splicing in the aldo-keto reductase superfamily: implications for protein nomenclature.

scientific article published on 05 January 2013

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone

scientific article published on 14 September 2007

Anatomical and cellular localization of neuroactive 5 alpha/3 alpha-reduced steroid-synthesizing enzymes in the spinal cord

scientific journal article

Androgen biosynthesis in castration-resistant prostate cancer

scientific article

Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione

scientific article (publication date: 23 October 2009)

Automating Predictive Toxicology Using ComptoxAI

scientific article published in 2022

Benzo[a]pyrene-7,8-dihydrodiol promotes checkpoint activation and G2/M arrest in human bronchoalveolar carcinoma H358 cells

scientific article published on 17 November 2006

Bromoacetamido analogs of indomethacin and mefenamic acid as affinity-labeling agents and mechanistic probes for prostaglandin H2 synthase

scientific article published on 01 January 1995

Bromoacetamido-analogs of indomethacin and mefenamic acid affinity-label prostaglandin H2 synthase at two sites

scientific article published on 01 January 1997

Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate

scientific article published in December 2004

Characterization of dihydrodiol dehydrogenase in human liver and lung.

scientific article published in July 1990

Characterization of dihydrodiol dehydrogenase in rat H-4IIe hepatoma cells.

scientific article published on December 1989

Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile

scientific article published in August 1999

Characterization of mercapturic acid and glutathionyl conjugates of benzo[a]pyrene-7,8-dione by two-dimensional NMR.

scientific article published in May 1992

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling comp

scientific article published on 16 July 2009

Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence

scientific article published on 01 November 1996

Cloning and sequencing of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase ⬇️

scientific article published on May 15, 1991

Cloning, sequencing, and functional analysis of the 5'-flanking region of the rat 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase gene.

scientific article published on September 1995

Clues to the development of mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase: comparison of steroidal and nonsteroidal Michael acceptors and epoxides

scientific article published on 01 August 1991

Co-oxidation by cyclooxygenases

scientific article

Comparative anatomy of the aldo–keto reductase superfamily ⬇️

scientific article (publication date: 15 September 1997)

Comparison of p53 mutations induced by PAH o-quinones with those caused by anti-benzo[a]pyrene diol epoxide in vitro: role of reactive oxygen and biological selection

scientific article published on November 2006

Comparisons of (+/-)-benzo[a]pyrene-trans-7,8-dihydrodiol activation by human cytochrome P450 and aldo-keto reductase enzymes: effect of redox state and expression levels.

scientific article

Competing roles of aldo-keto reductase 1A1 and cytochrome P4501B1 in benzo[a]pyrene-7,8-diol activation in human bronchoalveolar H358 cells: role of AKRs in P4501B1 induction

scientific article published on January 2006

Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts.

scientific article published on February 2005

Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer

scientific article published on 04 September 2018

Contribution of dihydrodiol dehydrogenase to the metabolism of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in fortified rat liver subcellular fractions

scientific article published on 01 September 1992

Conversion of Human Steroid 5 -Reductase (AKR1D1) into 3 -Hydroxysteroid Dehydrogenase by Single Point Mutation E120H: EXAMPLE OF PERFECT ENZYME ENGINEERING

scientific article

Correction to "Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone"

scientific article published on 30 October 2019

Correction to Quantitative Detection of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Using Chemical Tagging and qPCR.

scientific article published on 30 July 2014

Correction: Unconventional Gas and Oil Drilling Is Associated with Increased Hospital Utilization Rates

scientific article published on 28 August 2015

Crystal Structure of Human Liver  4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

scientific article

Crystal Structure of Perakine Reductase, Founding Member of a Novel Aldo-Keto Reductase (AKR) Subfamily That Undergoes Unique Conformational Changes during NADPH Binding

scientific article published on 30 March 2012

Crystal structure of human type III 3alpha-hydroxysteroid dehydrogenase/bile acid binding protein complexed with NADP(+) and ursodeoxycholate

scientific article

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer ⬇️

scientific article published on March 29, 2012

Current advances in intratumoral androgen metabolism in castration-resistant prostate cancer.

scientific article published on June 2016

Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase

scientific article

Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells

scientific article published on May 1993

DNA strand scission by polycyclic aromatic hydrocarbon o-quinones: role of reactive oxygen species, Cu(II)/Cu(I) redox cycling, and o-semiquinone anion radicals,

scientific article published on 01 July 1997

Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues

scientific article

Detection of an Fe2+-protoporphyrin-IX intermediate during aspirin-treated prostaglandin H2 synthase II catalysis of arachidonic acid to 15-HETE

scientific article published on 01 June 1997

Detoxication of benzo[a]pyrene-7,8-dione by sulfotransferases (SULTs) in human lung cells

scientific article (publication date: 24 August 2012)

Detoxication of structurally diverse polycyclic aromatic hydrocarbon (PAH) o-quinones by human recombinant catechol-O-methyltransferase (COMT) via O-methylation of PAH catechols

scientific article (publication date: 22 July 2011)

Development of Potent and Selective Indomethacin Analogues for the Inhibition of AKR1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase/Prostaglandin F Synthase) in Castrate-Resistant Prostate Cancer

scientific article

Development of Potent and Selective Inhibitors of Aldo–Keto Reductase 1C3 (Type 5 17β-Hydroxysteroid Dehydrogenase) Based on N-Phenyl-Aminobenzoates and Their Structure–Activity Relationships ⬇️

scientific article published on February 15, 2012

Development of a genotyping microarray for studying the role of gene-environment interactions in risk for lung cancer

scientific article published on December 2013

Development of affinity labeling agents based on nonsteroidal anti-inflammatory drugs: labeling of the nonsteroidal anti-inflammatory drug binding site of 3 alpha-hydroxysteroid dehydrogenase

scientific article published on 01 December 1991

Development of nonsteroidal anti-inflammatory drug analogs and steroid carboxylates selective for human aldo-keto reductase isoforms: potential antineoplastic agents that work independently of cyclooxygenase isozymes

scientific article published on 8 October 2004

Dexamethasone regulation of the rat 3alpha-hydroxysteroid/dihydrodiol dehydrogenase gene

scientific article published on 01 March 1998

Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism

scientific article

Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones.

scientific article

Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

scientific article published on 7 January 2011

Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase

scientific article published in October 1996

Dissection of the physiological interconversion of 5alpha-DHT and 3alpha-diol by rat 3alpha-HSD via transient kinetics shows that the chemical step is rate-determining: effect of mutating cofactor and substrate-binding pocket residues on catalysis

scientific article published in September 2004

Editorial. 17th International Workshop on the Enzymology and Molecular Biology of Carbonyl Metabolism

scientific article published in June 2015

Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency

scientific article published on May 2015

Electrophoretic and immunochemical characterization of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenases of rat tissues

scientific article published on September 1988

Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: implications for prostate cancer progression

scientific article

Elucidation of a complete kinetic mechanism for a mammalian hydroxysteroid dehydrogenase (HSD) and identification of all enzyme forms on the reaction coordinate: the example of rat liver 3alpha-HSD (AKR1C9)

scientific article published on 11 September 2007

Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase

scientific article published in July 1998

Engineering steroid hormone specificity into aldo-keto reductases

scientific article published in January 2001

Environmental exposomics and lung cancer risk assessment in the Philadelphia metropolitan area using ZIP code-level hazard indices

scientific article published on 21 February 2021

Environmental health research recommendations from the Inter-Environmental Health Sciences Core Center Working Group on unconventional natural gas drilling operations

scientific article

Estrogen biosynthesis in human H295 adrenocortical carcinoma cells.

scientific article

Estrogen receptor-dependent and independent roles of benzo[a]pyrene in Ishikawa cells

scientific article published on 01 November 2020

Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells

scientific article (publication date: 13 May 2008)

Evidence that enzyme-generated aromatic Michael acceptors covalently modify the nucleotide-binding site of 3 alpha-hydroxysteroid dehydrogenase

scientific article published on August 1990

Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase

scientific article published on 01 July 1992

Examination of the differences in structure-function of human and rat 3alpha-hydroxysteroid dehydrogenase

scientific article published in February 2003

Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo

scientific article published on 01 August 1999

Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione

scientific article published on 01 May 1998

Formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) by PAH o-quinones: involvement of reactive oxygen species and copper(II)/copper(I) redox cycling

scientific article published on June 2005

Generation of Reactive Oxygen Species during the Enzymatic Oxidation of Polycyclic Aromatic Hydrocarbontrans-Dihydrodiols Catalyzed by Dihydrodiol Dehydrogenase

scientific article published on 01 January 1996

Genomics of smoking exposure and cessation: lessons for cancer prevention and treatment

scientific article published on 31 March 2008

Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification.

scientific article published on 6 September 2017

Geographic Differences in Lung Cancer Incidence: A Study of a Major Metropolitan Area within Southeastern Pennsylvania

scientific article published on 18 December 2020

Hormonal control of Leydig cell differentiation

scientific article published on 01 January 1991

Hormonal regulation of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol

scientific article published on 01 March 1992

Human aldo-keto reductases and the metabolic activation of polycyclic aromatic hydrocarbons

scientific article

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action

scientific article published on 12 December 2003

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

scientific article published on 12 February 2009

Human hydroxysteroid dehydrogenases and pre-receptor regulation: insights into inhibitor design and evaluation.

scientific article

Human type 3 3alpha-hydroxysteroid dehydrogenase (aldo-keto reductase 1C2) and androgen metabolism in prostate cells.

scientific article

Hydroxysteroid dehydrogenases and pre-receptor regulation of steroid hormone action.

scientific article

Hydroxysteroid dehydrogenases. New drug targets of the aldo-keto reductase superfamily

scientific article published on 01 January 1997

Identification of benzo[a]pyrene-7,8-dione as an authentic metabolite of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene in isolated rat hepatocytes

scientific article published on November 1995

Identification of the major oxidative 3alpha-hydroxysteroid dehydrogenase in human prostate that converts 5alpha-androstane-3alpha,17beta-diol to 5alpha-dihydrotestosterone: a potential therapeutic target for androgen-dependent disease

scientific article published on 22 September 2005

Identification of the molecular switch that regulates access of 5alpha-DHT to the androgen receptor

scientific article

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase

scientific article published in May 2000

In-Depth Dissection of the P133R Mutation in Steroid 5β-Reductase (AKR1D1): A Molecular Basis of Bile Acid Deficiency

scientific article

Inactivation of delta 5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids

scientific article published on 01 May 1982

Inactivation of delta5-3-ketosteroid isomerase(s) from beef adrenal cortex by beta, gamma-acetylenic ketosteroids

scientific article published on March 1982

Inactivation of Δ5-3-oxo steroid isomerase with active-site-directed acetylenic steroids ⬇️

scientific article published on January 1, 1981

Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer

scientific article published in March 2006

Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma

scientific article published on 01 March 2006

Indomethacin and glucocorticoid metabolism in rat liver cytosol

scientific article published on 01 December 1986

Indomethacin-sensitive 3 alpha-hydroxysteroid dehydrogenase in rat tissues

scientific article published on 01 March 1985

Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells

scientific article published on 20 November 2019

Inhibition of 5 beta-dihydrocortisone reduction in rat liver cytosol: a rapid spectrophotometric screen for nonsteroidal anti-inflammatory drug potency

scientific article published on 01 June 1985

Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex

scientific article

Inhibition of progesterone synthesis in normal and transformed human placental cells by tight binding inhibitors of 3 beta-hydroxysteroid dehydrogenase

scientific article published on 01 May 1988

Inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3): overview and structural insights.

scientific article

Integration of steroid research: Perspectives on environment factors, homeostasis in health, and disease treatment ⬇️

scientific article published on May 1, 2011

Intense androgen-deprivation therapy with abiraterone acetate plus leuprolide acetate in patients with localized high-risk prostate cancer: results of a randomized phase II neoadjuvant study

scientific article

Interception of benzo[a]pyrene-7,8-dione by UDP glucuronosyltransferases (UGTs) in human lung cells

scientific article (publication date: 21 October 2013)

Irreversible inactivation of delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni by acetylenic suicide substrates. Mechanism of formation and properties of the steroid-enzyme adduct.

scientific article published on July 1981

Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.

scientific article published on February 1999

Linkage of an acetylenic secosteroid suicide substrate to the active site of delta 5-3-ketosteroid isomerase. Isolation and characterization of a tetrapeptide

scientific article published on 01 July 1981

Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.

scientific article

Mammalian 3 alpha-hydroxysteroid dehydrogenases

scientific article published on September 1996

Mass spectrometric studies of a modified active-site tetrapeptide from delta 5-3-ketosteroid isomerase of Pseudomonas testosteroni

scientific article published on November 1982

Mechanism Based Inhibition of Hydroxysteroid Dehydrogenases ⬇️

scientific article published on January 1, 1991

Mechanism-based inactivation of COX-1 by red wine m-hydroquinones: a structure-activity relationship study

scientific article published in November 2004

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease

scientific article

Mechanisms of drug resistance that target the androgen axis in castration resistant prostate cancer (CRPC).

scientific article

Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct

scientific article (publication date: 21 May 2012)

Metabolism of a representative oxygenated polycyclic aromatic hydrocarbon (PAH) phenanthrene-9,10-quinone in human hepatoma (HepG2) cells.

scientific article

Metabolism of an Alkylated Polycyclic Aromatic Hydrocarbon 5-Methylchrysene in Human Hepatoma (HepG2) Cells.

scientific article

Metabolism of benzo[a]pyrene in human bronchoalveolar H358 cells using liquid chromatography-mass spectrometry

scientific article

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily

scientific article

Molecular determinants of steroid recognition and catalysis in aldo-keto reductases. Lessons from 3alpha-hydroxysteroid dehydrogenase.

scientific article

Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences

scientific article published on 7 February 2006

Molecular endocrinology of hydroxysteroid dehydrogenases

scientific article published on June 1997

Multidrug resistance protein (MRP) 4 attenuates benzo[a]pyrene-mediated DNA-adduct formation in human bronchoalveolar H358 cells.

scientific article published on 30 November 2011

Mutagenesis of 3α-Hydroxysteroid Dehydrogenase Reveals a “Push−Pull” Mechanism for Proton Transfer in Aldo−Keto Reductases ⬇️

scientific article published on March 10, 1998

Mutation of nicotinamide pocket residues in rat liver 3 alpha-hydroxysteroid dehydrogenase reveals different modes of cofactor binding

scientific article published on 01 January 2000

N-Benzoyl anthranilic acid derivatives as selective inhibitors of aldo-keto reductase AKR1C3.

scientific article published on 22 July 2012

New frontiers in androgen biosynthesis and metabolism.

scientific article

Non-K-region o-quinones as enzyme-generated inactivators of dihydrodiol dehydrogenase

scientific article published on May 1989

Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors ⬇️

scientific article published on July 29, 2010

Oestrogen-induced cholesterol and fatty acid biosynthesis in Xenopus laevis liver during vitellogenic response

scientific article published on August 1978

Oestrogen-stimulated cholesterol and lipid synthesis in Xenopus laevis liver

scientific article published on 01 November 1973

On the number of steroid-binding sites of delta 5-3-oxosteroid isomerase

scientific article published on 01 April 1980

Overexpression and mutagenesis of the cDNA for rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis.

scientific article

Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride.

scientific article published on 12 January 2012

Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.

scientific article

Oxidation of the trans-3,4-dihydrodiol metabolites of the potent carcinogen 7,12-dimethylbenz(a)anthracene and other benz(a)anthracene derivatives by 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase: effects of methyl substitution on velocity and st

scientific article published in March 1988

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

scientific article

Pentafluorosulfanyl-containing flufenamic acid analogs: Syntheses, properties and biological activities

scientific article

Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species

scientific article published on May 2006

Polycyclic aromatic hydrocarbon (PAH) ortho-quinone conjugate chemistry: kinetics of thiol addition to PAH ortho-quinones and structures of thioether adducts of naphthalene-1,2-dione

scientific article published on September 28, 1992

Polycyclic aromatic hydrocarbon o-quinones inhibit the activity of the catalytic fragment of protein kinase C.

scientific article

Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia

scientific article published on 25 March 2019

Potential Metabolic Activation of Representative Alkylated Polycyclic Aromatic Hydrocarbons 1-Methylphenanthrene and 9-Ethylphenanthrene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells

scientific article

Potential Metabolic Activation of a Representative C2-Alkylated Polycyclic Aromatic Hydrocarbon 6-Ethylchrysene Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells

scientific article

Potential Metabolic Activation of a Representative C4-Alkylated Polycyclic Aromatic Hydrocarbon Retene (1-Methyl-7-isopropyl-phenanthrene) Associated with the Deepwater Horizon Oil Spill in Human Hepatoma (HepG2) Cells

scientific article published on 9 March 2017

Pre-receptor regulation of the androgen receptor

scientific article

Promiscuity and diversity in 3-ketosteroid reductases.

scientific article published on 10 December 2014

Purification and properties of 3 alpha-hydroxysteroid dehydrogenase from rat brain cytosol. Inhibition by nonsteroidal anti-inflammatory drugs and progestins.

scientific article

Purification and properties of a 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol and its inhibition by anti-inflammatory drugs

scientific article published on September 1984

Pyrimidine-based tricyclic molecules as potent and orally efficacious inhibitors of wee1 kinase

scientific article published on 6 August 2014

Quantification of benzo[a]pyrene diol epoxide DNA-adducts by stable isotope dilution liquid chromatography/tandem mass spectrometry

scientific article published on January 2006

Quantitation of benzo[a]pyrene metabolic profiles in human bronchoalveolar (H358) cells by stable isotope dilution liquid chromatography-atmospheric pressure chemical ionization mass spectrometry

scientific article (publication date: 21 November 2011)

Radiochemical detection of dihydrodiol dehydrogenase: distribution of the enzyme in male Sprague-Dawley rat tissues and its sensitivity to inhibition by indomethacin and 6-medroxyprogesterone acetate

scientific article published on February 1987

Rat dihydrodiol dehydrogenase: complexity of gene structure and tissue-specific and sexually dimorphic gene expression

scientific article published on January 1994

Rat liver 3 alpha-hydroxysteroid dehydrogenase.

scientific article published in April 1986

Rate of steroid double-bond reduction catalysed by the human steroid 5β-reductase (AKR1D1) is sensitive to steroid structure: implications for steroid metabolism and bile acid synthesis

scientific article

Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.

scientific article

Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.

scientific article published in March 1993

Regio- and stereospecificity of homogeneous 3 alpha-hydroxysteroid-dihydrodiol dehydrogenase for trans-dihydrodiol metabolites of polycyclic aromatic hydrocarbons

scientific article published in May 1986

Regiospecific oxidation of polycyclic aromatic phenols to quinones by hypervalent iodine reagents

scientific article published on March 2010

Regulation of Benzo[a]pyrene-Mediated DNA- and Glutathione-Adduct Formation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Human Lung Cells ⬇️

scientific article published on October 28, 2010

Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents.

scientific article

Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine

scientific article published on 01 August 1998

Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone

scientific article published on 08 November 2018

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism

scientific article

Role of human type 3 3alpha-hydroxysteroid dehydrogenase (AKR1C2) in androgen metabolism of prostate cancer cells

scientific article published on February 2003

Role of quinones in toxicology.

scientific article

Ryanodine receptor-mediated rapid increase in intracellular calcium induced by 7,8-benzo(a)pyrene quinone in human and murine leukocytes

scientific article

Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

scientific article published on 31 December 2014

Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase

scientific article published on 01 August 1994

Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library

scientific article

Sex differences in indomethacin-sensitive 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol

scientific article published on 01 October 1985

Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

scientific article published on 12 August 2016

Single-molecule enzymology of steroid transforming enzymes: Transient kinetic studies and what they tell us.

scientific article

Specificity of Human Aldo-Keto Reductases, NAD(P)H:Quinone Oxidoreductase, and Carbonyl Reductases to Redox-Cycle Polycyclic Aromatic Hydrocarbon Diones and 4-Hydroxyequilenin-o-quinone ⬇️

scientific article published on September 29, 2011

Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism.

scientific article

Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death

scientific article published in July 2001

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1–AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway ⬇️

scientific article published on July 1, 2011

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

scientific article

Steroid-binding site residues dictate optimal substrate positioning in rat 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD or AKR1C9).

scientific article published in February 2003

Strategies for synthesis of adducts of omicron-quinone metabolites of carcinogenic polycyclic aromatic hydrocarbons with 2'-deoxyribonucleosides

scientific article published on 9 January 2008

Structural and Functional Biology of Aldo-Keto Reductase Steroid Transforming Enzymes

scientific article published on 01 April 2019

Structure and function of 3 alpha-hydroxysteroid dehydrogenase

scientific article published on 01 January 1997

Structure-function aspects and inhibitor design of type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3)

scientific article (publication date: 22 January 2001)

Structure-function of human 3 alpha-hydroxysteroid dehydrogenases: genes and proteins.

scientific article published on February 2004

Structure-function relationships in 3alpha-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms.

scientific article

Studies on the biosynthesis, assembly and secretion of vitellogenin, an oestrogen-induced multicomponent protein

scientific article published on January 1977

Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)

scientific article

Suppressed expression of type 2 3alpha/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) in endometrial hyperplasia and carcinoma.

scientific article

Synthesis and characterization of polycyclic aromatic hydrocarbon o-quinone depurinating N7-guanine adducts.

scientific article

Synthesis and evaluation of non-steroidal mechanism-based inactivators of 3 alpha-hydroxysteroid dehydrogenase

scientific article

Synthesis of (13)C2-Benzo[a]pyrene and its 7,8-Dihydrodiol and 7,8-Dione Implicated as Carcinogenic Metabolites

scientific article (publication date: 21 July 2008)

Synthesis of (13)C4-labelled oxidized metabolites of the carcinogenic polycyclic aromatic hydrocarbon benzo[a]pyrene

scientific article (publication date: September 2012)

Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues.

scientific article published on 20 February 2008

Synthesis of phenol and quinone metabolites of benzo[a]pyrene, a carcinogenic component of tobacco smoke implicated in lung cancer

scientific article

Synthesis of the o-quinones and other oxidized metabolites of polycyclic aromatic hydrocarbons implicated in carcinogenesis

scientific article published in March 2004

Targeted inhibitors for steroid transforming enzymes

scientific article published on 01 May 2011

The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones

scientific article (publication date: 2012)

The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

scientific article

The aldo-keto reductase (AKR) superfamily: an update

scientific article published in January 2001

The aldo-keto reductase superfamily homepage

scientific article published in February 2003

The aldo-keto reductases (AKRs): Overview

scientific article

The arginine 276 anchor for NADP(H) dictates fluorescence kinetic transients in 3 alpha-hydroxysteroid dehydrogenase, a representative aldo-keto reductase

scientific article published on 01 June 1999

The biochemical basis for increased testosterone production in theca cells propagated from patients with polycystic ovary syndrome

scientific article

The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function

scientific article published on 24 December 2010

The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

scientific article published on September 1991

The pattern of p53 mutations caused by PAH o-quinones is driven by 8-oxo-dGuo formation while the spectrum of mutations is determined by biological selection for dominance

scientific article published on May 2008

The rate-determining steps of aldo-keto reductases (AKRs), a study on human steroid 5β-reductase (AKR1D1).

scientific article published on 11 December 2014

The role of toxicological science in meeting the challenges and opportunities of hydraulic fracturing

journal article published in 2014

The roles of aldo-keto reductases in steroid hormone action.

scientific article

The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation

scientific article

Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily

scientific article

Tibolone is metabolized by the 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four human isozymes of the aldo-keto reductase 1C subfamily: inversion of stereospecificity with a delta5(10)-3-ketosteroid

scientific article published on 21 September 2004

Tibolone metabolism in human liver is catalyzed by 3alpha/3beta-hydroxysteroid dehydrogenase activities of the four isoforms of the aldo-keto reductase (AKR)1C subfamily

scientific article

Transcript profiling of the androgen signal in normal prostate, benign prostatic hyperplasia, and prostate cancer

scientific article published on 7 September 2006

Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs.

scientific article

Unconventional gas and oil drilling is associated with increased hospital utilization rates

journal article published in 2015

Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells

scientific article

Using Biochemistry and Biophysics to Extinguish Androgen Receptor Signalling in Prostate Cancer

scientific article published on 31 December 2020

p53 Mutagenesis by benzo[a]pyrene derived radical cations

scientific article published on 9 August 2012

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