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List of works by Stepan Gambaryan

A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling.

scientific article published in August 2014

A review and discussion of platelet nitric oxide and nitric oxide synthase: do blood platelets produce nitric oxide from L-arginine or nitrite?

scientific article published on May 2015

Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146.

scientific article

Activation of Cardiac c-Jun NH 2 -Terminal Kinases and p38-Mitogen–Activated Protein Kinases With Abrupt Changes in Hemodynamic Load

scientific article published on 01 May 2001

Activation of cGMP-dependent protein kinase Ibeta inhibits interleukin 2 release and proliferation of T cell receptor-stimulated human peripheral T cells

scientific article published on 09 November 2000

Age dependent differences in the functional and morphological impairment of kidney following cisplatin administration

scientific article published in January 1990

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

scientific article published on 12 January 2017

Blood supply to the amphibian mesonephros

scientific article published on 01 January 1993

Carbonic anhydrases are producers of S-nitrosothiols from inorganic nitrite and modulators of soluble guanylyl cyclase in human platelets

scientific article published on 29 April 2016

Cloning and characterization of the transport modifier RS1 from rabbit which was previously assumed to be specific for Na+-D-glucose cotransport

scientific article published in February 1999

Cross-talk of inhibitory and stimulatory signalling pathways of human platelets.

scientific article

Cyclic Nucleotide-dependent Protein Kinases Target ARHGAP17 and ARHGEF6 Complexes in Platelets.

scientific article published on 27 October 2015

Cyclic nucleotide-regulated proliferation and differentiation vary in human hematopoietic progenitor cells derived from healthy persons, tumor patients, and chronic myelocytic leukemia patients

scientific article published on 01 February 2008

Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases

scientific journal article

Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay.

scientific article published on 15 March 2013

Development of the metanephros in the chick: maturation of glomerular size and nephron length

scientific article published on January 1, 1992

Differential regulation of platelet inhibition by cGMP- and cAMP-dependent protein kinases

Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis ⬇️

scientific article published on September 11, 2012

Differentiation of cGMP-dependent and -independent nitric oxide effects on platelet apoptosis and reactive oxygen species production using platelets lacking soluble guanylyl cyclase

scientific article published on 28 July 2011

Disruption of cardiac Ena-VASP protein localization in intercalated disks causes dilated cardiomyopathy

scientific article published on 21 August 2003

Distribution, cellular localization, and postnatal development of VASP and Mena expression in mouse tissues

scientific article published on 23 November 2001

Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets?

scientific article published on 01 May 2012

Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro

scientific article

Drug excretion mediated by a new prototype of polyspecific transporter

scientific journal article

Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists

scientific article published on 21 November 2013

Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation

scientific article

Effects of dietary salt on adrenomedullin and its receptor mRNAs in rat kidney.

scientific article

Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets

scientific article

Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator

scientific article published on August 1995

Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells

scientific journal article

Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis

scientific article published on 11 August 2016

Erythrocytes do not produce biologically active NO.

scientific article

Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression

scientific journal article

Feedback Regulation of Syk by Protein Kinase C in Human Platelets

scientific article published on 25 December 2019

Fluorescent sensors for rapid monitoring of intracellular cGMP

scientific article published on 01 January 2006

Frog urinary bladder epithelial cells express TLR4 and respond to bacterial LPS by increase of iNOS expression and l-arginine uptake

scientific article published on 26 September 2012

Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects

scientific article published on 01 July 1998

Functional and morphological aspects of thallium-induced nephrotoxicity in rats

scientific article published on 01 February 1995

Functional hyper-IL-6 from vaccinia virus-colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy

scientific article

Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes.

scientific article published in January 2002

Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes.

scientific article published in August 2004

Human blood platelets lack nitric oxide synthase activity

scientific article published on 31 October 2014

Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice.

scientific article published on 19 July 2011

Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation

scientific article published on 8 August 2017

Hypoxia inhibits the regulatory volume decrease in red blood cells of common frog (Rana temporaria)

scientific article published on 01 March 2018

Immune escape of AKT overexpressing ovarian cancer cells ⬇️

scientific article published on March 4, 2013

Immunofluorescent imaging of beta 1- and beta 2-adrenergic receptors in rat kidney.

scientific article

Immunolocalization of soluble guanylyl cyclase subunits in rat kidney

scientific article published on 01 January 1995

Increased effects of C-type natriuretic peptide on cardiac ventricular contractility and relaxation in guanylyl cyclase A-deficient mice

scientific article

Increased effects of C-type natriuretic peptide on contractility and calcium regulation in murine hearts overexpressing cyclic GMP-dependent protein kinase I.

scientific article

Increased sensitivity to endothelial nitric oxide (NO) contributes to arterial normotension in mice with vascular smooth muscle-selective deletion of the atrial natriuretic peptide (ANP) receptor

scientific article published on 11 March 2003

Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats

scientific article published on 01 June 1990

Inhibition of cGMP-dependent protein kinase II by its own splice isoform.

scientific article published on May 2002

Insulin inhibition of platelet-endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets

scientific article published on 12 February 2008

Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase.

scientific article published in September 2009

Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK

scientific article (publication date: 14 March 2003)

KATP channels are not essential for pressure-dependent control of renin secretion

scientific article published on April 1998

KT5823 inhibits cGMP-dependent protein kinase activity in vitro but not in intact human platelets and rat mesangial cells

scientific article (publication date: 27 October 2000)

L-Arginine counteracts nitric oxide deficiency and improves the recovery phase of ischemic acute renal failure in rats

scientific article

L-Arginine does not affect renal morphology and cell survival in ischemic acute renal failure in rats

scientific article published on 30 June 2005

Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase.

scientific article published on September 2013

Localization of cGMP-dependent protein kinase type II in rat brain.

scientific article published in January 2001

Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors

scientific article published on 01 July 2012

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice.

scientific article

Mena/VASP and αII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.

scientific article published on 12 August 2013

Multifaceted effects of arachidonic acid and interaction with cyclic nucleotides in human platelets

scientific article published on 13 September 2018

NAD Metabolome Analysis in Human Cells Using ¹H NMR Spectroscopy

scientific article published on 06 December 2018

NO inhibits platelet apoptosis by cGMP-dependent and-independent pathways.

scientific article

NO-synthase-/NO-independent regulation of human and murine platelet soluble guanylyl cyclase activity

scientific article published on 14 May 2008

Neisseria meningitidis induces platelet inhibition and increases vascular endothelial permeability via nitric oxide regulated pathways.

scientific article

Ontogenetic aspects of thallium-induced nephrotoxicity in rats

scientific article published on 01 May 1996

Orai1-induced store-operated Ca2+entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets

scientific article published on 01 April 2014

Oxidized LDL and its compound lysophosphatidylcholine potentiate AngII-induced vasoconstriction by stimulation of RhoA.

scientific article

PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling

scientific article

Phosphatidylserine surface expression and integrin alpha IIb beta 3 activity on thrombin/convulxin stimulated platelets/particles of different sizes

scientific article published on 20 November 2008

Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor

scientific article

Phosphoproteome of resting human platelets

scientific article

Phosphoproteomics of human platelets: A quest for novel activation pathways

scientific article

Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation.

scientific article published in August 2013

Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase

scientific journal article

Platelet Hemostasis Reactions at Different Temperatures Correlate with Intracellular Calcium Concentration

scientific article published in 2022

Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway

scientific article published on 23 June 2005

Platelet inhibitory effects of the NO independent sGC stimulator riociguat (Bay 63-2561)

scientific article published on 29 August 2013

Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS

scientific article

Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase.

scientific article

Potential pitfalls with the use of acetoxy (CH(3)COO) drugs in studies on nitric oxide synthase in platelets

scientific article published on 18 September 2012

Presynaptic role of cGMP-dependent protein kinase during long-lasting potentiation.

scientific article

Prostaglandin E2 inhibits vasotocin-induced osmotic water permeability in the frog urinary bladder by EP1-receptor-mediated activation of NO/cGMP pathway.

scientific article published on 15 March 2007

Protective effect of antiinflammatory corticosteroid triamcinolone in cisplatin nephrotoxicity

scientific article published on 01 January 1994

Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis

scientific article

Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis

scientific article published on 22 November 2004

Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.

scientific article

Roles of cGMP/cGMP-dependent protein kinase in platelet activation

scientific article published on 01 October 2004

Secretion of endogenous lithium in teleost kidneys as a probable reflection of Na+ and water secretion in their renal proximal tubules

scientific article published on 01 January 1990

Single L-type Ca(2+) channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice

scientific article published on November 2003

Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets

scientific article published on 07 March 2013

Specific PKG inhibitors: do they really exist?

scientific article published in August 2011

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition

scientific article published on 9 November 2016

The Thr715Pro variant impairs terminal glycosylation of P-selectin

scholarly article by Hariharan Subramanian et al published November 2012 in Thrombosis and Haemostasis

The effect of hydroxyl-containing dithiocarbamates on cisplatin-induced long-term renal dysfunction in Wistar rats

scientific article published on 01 October 1993

The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies

scientific article

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

scientific article

The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice

scientific article published on July 2009

The natriuretic peptide/guanylyl cyclase-A system functions as a stress-responsive regulator of angiogenesis in mice

The oligopeptide DT‐2 is a specific PKG I inhibitor only in vitro, not in living cells ⬇️

scientific article published on October 1, 2012

The prevention of cisplatin-induced renal dysfunction by hydroxyl-containing dithiocarbamates ⬇️

scientific article published on February 1, 1991

The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood

scientific article published on 18 August 2015

The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets

scientific article published on 11 January 2012

Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex

scientific article

Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase

scientific article published on 21 September 2006

Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways.

scientific article

Triiodothyronine (T3) increases cisplatin nephrotoxicity in young and adult rats

scientific article published on 01 December 1990

Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets

scientific article published on 13 September 2016

Vasodilator-stimulated phosphoprotein-deficient mice demonstrate increased platelet activation but improved renal endothelial preservation and regeneration in passive nephrotoxic nephritis.

scientific article

Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation

scientific journal article

What can proteomics tell us about platelets?

scientific article published on March 2014

[Ureido-¹⁵N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity

scientific article published on 28 June 2014

cGMP and cAMP pathways rearrange ARHGAP17 and ARHGEF6 protein complexes to control Rac1 in platelets

scientific article published on 2 September 2015

cGMP and cGMP-dependent protein kinase in platelets and blood cells.

scientific article published on January 2009

cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene.

scientific article published on 29 May 2003

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