List of works - Flemming Cornelius

A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase

scientific article published on 22 January 2013

A voltage-activated cation transport pathway associated with the sodium pump

scientific article published on December 1991

ATP binding equilibria of the Na(+),K(+)-ATPase

scientific article

Binding of cardiotonic steroids to Na<sup>+</sup>,K<sup>+</sup>-ATPase in the E2P state

scientific article published on 01 January 2021

Capturing suboptical dynamic structures in lipid bilayer patches formed from free-standing giant unilamellar vesicles.

scientific article published on 13 July 2017

Cholesterol modulation of molecular activity of reconstituted shark Na+,K(+)-ATPase

scientific article published on 01 May 1995

Cholesterol-dependent interaction of polyunsaturated phospholipids with Na,K-ATPase

scientific article

Cis-allosteric effects of cytoplasmic Na+/K+ discrimination at varying pH. Low-affinity multisite inhibition of cytoplasmic K+ in reconstituted Na+/K(+)-ATPase engaged in uncoupled Na(+)-efflux

scientific article published on July 27, 1992

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

scientific article published in Nature

Crystal structure of the sodium-potassium pump at 2.4 A resolution

scientific article

Direct activation of gastric H,K-ATPase by N-terminal protein kinase C phosphorylation. Comparison of the acute regulation mechanisms of H,K-ATPase and Na,K-ATPase

scientific article published on March 2003

Distinct pH dependencies of Na+/K+-selectivity at the two faces of Na,K-ATPase.

scientific article

Diversity of the E2P Phosphoforms of Na, K-ATPase

scientific article published in November 1997

E2P Phosphoforms of Na,K-ATPase. I. Comparison of Phosphointermediates Formed from ATP and Piby Their Reactivity toward Hydroxylamine and Vanadate†

scientific article published in September 1998

E2P Phosphoforms of Na,K-ATPase. II. Interaction of Substrate and Cation-Binding Sites in PiPhosphorylation of Na,K-ATPase†

scientific article published in November 1998

Electrogenic pump current of sarcoplasmic reticulum Ca(2+)-ATPase reconstituted at high lipid/protein ratio

scientific article published in June 1991

Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na+,K+-ATPase

scientific article published in January 2017

Exploring the raft-hypothesis by probing planar bilayer patches of free-standing giant vesicles at nanoscale resolution, with and without Na,K-ATPase

scientific article published on 8 September 2016

FXYD proteins reverse inhibition of the Na+-K+ pump mediated by glutathionylation of its beta1 subunit

scientific article

First crystal structures of Na+,K+-ATPase: new light on the oldest ion pump.

scientific article published on December 2011

Fluorescent Styryl Dyes as Probes for Na,K-ATPase Reaction

scientific article published in November 1997

Fluorescent styryl dyes as probes for Na,K-ATPase reaction mechanism: significance of the charge of the hydrophilic moiety of RH dyes

scientific article published in December 1995

Functional modulation of the sodium pump: the regulatory proteins "Fixit".

scientific article

Functional reconstitution of the sodium pump. Kinetics of exchange reactions performed by reconstituted Na/K-ATPase ⬇️

scientific article published on March 7, 1991

Functional regulation of reconstituted Na,K-ATPase by protein kinase A phosphorylation

scientific article published on 01 February 1996

Functional significance of the shark Na,K-ATPase N-terminal domain. Is the structurally variable N-Terminus involved in tissue-specific regulation by FXYD proteins?

scientific article published in October 2005

General and specific lipid-protein interactions in Na,K-ATPase

scientific article published on 16 March 2015

Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion

scientific article published on March 2016

Hydrophobic ion interaction on Na+ activation and dephosphorylation of reconstituted Na+,K(+)-ATPase

scientific article published on 01 May 1995

Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of Na,K-ATPase by protein kinase c via a novel member of the FXYDY family

scientific article published on November 2000

Identification of electric-field-dependent steps in the Na(+),K(+)-pump cycle

scientific article

Inhibition of K+ transport through Na+, K+-ATPase by capsazepine: role of membrane span 10 of the α-subunit in the modulation of ion gating

scientific article (publication date: 2014)

Inorganic phosphate in Ehrlich ascites tumor cells and its distribution across the cell membrane

scientific article published on 01 August 1978

Interaction between Substrate Site and Cation Binding Sites in PiPhosphorylation of Na,K-ATPase

scientific article published in November 1997

Interaction between cardiotonic steroids and Na,K-ATPase. Effects of pH and ouabain-induced changes in enzyme conformation

scientific article published in October 2009

Interaction of ATP with the phosphoenzyme of the Na+,K+-ATPase

scientific article published in February 2010

Interaction of FXYD10 (PLMS) with Na,K-ATPase from shark rectal glands. Close proximity of Cys74 of FXYD10 to Cys254 in the a domain of the alpha-subunit revealed by intermolecular thiol cross-linking

scientific article published on 26 May 2005

Interaction of N-terminal peptide analogues of the Na+,K+-ATPase with membranes

scientific article published on 06 March 2018

Intrinsic reaction-cycle time scale of Na+,K+-ATPase manifests itself in the lipid-protein interactions of nonequilibrium membranes

scientific article

Investigation of the enzymatic activity of the Na+,K+-ATPase via isothermal titration microcalorimetry

scientific article published in August 2010

K+-dependence of electrogenic transport by the NaK-ATPase

scientific article published on 01 January 1998

Kinetic investigations of the mechanism of the rate-determining step of the Na+,K+-ATPase pump cycle

scientific article published in April 2003

Kinetics of K(+) occlusion by the phosphoenzyme of the Na(+),K(+)-ATPase

scientific article

Mechanism of the rate-determining step of the Na(+),K(+)-ATPase pump cycle

scientific article

Membrane accessibility of glutathione

scientific article published on 30 July 2015

Modulation of FXYD interaction with Na,K-ATPase by anionic phospholipids and protein kinase phosphorylation

scientific article published on 09 February 2007

Modulation of Na,K-ATPase and Na-ATPase activity by phospholipids and cholesterol. I. Steady-state kinetics

scientific article published in July 2001

Modulation of Na,K-ATPase by associated small transmembrane regulatory proteins and by lipids.

scientific article

Modulation of Na,K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kinetics

scientific article

Na+-Na+ exchange mediated by (Na+ + K+)-ATPase reconstituted into liposomes. Evaluation of pump stoichiometry and response to ATP and ADP.

scientific article published in August 1985

New crystal structures of PII-type ATPases: excitement continues.

scientific article published on 18 July 2013

Non-equivalent cytoplasmic Na+ sites and their susceptibility to transmembrane interaction from extracellular Na+.

scientific article published in January 1988

PKA and PKC phosphorylation of gastric H,K-ATPase

scientific article published on 01 April 2003

Phosphorylation/dephosphorylation of reconstituted shark Na+,K(+)-ATPase: one phosphorylation site per alpha beta protomer

scientific article published on 01 May 1995

Protein kinase C phosphorylation of purified Na,K-ATPase: C-terminal phosphorylation sites at the alpha- and gamma-subunits close to the inner face of the plasma membrane

scientific article published on April 2002

Rate determination in phosphorylation of shark rectal Na,K-ATPase by ATP: temperature sensitivity and effects of ADP.

scientific article published on August 1999

Rb(+) occlusion stabilized by vanadate in gastric H(+)/K(+)-ATPase at 25°C

scientific article published on 21 September 2010

Reconstitution of (Na+ + K+)-ATPase into phospholipid vesicles with full recovery of its specific activity

scientific article published on 01 May 1984

Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from shark: molecular cloning, sequence, expression, cellular distribution, and functional effects of PLMS.

scientific article published on 21 July 2003

Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation

scientific article

Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.

scientific article

Spatial distribution and activity of Na(+)/K(+)-ATPase in lipid bilayer membranes with phase boundaries

scientific article published on 16 March 2016

Susceptibility of β1 Na+-K+ Pump Subunit to Glutathionylation and Oxidative Inhibition Depends on Conformational State of Pump ⬇️

scientific article published on February 21, 2012

Tension-length behaviour of a molluscan smooth muscle related to filament organisation

scientific article published in February 1978

The effect of cytoplasmic K+ on the activity of the Na+/K(+)-ATPase

scientific article published in August 1991

The regulation of tension in a chemically skinned molluscan smooth muscle: effect of Mg2+ on the Ca2+-activated tension generation

scientific article published on June 1980

The sided action of Na+ and of K+ on reconstituted shark (Na+ + K+)-ATPase engaged in Na+-Na+ exchange accompanied by ATP hydrolysis. I. The ATP activation curve

scientific article published on 01 November 1987

The sided action of Na+ on reconstituted shark Na+/K+-ATPase engaged in Na+-Na+ exchange accompanied by ATP hydrolysis. II. Transmembrane allosteric effects on Na+ affinity

scientific article published in October 1988

The voltage-sensitive dye RH421 detects a Na+,K+-ATPase conformational change at the membrane surface.

scientific article published on 20 January 2017

Themes in ion pump regulation

scientific article published on 01 April 2003

Tonic contraction and the control of relaxation in a chemically skinned molluscan smooth muscle ⬇️

scientific article published on May 1, 1982

Uncoupled Na+-efflux on reconstituted shark Na,K-ATPase is electrogenic

scientific article published on 01 April 1989

Variable stoichiometry in reconstituted shark Na,K-ATPase engaged in uncoupled efflux

scientific article published on 01 July 1990

List of works by Flemming Cornelius

A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase

A voltage-activated cation transport pathway associated with the sodium pump

ATP binding equilibria of the Na(+),K(+)-ATPase

Binding of cardiotonic steroids to Na<sup>+</sup>,K<sup>+</sup>-ATPase in the E2P state

Capturing suboptical dynamic structures in lipid bilayer patches formed from free-standing giant unilamellar vesicles.

Cholesterol modulation of molecular activity of reconstituted shark Na+,K(+)-ATPase

Cholesterol-dependent interaction of polyunsaturated phospholipids with Na,K-ATPase

Cis-allosteric effects of cytoplasmic Na+/K+ discrimination at varying pH. Low-affinity multisite inhibition of cytoplasmic K+ in reconstituted Na+/K(+)-ATPase engaged in uncoupled Na(+)-efflux

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

Crystal structure of the sodium-potassium pump at 2.4 A resolution

Direct activation of gastric H,K-ATPase by N-terminal protein kinase C phosphorylation. Comparison of the acute regulation mechanisms of H,K-ATPase and Na,K-ATPase

Distinct pH dependencies of Na+/K+-selectivity at the two faces of Na,K-ATPase.

Diversity of the E2P Phosphoforms of Na, K-ATPase

E2P Phosphoforms of Na,K-ATPase. I. Comparison of Phosphointermediates Formed from ATP and Piby Their Reactivity toward Hydroxylamine and Vanadate†

E2P Phosphoforms of Na,K-ATPase. II. Interaction of Substrate and Cation-Binding Sites in PiPhosphorylation of Na,K-ATPase†

Electrogenic pump current of sarcoplasmic reticulum Ca(2+)-ATPase reconstituted at high lipid/protein ratio

Electrostatic Stabilization Plays a Central Role in Autoinhibitory Regulation of the Na+,K+-ATPase

Exploring the raft-hypothesis by probing planar bilayer patches of free-standing giant vesicles at nanoscale resolution, with and without Na,K-ATPase

FXYD proteins reverse inhibition of the Na+-K+ pump mediated by glutathionylation of its beta1 subunit

First crystal structures of Na+,K+-ATPase: new light on the oldest ion pump.

Fluorescent Styryl Dyes as Probes for Na,K-ATPase Reaction

Fluorescent styryl dyes as probes for Na,K-ATPase reaction mechanism: significance of the charge of the hydrophilic moiety of RH dyes

Functional modulation of the sodium pump: the regulatory proteins "Fixit".

Functional reconstitution of the sodium pump. Kinetics of exchange reactions performed by reconstituted Na/K-ATPase ⬇️

Functional regulation of reconstituted Na,K-ATPase by protein kinase A phosphorylation

Functional significance of the shark Na,K-ATPase N-terminal domain. Is the structurally variable N-Terminus involved in tissue-specific regulation by FXYD proteins?

General and specific lipid-protein interactions in Na,K-ATPase

Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion

Hydrophobic ion interaction on Na+ activation and dephosphorylation of reconstituted Na+,K(+)-ATPase

Identification of a phospholemman-like protein from shark rectal glands. Evidence for indirect regulation of Na,K-ATPase by protein kinase c via a novel member of the FXYDY family

Identification of electric-field-dependent steps in the Na(+),K(+)-pump cycle

Inhibition of K+ transport through Na+, K+-ATPase by capsazepine: role of membrane span 10 of the α-subunit in the modulation of ion gating

Inorganic phosphate in Ehrlich ascites tumor cells and its distribution across the cell membrane

Interaction between Substrate Site and Cation Binding Sites in PiPhosphorylation of Na,K-ATPase

Interaction between cardiotonic steroids and Na,K-ATPase. Effects of pH and ouabain-induced changes in enzyme conformation

Interaction of ATP with the phosphoenzyme of the Na+,K+-ATPase

Interaction of FXYD10 (PLMS) with Na,K-ATPase from shark rectal glands. Close proximity of Cys74 of FXYD10 to Cys254 in the a domain of the alpha-subunit revealed by intermolecular thiol cross-linking

Interaction of N-terminal peptide analogues of the Na+,K+-ATPase with membranes

Intrinsic reaction-cycle time scale of Na+,K+-ATPase manifests itself in the lipid-protein interactions of nonequilibrium membranes

Investigation of the enzymatic activity of the Na+,K+-ATPase via isothermal titration microcalorimetry

K+-dependence of electrogenic transport by the NaK-ATPase

Kinetic investigations of the mechanism of the rate-determining step of the Na+,K+-ATPase pump cycle

Kinetics of K(+) occlusion by the phosphoenzyme of the Na(+),K(+)-ATPase

Mechanism of the rate-determining step of the Na(+),K(+)-ATPase pump cycle

Membrane accessibility of glutathione

Modulation of FXYD interaction with Na,K-ATPase by anionic phospholipids and protein kinase phosphorylation

Modulation of Na,K-ATPase and Na-ATPase activity by phospholipids and cholesterol. I. Steady-state kinetics

Modulation of Na,K-ATPase by associated small transmembrane regulatory proteins and by lipids.

Modulation of Na,K-ATPase by phospholipids and cholesterol. II. Steady-state and presteady-state kinetics

Na+-Na+ exchange mediated by (Na+ + K+)-ATPase reconstituted into liposomes. Evaluation of pump stoichiometry and response to ATP and ADP.

New crystal structures of PII-type ATPases: excitement continues.

Non-equivalent cytoplasmic Na+ sites and their susceptibility to transmembrane interaction from extracellular Na+.

PKA and PKC phosphorylation of gastric H,K-ATPase

Phosphorylation/dephosphorylation of reconstituted shark Na+,K(+)-ATPase: one phosphorylation site per alpha beta protomer

Protein kinase C phosphorylation of purified Na,K-ATPase: C-terminal phosphorylation sites at the alpha- and gamma-subunits close to the inner face of the plasma membrane

Rate determination in phosphorylation of shark rectal Na,K-ATPase by ATP: temperature sensitivity and effects of ADP.

Rb(+) occlusion stabilized by vanadate in gastric H(+)/K(+)-ATPase at 25°C

Reconstitution of (Na+ + K+)-ATPase into phospholipid vesicles with full recovery of its specific activity

Regulation of Na,K-ATPase by PLMS, the phospholemman-like protein from shark: molecular cloning, sequence, expression, cellular distribution, and functional effects of PLMS.

Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation

Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.

Spatial distribution and activity of Na(+)/K(+)-ATPase in lipid bilayer membranes with phase boundaries

Susceptibility of β1 Na+-K+ Pump Subunit to Glutathionylation and Oxidative Inhibition Depends on Conformational State of Pump ⬇️

Tension-length behaviour of a molluscan smooth muscle related to filament organisation

The effect of cytoplasmic K+ on the activity of the Na+/K(+)-ATPase

The regulation of tension in a chemically skinned molluscan smooth muscle: effect of Mg2+ on the Ca2+-activated tension generation

The sided action of Na+ and of K+ on reconstituted shark (Na+ + K+)-ATPase engaged in Na+-Na+ exchange accompanied by ATP hydrolysis. I. The ATP activation curve

The sided action of Na+ on reconstituted shark Na+/K+-ATPase engaged in Na+-Na+ exchange accompanied by ATP hydrolysis. II. Transmembrane allosteric effects on Na+ affinity

The voltage-sensitive dye RH421 detects a Na+,K+-ATPase conformational change at the membrane surface.

Themes in ion pump regulation

Tonic contraction and the control of relaxation in a chemically skinned molluscan smooth muscle ⬇️

Uncoupled Na+-efflux on reconstituted shark Na,K-ATPase is electrogenic

Variable stoichiometry in reconstituted shark Na,K-ATPase engaged in uncoupled efflux