List of works - Rocio Sotillo

Acquisition of chromosome instability is a mechanism to evade oncogene addiction

scientific article published on 06 February 2020

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.

scientific article

Cellular Prion Protein PrPC and Ecto-5'-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy

scientific article

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

scientific article

Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

scientific article published on 29 May 2019

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

scientific article published in May 2005

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

scientific article published on 17 August 2003

Driving the cell cycle to cancer.

scientific article

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

scientific journal article

Is aneuploidy deciding your fate?

scientific article published on 3 April 2014

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

scientific article published in July 2000

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

scientific article

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

scientific article

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

scientific article

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

scientific article

Metabolic shifts in residual breast cancer drive tumor recurrence

scientific article published on 15 May 2017

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

scientific article

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

scientific article published on 08 June 2016

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation

scientific article

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

scientific article

Plk1 overexpression induces chromosomal instability and suppresses tumor development

scientific article published in Nature Communications

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

scientific article published on 23 July 2019

Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

scientific article published on 03 March 2020

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition

scientific article published on 15 June 2021

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

scientific article published on December 2009

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.

scientific article

List of works by Rocio Sotillo

Acquisition of chromosome instability is a mechanism to evade oncogene addiction

Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases.

Cellular Prion Protein PrPC and Ecto-5'-Nucleotidase Are Markers of the Cellular Stress Response to Aneuploidy

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Driving the cell cycle to cancer.

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

Is aneuploidy deciding your fate?

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.

Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Metabolic shifts in residual breast cancer drive tumor recurrence

Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

Negative Selection and Chromosome Instability Induced by Mad2 Overexpression Delay Breast Cancer but Facilitate Oncogene-Independent Outgrowth

Pan-cancer analysis distinguishes transcriptional changes of aneuploidy from proliferation

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

Plk1 overexpression induces chromosomal instability and suppresses tumor development

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

Targeting alveolar macrophages shows better treatment response than deletion of interstitial macrophages in EGFR mutant lung adenocarcinoma

The phosphatase PRL-3 affects intestinal homeostasis by altering the crypt cell composition

Very CIN-ful: whole chromosome instability promotes tumor suppressor loss of heterozygosity

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.