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List of works by Josep M. Canals

7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway

scientific article published on 24 May 2017

A brain-derived neurotrophic factor (BDNF) related system is involved in the maintenance of the polyinnervate Torpedo electric organ

scientific article published in July 1997

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

scientific article published on 29 May 2013

Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

scientific article

Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

scientific article published on 6 July 2012

Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

scientific article published on 26 January 2009

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

scientific article published on 12 August 2010

Arsenic and fluoride induce neural progenitor cell apoptosis ⬇️

scientific article published on March 23, 2011

Association between BDNF Val66Met polymorphism and age at onset in Huntington disease.

scientific article published in September 2005

BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

scientific article published on 13 May 2010

BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

scientific article

Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease

scientific article published in June 2005

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

scientific article

Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

scientific article published on September 2004

CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease

scientific article published on 02 December 2019

Cellular and molecular mechanisms involved in the selective vulnerability of striatal projection neurons in Huntington's disease.

scientific article published on November 2006

Characterization of a rabbit serum raised against a botulinum toxin type a binding protein from presynaptic plasma membranes from Torpedo electric organ

scientific article published in April 1995

Characterization of presynaptic proteins involved in synaptic vesicle exocytosis in the nervous system of Torpedo marmorata

scientific article published in July 1997

Cloning, characterization and expression of the cDNA encoding a neuron-specific α-tubulin isoform highly represented in the electric lobe of Torpedo marmorata ⬇️

scientific article published on June 9, 1995

Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons

scientific article published in August 2003

Cryopreservation of dissociated human embryonic stem cells in the presence of ROCK inhibitor

scientific article published on July 2009

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article

Development of a transplantable glioma tumour model from genetically engineered mice: MRI/MRS/MRSI characterisation

scientific article published on 21 June 2016

Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections

scientific article published in September 2000

Differential distribution of syntaxin isoforms 1A and 1B in the rat central nervous system

scientific article published in December 1996

Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease

scientific article published in November 1998

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

scientific article published on 8 March 2012

Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine

scientific article published in July 2004

Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling

scientific article published on 23 October 2007

Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation.

scientific article

Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury

scientific article published on 28 January 2005

Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum

scientific article published on April 2002

Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.

scientific article

Expression of synaptosomal-associated protein SNAP-25 in endocrine anterior pituitary cells.

scientific article published in April 1996

Fast and efficient neural conversion of human hematopoietic cells

scientific article

Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

scientific article published on 10 June 2015

Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.

scientific article published on 30 December 2015

Functional reconstitution of KCl-evoked, Ca(2+)-dependent acetylcholine release system in Xenopus oocytes microinjected with presynaptic plasma membranes and synaptic vesicles

scientific article published in April 1996

Genetic Rescue of Mitochondrial and Skeletal Muscle Impairment in an Induced Pluripotent Stem Cells Model of Coenzyme Q10 Deficiency.

scientific article published on 4 May 2017

Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons

scientific article

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

scientific article

Human Pluripotent Stem Cell-Derived Neurons Are Functionally Mature In Vitro and Integrate into the Mouse Striatum Following Transplantation

scientific article published on 30 April 2020

Human embryonic mesenchymal lung-conditioned medium promotes differentiation to myofibroblast and loss of stemness phenotype in lung adenocarcinoma cell lines

scientific article published on 26 January 2022

Human t-DARPP is induced during striatal development

scientific article published on 27 July 2016

In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules.

scientific article published on 6 September 2006

Increased opioid dependence in a mouse model of panic disorder

scientific article

Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease

scientific article

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.

scientific article published on July 1999

Insights in spatio-temporal characterization of human fetal neural stem cells

scientific article published on 25 January 2017

Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells.

scientific article published on September 2007

Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors

scientific article published in November 2006

Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism.

scientific article published on December 2006

Myeloid C/EBPβ deficiency reshapes microglial gene expression and is protective in experimental autoimmune encephalomyelitis

scientific article published on 16 March 2017

Neuropeptide Y alters sedation through a hypothalamic Y1-mediated mechanism

scientific article published in June 2001

Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells.

scientific article

Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease.

scientific article

Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease.

scientific article

Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease

scientific article

Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling

scientific article

Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.

scientific article published in October 1999

Novel cryopreservation method for dissociated human embryonic stem cells in the presence of a ROCK inhibitor.

scientific article

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

scientific article

Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

scientific article

Quantitative high-throughput gene expression profiling of human striatal development to screen stem cell-derived medium spiny neurons

scientific article published on 16 September 2015

RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death

scientific article published on 16 April 2015

Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

scientific article published in February 2006

Role of structural domains for maize gamma-zein retention in Xenopus oocytes

scientific article published in January 1994

Spontaneously Arising Canine Glioma as a Potential Model for Human Glioma.

scientific article published on 19 January 2016

The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum.

scientific article

TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal ganglia

scientific article published in December 2001

Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra

scientific journal article

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