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List of works by Josep M. Canals

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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

scientific article published on 8 March 2012
Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease.

scientific article published on September 2004
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor.

scientific article published in October 1999
Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes.

scientific article published on July 1999
Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease.

scientific article
Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

scientific article
Altered P2X7-receptor level and function in mouse models of Huntington's disease and therapeutic efficacy of antagonist administration.

scientific article published on 26 January 2009
Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain

scientific article published in February 2006
Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease.

scientific article
Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

scientific article
Novel cryopreservation method for dissociated human embryonic stem cells in the presence of a ROCK inhibitor.

scientific article
A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

scientific article published on 29 May 2013
BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.

scientific article published on 13 May 2010
Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson's disease patients.

scientific article
Brain-derived neurotrophic factor modulates dopaminergic deficits in a transgenic mouse model of Huntington's disease

scientific article published in June 2005
Mutant huntingtin impairs the post-Golgi trafficking of brain-derived neurotrophic factor but not its Val66Met polymorphism.

scientific article published on December 2006
Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease

scientific article
Differential distribution of syntaxin isoforms 1A and 1B in the rat central nervous system

scientific article published in December 1996
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation.

scientific article published on 10 June 2015
Neuroprotection by GDNF-secreting stem cells in a Huntington's disease model: optical neuroimage tracking of brain-grafted cells.

scientific article
PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.

scientific article
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.

scientific article published on 01 January 2001
Neuropeptide Y alters sedation through a hypothalamic Y1-mediated mechanism

scientific article published in June 2001
Disruption of EphA/ephrin-a signaling in the nigrostriatal system reduces dopaminergic innervation and dissociates behavioral responses to amphetamine and cocaine

scientific article published in July 2004
Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease

scientific article published on 01 January 2000
Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus.

scientific article
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease

scientific article published in November 1998
Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling

scientific article
Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum

scientific article published on April 2002
Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease.

scientific article published on 12 August 2010
Disruption of striatal glutamatergic transmission induced by mutant huntingtin involves remodeling of both postsynaptic density and NMDA receptor signaling

scientific article published on 23 October 2007
Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons

scientific article published in August 2003
Endogenous brain-derived neurotrophic factor protects dopaminergic nigral neurons against transneuronal degeneration induced by striatal excitotoxic injury

scientific article published on 28 January 2005
Arsenic and fluoride induce neural progenitor cell apoptosis

scientific article published on March 23, 2011
Vesicular glutamate transporter 3 (VGLUT3) identifies spatially segregated excitatory terminals in the rat substantia nigra

scientific journal article
Association between BDNF Val66Met polymorphism and age at onset in Huntington disease.

scientific article published in September 2005
BH3-only proteins Bid and Bim(EL) are differentially involved in neuronal dysfunction in mouse models of Huntington's disease

scientific article
Interplay of leukemia inhibitory factor and retinoic acid on neural differentiation of mouse embryonic stem cells.

scientific article published on September 2007
Role of structural domains for maize gamma-zein retention in Xenopus oocytes

scientific article published in January 1994
In vivo evaluation of EPO-secreting cells immobilized in different alginate-PLL microcapsules.

scientific article published on 6 September 2006
The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum.

scientific article published on 01 June 1999
Fast and efficient neural conversion of human hematopoietic cells

scientific article
Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

scientific article
Cellular and molecular mechanisms involved in the selective vulnerability of striatal projection neurons in Huntington's disease.

scientific article published on November 2006
Forced cell cycle exit and modulation of GABAA, CREB, and GSK3β signaling promote functional maturation of induced pluripotent stem cell-derived neurons.

scientific article published on 30 December 2015
Distinct roles of the Y1 and Y2 receptors on neuropeptide Y-induced sensitization to sedation.

scientific article
Age-dependent decline of motor neocortex but not hippocampal performance in heterozygous BDNF mice correlates with a decrease of cortical PSD-95 but an increase of hippocampal TrkB levels.

scientific article published on 6 July 2012
Mice heterozygous for neurotrophin-3 display enhanced vulnerability to excitotoxicity in the striatum through increased expression of N-methyl-D-aspartate receptors

scientific article published in November 2006
7,8-dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway

scientific article published on 24 May 2017
Cryopreservation of dissociated human embryonic stem cells in the presence of ROCK inhibitor

scientific article published on July 2009

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