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List of works by Jan Weber

A novel TaqMan real-time PCR assay to estimate ex vivo human immunodeficiency virus type 1 fitness in the era of multi-target (pol and env) antiretroviral therapy

scientific article published in August 2003

A picomolar inhibitor of resistant strains of human immunodeficiency virus protease identified by a combinatorial approach.

scientific article

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

scientific article published on 18 December 2017

Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase

scientific article published on December 1997

Contribution of human immunodeficiency virus type 1 minority variants to reduced drug susceptibility in patients on an integrase strand transfer inhibitor-based therapy

scientific article

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

scientific article

Development of 5' LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

scientific article published on 19 February 2016

Diminished replicative fitness of primary human immunodeficiency virus type 1 isolates harboring the K65R mutation

scientific article published on March 2005

Does BCA3 Play a Role in the HIV-1 Replication Cycle?

scientific article published on 20 April 2018

Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

scientific article

Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART.

scientific article published on 28 March 2018

Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination

scientific article published on 26 November 2020

Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action

scientific article

Highly functionalized and potent antiviral cyclopentane derivatives formed by a tandem process consisting of organometallic, transition-metal-catalyzed, and radical reaction steps.

scientific article published on 10 July 2014

Human Immunodeficiency Virus Type 1 Resistance or Cross-Resistance to Nonnucleoside Reverse Transcriptase Inhibitors Currently under Development as Microbicides

scientific article published in 2011

Human epithelial beta-defensins 2 and 3 inhibit HIV-1 replication

scientific article

Human immunodeficiency virus type 1 resistance or cross-resistance to nonnucleoside reverse transcriptase inhibitors currently under development as microbicides

scientific article

Identification of low-molecular weight inhibitors of HIV-1 reverse transcriptase using a cell-based high-throughput screening system.

scientific article

Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation

scientific article published in July 2008

Impaired human immunodeficiency virus type 1 replicative fitness in atypical viremic non-progressor individuals

scientific article published on 20 March 2017

Increased levels of human beta-defensins mRNA in sexually HIV-1 exposed but uninfected individuals

scientific article

Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation.

scientific article published on 11 July 2018

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

scientific article

Novel influenza inhibitors designed to target PB1 interactions with host importin RanBP5

scientific article published on 08 February 2019

Novel method for simultaneous quantification of phenotypic resistance to maturation, protease, reverse transcriptase, and integrase HIV inhibitors based on 3'Gag(p2/p7/p1/p6)/PR/RT/INT-recombinant viruses: a useful tool in the multitarget era of ant

scientific article published on 31 May 2011

Novel recombinant virus assay for measuring susceptibility of human immunodeficiency virus type 1 group M subtypes to clinically approved drugs

scientific article published on 29 April 2009

PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core

scientific article published on 24 October 2017

Protective hybrid coating containing silver, copper and zinc cations effective against human immunodeficiency virus and other enveloped viruses

scientific article

Purine analogs as phosphatidylinositol 4-kinase IIIβ inhibitors

scientific article

Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology

scientific article published on 22 December 2016

Resistance mutations outside the integrase coding region have an effect on human immunodeficiency virus replicative fitness but do not affect its susceptibility to integrase strand transfer inhibitors

scientific article (publication date: 2013)

Role of Baseline pol Genotype in HIV-1 Fitness Evolution

scientific article

Role of the human immunodeficiency virus type 1 envelope gene in viral fitness.

scientific article

Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors

scientific article published in May 2001

Sensitive cell-based assay for determination of human immunodeficiency virus type 1 coreceptor tropism.

scientific article published on 13 March 2013

Synthesis and biological activity of benzo-fused 7-deazaadenosine analogues. 5- and 6-substituted 4-amino- or 4-alkylpyrimido[4,5-b]indole ribonucleosides.

scientific article published on 17 June 2013

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4'-C-methylribonucleosides.

scientific article published on 31 October 2015

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

scientific article published on 16 June 2016

The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells.

scientific article

Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes

scientific article published on 29 July 2020

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor

scientific article published on 9 March 2015

Unusual binding mode of an HIV-1 protease inhibitor explains its potency against multi-drug-resistant virus strains

scientific article

Upregulation of mRNA Expression of ADGRD1/GPR133 and ADGRG7/GPR128 in SARS-CoV-2-Infected Lung Adenocarcinoma Calu-3 Cells

Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness

scientific article published on 11 May 2006

Use of four next-generation sequencing platforms to determine HIV-1 coreceptor tropism

scientific article

Viral drug resistance and fitness.

scientific article published on January 2008

Viral fitness: relation to drug resistance mutations and mechanisms involved: nucleoside reverse transcriptase inhibitor mutations.

scientific article published on March 2007

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