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List of works by David P. Fairlie

A Comparative Study of Impedance versus Optical Label-Free Systems Relative to Labelled Assays in a Predominantly Gi Coupled GPCR (C5aR) Signalling.

scientific article

A Cyclic Metallopeptide Induces α Helicity in Short Peptide Fragments of Thermolysin

scientific article published on 01 January 2003

A Cyclic β-Strand Tripeptide with an α-Helix Like CD Spectrum

scientific article published on 01 July 2009

A Novel Long-Range n to π* Interaction Secures the Smallest known α-Helix in Water

scientific article published on 08 November 2019

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

scientific article published on 01 December 2019

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

scientific article published in May 2003

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

scientific article published on 01 November 2019

A dual-purpose synthetic colloidal platform for protease mapping: substrate profiling for Dengue and West Nile virus proteases

scientific article

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

scientific article

A peculiar toxicity manifested by platinum(II)amines in rats: Gastric distension after intraperitoneal administration

article

A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis

scientific article

A potent antagonist of protease-activated receptor 2 that inhibits multiple signaling functions in human cancer cells.

scientific article published on 20 December 2017

A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

scientific article published in January 2003

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

scientific article published on 26 September 2016

Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in MR1

scientific article published on 01 July 2020

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

scientific article published on October 2001

Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles

scientific article published on 22 July 2019

Amyloid Formation from an α‐Helix Peptide Bundle Is Seeded by 310‐Helix Aggregates ⬇️

scientific article published on December 15, 2010

An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

scientific article published on 8 November 2016

An Inhibitor of Phospholipase A2 Group IIA Modulates Adipocyte Signaling and Protects Against Diet-Induced Metabolic Syndrome in Rats ⬇️

scientific article published on September 1, 2012

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

scientific article published on 30 March 2012

An interaction between the methyltransferase and RNA dependent RNA polymerase domains of the West Nile virus NS5 protein

scientific article published on 5 June 2013

An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation.

scientific article

An overview on the identification of MAIT cell antigens.

scientific article published on 14 April 2018

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

scientific article published on 25 October 2011

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

scientific article published on 16 July 2016

Anti-inflammatory activity of the isoquinoline alkaloid, tetrandrine, against established adjuvant arthritis in rats

article

Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents

scientific article published in May 2000

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

scientific article published on June 1999

Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat.

scientific article published in September 2002

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

scientific article

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

scientific article

Antimalarial activity of the anticancer histone deacetylase inhibitor SB939.

scientific article

Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components

scientific article published on 22 September 2010

Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.

scientific article

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

scientific article

Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity.

scientific article published on 17 December 2015

Beta-strand mimicking macrocyclic amino acids: templates for protease inhibitors with antiviral activity.

scientific article published on January 2002

Biased Signaling by Agonists of Protease Activated Receptor 2.

scientific article published on 7 February 2017

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

scientific article published on March 2014

Bicyclic Helical Peptides as Dual Inhibitors Selective for Bcl2A1 and Mcl-1 Proteins

scientific article published on 27 March 2018

C5a receptor (CD88) inhibition improves hypothermia-induced neuroprotection in an in vitro ischemic model.

scientific article published on 17 January 2012

C5a, but not C5a-des Arg, induces upregulation of heteromer formation between complement C5a receptors C5aR and C5L2.

scientific article published on 24 September 2013

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

scientific article

C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue.

scientific article published on 25 October 2013

Catalyst-Free N-Arylation Using Unactivated Fluorobenzenes

scientific article published on 02 July 2012

Catalytically active Dengue virus NS3 protease forms aggregates that are separable by size exclusion chromatography.

scientific article published on July 2002

Cell phenotype as a target of drug therapy in chronic inflammatory diseases

scientific article published on 01 February 2000

Characterisation of TNF-α-related peptides by high-performance liquid chromatography—mass spectrometry and high-performance liquid chromatography—tandem mass spectrometry

scientific article published on 01 August 1993

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

article

Chemical Approaches to Modulating Complement-Mediated Diseases.

scientific article published on 4 October 2017

Chemically Diverse Helix-Constrained Peptides Using Selenocysteine Crosslinking

scientific article published on 20 February 2018

Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity

scientific article published on 18 July 2002

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

scientific article

Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.

scientific article published on 20 January 2005

Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury

scientific article

Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors

scientific article

Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist

scientific article

Comparative α-helicity of cyclic pentapeptides in water

scientific article

Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets

scientific article published in February 2015

Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche

scientific article published on May 2014

Complement component C2, inhibiting a latent serine protease in the classical pathway of complement activation.

scientific article published in September 2009

Computer Modelling and Synthesis of Deoxy and Monohydroxy Analogues of a Ribitylaminouracil Bacterial Metabolite that Potently Activates Human T Cells

scientific article published on 07 November 2019

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

scientific article

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

scientific article

Consecutive Cyclic Pentapeptide Modules Form Shortα-Helices that are Very Stable to Water and Denaturants

scientific article published on 01 May 2004

Constraining cyclic peptides to mimic protein structure motifs.

scientific article

Contiguous hydrophobic and charged surface patches in short helix-constrained peptides drive cell permeability

scientific article published on 21 December 2017

Correction: Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency

scientific article published on 23 November 2016

Crystal Structure of the Dithiol Oxidase DsbA Enzyme from Proteus Mirabilis Bound Non-covalently to an Active Site Peptide Ligand

scientific article

Crystal Structures of Protein-Bound Cyclic Peptides

scientific article published on 02 May 2019

Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

scientific article

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

scientific article published in December 1999

Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed

scientific article

Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists

scientific article published on 29 August 2015

Cycloadditions of isobenzofuran to a constrained template bearing neighboring dienophiles

scientific article published in May 2003

Cyclooligomerization of a helix-bearing template into macrocycles bearing multiple helices

scientific article

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

scientific article published on 01 December 2021

Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid.

scientific article published on December 2006

Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints

scientific article published in March 2003

Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions

scientific article published on 10 June 2016

Diet-induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

scientific article

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

scientific article published on 3 March 2010

Diverse MR1-restricted T cells in mice and humans

scientific article published on 21 May 2019

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

scientific article

Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun.

scientific article published on 21 June 2017

Downsizing a human inflammatory protein to a small molecule with equal potency and functionality.

scientific article

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

scientific article

Downsizing the BAD BH3 peptide to small constrained α-helices with improved ligand efficiency.

scientific article published on 7 November 2016

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. ⬇️

scientific article published on 6 February 2017

Editorial (Hot Topic: Chemical Biology Down Under)

scientific article published on 01 January 2012

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth.

scientific article published on 23 December 2016

Efficient chemical synthesis of human complement protein C3a

scientific article

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

scientific article published on 21 September 2020

Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma

scientific article published on 7 March 2018

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

scientific article published on 18 August 2004

Erratum to "Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites" [Int. J. Parasitol. Drugs Drug Res. 5 (2015) 117-126].

scientific article published on 30 May 2016

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor

scientific article

Ex vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax

scientific article

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

scientific article published on 24 August 2017

Facile synthesis of mono- and bis-methylated Fmoc-Dap, -Dab and -Orn amino acids

scientific article published on 01 March 2015

Flavones are inhibitors of HIV-1 proteinase

scientific article (publication date: 30 October 1992)

Flexibility versus Rigidity for Orally Bioavailable Cyclic Hexapeptides

scientific article published on 07 October 2015

Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent

scientific article published in November 2004

Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

scientific article published on 16 July 2021

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

scientific article published on 10 June 2015

Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3.

scientific article published on 7 November 2006

Glucuronic acid as a helix-inducing linker in short peptides.

scientific article published on 12 February 2018

HDAC inhibitors: modulating leukocyte differentiation, survival, proliferation and inflammation.

scientific article published on 25 October 2011

HDACs and their inhibitors in immunology: teaching anticancer drugs new tricks

scientific article published on 01 January 2012

Helix Nucleation by the Smallest Known α-Helix in Water.

scientific article

Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception.

scientific article

Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.

scientific article published on 21 October 2016

Hepta and octapeptide agonists of protease-activated receptor 2.

scientific article

Histone Deacetylase Inhibitors Promote Mitochondrial Reactive Oxygen Species Production and Bacterial Clearance by Human Macrophages.

scientific article published on 28 December 2015

Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages

scientific article

Histone deacetylase enzymes as drug targets for the control of the sheep blowfly, Lucilia cuprina

scientific article published on 9 October 2015

Histone deacetylase inhibitors and periodontal bone loss.

scientific article published on 11 July 2011

Histone deacetylase inhibitors as suppressors of bone destruction in inflammatory diseases.

scientific article published on 16 December 2011

Histone deacetylase inhibitors in inflammatory disease.

scientific article published on January 2009

Histone deacetylases (HDAC) in physiological and pathological bone remodelling

scientific article published on 29 November 2016

Histone deacetylases as regulators of inflammation and immunity ⬇️

scientific article published on May 12, 2011

Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases

scientific article

Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion

scientific article published on 24 January 2003

Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

scientific article published on 08 June 2020

Human blood MAIT cell subsets defined using MR1 tetramers.

scientific article published on 13 February 2018

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

scientific article published on 19 August 2016

Hydroxyquinones are competitive non-peptide inhibitors of HIV-1 proteinase

scientific article published on November 1995

IL-23 costimulates antigen-specific MAIT cell activation and enables vaccination against bacterial infection

scientific article published on 01 November 2019

Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds.

scientific article published on 11 February 2013

Identification of brain metastasis genes and therapeutic evaluation of histone deacetylase inhibitors in a clinically relevant model of breast cancer brain metastasis

article

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

scientific article published on 22 June 2015

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

scientific article published on 12 September 2014

In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses.

scientific article

Inflammatory lipid mediators in adipocyte function and obesity.

scientific article published on February 2010

Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.

scientific article published on 16 September 2013

Inhibiting histone deacetylase 1 suppresses both inflammation and bone loss in arthritis

scientific article published on 31 March 2015

Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist

article

Inhibition of HIV-1 proteinase by metal ions ⬇️

scientific article (publication date: June 1992)

Inhibition of Inflammation and Fibrosis by a Complement C5a Receptor Antagonist in DOCA-Salt Hypertensive Rats

article

Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site

scientific article

Inhibitors of class I histone deacetylases attenuate thioacetamide-induced liver fibrosis in mice by suppressing hepatic type 2 inflammation

scientific article published on 17 August 2019

Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats

scientific article published on 9 February 2006

Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro

scientific article published on 01 December 2011

Inhibitors selective for HDAC6 in enzymes and cells ⬇️

scientific article published on October 12, 2010

Inhibitory effects of bisbenzylisoquinolines on synthesis of the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

scientific article published in January 1993

Insecticidal activities of histone deacetylase inhibitors against a dipteran parasite of sheep, Lucilia cuprina

scientific article (publication date: 10 January 2017)

Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies

scientific article published on 19 October 2006

Irritancy and anti-inflammatory activity of bis(η5-cyclopentadienyl)titanium(IV) complexes in rats

scientific article published on 01 March 1987

Left- and right-handed alpha-helical turns in homo- and hetero-chiral helical scaffolds

scientific article published in November 2009

Linkage isomerism in the binding of pentapeptide Ac-His(Ala)3His-NH2 to (ethylenediamine)palladium(II): effect of the binding mode on peptide conformation

scientific article

Lipopolysaccharide promotes Drp1-dependent mitochondrial fission and associated inflammatory responses in macrophages

scientific article published on 20 July 2020

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

scientific article published in June 1999

Lymphoid suppression by cis-platinum(II)amines

scientific article published on 01 March 1982

Lysine Deacetylases and Regulated Glycolysis in Macrophages.

scientific article

Lysine acetylation in obesity, diabetes and metabolic disease.

scientific article

Lysine acetylation in sexual stage malaria parasites is a target for antimalarial small molecules.

scientific article

MAIT Cells Upregulate α4β7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques

article

MAIT cells protect against pulmonary Legionella longbeachae infection ⬇️

scientific article published in Nature Communications

MAIT cells regulate NK cell-mediated tumor immunity

scientific article published on 06 August 2021

MR1 presents microbial vitamin B metabolites to MAIT cells

scientific article

Mapping transmembrane residues of proteinase activated receptor 2 (PAR2) that influence ligand-modulated calcium signaling.

scientific article

Matching cavities in g protein-coupled receptors to infer ligand-binding sites

scientific article published on 30 April 2012

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

scientific article published on 24 November 2015

Metal clips induce folding of a short unstructured peptide into an alpha-helix via turn conformations in water. Kinetic versus thermodynamic products.

scientific article

Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities

scientific article published on 21 October 2019

Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus.

scientific article

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

scientific article

Modulation of ligand selectivity by mutation of the first extracellular loop of the human C5a receptor

scientific article

Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection

scientific article

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

scientific article published on 4 May 2016

Mutagenesis of the West Nile virus NS2B cofactor domain reveals two regions essential for protease activity

scientific article

New cysteine derivatives with antiproliferative activity on melanoma cells.

scientific article published in March 2006

New insights into growth hormone action.

scientific article

Non-peptidic anti-AIDS agents: inhibition of HIV-1 proteinase by disulfonates

scientific article (publication date: 30 October 1992)

Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1.

scientific article published in March 2010

Nonpeptide ligands that target peptide-activated GPCRs in inflammation.

scientific article

Nonpeptidic ligands for peptide-activated G protein-coupled receptors.

scientific article published on July 2007

Novel Agonists and Antagonists for Human Protease Activated Receptor 2 ⬇️

scientific article published on October 28, 2010

Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice ⬇️

scientific article published on November 10, 2010

Novel cylindrical, conical, and macrocyclic peptides from the cyclooligomerization of functionalized thiazole amino acids

scientific article published in January 2001

Nutrient and immune sensing are obligate pathways in metabolism, immunity, and disease

scientific article published on 11 June 2015

Orally Absorbed Cyclic Peptides

scientific article published on 25 May 2017

Organic Azide Inhibitors of Cysteine Proteases

article

Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

scientific article

PAR2 Modulators Derived from GB88.

scientific article

PAR2-induced inflammatory responses in human kidney tubular epithelial cells

scientific article published on 2 January 2013

Pathway-selective antagonism of proteinase activated receptor 2.

scientific article

Peptide inhibitors of the Escherichia coli DsbA oxidative machinery essential for bacterial virulence

scientific article

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis

scientific article published on 25 March 2019

Platinum drugs: Combined anti-lymphoproliferative and nephrotoxicity assay in rats

scientific article published on 01 January 1980

Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

scientific article

Potent Small Agonists of Protease Activated Receptor 2.

scientific article published on 30 November 2015

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity

scientific article published on 07 January 2020

Potent antimalarial activity of histone deacetylase inhibitor analogues.

scientific article published on 22 January 2008

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity

scientific article published on 26 August 2008

Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships.

scientific article published on 23 October 2015

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

scientific article published in April 2004

Potent heterocyclic ligands for human complement c3a receptor

scientific article published on 8 October 2014

Product release is rate-limiting for catalytic processing by the Dengue virus protease

scientific article

Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells

scientific article

Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites

scientific article published on 20 June 2015

Profiling the enzymatic properties and inhibition of human complement factor B.

scientific article published on 5 October 2007

Protease activated receptor 2 (PAR2) modulators: a patent review (2010-2015).

scientific article published on 3 March 2016

Protease activated receptor 2 controls myelin development, resiliency and repair

scientific article published on 18 September 2017

Protease inhibitors in the clinic.

scientific article

Protease-activated receptor 2 does not contribute to renal inflammation or fibrosis in the obstructed kidney

scientific article published on 31 July 2019

Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea

scientific article published on 24 January 2006

Proteases universally recognize beta strands in their active sites

scientific article (publication date: March 2005)

Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats

scientific article

Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine

scientific article

Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

scientific article

Protein α-turns recreated in structurally stable small molecules

scientific article

Proteolysis of human hemoglobin by schistosome cathepsin D.

scientific article

Quinazolinone derivatives as inhibitors of homologous recombinase RAD51.

scientific article

Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients

scientific article

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

scientific article

Recipient mucosal-associated invariant T cells control GVHD within the colon

scientific article

Recognition of Vitamin B Precursors and Byproducts by Mucosal Associated Invariant T Cells

scientific article

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

scientific article

Regioselective Synthesis of Antiparallel Loops on a Macrocyclic Scaffold Constrained by Oxazoles and Thiazoles

scientific article published on 01 October 2002

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

scientific article published on 7 October 2015

Review stapling peptides using cysteine crosslinking.

scientific article published on 14 May 2016

Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfide oxidases

scientific article

Selective hexapeptide agonists and antagonists for human complement C3a receptor

scientific article published in July 2010

Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loops

scientific article

Simultaneous uncoupled expression and purification of the Dengue virus NS3 protease and NS2B co-factor domain.

scientific article published on 29 November 2015

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

scientific article published on 19 October 2004

Small Peptides Do Not Inhibit Human Non-Pancreatic Secretory Phospholipase-A2 (Type IIA)

scientific article published on 01 August 2000

Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.

scientific article published in August 1998

Small molecule inhibitors of disulfide bond formation by the bacterial DsbA-DsbB dual enzyme system

scientific article published on 27 January 2015

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

scientific article

Species dependence for binding of small molecule agonist and antagonists to the C5a receptor on polymorphonuclear leukocytes

scientific article published in June 2001

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

scientific article published on 08 March 2017

Stereoelectronic effects dictate molecular conformation and biological function of heterocyclic amides.

scientific article

Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles.

scientific article

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

scientific article

Structure, function and pathophysiology of protease activated receptors.

scientific article published on 26 January 2011

Structure-Activity Relationships of Wollamide Cyclic Hexapeptides with Activity against Drug-Resistant and Intracellular

scientific article published on 26 February 2019

Structure-activity relationships for substrate-based inhibitors of human complement factor B.

scientific article published in October 2009

Structures of peptide agonists for human protease activated receptor 2.

scientific article

Studies of the interaction of potassium(I), calcium(II), magnesium(II), and copper(II) with cyclosporin A.

scientific article published in October 2003

Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates.

scientific article published on 16 November 2006

Synthesis of the Thiazole–Thiazoline Fragment of Largazole Analogues

scientific article published on 08 November 2011

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

scientific article

Targeting HIV-1 protease: a test of drug-design methodologies

scientific article published on February 1995

Targeting quorum sensing and competence stimulation for antimicrobial chemotherapy

scientific article

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.

scientific article published on 22 February 2017

The future of peptide-based drugs

scientific article

The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1.

scientific article published on 04 April 2016

The molecular basis underpinning the potency and specificity of MAIT cell antigens

scientific article published on 02 March 2020

The possible origin of free radicals from amyloid beta peptides in Alzheimer's disease.

scientific article

The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding

scientific article

The use of live-animal micro-computed tomography to determine the effect of a novel phospholipase A2 inhibitor on alveolar bone loss in an in vivo mouse model of periodontitis.

scientific article

The α-proteobacteria Wolbachia pipientis protein disulfide machinery has a regulatory mechanism absent in γ-proteobacteria.

scientific article

Therapeutic targets in inflammatory disease

scientific article

Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery.

scientific article published on 22 May 2015

Tolyporphin Macrocycles from the Cyanobacterium Tolypothrix nodosa Selectively Bind Copper and Silver and Reverse Multidrug Resistance

scientific article

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

scientific article published on 7 December 2016

Total Synthesis, Structure, and Oral Absorption of a Thiazole Cyclic Peptide, Sanguinamide A

scientific article published on 06 November 2012

Toward drugs for protease-activated receptor 2 (PAR2).

scientific article published on 30 July 2013

Toward peptide-based inhibitors as therapies for Parkinson's disease.

scientific article published on 29 October 2015

Towards isozyme-selective HDAC inhibitors for interrogating disease.

scientific article published on January 2012

Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.

scientific article published on 10 May 2016

Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1

scientific article

Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells

scientific article published on June 1997

Twists or turns: stabilising alpha vs. beta turns in tetrapeptides

scientific article published on 03 October 2019

Unexpected photolytic decomposition of alkyl azides under mild conditions

scientific article published on 22 August 2007

Update 1 of: Beta-strand mimetics.

scientific article published on 12 April 2010

Virtual Screening of Peptide and Peptidomimetic Fragments Targeted to Inhibit Bacterial Dithiol Oxidase DsbA

scientific article

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