List of works - David P. Fairlie

The future of peptide-based drugs

scientific article

MR1 presents microbial vitamin B metabolites to MAIT cells

scientific article

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

scientific article published in December 1999

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

scientific article

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

article

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

scientific article

Histone deacetylases as regulators of inflammation and immunity

scientific article published on May 12, 2011

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

scientific article

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

scientific article

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

scientific article published on October 2001

Proteases universally recognize beta strands in their active sites

scientific article (publication date: March 2005)

Structure, function and pathophysiology of protease activated receptors.

scientific article published on 26 January 2011

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

scientific article

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

scientific article published on 22 June 2015

Inflammatory lipid mediators in adipocyte function and obesity.

scientific article published on February 2010

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

scientific article published in June 1999

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

scientific article

Histone deacetylase inhibitors in inflammatory disease.

scientific article published on January 2009

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

scientific article published on October 6, 2014

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

scientific article published on 3 March 2010

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

scientific article published on 26 September 2016

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

scientific article

New insights into growth hormone action.

scientific article

Protease inhibitors in the clinic.

scientific article

A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

scientific article published in January 2003

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

scientific article published on 19 August 2016

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

scientific article published on 4 May 2016

Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

scientific article

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

scientific article published on March 2014

Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche

scientific article published on May 2014

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

scientific article

Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

scientific article

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

scientific article

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

scientific article published on 10 June 2015

Potent antimalarial activity of histone deacetylase inhibitor analogues.

scientific article published on 22 January 2008

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

scientific article

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

scientific article published on 18 August 2004

Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity

scientific article published on 18 July 2002

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

scientific article published on June 1999

Proteolysis of human hemoglobin by schistosome cathepsin D.

scientific article

Targeting HIV-1 protease: a test of drug-design methodologies

scientific article published on February 1995

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

scientific article published on 30 March 2012

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

scientific article published on 25 October 2011

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

scientific article

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

scientific article published on 6 February 2017

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

scientific article

Comparative α-helicity of cyclic pentapeptides in water

scientific article

Lysine acetylation in obesity, diabetes and metabolic disease.

scientific article

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

scientific article

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

scientific article published on 12 September 2014

List of works by David P. Fairlie

The future of peptide-based drugs

MR1 presents microbial vitamin B metabolites to MAIT cells

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

T-cell activation by transitory neo-antigens derived from distinct microbial pathways

Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Histone deacetylases as regulators of inflammation and immunity

Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion

Activity of recombinant dengue 2 virus NS3 protease in the presence of a truncated NS2B co-factor, small peptide substrates, and inhibitors.

Proteases universally recognize beta strands in their active sites

Structure, function and pathophysiology of protease activated receptors.

Recognition of vitamin B metabolites by mucosal-associated invariant T cells

Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers

Inflammatory lipid mediators in adipocyte function and obesity.

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells

Histone deacetylase inhibitors in inflammatory disease.

Constraining Cyclic Peptides To Mimic Protein Structure Motifs

Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.

A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage.

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

New insights into growth hormone action.

Protease inhibitors in the clinic.

A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation

Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.

Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

Complement c5a receptor facilitates cancer metastasis by altering T-cell responses in the metastatic niche

Structure of West Nile virus NS3 protease: ligand stabilization of the catalytic conformation

Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Potent antimalarial activity of histone deacetylase inhibitor analogues.

Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

Proteolysis of human hemoglobin by schistosome cathepsin D.

Targeting HIV-1 protease: a test of drug-design methodologies

An antagonist of human protease activated receptor-2 attenuates PAR2 signaling, macrophage activation, mast cell degranulation, and collagen-induced arthritis in rats

Antagonism of Protease-Activated Receptor 2 Protects against Experimental Colitis

Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110).

Comparative α-helicity of cyclic pentapeptides in water

Lysine acetylation in obesity, diabetes and metabolic disease.

C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable