List of works - Isabelle Janoueix-Lerosey

68Ga-DOTATOC and FDG PET Imaging of Preclinical Neuroblastoma Models

scientific article published on September 2016

ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome

scientific article published on 9 November 2011

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

scientific article published on 01 June 2010

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

scientific article

Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.

scientific article published on 11 January 2018

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

scientific article

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours.

scientific article published on 12 April 2010

BET and CDK Inhibition Reveal Differences in the Proliferation Control of Sympathetic Ganglion Neuroblasts and Adrenal Chromaffin Cells

scientific article published on 01 June 2022

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

scientific article published in May 2009

Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis

scientific article

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

scientific article

Characterization of amplicons in neuroblastoma: High-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes

article

Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport

scientific journal article

Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

scientific article

Cholinergic switch associated with morphological differentiation in neuroblastoma

scientific article published in December 2009

Clinical characteristics and outcome of patients with neuroblastoma presenting genomic amplification of loci other than MYCN.

scientific article

Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma

scientific article published on February 2003

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

scientific article

Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization

scientific article

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

scientific article

Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis.

scientific article published on 9 June 2015

Emergence of new ALK mutations at relapse of neuroblastoma

scientific article

Gene expression profiling of 1p35-36 genes in neuroblastoma

scientific article published on August 2004

Germline gain-of-function mutations of ALK disrupt central nervous system development

scientific article published in March 2011

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

scientific article

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

article

HMCan-diff: a method to detect changes in histone modifications in cells with different genetic characteristics

scientific article published on 3 January 2017

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

scientific article

High-resolution mapping of amplicons of the short arm of chromosome 1 in two neuroblastoma tumors by microarray-based comparative genomic hybridization

scientific article

Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice

scientific article

Identification of a specific effector of the small GTP-binding protein Rap2

scientific article

Interaction of a Golgi-associated kinesin-like protein with Rab6

scientific article

Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment

scientific article

Learning smoothing models of copy number profiles using breakpoint annotations

scientific article

Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development

scientific article published on December 2015

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

scientific article published on 18 August 2010

Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma

scientific article published on 31 August 2007

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

scientific article published in November 2011

Molecular analysis of chromosome arm 17q gain in neuroblastoma

scientific article published on 01 July 2000

Molecular pathogenesis of peripheral neuroblastic tumors

scientific article published on 18 March 2010

Overall genomic pattern is a predictor of outcome in neuroblastoma

scientific article

Phosphorylation of Rap1GAP during the Cell Cycle

scientific article published on 01 July 1994

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

scientific article

Preferential occurrence of chromosome breakpoints within early replicating regions in neuroblastoma

scientific article published on 14 December 2005

Prognostic impact of gene expression-based classification for neuroblastoma.

scientific article published on 21 June 2010

QuantumClone: Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

scientific article published on 12 January 2018

Radiogenomics of neuroblastomas: Relationships between imaging phenotypes, tumor genomic profile and survival.

scientific article published on 25 September 2017

Recent insights into the biology of neuroblastoma

scientific article

Regulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastoma

scientific article

Regulation of the GTPase activity of the ras-related rap2 protein

scientific article published in November 1992

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

scientific article published on 29 June 2015

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

scientific article published on 01 October 2019

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

scientific article published on 17 September 2014

SV-Bay: structural variant detection in cancer genomes using a Bayesian approach with correction for GC-content and read mappability

scientific article published on 6 January 2016

SVDetect: a tool to identify genomic structural variations from paired-end and mate-pair sequencing data

scientific article

SegAnnDB: interactive Web-based genomic segmentation

scientific article

Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence

scientific article published on 10 February 2016

Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

scientific article published on 10 November 2011

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

scientific article published on October 2008

Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain.

scientific article published on May 2005

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma

scientific article published on 31 May 2019

The ALK receptor in sympathetic neuron development and neuroblastoma

scientific article

The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking

scientific article published on 17 January 2011

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

scientific article published on 28 January 2016

The sympathetic nervous system: malignancy, disease, and novel functions.

scientific article published on 5 April 2018

Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression

scientific article published on 19 September 2012

Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6

scientific journal article

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment

scientific article

Use of the Two-Hybrid System to Identify Rab-Interacting Proteins

scientific article published on 01 April 2000

VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles

scientific article

Variety and complexity of chromosome 17 translocations in neuroblastoma

scientific article published on February 2004

Whole exome sequencing of cell-free DNA reveals temporo-spatial heterogeneity and identifies treatment-resistant clones in neuroblastoma

scientific article published on 30 November 2017

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

scientific article

[ALK, a key gene in the pathogenesis of neuroblastoma].

scientific article

[Genetic alterations in neuroblastoma and their usefulness for clinical management]

scientific article published on 01 May 2011

List of works by Isabelle Janoueix-Lerosey

68Ga-DOTATOC and FDG PET Imaging of Preclinical Neuroblastoma Models

ALK germline mutations in patients with neuroblastoma: a rare and weakly penetrant syndrome

Accumulation of Segmental Alterations Determines Progression in Neuroblastoma

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours.

BET and CDK Inhibition Reveal Differences in the Proliferation Control of Sympathetic Ganglion Neuroblasts and Adrenal Chromaffin Cells

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics

Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis

Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome

Characterization of amplicons in neuroblastoma: High-resolution mapping using DNA microarrays, relationship with outcome, and identification of overexpressed genes

Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport

Characterization of rearrangements involving the ALK gene reveals a novel truncated form associated with tumor aggressiveness in neuroblastoma

Cholinergic switch associated with morphological differentiation in neuroblastoma

Clinical characteristics and outcome of patients with neuroblastoma presenting genomic amplification of loci other than MYCN.

Combined 24-color karyotyping and comparative genomic hybridization analysis indicates predominant rearrangements of early replicating chromosome regions in neuroblastoma

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

Control-free calling of copy number alterations in deep-sequencing data using GC-content normalization

Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS.

Deep Sequencing Reveals Occurrence of Subclonal ALK Mutations in Neuroblastoma at Diagnosis.

Emergence of new ALK mutations at relapse of neuroblastoma

Gene expression profiling of 1p35-36 genes in neuroblastoma

Germline gain-of-function mutations of ALK disrupt central nervous system development

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma

HMCan-diff: a method to detect changes in histone modifications in cells with different genetic characteristics

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

High-resolution mapping of amplicons of the short arm of chromosome 1 in two neuroblastoma tumors by microarray-based comparative genomic hybridization

Hyperactivation of Alk induces neonatal lethality in knock-in AlkF1178L mice

Identification of a specific effector of the small GTP-binding protein Rap2

Interaction of a Golgi-associated kinesin-like protein with Rab6

Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment

Learning smoothing models of copy number profiles using breakpoint annotations

Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

Methylation-associated PHOX2B gene silencing is a rare event in human neuroblastoma

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

Molecular analysis of chromosome arm 17q gain in neuroblastoma

Molecular pathogenesis of peripheral neuroblastic tumors

Overall genomic pattern is a predictor of outcome in neuroblastoma

Phosphorylation of Rap1GAP during the Cell Cycle

Predicting outcomes for children with neuroblastoma using a multigene-expression signature: a retrospective SIOPEN/COG/GPOH study

Preferential occurrence of chromosome breakpoints within early replicating regions in neuroblastoma

Prognostic impact of gene expression-based classification for neuroblastoma.

QuantumClone: Clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

Radiogenomics of neuroblastomas: Relationships between imaging phenotypes, tumor genomic profile and survival.

Recent insights into the biology of neuroblastoma

Regulation by miR181 family of the dependence receptor CDON tumor suppressive activity in neuroblastoma

Regulation of the GTPase activity of the ras-related rap2 protein

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade

Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers

SV-Bay: structural variant detection in cancer genomes using a Bayesian approach with correction for GC-content and read mappability

SVDetect: a tool to identify genomic structural variations from paired-end and mate-pair sequencing data

SegAnnDB: interactive Web-based genomic segmentation

Segmental Chromosomal Aberrations in Localized Neuroblastoma Can be Detected in Formalin-Fixed Paraffin-Embedded Tissue Samples and Are Associated With Recurrence

Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma

Stepwise occurrence of a complex unbalanced translocation in neuroblastoma leading to insertion of a telomere sequence and late chromosome 17q gain.

Study of chromatin remodeling genes implicates SMARCA4 as a putative player in oncogenesis in neuroblastoma

The ALK receptor in sympathetic neuron development and neuroblastoma

The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking

The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation

The sympathetic nervous system: malignancy, disease, and novel functions.

Two cases of localized neuroblastoma with multiple segmental chromosomal alterations and metastatic progression

Two-hybrid system screen with the small GTP-binding protein Rab6. Identification of a novel mouse GDP dissociation inhibitor isoform and two other potential partners of Rab6

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment

Use of the Two-Hybrid System to Identify Rab-Interacting Proteins

VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles

Variety and complexity of chromosome 17 translocations in neuroblastoma

Whole exome sequencing of cell-free DNA reveals temporo-spatial heterogeneity and identifies treatment-resistant clones in neuroblastoma

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

[ALK, a key gene in the pathogenesis of neuroblastoma].

[Genetic alterations in neuroblastoma and their usefulness for clinical management]