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List of works by Curt D. Sigmund

A Clinical Link Between Peroxisome Proliferator-Activated Receptor γ and the Renin–Angiotensin System ⬇️

scientific article published on April 1, 2013

A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity

scientific article

A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et a

scientific article published on 29 October 2008

A second chance for a PPARγ targeted therapy?

scientific article published in January 2012

ACE, ACE inhibitors, and other JNK

scientific article published on 01 January 2004

Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation

scientific article published on 10 February 2011

Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels

scientific article

Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake

scientific article

Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin

scientific article

Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity

article

Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model

scientific article published on 22 March 2004

Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue

scientific article published on 06 May 2013

An androgen-inducible proximal tubule-specific Cre recombinase transgenic model

scientific article published on 2 April 2008

Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin

scientific article published on 24 January 2018

Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology

scientific article published on 01 July 2018

Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice

scientific article published on 8 March 2004

Angiotensin Type 1a Receptors in the Subfornical Organ Are Required for Deoxycorticosterone Acetate-Salt Hypertension ⬇️

scientific article published on December 24, 2012

Angiotensin mutant mice: a focus on the brain renin-angiotensin system.

scientific article

Angiotensinergic Signaling in the Brain Mediates Metabolic Effects of Deoxycorticosterone (DOCA)-Salt in C57 Mice ⬇️

scientific article published on January 24, 2011

Angiotensinogen modulates renal vasculature growth

scientific article published on 24 April 2006

Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants

scientific article published on 15 September 2014

Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli ⬇️

scientific article published on June 11, 1984

Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination

scientific article published on 01 January 2000

Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta.

scientific article

Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt

scientific article published on 20 April 2015

Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice

scientific article

Calcium/calmodulin-dependent kinase II inhibition in smooth muscle reduces angiotensin II-induced hypertension by controlling aortic remodeling and baroreceptor function

scientific article

Cardiovascular Consequences of Genetic Variation at −6/235 in Human Angiotensinogen Using “Humanized” Gene-Targeted Mice ⬇️

scientific article published on September 7, 2010

Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen

scientific article published in January 2003

Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.

scientific article

Cerebral vascular effects of angiotensin II: new insights from genetic models

scientific article published in April 2006

Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase

scientific article published on 28 July 2009

Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes.

scientific article published on February 1996

Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data.

scientific article

Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury

scientific article

Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension.

scientific article

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension

scientific article published on 11 June 2019

Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression.

scientific article published on 19 September 2001

Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E

scientific article published on 06 November 2019

Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism

scientific article

Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase.

scientific article

Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice.

scientific article

Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat.

scientific article

Differential control of calcium homeostasis and vascular reactivity by Ca2+/calmodulin-dependent kinase II.

scientific article

Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice

scientific article

Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue

scientific article published on 01 November 1990

Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II.

scientific article published on 5 October 2004

Differential requirement for SLP-76 domains in T cell development and function

scientific article published on 01 December 2001

Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system ⬇️

scientific article published on November 2, 2011

Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature?

scientific article published on 03 February 2010

Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle

scientific article published on 27 February 2013

Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension

scientific article published on 13 June 2018

Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus.

scientific article published on 16 July 2008

Editorial: Revised Guidelines to Enhance the Rigor and Reproducibility of Research Published in American Physiological Society Journals

scientific article published on 17 October 2018

Effect of selective expression of dominant-negative PPARγ in pro-opiomelanocortin neurons on the control of energy balance

scientific article published on 13 May 2016

Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay.

scientific article published in February 2003

Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo

scientific article published on 01 July 1999

Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia.

scientific article

Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension

scientific article published on 08 April 2022

Endothelial PPAR-γ Protects Against Vascular Thrombosis by Downregulating P-Selectin ExpressionSignificance

scientific article (publication date: 12 February 2015)

Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress

scientific article published on 13 November 2015

Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging.

scientific article

Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension

scientific article published on 20 May 2019

Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency.

scientific article

Endothelial dysfunction and blood pressure variability in selected inbred mouse strains

scientific article published in January 2002

Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet.

scientific article published on 31 July 2008

Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression

scientific article

Evidence for intraventricular secretion of angiotensinogen and angiotensin by the subfornical organ using transgenic mice.

scientific article published on 10 May 2017

Evidence supporting a functional role for intracellular renin in the brain

scientific article published on 30 January 2006

Expression and regulation of the renin gene

scientific article published on 01 November 1992

Expression of the Cytoplasmic Tail of LMP1 in Mice Induces Hyperactivation of B Lymphocytes and Disordered Lymphoid Architecture

scientific article published on 01 August 2004

Expression of the human renin gene in transgenic mice throughout ontogeny

scientific article published on 01 October 1993

Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice

scientific article published on 14 January 2016

From molecules to medicine: a future cure for preeclampsia?

scientific article

Functional characterization of polymorphisms in the kidney enhancer of the human renin gene

scientific article published on 07 December 2006

Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice.

scientific article

Gene expression profiling of potential PPARgamma target genes in mouse aorta

scientific article

Genetic Interference With Endothelial PPAR-γ (Peroxisome Proliferator-Activated Receptor-γ) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7.

scientific article published on 3 July 2017

Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase

scientific article published on 01 January 2001

Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response.

scientific article published on 19 October 2006

Genetic basis of hypertension: revisiting angiotensinogen.

scientific article

Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen

scientific article published on 28 November 2000

Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism

scientific article

Genetic manipulation of the renin–angiotensin system in the kidney ⬇️

scientific article published on September 1, 2001

Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells

scientific article published on 26 April 2004

Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference

scientific article

Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice

scientific article published on 18 August 2005

HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression

scientific article published on 01 November 2003

Highly Regulated Cell Type-restricted Expression of Human Renin in Mice Containing 140- or 160-Kilobase Pair P1 Phage Artificial Chromosome Transgenes

scientific article published in Journal of Biological Chemistry

How Is the Brain Renin-Angiotensin System Regulated?

scientific article

Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle.

scientific article published on 15 May 2017

Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.

scientific article published on 22 June 2015

Hypertension: A Disease That Strikes Around the Clock.

scientific article published on 18 January 2016

Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin

scientific article published on 09 December 2008

Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin

scientific article published on September 2004

Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression

scientific article published in September 2008

Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription

scientific journal article

Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation

scientific article published on 29 June 2000

Inactivation of NADPH oxidase organizer 1 results in severe imbalance

scientific article

Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule

scientific article published on 13 January 2004

Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.

scientific article

Inflaming hypothalamic neurons raises blood pressure

scientific article published on July 2011

Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation

scientific article published on 01 November 2018

Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension.

scientific article published on March 2008

Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling.

scientific article published on 19 February 2008

Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction

scientific article published on 3 November 2015

Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction.

scientific article

Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells

scientific article published on 7 September 2006

Introduction to the American Heart Association's Hypertension Strategically Focused Research Network.

scientific article published on 22 February 2016

Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin?

scientific article published on 04 September 2007

Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice.

scientific article

Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.

scientific article published on November 2006

Local production of angiotensin II in the subfornical organ causes elevated drinking

scientific article published on April 2007

Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model

scientific article

Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase

scientific article published on 01 February 2002

Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ.

scientific article

Meeting report: Physiological Genomics of Cardiovascular Disease: from Technology to Physiology.

scientific article published in January 2002

Metabolic rate regulation by the renin-angiotensin system: brain vs. body

scientific article published on 12 April 2012

Microarray Analysis of Hypertension.

scientific article published on January 2017

Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system

scientific article

Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome

scientific journal article

Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma.

scientific article

Munc18c regulates insulin-stimulated glut4 translocation to the transverse tubules in skeletal muscle

scientific article

Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects

scientific article published on 21 December 2017

Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development

scientific article published on 30 August 2016

Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism

scientific article

Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice

scientific article published on 15 July 1999

Nuclear localization of angiotensinogen in astrocytes.

scientific article published on 23 September 2004

On stress and pressure

scientific article published in Nature

Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior

scientific article

Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.

scientific article published on 13 November 2011

Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage

scientific article

PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice

scientific article published on 26 January 2004

PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake".

scientific article published on 4 March 2009

PPARγ Regulation in Hypertension and Metabolic Syndrome.

scientific article published on December 2015

PPARγ and retinol binding protein 7 form a regulatory hub promoting antioxidant properties of the endothelium.

scientific article

PPARγ: no SirT, no service.

scientific article published in February 2013

Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse.

scientific article published on 3 December 2002

Pioglitazone attenuates valvular calcification induced by hypercholesterolemia

scientific article published on 3 January 2013

Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism

scientific article published on 6 October 2017

Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes

scientific article

Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin.

scientific article published on 12 October 2009

Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.

scientific article

RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney.

scientific article

Regulation of renin expression and blood pressure by vitamin D(3).

scientific article

Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6 ⬇️

scientific article published on January 25, 2012

Regulation of renin gene expression by oxidative stress

scientific article published on 11 May 2009

Renal proximal tubule angiotensin AT1A receptors regulate blood pressure

scientific article

Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice.

scientific article published on December 2008

Retinoic acid-mediated activation of the mouse renin enhancer.

scientific article

Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin ⬇️

scientific article published on 23 March 2017

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity

scientific article published on 21 March 2019

Role of CaMKII in Ang-II-dependent small artery remodeling

scientific article published on 19 September 2016

Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging

scientific article published on 24 April 2009

Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation

scientific article

Role of proximal promoter elements in regulation of renin gene transcription

scientific article

Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension

scientific article

Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2

scientific article

Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism

scientific article published on 5 September 2017

Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension

scientific article

Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo

scientific article

Spontaneous stroke in a genetic model of hypertension in mice

scientific article published in June 2005

Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase

scientific article published on 23 September 2004

Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen.

scientific article published on 20 June 2002

Suppression of Resting Metabolism by the Angiotensin AT2 Receptor

scientific article published on 27 July 2016

Targeting brain AT1 receptors by RNA interference

scientific article published on 27 December 2005

Team exercise

scientific article published on 18 November 2009

The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells

scientific article published on 2 January 2007

The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system

scientific article

The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance

scientific article

The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene

scientific article published in January 2002

The earliest metanephric arteriolar progenitors and their role in kidney vascular development

scientific article

The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression

scientific article published on 21 September 2006

The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice

scientific article published on October 1997

The microRNA-processing enzyme dicer maintains juxtaglomerular cells

scientific article

Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice

scientific article published in July 1990

Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1).

scientific article published on July 1995

Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells

scientific article published on January 1997

Transgenic animal models as tools for studying renal developmental physiology

scientific article published on December 1996

Transgenic animals in the study of blood pressure regulation and hypertension.

scientific article published on November 1995

Transgenic mice for studies of the renin-angiotensin system in hypertension.

scientific article published in August 2004

Twists and turns in the search for the elusive renin processing enzyme: focus on "Cathepsin B is not the processing enzyme for mouse prorenin".

scientific article published on 17 March 2010

Untraditional methods for targeting the kidney in transgenic mice.

scientific article published on December 2003

Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism.

scientific article published on 18 September 2008

Vascular versus tubular renin: role in kidney development

scientific article

Vasopressin: the missing link for preeclampsia?

scientific article

Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis.

scientific article

Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis.

scientific article published on 7 February 2007

mTORC1 Signaling Contributes to Drinking But Not Blood Pressure Responses to Brain Angiotensin II.

scientific article published on 2 June 2016

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