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List of works by Jan Cools

A RP-UFLC Assay for Protein Tyrosine Phosphatases: Focus on Protein Tyrosine Phosphatase Non-Receptor Type 2 (PTPN2).

scientific article published on 4 June 2015

A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA+ and total RNA sequencing

scientific article published on 28 June 2018

A fly's view of the hematopoietic niche ⬇️

scientific article published on February 1, 2012

A man with FIP1L1/PDGFRA-positive chronic eosinophilic leukemia

scientific article

A new NDE1/PDGFRB fusion transcript underlying chronic myelomonocytic leukaemia in Noonan Syndrome

scientific article published on 15 February 2007

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias

scientific article

A novel cryptic translocation t(12;17)(p13;p12-p13) in a secondary acute myeloid leukemia results in a fusion of the ETV6 gene and the antisense strand of the PER1 gene.

scientific article

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

scientific article published in 2023

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

scientific article

ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia

scientific article published on 9 October 2014

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

scientific article

Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis

scientific article (publication date: April 2005)

Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

scientific article

Activity of dasatinib, a dual SRC/ABL kinase inhibitor, and IPI-504, a heat shock protein 90 inhibitor, against gastrointestinal stromal tumor-associated PDGFRAD842V mutation.

scientific article published on September 2008

Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion

scientific article published in January 2008

Anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with the variant RNF213-, ATIC- and TPM3-ALK fusions is characterized by copy number gain of the rearranged ALK gene.

scientific article

Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery

scientific article published on 27 November 2018

Antileukemic effects of the novel, mutant FLT3 inhibitor NVP-AST487: effects on PKC412-sensitive and -resistant FLT3-expressing cells

scientific article published on 26 September 2008

BMI1, the polycomb-group gene, is recurrently targeted by genomic rearrangements in progressive B-cell leukemia/lymphoma.

scientific article published on 19 July 2013

Blood disorders stepping into the limelight

scientific article published on 27 January 2016

CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor

scientific article

CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy

scientific article (publication date: November 2003)

Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions.

scientific article published in April 2005

Characterization of the genome-wide TLX1 binding profile in T-cell acute lymphoblastic leukemia

scientific article

Chromosomal aberrations and fusion genes in myeloid malignancies ⬇️

scientific article published on August 1, 2012

Chronic myeloproliferative disorders: a tyrosine kinase tale.

scientific article

Clinical and molecular features of FIP1L1-PDFGRA (+) chronic eosinophilic leukemias.

scientific article published in April 2004

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRbeta-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique.

scientific article

Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia

scientific article

Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia

Cryptic chromosomal aberrations waiting to be discovered

scientific article published on 01 February 2006

DDX3X-MLLT10 fusion in adults with NOTCH1 positive T-cell acute lymphoblastic leukemia

scientific article published on 28 February 2014

Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system.

scientific article published on 20 November 2017

Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

scientific article

Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia

scientific article published on 05 May 2016

Detection of clonal blood cells with specific chromosomal abnormalities in the general population

scientific article

Development of a siRNA and shRNA screening system based on a kinase fusion protein

scientific article published on 26 April 2012

Distinct Acute Lymphoblastic Leukemia (ALL)-associated Janus Kinase 3 (JAK3) Mutants Exhibit Different Cytokine-Receptor Requirements and JAK Inhibitor Specificities

scientific article

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

scientific article published on 15 April 2007

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

scientific article published on 3 April 2003

Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with a t(4;12)(q11-q12;p13) or t(5;12)(q31;p13).

scientific article published on March 2002

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

scientific article

FIP1L1-PDGFRA in chronic eosinophilic leukemia and BCR-ABL1 in chronic myeloid leukemia affect different leukemic cells

scientific article published on 11 January 2007

FIP1L1-PDGFRalpha D842V, a novel panresistant mutant, emerging after treatment of FIP1L1-PDGFRalpha T674I eosinophilic leukemia with single agent sorafenib

scientific article published on 12 February 2009

FIP1L1/PDGFRalpha's Kit to stimulate mast cells

scientific article published on 01 September 2008

FLT1 kinase is a mediator of radioresistance and survival in head and neck squamous cell carcinoma.

scientific article published on 16 September 2013

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia

scientific article published on 22 February 2019

Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32).

scientific article published on 15 February 2005

Fusion of ETV6 to GOT1 in a case with myelodysplastic syndrome and t(10;12)(q24;p13)

scientific article published on 01 June 2006

Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia

scientific article published on 12 September 2004

Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia ⬇️

scientific article (publication date: October 1997)

Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13).

scientific article

Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified

scientific article published on 17 June 2021

G-749, a novel FLT3 kinase inhibitor, can overcome drug resistance for the treatment of acute myeloid leukemia

scientific article published on 14 February 2014

Gene Expression Profiling Reveals Clear Differences Between EBV-Positive and EBV-Negative Posttransplant Lymphoproliferative Disorders

article

Generation of the Fip1l1-Pdgfra fusion gene using CRISPR/Cas genome editing

scientific article published on 8 March 2016

Genetic and epigenetic studies offer new therapeutic options for the treatment of T-cell acute lymphoblastic leukemia ⬇️

scientific article published on March 1, 2012

Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia.

scientific article

Genomic alterations of the JAK2 and PDL loci occur in a broad spectrum of lymphoid malignancies

scientific article

Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia

scientific article published on 01 January 1999

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype

scientific article

HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development.

scientific article published in March 2018

Hedgehog pathway activation in T-cell acute lymphoblastic leukemia predicts response to SMO and GLI1 inhibitors

scientific article

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

scientific article published on 19 December 2014

Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia.

scientific article published on 16 October 2008

High accuracy mutation detection in leukemia on a selected panel of cancer genes

scientific article (publication date: 2012)

Identification and characterization of novel oncogenes in chronic eosinophilic leukemia and T-cell acute lymphoblastic leukemia

scientific article published on January 1, 2010

Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA

scientific article

Identification of novel FLT3 kinase inhibitors.

scientific article

Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor

scientific article (publication date: August 2002)

Improvements in the survival of children and adolescents with acute lymphoblastic leukemia ⬇️

scientific article published on May 1, 2012

In vitro validation of gamma-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia.

scientific article

Integrative genomic and transcriptomic analysis identified candidate genes implicated in the pathogenesis of hepatosplenic T-cell lymphoma

scientific article

Interstitial del(14)(q) involving IGH: a novel recurrent aberration in B-NHL

scientific article published on 24 May 2007

Intestinal neurofibromatosis is a subtype of familial GIST and results from a dominant activating mutation in PDGFRA.

scientific article published on December 2006

Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases

scientific article

Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis

scientific article

JAK kinase inhibitors for the treatment of acute lymphoblastic leukemia

scientific article published on 26 July 2015

JAK1 mutation analysis in T-cell acute lymphoblastic leukemia cell lines.

scientific article published on 27 January 2009

JAK2 rearrangements, including the novel SEC31A-JAK2 fusion, are recurrent in classical Hodgkin lymphoma

scientific article published on 15 February 2011

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

scientific article (publication date: 5 September 2014)

JAK3 mutations and HOXA9 expression are important cooperating events in T-cell acute lymphoblastic leukemia

scientific article published on 04 April 2018

JAK3 specific kinase inhibitors: when specificity is not enough.

scientific article

KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q33;q32).

scientific article published in January 2005

Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia

scientific article published on June 2011

MOHITO, a novel mouse cytokine-dependent T-cell line, enables studies of oncogenic signaling in the T-cell context

scientific article

Malt1 self-cleavage is critical for regulatory T cell homeostasis and anti-tumor immunity in mice

scientific article published on 07 August 2018

Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants

scientific article

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

scientific article published on 18 August 2010

Mismatch repair deficiency endows tumors with a unique mutation signature and sensitivity to DNA double-strand breaks

scientific article

Molecular cytogenetic study of 126 unselected T-ALL cases reveals high incidence of TCRbeta locus rearrangements and putative new T-cell oncogenes

scientific article published on 4 May 2006

Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation

scientific article published in April 2007

Monitoring of Leukemia Clones in B-cell Acute Lymphoblastic Leukemia at Diagnosis and During Treatment by Single-cell DNA Amplicon Sequencing

scientific article published on 10 March 2022

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia.

scientific article published on 30 August 2017

Mutant JAK3 signaling is increased by loss of wild type JAK3 or by acquiring secondary JAK3 mutations in T-ALL.

scientific article published on 29 November 2017

Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation

scientific article

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma

scientific article published on 26 July 2011

Mutation of the receptor tyrosine phosphatase PTPRC (CD45) in T-cell acute lymphoblastic leukemia

scientific article

Mutations close in on gene regulation ⬇️

scientific article published on July 4, 2013

New flow cytometry in hematologic malignancies

scientific article published on December 2009

New opportunities and new problems for acute myeloid leukemia treatment

scientific article published in June 2012

Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1.

scientific article published on 09 January 2014

Novel approaches to therapy of hypereosinophilic syndromes

scientific article published on August 2007

Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

scientific article published on 06 July 2021

Overexpression of wild-type IL-7Rα promotes T-cell acute lymphoblastic leukemia/lymphoma

scientific article published on 01 September 2021

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

scientific article published in 2022

PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease.

scientific article published on May 2003

PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia

scientific article published on 24 June 2021

PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia

scientific article published on 6 May 2011

Ponatinib is active against imatinib-resistant mutants of FIP1L1-PDGFRA and KIT, and against FGFR1-derived fusion kinases

scientific article

Prediction of resistance to small molecule FLT3 inhibitors: implications for molecularly targeted therapy of acute leukemia

scientific article published in September 2004

Primetime for chemotherapy in acute myeloid leukemia

scientific article published on December 2012

Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling

scientific article published on 8 January 2016

RHOA mutations in peripheral T cell lymphoma

scientific article published on 01 April 2014

RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications

scientific article published on 05 May 2016

Rearrangement of NOTCH1 or BCL3 can independently trigger progression of CLL

scientific article published on 01 April 2012

Recent breakthroughs in the understanding and management of chronic eosinophilic leukemia.

scientific article published on September 2009

Resolutions for the New Year

scientific article published on January 2016

Role of GRB2‐associated binder 1 in epidermal growth factor receptor‐induced signaling in head and neck squamous cell carcinoma ⬇️

scientific article published on August 28, 2012

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Single-cell sequencing reveals the origin and the order of mutation acquisition in T-cell acute lymphoblastic leukemia.

scientific article

Sorafenib is a potent inhibitor of FIP1L1-PDGFRalpha and the imatinib-resistant FIP1L1-PDGFRalpha T674I mutant

scientific article published on 27 April 2006

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

scientific article published on 01 October 2019

T-ALL: Home Is where the CXCL12 Is.

scientific article published in June 2015

T-cell acute lymphoblastic leukemias express a unique truncated FAT1 isoform that cooperates with NOTCH1 in leukemia development

scientific article published on 04 December 2018

TV6 and PDGFRB: a license to fuse

scientific article published on 01 February 2007

Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia

scientific article (publication date: October 2015)

Targeting PIM kinases impairs survival of hematopoietic cells transformed by kinase inhibitor-sensitive and kinase inhibitor-resistant forms of Fms-like tyrosine kinase 3 and BCR/ABL.

scientific article

The CCR4-NOT complex is a tumor suppressor in Drosophila melanogaster eye cancer models

scholarly article by Carmen Vicente published in August 2018

The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management.

scientific article published on 20 November 2003

The Long Non-coding RNA Anticipates Foxp3 Expression in Regulatory T Cells

scientific article published on 25 September 2018

The N676D and G697R mutations in the kinase domain of FLT3 confer resistance to the inhibitor AC220.

scientific article

The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells

scientific article published on June 2001

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

scientific article

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

scientific article

The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.

scientific article published on 24 July 2017

The XPO1 inhibitor KPT-8602 synergizes with dexamethasone in acute lymphoblastic leukemia

scientific article published on 21 August 2020

The ability of sorafenib to inhibit oncogenic PDGFRbeta and FLT3 mutants and overcome resistance to other small molecule inhibitors

scientific article published on January 2007

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

scientific article

The genetics and molecular biology of T-ALL.

scientific article published on 23 January 2017

The genomic landscape of adult T cell leukemia/lymphoma

scientific article published on October 2015

The hypereosinophilic syndrome: idiopathic or not, that is the question

scientific article published in May 2005

The novel t(11;12;18)(q21;q13;q21) represents a variant translocation of the t(11;18)(q21;q21) associated with MALT-type lymphoma

scientific article published on 01 September 2002

The origin of relapse in pediatric T-cell acute lymphoblastic leukemia

scientific article published on November 2015

The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL.

scientific article published on 21 June 2018

The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo

scientific article published on 19 July 2005

The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V.

scientific article published on 17 February 2014

Transition from EML1-ABL1 to NUP214-ABL1 positivity in a patient with acute T-lymphoblastic leukemia

scientific article published on 05 October 2006

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

scientific article published on 11 June 2019

Uniform sensitivity of FLT3 activation loop mutants to the tyrosine kinase inhibitor midostaurin.

scientific article

Upregulation of MAPK Negative Feedback Regulators and RET in Mutant ALK Neuroblastoma: Implications for Targeted Treatment

scientific article

Using the hemoglobin switch for the treatment of sickle cell disease

scientific article published in February 2012

Variable sensitivity of FLT3 activation loop mutations to the small molecule tyrosine kinase inhibitor MLN518.

scientific article published on 15 July 2004

When splicing turns bad ⬇️

scientific article published on January 1, 2012

e6-a2 BCR-ABL1 fusion in T-cell acute lymphoblastic leukemia

scientific article published on 01 February 2005

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