List of works - Elisa de Stanchina

A combinatorial strategy for treating KRAS-mutant lung cancer

scientific article published on 22 June 2016

A microRNA component of the p53 tumour suppressor network

scientific article

Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1.

scientific article

Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma

scientific article

Antitumorigenic potential of STAT3 alternative splicing modulation ⬇️

scientific article published on October 17, 2011

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

scientific article published on 02 September 2015

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

scientific article published on 13 June 2016

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

scientific article

Comparison of Corticotropin-Releasing Factor, Dexamethasone, and Temozolomide: Treatment Efficacy and Toxicity in U87 and C6 Intracranial Gliomas ⬇️

scientific article published on March 8, 2011

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

scientific article published on 10 January 2017

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

scientific article published on 10 February 2016

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

scientific article

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

scientific article

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

scientific article published on 14 September 2009

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

scientific article published on 11 June 2012

Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene

scientific article

Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

scientific article

Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy

scientific article

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

scientific article published on 21 December 2008

Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas

scientific article

Genomic complexity and AKT dependence in serous ovarian cancer

scientific article published on January 2012

HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation

scientific article published on 5 September 2012

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

scholarly article

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

scientific article published on 13 May 2013

Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase

scientific article published on 12 June 2011

Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging

scientific article published on 18 January 2011

Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor

scientific article

Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype ⬇️

scientific article published on July 10, 2012

Infrastructure needs for translational integration of mouse and human trials

scientific article published on December 2013

Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death

scientific article published on 26 February 2013

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

scientific article

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

scientific article published on 29 March 2016

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.

scientific article

Loss of BAP1 function leads to EZH2-dependent transformation

scientific article published on 5 October 2015

Loss of p53 impedes the antileukemic response to BCR-ABL inhibition

scholarly article

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

scientific article

MLN0128, an ATP-competitive mTOR kinase inhibitor with potent in vitro and in vivo antitumor activity, as potential therapy for bone and soft-tissue sarcoma

scientific article

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity

scientific article published on 6 February 2010

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

scientific article published on March 2016

Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.

scientific article published on 11 April 2013

Oncogenic ras and p53 cooperate to induce cellular senescence

scientific article

Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling

scientific article

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer

scientific article

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

scientific article published on 18 May 2016

Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody

scientific article

PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis

scientific article published on 19 January 2016

PML is a direct p53 target that modulates p53 effector functions

scientific journal article

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

scientific article

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

scientific article

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

scientific article

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

scientific article published on November 13, 2012

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides

scientific article published on 17 January 2009

SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer

scientific article published on 17 April 2017

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

scientific article

Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

scientific article

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis

scientific article published on July 2013

The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial

scientific article

The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells

scientific article

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

scientific article published on April 2007

The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo

scientific article published on 10 March 2009

Tumor Inhibition by Enzalutamide in a Xenograft Model of Ovarian Cancer

scientific article published on 8 November 2016

p400 is required for E1A to promote apoptosis

scientific article

β4 Integrin signaling induces expansion of prostate tumor progenitors

scientific article published on 25 January 2013

List of works by Elisa de Stanchina

A combinatorial strategy for treating KRAS-mutant lung cancer

A microRNA component of the p53 tumour suppressor network

Acquired resistance of EGFR-mutant lung adenocarcinomas to afatinib plus cetuximab is associated with activation of mTORC1.

Afatinib plus Cetuximab Delays Resistance Compared to Single-Agent Erlotinib or Afatinib in Mouse Models of TKI-Naïve EGFR L858R-Induced Lung Adenocarcinoma

Antitumorigenic potential of STAT3 alternative splicing modulation ⬇️

BRAF Mutants Evade ERK-Dependent Feedback by Different Mechanisms that Determine Their Sensitivity to Pharmacologic Inhibition

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

Comparison of Corticotropin-Releasing Factor, Dexamethasone, and Temozolomide: Treatment Efficacy and Toxicity in U87 and C6 Intracranial Gliomas ⬇️

DNA Polymerase Beta Germline Variant Confers Cellular Response to Cisplatin Therapy

Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer

E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis

Escape Mutations, Ganciclovir Resistance, and Teratoma Formation in Human iPSCs Expressing an HSVtk Suicide Gene

Feedback suppression of PI3Kα signaling in PTEN-mutated tumors is relieved by selective inhibition of PI3Kβ.

Frequent disruption of the RB pathway in indolent follicular lymphoma suggests a new combination therapy

Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas

Genomic complexity and AKT dependence in serous ovarian cancer

HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase

Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging

Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor

Impact of Combined mTOR and MEK Inhibition in Uveal Melanoma Is Driven by Tumor Genotype ⬇️

Infrastructure needs for translational integration of mouse and human trials

Inhibition of mutant GNAQ signaling in uveal melanoma induces AMPK-dependent autophagic cell death

Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinase inhibitors

JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.

Loss of BAP1 function leads to EZH2-dependent transformation

Loss of p53 impedes the antileukemic response to BCR-ABL inhibition

Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

MLN0128, an ATP-competitive mTOR kinase inhibitor with potent in vitro and in vivo antitumor activity, as potential therapy for bone and soft-tissue sarcoma

Maitake beta-glucan promotes recovery of leukocytes and myeloid cell function in peripheral blood from paclitaxel hematotoxicity

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT.

Monitoring afatinib treatment in HER2-positive gastric cancer with 18F-FDG and 89Zr-trastuzumab PET.

Oncogenic ras and p53 cooperate to induce cellular senescence

Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling

Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

Overcoming resistance to HER2-targeted therapy with a novel HER2/CD3 bispecific antibody

PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis

PML is a direct p53 target that modulates p53 effector functions

Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

Relief of Profound Feedback Inhibition of Mitogenic Signaling by RAF Inhibitors Attenuates Their Activity in BRAFV600E Melanomas ⬇️

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides

SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

Significant blockade of multiple receptor tyrosine kinases by MGCD516 (Sitravatinib), a novel small molecule inhibitor, shows potent anti-tumor activity in preclinical models of sarcoma

The IL-6/JAK/Stat3 feed-forward loop drives tumorigenesis and metastasis

The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial

The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo

Tumor Inhibition by Enzalutamide in a Xenograft Model of Ovarian Cancer

p400 is required for E1A to promote apoptosis

β4 Integrin signaling induces expansion of prostate tumor progenitors