List of works - David Blum

3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

scientific article

6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.

scientific article published in August 2001

A critical evaluation of adenosine A2A receptors as potentially "druggable" targets in Huntington's disease.

scientific article published on January 2008

A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

scientific article published in June 2003

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

scientific article published on 8 July 2009

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

scientific article published on 29 June 2021

A2A R-induced transcriptional deregulation in astrocytes: An in vitro study

scientific article published on 22 July 2019

A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

scientific article published on 6 November 2010

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

article

Adenosine Receptors and Alzheimer’s Disease

Adenosine Receptors in Huntington’s Disease

Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics.

scientific article

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

scientific article published on 31 October 2014

Altered neuronal excitability in cerebellar granule cells of mice lacking calretinin.

scientific article

Alzheimer's disease risk, obesity and tau: is insulin resistance guilty?

scientific article published in May 2013

Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease

scientific article published in January 2013

Association between caffeine intake and age at onset in Huntington's disease

scientific article

Association of corticobasal degeneration and Huntington's disease: can Tau aggregates protect Huntingtin toxicity?

scientific article published in May 2009

Atypical, non-standard functions of the microtubule associated Tau protein

scientific article published on 29 November 2017

Beneficial Effect of a Selective Adenosine A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

article

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

scientific article published on 29 March 2014

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.

scientific article published on 4 May 2011

Biochemistry of Tau in Alzheimer's disease and related neurological disorders.

scientific article published on April 2008

Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

scientific article published on 19 January 2019

Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice

scientific article published on 13 November 2020

Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy

scientific article published on 01 October 2019

Central Nervous System and Peripheral Inflammatory Processes in Alzheimer's Disease: Biomarker Profiling Approach.

scientific article

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

scientific article

Chronic intoxication with 3-nitropropionic acid in rats induces the loss of striatal dopamine terminals without affecting nigral cell viability.

scientific article

Citicoline is not protective in experimental models of Huntington's disease

scientific article

Clearance of manganese from the rat substantia nigra following intra-nigral microinjections

scientific article

Clinical potential of minocycline for neurodegenerative disorders

scientific article

Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion

scientific article published on 10 May 2014

Consensus brain-derived protein, extraction protocol for the study of human and murine brain proteome using both 2D-DIGE and mini 2DE immunoblotting. ⬇️

scientific article

Controlled delivery of glial cell line-derived neurotrophic factor by a single tetracycline-inducible AAV vector.

scientific article published on 16 January 2007

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease ⬇️

scientific article published on September 12, 2011

Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms

scientific article published in February 2004

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

scientific article published on 12 October 2018

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

scientific article published on 19 October 2015

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

scientific article published in December 2017

Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.

scientific article published on 18 December 2012

Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase

scientific article

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

scientific article

Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

scientific article published on April 2009

Editorial: Purinergic Signaling in Health and Disease

scientific article published on 04 February 2020

Effects of remifentanil on N-methyl-D-aspartate receptor: an electrophysiologic study in rat spinal cord

scientific article published in June 2005

Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration

scientific article

Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

scientific article published on 22 June 2021

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

article

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

scientific article published on 01 November 2019

Extracellular toxicity of 6-hydroxydopamine on PC12 cells.

scientific article published on April 2000

Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains

scientific article published on 10 May 2010

From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

scientific article published on April 2014

From tau phosphorylation to tau aggregation: what about neuronal death?

scientific article published on August 2010

Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease

scientific article published on 9 January 2007

Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro

scientific article published on 27 February 2020

Hippocampal BDNF expression in a tau transgenic mouse model.

scientific article published in May 2012

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

scientific article published on 5 November 2016

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.

scientific article published on 16 December 2010

Human platelet concentrates: a source of solvent/detergent-treated highly enriched brain-derived neurotrophic factor

scientific article

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.

scientific article published on 19 January 2018

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

scientific article published on 16 February 2022

Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid.

scientific article published in September 2004

Increased tauopathy drives microglia-mediated clearance of beta-amyloid.

scientific article published on 23 June 2016

Lack of minocycline efficiency in genetic models of Huntington's disease

scientific article published on January 2007

Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology?

scientific article published on September 2011

MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance.

scientific article published on 23 December 2015

Mammalian Brain Ca<sup>2+</sup> Channel Activity Transplanted into <i>Xenopus laevis</i> Oocytes

scientific article published on 02 May 2022

Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study

scientific article

Minocycline in phenotypic models of Huntington's disease

scientific article published in February 2005

Minocycline-induced activation of tetracycline-responsive promoter.

scientific article published on December 2003

Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?

scientific article published in September 2010

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

scientific article published on 20 August 2014

Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ?

scientific article published on 13 February 2018

Mycoplasmas as gene therapy vectors?

scientific article published in January 1999

Myotonic Dystrophy: an RNA Toxic Gain of Function Tauopathy?

scientific article published on 01 January 2019

NLRP3 inflammasome activation drives tau pathology

scientific article published on 20 November 2019

NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.

scientific article

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

scientific article published in 2024

Neuroprotective effect of zVAD against the neurotoxin 3-nitropropionic acid involves inhibition of calpain.

scientific article published in October 2005

Neuroprotective gene therapy for Parkinson's disease.

scientific article

Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model.

scientific article published in June 2012

New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease

scientific article published on 27 March 2019

Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology

scientific article published on 17 January 2020

Novel Lipidized Analog of Prolactin-Releasing Peptide Improves Memory Impairment and Attenuates Hyperphosphorylation of Tau Protein in a Mouse Model of Tauopathy.

scientific article published in January 2018

Nuclear factor-kappa B activation in permanent intraluminal focal cerebral ischemia in the rat

scientific article published on 01 July 2000

Observations in THY-Tau22 mice that resemble behavioral and psychological signs and symptoms of dementia

scientific article published on 12 December 2012

Omics analysis of mouse brain models of human diseases.

scientific article

Overexpression of mouse IsK protein fused to green fluorescent protein induces apoptosis of human astroglioma cells.

scientific article published on September 2007

PTU-induced hypothyroidism in rats leads to several early neuropathological signs of Alzheimer's disease in the hippocampus and spatial memory impairments

scientific article

Premature ovarian aging in mice deficient for Gpr3.

scientific article

Progressive age-related cognitive decline in tau mice.

scientific article published in January 2013

RLU and studies using the luciferase reporter gene

scientific article published in August 1998

Recombinant AAV Viral Vectors Serotype 1, 2, and 5 Mediate Differential Gene Transfer Efficiency in Rat Striatal Fetal Grafts

scientific article

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

scientific article published on 01 November 2018

Rescue of impaired late-phase long-term depression in a tau transgenic mouse model.

scientific article

Role of the Tau N-terminal region in microtubule stabilization revealed by new endogenous truncated forms

scientific article published on 14 May 2015

Solvent-detergent filtered (S/D-F) fresh frozen plasma and cryoprecipitate minipools prepared in a newly designed integral disposable processing bag system

scientific article published on 23 September 2009

Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease

scientific article

Striatal and cortical neurochemical changes induced by chronic metabolic compromise in the 3-nitropropionic model of Huntington's disease.

scientific article published in August 2002

Tacrolimus-induced nephrotoxicity in mice is associated with microRNA deregulation.

scientific article

Tau and cognitive disorders: a role for T lymphocytes

scientific article published on 10 October 2017

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

scientific article published in February 2018

Tau deletion promotes brain insulin resistance

scientific article

Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker

scientific article published on 25 August 2012

Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment.

scientific article published in April 2012

Tau protein: function and pathology

scientific article published on 15 August 2012

Tau, Diabetes and Insulin

scientific article published on 01 January 2019

Tau- but not Aß -pathology enhances NMDAR-dependent depotentiation in AD-mouse models

scientific article published on 09 December 2019

The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer's Disease

scientific article published on 03 August 2018

The Chemokine MIP-1α/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory

scientific article

The Role of Adenosine Tone and Adenosine Receptors in Huntington's Disease

article

The adenosine A1 receptor agonist adenosine amine congener exerts a neuroprotective effect against the development of striatal lesions and motor impairments in the 3-nitropropionic acid model of neurotoxicity.

scientific article published in October 2002

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

scientific article published on 11 August 2016

The neuroprotective activity of heat-treated human platelet lysate biomaterials manufactured from outdated pathogen-reduced (amotosalen/UVA) platelet concentrates

scientific article published on 31 October 2019

The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease

scientific journal article

Thyroid Hormone Supplementation Restores Spatial Memory, Hippocampal Markers of Neuroinflammation, Plasticity-Related Signaling Molecules, and β-Amyloid Peptide Load in Hypothyroid Rats

scientific article published on 23 May 2018

Topological analysis of striatal lesions induced by 3-nitropropionic acid in the Lewis rat.

scientific article published in June 2001

Unlike MPP+, apoptosis induced by 6-OHDA in PC12 cells is independent of mitochondrial inhibition

scientific article published on December 1996

Worsening of Huntington disease phenotype in CB1 receptor knockout mice

scientific article

[Brain insulin signaling and Tau: impact for Alzheimer's disease and Tauopathies]

scientific article published on 01 November 2018

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

scientific article

List of works by David Blum

3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.

6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.

A critical evaluation of adenosine A2A receptors as potentially "druggable" targets in Huntington's disease.

A dual role of adenosine A2A receptors in 3-nitropropionic acid-induced striatal lesions: implications for the neuroprotective potential of A2A antagonists.

A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

A2A R-induced transcriptional deregulation in astrocytes: An in vitro study

A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

Adenosine Augmentation Evoked by an ENT1 Inhibitor Improves Memory Impairment and Neuronal Plasticity in the APP/PS1 Mouse Model of Alzheimer’s Disease

Adenosine Receptors and Alzheimer’s Disease

Adenosine Receptors in Huntington’s Disease

Adenosine receptors and Huntington's disease: implications for pathogenesis and therapeutics.

Aging, but not tau pathology, impacts olfactory performances and somatostatin systems in THY-Tau22 mice.

Altered neuronal excitability in cerebellar granule cells of mice lacking calretinin.

Alzheimer's disease risk, obesity and tau: is insulin resistance guilty?

Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease

Association between caffeine intake and age at onset in Huntington's disease

Association of corticobasal degeneration and Huntington's disease: can Tau aggregates protect Huntingtin toxicity?

Atypical, non-standard functions of the microtubule associated Tau protein

Beneficial Effect of a Selective Adenosine A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology

Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.

Biochemistry of Tau in Alzheimer's disease and related neurological disorders.

Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

Brain network remodelling reflects tau-related pathology prior to memory deficits in Thy-Tau22 mice

Caffeine Consumption During Pregnancy Accelerates the Development of Cognitive Deficits in Offspring in a Model of Tauopathy

Central Nervous System and Peripheral Inflammatory Processes in Alzheimer's Disease: Biomarker Profiling Approach.

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

Chronic intoxication with 3-nitropropionic acid in rats induces the loss of striatal dopamine terminals without affecting nigral cell viability.

Citicoline is not protective in experimental models of Huntington's disease

Clearance of manganese from the rat substantia nigra following intra-nigral microinjections

Clinical potential of minocycline for neurodegenerative disorders

Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion

Consensus brain-derived protein, extraction protocol for the study of human and murine brain proteome using both 2D-DIGE and mini 2DE immunoblotting. ⬇️

Controlled delivery of glial cell line-derived neurotrophic factor by a single tetracycline-inducible AAV vector.

D-β-Hydroxybutyrate Is Protective in Mouse Models of Huntington's Disease ⬇️

Death of cortical and striatal neurons induced by mitochondrial defect involves differential molecular mechanisms

Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Design and synthesis of fused tetrahydroisoquinoline-iminoimidazolines

Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.

Dual role of MUC1 mucin in kidney ischemia-reperfusion injury: Nephroprotector in early phase, but pro-fibrotic in late phase

Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain

Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.

Editorial: Purinergic Signaling in Health and Disease

Effects of remifentanil on N-methyl-D-aspartate receptor: an electrophysiologic study in rat spinal cord

Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration

Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Extracellular toxicity of 6-hydroxydopamine on PC12 cells.

Filamin-A and Myosin VI colocalize with fibrillary Tau protein in Alzheimer's disease and FTDP-17 brains

From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

From tau phosphorylation to tau aggregation: what about neuronal death?

Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease

Heat-treated human platelet pellet lysate modulates microglia activation, favors wound healing and promotes neuronal differentiation in vitro

Hippocampal BDNF expression in a tau transgenic mouse model.

Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.

Human platelet concentrates: a source of solvent/detergent-treated highly enriched brain-derived neurotrophic factor

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism.

Impaired Glucose Homeostasis in a Tau Knock-In Mouse Model

Increased Alix (apoptosis-linked gene-2 interacting protein X) immunoreactivity in the degenerating striatum of rats chronically treated by 3-nitropropionic acid.

Increased tauopathy drives microglia-mediated clearance of beta-amyloid.

Lack of minocycline efficiency in genetic models of Huntington's disease

Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology?

MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance.

Mammalian Brain Ca<sup>2+</sup> Channel Activity Transplanted into <i>Xenopus laevis</i> Oocytes

Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study

Minocycline in phenotypic models of Huntington's disease

Minocycline-induced activation of tetracycline-responsive promoter.

Molecular actors in Alzheimer's disease: which diagnostic and therapeutic consequences?

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

Mutual relationship between Tau and central insulin signalling: consequences for AD and Tauopathies ?

Mycoplasmas as gene therapy vectors?

Myotonic Dystrophy: an RNA Toxic Gain of Function Tauopathy?

NLRP3 inflammasome activation drives tau pathology

NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice