List of works - Yukari Fujimoto

A Comprehensive Study of Interaction between Peptidoglycan Fragments and Extracelluar Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB.

scientific article published on 29 August 2017

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

scientific article

A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade

scientific article published on 18 January 2006

Autophagic control of listeria through intracellular innate immune recognition in drosophila

scientific article published on 06 July 2008

Bisphenol A 3,4-quinone induces the conversion of xanthine dehydrogenase into oxidase in vitro

scientific article published on 2 June 2010

Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus

scientific article published on 13 February 2009

Characterization of a Novel d-Glycero-d-talo-oct-2-ulosonic acid-substituted Lipid A Moiety in the Lipopolysaccharide Produced by the Acetic Acid Bacterium Acetobacter pasteurianus NBRC 3283.

scientific article published on 18 August 2016

Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment

scientific article

Chemical Synthesis of d-glycero-d-manno-Heptose 1,7-Bisphosphate and Evaluation of Its Ability to Modulate NF-κB Activation

scientific article published on 25 May 2017

Chemical synthesis of Helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory responses.

scientific article published on 16 November 2011

Chemical synthesis of bacterial lipid A

Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism

scientific article published on January 2007

Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.

scientific article

Convergent Synthesis of Digalactosyl Diacylglycerols

scientific article published on 28 November 2017

Corrigendum to “Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines” [Molecular Immunology 44 (2007) 3100–3111]

scholarly article by Akiko Uehara et al published July 2008 in Molecular Immunology

Design and Discovery of Covalent α-GalCer Derivatives as Potent CD1d Ligands

scientific article published on 28 January 2020

Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments

scientific article published on 26 July 2006

Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B.

scientific article

Efficient Synthesis of (–)-Hanishin, (–)-Longamide B, and (–)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates

Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica

scientific article published on 8 April 2017

Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction

scientific article published on 5 February 2007

Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.

scientific article published on 21 December 2010

Formal Total Synthesis of l-Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System.

scientific article published on 20 December 2016

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.

scientific article published on 28 July 2017

Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library

scientific article

Highly β-Selective Mannosylation towards Manβ1-4GlcNAc Synthesis: TMSB(C6F5)4as a Lewis Acid/Cation Trap Catalyst

Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus

scientific article

Human serum amyloid P component is a novel peptidoglycan recognition protein inducing complement-independent phagocytosis of Staphylococcus aureus

scholarly article by J.-H. An et al published December 2013 in Molecular Immunology

Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).

scientific article published on 10 January 2007

Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses

scientific article

Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d

scientific article published on 20 September 2016

Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities

scientific article

Microbial Glycoconjugates Recognition with TLRs and NLRs in Innate Immunity

Molecular basis for bacterial peptidoglycan recognition by LysM domains

scientific article

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine

scientific article published on 5 November 2007

Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant

scientific article published on 16 September 2009

Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

scientific article published on 01 January 2005

NickelButadiene Catalytic System for the Cross-Coupling of Bromoalkanoic Acids with Alkyl Grignard Reagents: A Practical and Versatile Method for Preparing Fatty Acids

scientific article published on 01 February 2013

Nod1 ligands induce site-specific vascular inflammation.

scientific article

Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo

scientific journal article

One Step and Convenient Preparations of 4-Hydroxyretinal and 4-Oxoretinal

article by Masaru Hashimoto et al published November 1999 in Synthetic Communications

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation

scientific article published on 28 February 2012

Peptidoglycan microarray as a novel tool to explore protein-ligand recognition

scientific article published on 16 January 2016

Physical properties of new phenylpyrimidine type ferroelectric liquid crystals

Physical properties of novel biphenyl and phenylpyrimidine type ferroelectric liquid crystals

Potent Th2 Cytokine Bias of Natural Killer T Cell by CD1d Glycolipid Ligands: Anchoring Effect of Polar Groups in the Lipid Component

scientific article published on 29 June 2018

Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor

Regioselective phosphorylation of myo-inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol

scientific article published on 21 June 2016

SUGAR SYNTHESIS BY MICROFLUIDIC TECHNIQUES

scholarly article published 17 September 2016

Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes

scientific article published on 25 July 2006

Self and nonself recognition with bacterial and animal glycans, surveys by synthetic chemistry

scientific article published on January 2010

Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).

scientific article published on 27 June 2013

Solid-phase Synthesis of Bacterial Cell Wall Peptidoglycan Fragments

Solution and biologically relevant conformations of enantiomeric 11-cis-locked cyclopropyl retinals

scientific article

Stereoselective Glycosylation of 3-Deoxy-d-manno-2-octulosonic Acid with Batch and Microfluidic Methods

Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells

scientific article published on 30 June 2009

Structures, Synthesis, and Human Nod1 Stimulation of Immunostimulatory Bacterial Peptidoglycan Fragments in the Environment ⬇️

scientific article published on February 22, 2011

Syntheses and physical properties of new biphenyl and phenylpyrimidine type ferroelectric liquid crystals

Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus

scientific article published on 26 June 2013

Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A.

scientific article published on 23 March 2012

Synthesis of 11-cis-locked bicyclo[5.1.0]octanyl retinal and an enantioselective binding to bovine opsin

scientific article published in May 2002

Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity

Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation

scientific article published on 21 November 2016

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses

article

Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions

Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions

scientific article published on January 2008

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity

scientific article

Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities

scientific article published on 07 July 2006

Synthesis of peptidoglycan fragments and evaluation of their biological activity

scientific article published on 6 December 2005

Synthesis ofRubrivivax gelatinosusLipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory Activities

Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

scientific article published on 24 September 2019

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane

scientific journal article

The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

scientific article published on 01 May 2020

The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation

scientific article

Toll-like receptors, NOD1, and NOD2 in oral epithelial cells.

scientific article

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids

scientific article

Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NOD1 and NOD2 in oral epithelial cells

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines

scientific article published on 02 April 2007

Visible-light-mediated decarboxylative benzoyloxylation of β-hydroxy amino acids and its application to synthesis of functional 1,2-amino alcohol derivatives

scholarly article by Shinsuke Inuki et al published October 2015 in Tetrahedron Letters

List of works by Yukari Fujimoto

A Comprehensive Study of Interaction between Peptidoglycan Fragments and Extracelluar Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB.

A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation

A synthetic peptidoglycan fragment as a competitive inhibitor of the melanization cascade

Autophagic control of listeria through intracellular innate immune recognition in drosophila

Bisphenol A 3,4-quinone induces the conversion of xanthine dehydrogenase into oxidase in vitro

Characterization of N-terminal structure of TLR2-activating lipoprotein in Staphylococcus aureus

Characterization of a Novel d-Glycero-d-talo-oct-2-ulosonic acid-substituted Lipid A Moiety in the Lipopolysaccharide Produced by the Acetic Acid Bacterium Acetobacter pasteurianus NBRC 3283.

Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment

Chemical Synthesis of d-glycero-d-manno-Heptose 1,7-Bisphosphate and Evaluation of Its Ability to Modulate NF-κB Activation

Chemical synthesis of Helicobacter pylori lipopolysaccharide partial structures and their selective proinflammatory responses.

Chemical synthesis of bacterial lipid A

Chemical synthesis of peptidoglycan fragments for elucidation of the immunostimulating mechanism

Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.

Convergent Synthesis of Digalactosyl Diacylglycerols

Corrigendum to “Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines” [Molecular Immunology 44 (2007) 3100–3111]

Design and Discovery of Covalent α-GalCer Derivatives as Potent CD1d Ligands

Differential release and distribution of Nod1 and Nod2 immunostimulatory molecules among bacterial species and environments

Discovery of a Novel Scaffold as an Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Based on the Pyrrolopiperazinone Alkaloid, Longamide B.

Efficient Synthesis of (–)-Hanishin, (–)-Longamide B, and (–)-Longamide B Methyl Ester through Piperazinone Formation from 1,2-Cyclic Sulfamidates

Employing BINOL-Phosphoroselenoyl Chloride for Selective Inositol Phosphorylation and Synthesis of Glycosyl Inositol Phospholipid from Entamoeba histolytica

Evidence of immunostimulating lipoprotein existing in the natural lipoteichoic acid fraction

Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.

Formal Total Synthesis of l-Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System.

Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.

Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library

Highly β-Selective Mannosylation towards Manβ1-4GlcNAc Synthesis: TMSB(C6F5)4as a Lewis Acid/Cation Trap Catalyst

Human SAP is a novel peptidoglycan recognition protein that induces complement-independent phagocytosis of Staphylococcus aureus

Human serum amyloid P component is a novel peptidoglycan recognition protein inducing complement-independent phagocytosis of Staphylococcus aureus

Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).

Innate immunomodulation by lipophilic termini of lipopolysaccharide; synthesis of lipid As from Porphyromonas gingivalis and other bacteria and their immunomodulative responses

Isolated Polar Amino Acid Residues Modulate Lipid Binding in the Large Hydrophobic Cavity of CD1d

Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities

Microbial Glycoconjugates Recognition with TLRs and NLRs in Innate Immunity

Molecular basis for bacterial peptidoglycan recognition by LysM domains

Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-1 (NOD1) recognizing minimum agonists, meso-diaminopimelic acid and meso-lanthionine

Multimeric bivalent immunogens from recombinant tetanus toxin HC fragment, synthetic hexasaccharides, and a glycopeptide adjuvant

Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in h

NickelButadiene Catalytic System for the Cross-Coupling of Bromoalkanoic Acids with Alkyl Grignard Reagents: A Practical and Versatile Method for Preparing Fatty Acids

Nod1 ligands induce site-specific vascular inflammation.

Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo

One Step and Convenient Preparations of 4-Hydroxyretinal and 4-Oxoretinal

Peptidoglycan as Nod1 ligand; fragment structures in the environment, chemical synthesis, and their innate immunostimulation

Peptidoglycan microarray as a novel tool to explore protein-ligand recognition

Physical properties of new phenylpyrimidine type ferroelectric liquid crystals

Physical properties of novel biphenyl and phenylpyrimidine type ferroelectric liquid crystals

Potent Th2 Cytokine Bias of Natural Killer T Cell by CD1d Glycolipid Ligands: Anchoring Effect of Polar Groups in the Lipid Component

Practical and Efficient Method for α-Sialylation with an Azide Sialyl Donor Using a Microreactor

Regioselective phosphorylation of myo-inositol with BINOL-derived phosphoramidites and its application for protozoan lysophosphatidylinositol

SUGAR SYNTHESIS BY MICROFLUIDIC TECHNIQUES

Sarcoidosis and NOD1 variation with impaired recognition of intracellular Propionibacterium acnes

Self and nonself recognition with bacterial and animal glycans, surveys by synthetic chemistry

Separation and characterization of the immunostimulatory components in unpolished rice black vinegar (kurozu).

Solid-phase Synthesis of Bacterial Cell Wall Peptidoglycan Fragments

Solution and biologically relevant conformations of enantiomeric 11-cis-locked cyclopropyl retinals

Stereoselective Glycosylation of 3-Deoxy-d-manno-2-octulosonic Acid with Batch and Microfluidic Methods

Structural prerequisites for endotoxic activity in the Limulus test as compared to cytokine production in mononuclear cells

Structures, Synthesis, and Human Nod1 Stimulation of Immunostimulatory Bacterial Peptidoglycan Fragments in the Environment ⬇️

Syntheses and physical properties of new biphenyl and phenylpyrimidine type ferroelectric liquid crystals

Synthesis and biological activity of phosphoglycolipids from Thermus thermophilus

Synthesis and immunomodulatory activities of Helicobacter pylori lipophilic terminus of lipopolysaccharide including lipid A.

Synthesis of 11-cis-locked bicyclo[5.1.0]octanyl retinal and an enantioselective binding to bovine opsin

Synthesis of Bacterial Glycoconjugates and Their Bio-functional Studies in Innate Immunity

Synthesis of Peptidoglycan Fragments from Enterococcus faecalis with Fmoc-Strategy for Glycan Elongation

Synthesis of characteristic Mycobacterium peptidoglycan (PGN) fragments utilizing with chemoenzymatic preparation of meso-diaminopimelic acid (DAP), and their modulation of innate immune responses

Synthesis of crosslinked peptidoglycan fragments for investigation of their immunobiological functions

Synthesis of diaminopimelic acid containing peptidoglycan fragments and tracheal cytotoxin (TCT) and investigation of their biological functions

Synthesis of lipid A and its analogues for investigation of the structural basis for their bioactivity

Synthesis of lipid A monosaccharide analogues containing acidic amino acid: Exploring the structural basis for the endotoxic and antagonistic activities

Synthesis of peptidoglycan fragments and evaluation of their biological activity

Synthesis ofRubrivivax gelatinosusLipid A and Analogues for Investigation of the Structural Basis for Immunostimulating and Inhibitory Activities

Synthetic Studies on FNC-RED and Its Analogues Containing an All syn-Cyclopentanetetrol Moiety

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane

The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation

Toll-like receptors, NOD1, and NOD2 in oral epithelial cells.

Total Synthesis of Cardiolipins Containing Chiral Cyclopropane Fatty Acids

Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NOD1 and NOD2 in oral epithelial cells

Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines

Visible-light-mediated decarboxylative benzoyloxylation of β-hydroxy amino acids and its application to synthesis of functional 1,2-amino alcohol derivatives