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List of works by Morris J. Birnbaum

A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

scientific article

A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition

scientific article published in July 2013

A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice

scientific article

A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle

scientific article (publication date: May 2001)

A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake ⬇️

scientific article published on August 1, 1997

ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate

scientific article

AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation

scientific article

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

scientific article

AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle.

scientific article

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

scientific article

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

scientific article published on August 2004

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

scientific article

AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut

scientific article

Activating AMP-activated protein kinase without AMP.

scientific article published in August 2005

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.

scientific article

Activation of SOCS-3 by resistin

scientific article

Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling

scientific article

Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition

scientific article (publication date: 15 September 2010)

Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease

scientific article

Akt recruits Dab2 to albumin endocytosis in the proximal tubule

scientific article

Akt-mediated foxo1 inhibition is required for liver regeneration.

scientific article published on 16 October 2015

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

scientific article published on 6 June 2007

Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation.

scientific article published on October 2000

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

scholarly article

Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function

scientific article

Akt1 regulates a JNK scaffold during excitotoxic apoptosis

scientific journal article

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

scientific article

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

scientific article published on August 2005

Akt2 and SGK3 are both determinants of postnatal hair follicle development.

scientific article published on 11 May 2009

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

scientific article

Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation

scientific article published on January 2004

An energetic tale of AMPK-independent effects of metformin.

scientific article published on 23 June 2010

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP

scientific article

Cell biology. ADaPting to energetic stress.

scientific article

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

scientific article

Cellular insulin action and insulin resistance

scientific article published on October 1993

Characterization of the mitogen-activated protein kinase/90-kilodalton ribosomal protein S6 kinase signaling pathway in 3T3-L1 adipocytes and its role in insulin-stimulated glucose transport

scientific article published on February 1994

Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity

scientific article published on 09 January 2009

Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation

scientific article published on 9 October 2008

Construction and characterization of a conditionally active version of the serine/threonine kinase Akt.

scientific article published on May 1998

Construction of human activity-based phosphorylation networks.

scientific article

Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure

scientific article published on 2 April 2009

Control of gluconeogenesis by metformin: does redox trump energy charge?

scientific article published on August 2014

Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia

scientific article published on 25 January 2004

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

scientific article published on December 2000

De-Meaning of Metabolism

scientific article published in Science

Diabetes. Dialogue between muscle and fat.

scientific article published in February 2001

Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation

scientific article published on June 1995

Differential regulation of Akt/protein kinase B isoforms during cell cycle progression

scientific article published on 21 January 2009

Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes

scientific article published on August 1999

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

scientific article published on 26 May 2016

Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c.

scientific article

Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment.

scientific article

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 ⬇️

scientific article published on November 1, 1997

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

scientific article published on July 2010

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle.

scientific article published in July 2000

Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.

scientific article published on 15 September 2010

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

scientific article

GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood-brain barrier hexose carrier

scientific article

GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization

scientific article

Genomics: Drugs, diabetes and cancer

scientific article

Glucagon: acute actions on hepatic metabolism.

scientific article published on 26 April 2016

Hepatic Gi signaling regulates whole-body glucose homeostasis.

scientific article published on 16 January 2018

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

scientific article

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

scientific article published on 5 February 2015

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

scientific article published on 12 May 2015

Identification of a nonneuronal isoform of synaptotagmin

scientific article

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

scientific article

Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation.

scientific article published on August 1999

Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis ⬇️

scientific article published on June 26, 1998

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

scientific article

Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P3 Production and Akt Activation.

scientific article

Insulin Increases the Association of Akt-2 with Glut4-containing Vesicles ⬇️

scientific article published on March 27, 1998

Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein

scientific article published on 14 December 2015

Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes

scientific article

Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway

scientific article published on 23 August 2010

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

scientific article published on 19 February 2012

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

scientific article (publication date: June 2001)

Insulin signaling in the adipocyte

article

Insulin signaling to hepatic lipid metabolism in health and disease.

scientific article published on 05 April 2011

Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle

scientific article published in June 1998

Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes.

scientific article

Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes

scientific article published on January 2000

Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Bα

scientific article published on 16 April 2008

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

scientific article published on 30 September 2003

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation

scientific article published in December 2006

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody

scientific article published on July 1986

Lack of AKT in adipocytes causes severe lipodystrophy.

scientific article published on 13 May 2016

Linker region of Akt1/protein kinase Bα mediates platelet-derived growth factor-induced translocation and cell migration

scientific article published on 22 July 2008

Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity

scientific article published on 28 October 2011

Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease

scientific article published on December 2007

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival

scientific article

Mechanisms of glucocorticoid hormone action

scientific article published on 01 January 1984

Memory CD8 T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

article

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

scientific article

Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.

scientific article

Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

scientific article published on 05 May 2013

Neuregulin signaling through a PI3K/Akt/Bad pathway in Schwann cell survival

scientific article published in April 2001

Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice

scientific article published on 6 October 2011

Of mice and men: not ExAKTly the same?

scientific article

On the InterAktion between hexokinase and the mitochondrion.

scientific article

Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration

scientific article published in Journal of Biological Chemistry

Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt

scientific article

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

scientific article

PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization.

scientific article

PPARγ contributes to PKM2 and HK2 expression in fatty liver

scientific article published on 14 February 2012

Pharma and Academia: What We Have Here Is a Failure to Communicate

scientific article published on 01 September 2016

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition

scientific article published on 12 May 2015

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

scientific article published on 10 February 2005

Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates

scientific article published on September 2003

Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner

scientific article published on May 1998

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c

scientific article

Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation.

scientific article

Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size.

scientific article published on 21 October 2005

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

scientific article

Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.

scientific article

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia

scientific article published on 01 September 2018

Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions

scientific article published on 21 August 2006

Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways.

scientific article published on 14 October 2013

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

scientific article

Regulation of angiogenesis by glycogen synthase kinase-3beta.

scientific article published on 7 August 2002

Regulation of fat cell mass by insulin in Drosophila melanogaster

scientific article published on 12 October 2009

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

scientific article published on September 1998

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

scientific article

Regulation of renal tubular glucose reabsorption by Akt2/PKBβ

scientific article

Rejoinder: Genetic Research into the Causes of Type 2 Diabetes Mellitus

scientific article published in August 2005

Retraction: Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways

article published in 2014

Role for Akt3/protein kinase Bgamma in attainment of normal brain size

scientific journal article

Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-L1 adipocytes

scientific article published on 25 August 2003

Role of Akt/protein kinase B in metabolism.

scientific article

Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis.

scientific article

Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth

scientific journal article

SHIPing news: a new way to keep your weight down

scientific article published in February 2005

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

scientific article published on 14 July 2016

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy

scientific article published on 13 March 2017

Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines

scientific article

Signal transduction. Sweet conundrum

scientific article

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.

scientific article published on 16 March 2016

TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages

scientific article published on 6 February 2012

Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

scientific article published on 26 March 2018

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

article by Benoit Viollet et al published 1 January 2003 in Journal of Clinical Investigation

The Combined Deletion of S6K1 and Akt2 Deteriorates Glycemic Control in a High-Fat Diet ⬇️

scientific article published on July 30, 2012

The Effects of Wortmannin on Rat Skeletal Muscle

scientific article published in Journal of Biological Chemistry

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

scientific article

The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis

scientific article

The Polycomb protein, Bmi1, regulates insulin sensitivity

scientific article

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin.

scientific article published in June 2015

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

scientific article published in February 2018

The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling

scientific article published on 27 October 2009

The physician's voice in the health care debate

scientific article published on October 2009

The regulation of AMP-activated protein kinase by H(2)O(2).

scientific article published on September 2001

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells

scientific article published on 7 February 2007

The role of FOXO in the regulation of metabolism.

scientific article

The role of FoxO in the regulation of metabolism.

scientific article

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

scientific article published on June 1999

The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo

scientific article published on 5 March 2015

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

scientific article

Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1

scientific journal article

Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

scientific article

Turning down insulin signaling.

scientific article

Turning point: Morris Birnbaum

scientific article published in November 2014

Unraveling the Regulation of Hepatic Metabolism by Insulin

scientific article published on 14 April 2017

When the usual insulin is just not enough

scholarly article

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).

scientific article published on 4 June 2015

mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion

scientific article published on 16 October 2017

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