List of works - Alexander Schramm

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

scientific article (publication date: March 2009)

The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma

scientific article published on December 2010

MYCN regulates oncogenic MicroRNAs in neuroblastoma

scientific article

Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

scientific article

Mutational dynamics between primary and relapse neuroblastomas.

scientific article

MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors.

scientific article

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

scientific article published in July 2012

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

scientific article

Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes

scientific article published in January 2006

Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

scientific article published in November 2005

Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

scientific article

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation

scientific article published on 5 August 2012

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors

scientific article

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.

scientific article published on 7 March 2013

Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.

scientific article published in September 2005

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

scientific article

ArrayCGH-based classification of neuroblastoma into genomic subgroups

scientific article published on December 2007

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

scientific article

High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma

scientific article

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

scientific article

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines

scientific article

Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma

scientific article

Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma

scientific article published on 17 December 2010

IL-2−driven Regulation of NK Cell Receptors With Regard to the Distribution of CD16+ and CD16− Subpopulations and In Vivo Influence After Haploidentical NK Cell Infusion

scientific article published on 01 February 2010

Third-generation zotarolimus-eluting and everolimus-eluting stents in all-comer patients requiring a percutaneous coronary intervention (DUTCH PEERS): a randomised, single-blind, multicentre, non-inferiority trial

scientific article published on October 31, 2013

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

scientific article

Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.

scientific article published on February 2008

Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness.

scientific article published on 13 April 2009

Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds

scientific article

Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma

scientific journal article

Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells.

scientific article published on March 2007

MicroRNAs in the pathogenesis of neuroblastoma.

scientific article published on 17 July 2008

Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis

scientific article

A mechanistic classification of clinical phenotypes in neuroblastoma

scientific article published on 01 December 2018

CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

scientific article

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

scientific article

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction

scientific article

Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry.

scientific article published on 15 January 2005

Targeted Therapy for Neuroblastoma: ALK Inhibitors.

scientific article published on 28 October 2013

Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome

scientific article published in March 2007

Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome

scientific article

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

scientific article

Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines suppresses growth of established neuroblastoma.

scientific article published on 11 August 2009

The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma.

scientific article published on February 2012

MiR-34a deficiency accelerates medulloblastoma formation in vivo

scientific article

A prospective multicenter study to compare the precision of posttraumatic internal orbital reconstruction with standard preformed and individualized orbital implants

scientific article published on 21 July 2016

High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors

scientific article published on February 2007

Advances and innovations in computer-assisted head and neck oncologic surgery

scientific article published in January 2012

Design of a modular protein-based MRI contrast agent for targeted application.

scientific article

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.

scientific article

List of works by Alexander Schramm

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

The miR-17-92 microRNA cluster regulates multiple components of the TGF-β pathway in neuroblastoma

MYCN regulates oncogenic MicroRNAs in neuroblastoma

Deep sequencing reveals differential expression of microRNAs in favorable versus unfavorable neuroblastoma

Mutational dynamics between primary and relapse neuroblastomas.

MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors.

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation

Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes

Prediction of clinical outcome and biological characterization of neuroblastoma by expression profiling

Accurate prediction of neuroblastoma outcome based on miRNA expression profiles

Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation

Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.

Gains and overexpression identify DEK and E2F3 as targets of chromosome 6p gains in retinoblastoma.

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

ArrayCGH-based classification of neuroblastoma into genomic subgroups

Accurate outcome prediction in neuroblastoma across independent data sets using a multigene signature

High ALK receptor tyrosine kinase expression supersedes ALK mutation as a determining factor of an unfavorable phenotype in primary neuroblastoma

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines

Chromosomal and microRNA expression patterns reveal biologically distinct subgroups of 11q- neuroblastoma

Polo-like kinase 1 is a therapeutic target in high-risk neuroblastoma

IL-2−driven Regulation of NK Cell Receptors With Regard to the Distribution of CD16+ and CD16− Subpopulations and In Vivo Influence After Haploidentical NK Cell Infusion

Third-generation zotarolimus-eluting and everolimus-eluting stents in all-comer patients requiring a percutaneous coronary intervention (DUTCH PEERS): a randomised, single-blind, multicentre, non-inferiority trial

Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

Targeting the phosphoinositide 3-kinase isoform p110delta impairs growth and survival in neuroblastoma cells.

Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness.

Meta-mining of neuroblastoma and neuroblast gene expression profiles reveals candidate therapeutic compounds

Dickkopf-3 is regulated by the MYCN-induced miR-17-92 cluster in neuroblastoma

Fractalkine (CX3CL1)- and interleukin-2-enriched neuroblastoma microenvironment induces eradication of metastases mediated by T cells and natural killer cells.

MicroRNAs in the pathogenesis of neuroblastoma.

Smac mimetic LBW242 sensitizes XIAP-overexpressing neuroblastoma cells for TNF-α-independent apoptosis

A mechanistic classification of clinical phenotypes in neuroblastoma

CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

Neuroblastoma tumorigenesis is regulated through the Nm23-H1/h-Prune C-terminal interaction

Identification of dynamic proteome changes upon ligand activation of Trk-receptors using two-dimensional fluorescence difference gel electrophoresis and mass spectrometry.

Targeted Therapy for Neuroblastoma: ALK Inhibitors.

Translating expression profiling into a clinically feasible test to predict neuroblastoma outcome

Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines suppresses growth of established neuroblastoma.

The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma.

MiR-34a deficiency accelerates medulloblastoma formation in vivo

A prospective multicenter study to compare the precision of posttraumatic internal orbital reconstruction with standard preformed and individualized orbital implants

High resolution tiling-path BAC array deletion mapping suggests commonly involved 3p21-p22 tumor suppressor genes in neuroblastoma and more frequent tumors

Advances and innovations in computer-assisted head and neck oncologic surgery

Design of a modular protein-based MRI contrast agent for targeted application.

The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia.