List of works - Wei Shi

A Divergent Synthesis of Triyne Natural Products and Glycosylated Analogues Using a Carbenoid Rearrangement

article published in 2005

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

scientific article

Chemical and chemoenzymatic synthesis of a trisaccharide fragment of Tsukamurella paurometabola lipoarabinomannan

Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans

scientific article published on 30 October 2010

Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F.

scientific article

Determination of the absolute configurations of synthetic daunorubicin analogues using vibrational circular dichroism spectroscopy and density functional theory

scientific article published on 01 August 2010

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

scientific article published on 22 January 2016

Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans

scientific article published on 17 February 2011

Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole ⬇️

scientific article published on January 1, 2010

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

scientific article published on 15 May 2019

Ipomoeassin-F inhibits the <i>in vitro</i> biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

scientific article published on 24 November 2020

Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling ⬇️

scientific article published on October 5, 2011

New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues

scientific article published on 12 December 2017

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

scientific article published on 10 December 2018

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle

scientific article published on 30 September 2020

Revealing the Pharmacophore of Ipomoeassin F through Molecular Editing

scientific article published on 21 March 2016

Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

scientific article published on 02 December 2020

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

scientific article published on 2 December 2016

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals

scientific article published on 21 November 2011

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

scientific article published on 26 May 2018

Structure–activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential antitumor agents ⬇️

scientific article published on January 14, 2011

Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin F.

scientific article

Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics

scientific article

Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents

scientific article published on 20 October 2009

Synthesis of daunorubicin analogues containing truncated aromatic cores and unnatural monosaccharide residues

scientific article published on 21 March 2007

Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer.

scientific article

List of works by Wei Shi

A Divergent Synthesis of Triyne Natural Products and Glycosylated Analogues Using a Carbenoid Rearrangement

Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells

Chemical and chemoenzymatic synthesis of a trisaccharide fragment of Tsukamurella paurometabola lipoarabinomannan

Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans

Design, synthesis and biological evaluation of fucose-truncated monosaccharide analogues of ipomoeassin F.

Determination of the absolute configurations of synthetic daunorubicin analogues using vibrational circular dichroism spectroscopy and density functional theory

Divergence of Antiangiogenic Activity and Hepatotoxicity of Different Stereoisomers of Itraconazole.

Effect of carbohydrate amino group modifications on the cytotoxicity of glycosylated 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans

Impact of Absolute Stereochemistry on the Antiangiogenic and Antifungal Activities of Itraconazole ⬇️

Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation

Ipomoeassin-F inhibits the <i>in vitro</i> biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor

Itraconazole Side Chain Analogues: Structure–Activity Relationship Studies for Inhibition of Endothelial Cell Proliferation, Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) Glycosylation, and Hedgehog Signaling ⬇️

New insights into structure-activity relationship of ipomoeassin F from its bioisosteric 5-oxa/aza analogues

Novel Tetrazole-Containing Analogues of Itraconazole as Potent Antiangiogenic Agents with Reduced Cytochrome P450 3A4 Inhibition

Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle

Revealing the Pharmacophore of Ipomoeassin F through Molecular Editing

Ring Expansion Leads to a More Potent Analogue of Ipomoeassin F

Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis.

Stereospecific metabolism of itraconazole by CYP3A4: dioxolane ring scission of azole antifungals

Structure-activity relationship study of itraconazole, a broad-range inhibitor of picornavirus replication that targets oxysterol-binding protein (OSBP)

Structure–activity relationships in glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans as DNA binding and potential antitumor agents ⬇️

Synergistic Contribution of Tiglate and Cinnamate to Cytotoxicity of Ipomoeassin F.

Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics

Synthesis and antibacterial activity of aminosugar-functionalized intercalating agents

Synthesis of daunorubicin analogues containing truncated aromatic cores and unnatural monosaccharide residues

Total Synthesis and Biological Evaluation of Ipomoeassin F and Its Unnatural 11R-Epimer.