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List of works by Han-Ming Shen

(−)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization ⬇️

scientific article published on October 8, 2012

3-O-acetylrubianol C (3AR-C) induces RIPK1-dependent programmed cell death by selective inhibition of IKKβ

scientific article published on 06 February 2020

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy.

scientific article published on 08 July 2013

A Novel Scoring System for Pivotal Autophagy-Related Genes Predicts Outcomes after Chemotherapy in Advanced Ovarian Cancer Patients

scientific article published on 18 September 2019

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission.

scientific article

A quantitative chemical proteomics approach to profile the specific cellular targets of andrographolide, a promising anticancer agent that suppresses tumor metastasis

scientific article

A role of autophagy in PTP4A3-driven cancer progression.

scientific article

A small-molecule protein-protein interaction inhibitor of PARP1 that targets its BRCT domain.

scientific article published on 7 January 2015

AMPK mediates a pro-survival autophagy downstream of PARP-1 activation in response to DNA alkylating agents

scientific article published on 29 November 2012

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion.

scientific article published on 22 January 2013

Aflatoxin B1-induced lipid peroxidation in rat liver.

scientific article

Andrographolide sensitizes cancer cells to TRAIL-induced apoptosis via p53-mediated death receptor 4 up-regulation.

scientific article

Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells.

scientific article published on 3 February 2012

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms.

scientific article

Anticancer effects of aloe-emodin on HepG2 cells: Cellular and proteomic studies.

scientific article published on 13 March 2007

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action.

scientific article published on 23 June 2017

Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin.

scientific article

At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy.

scientific article published on 24 December 2013

Autophagic cell death: Loch Ness monster or endangered species?

scientific article

Autophagy is a cell self-protective mechanism against arsenic-induced cell transformation

scientific article

Autophagy is a survival force via suppression of necrotic cell death.

scientific article published on 16 February 2012

Autophagy plays a protective role during zVAD-induced necrotic cell death.

scientific article published on February 2008

Autophagy, Inflammation, and Metabolism (AIM) Center in its second year

scientific article published on 15 July 2019

Autophagy: resetting glutamine-dependent metabolism and oxygen consumption.

scientific article published on 21 August 2012

Biomarkers for male reproductive health hazards: are they available?

scientific article

Bone marrow stromal cell-derived growth inhibitor serves as a stress sensor to induce autophagy

scientific article published on 16 January 2020

Brazilin Limits Inflammatory Responses through Induction of Prosurvival Autophagy in Rheumatoid Fibroblast-Like Synoviocytes

scientific article

CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma

scientific article

CRISPR system for genome engineering: the application for autophagy study.

scientific article published on 14 March 2017

Cadmium-induced apoptosis and phenotypic changes in mouse thymocytes

scientific article published on 01 June 2001

Calpain activation after mitochondrial permeability transition in microcystin-induced cell death in rat hepatocytes

scientific article published in February 2002

Chemopreventive activity of parthenolide against UVB-induced skin cancer and its mechanisms

journal article published in 2004

Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish.

scientific article published on 18 August 2017

Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines.

scientific article published on 30 December 2010

Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB.

scientific article published on 4 February 2010

Complementary and alternative medicine among Singapore cancer patients.

scientific article published in February 2010

Concerns over participation in genetic research among Malay-Muslims, Chinese and Indians in Singapore: a focus group study.

scientific article published in January 2004

Critical role of AMPK in redox regulation under glucose starvation

scientific article published on 02 March 2019

Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy

scientific article published in January 2015

Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.

scientific article

Critical role of calcium overloading in cadmium-induced apoptosis in mouse thymocytes.

scientific article

Critical role of oxidative stress and sustained JNK activation in aloe-emodin-mediated apoptotic cell death in human hepatoma cells. ⬇️

scientific article published on 14 August 2007

Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells.

scientific article published on 29 April 2006

Critical role of reactive oxygen species formation in microcystin-induced cytoskeleton disruption in primary cultured hepatocytes.

scientific article published in November 2001

Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells

scientific article published on May 2004

Cubic membrane formation supports cell survival of amoeba Chaos under starvation-induced stress.

scientific article published on 15 September 2017

Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.

scientific article

Curcumin targets the TFEB-lysosome pathway for induction of autophagy.

scientific article published on 28 September 2016

Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics

scientific article

Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling.

scientific article

Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality

scientific article published in May 2002

Detection of oxidative DNA damage in human sperm and the association with cigarette smoking.

scientific article published on September 1997

Development of a novel method for quantification of autophagic protein degradation by AHA labeling.

scientific article published on 24 March 2014

Dietary restriction protects against diethylnitrosamine-induced hepatocellular tumorigenesis by restoring the disturbed gene expression profile.

scientific article published on 06 March 2017

Differential regulatory functions of three classes of phosphatidylinositol and phosphoinositide 3-kinases in autophagy

scientific article

Docetaxel enhances lysosomal function through TFEB activation.

scientific article published on 23 May 2018

Does the increase of 8-hydroxydeoxyguanosine lead to poor sperm quality?

scientific article published on November 1997

Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells.

scientific article published on December 2005

Drug Target Identification Using an iTRAQ-Based Quantitative Chemical Proteomics Approach-Based on a Target Profiling Study of Andrographolide.

scientific article published on 2 December 2016

Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase

scientific article

Dual role of autophagy in hallmarks of cancer.

scientific article published on 19 December 2017

Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells

scientific article published on 01 April 2000

Dual suppressive effect of MTORC1 on autophagy: tame the dragon by shackling both the head and the tail.

scientific article published on 25 February 2013

Dysregulated autophagy in COPD: A pathogenic process to be deciphered

scientific article published on 03 April 2019

Ebselen induces apoptosis in HepG(2) cells through rapid depletion of intracellular thiols

scientific article

Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway.

scientific article published on June 2006

Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway.

scientific article published on May 2005

Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease

scientific article

Epigenetic silencing of glutaminase 2 in human liver and colon cancers

scientific article

Evaluation of oxidative stress in a group of adolescents exposed to a high level of aflatoxin B1--a multi-center and multi-biomarker study.

scientific article published on 27 August 2007

Exposure to acrylonitrile induced DNA strand breakage and sex chromosome aneuploidy in human spermatozoa

scientific article published in May 2003

FBS or BSA Inhibits EGCG Induced Cell Death through Covalent Binding and the Reduction of Intracellular ROS Production.

scientific article published on 18 October 2016

Generation of transgenic zebrafish with liver-specific expression of EGFP-Lc3: a new in vivo model for investigation of liver autophagy

scientific article published on 3 May 2012

Genotoxicity of microcystic cyanobacteria extract of a water source in China

scientific article published in June 1999

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

scientific article

Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma

scientific article published on 15 February 2008

Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways.

scientific article published in April 2015

Hydrogen sulfide protects HUVECs against hydrogen peroxide induced mitochondrial dysfunction and oxidative stress

scientific article

Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells.

scientific article published on April 2007

IKKbeta programs to turn on the GADD45alpha-MKK4-JNK apoptotic cascade specifically via p50 NF-kappaB in arsenite response

scientific article

Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS.

scientific article

IinQ attenuates systemic inflammatory responses via selectively impairing the Myddosome complex formation upon TLR4 ligation

scientific article

Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress.

scientific article

Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B.

scientific article published on 24 February 2017

Importance of TFEB acetylation in control of its transcriptional activity and lysosomal function in response to histone deacetylase inhibitors

scientific article published on 30 July 2018

In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line.

scientific article published on 26 February 2016

Individual and Area Level Socioeconomic Status and Its Association with Cognitive Function and Cognitive Impairment (Low MMSE) among Community-Dwelling Elderly in Singapore.

scientific article

Individual and area-level socioeconomic status and their association with depression amongst community-dwelling elderly in Singapore

scientific article

Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin)

scientific article published in April 2014

Inhibitory effect of emodin on tumor invasion through suppression of activator protein-1 and nuclear factor-kappaB.

scientific article

Integrated and comparative miRNA analysis of starvation-induced autophagy in mouse embryonic fibroblasts

scientific article published on 18 June 2015

Intracellular glutathione is a cofactor in methylseleninic acid-induced apoptotic cell death of human hepatoma HEPG(2) cells

scientific article published in August 2002

Intracellular thiol depletion causes mitochondrial permeability transition in ebselen-induced apoptosis

scientific article published on 01 August 2000

Involvement of oxidative stress in crystalline silica-induced cytotoxicity and genotoxicity in rat alveolar macrophages

scientific article published on 01 March 2000

Involvement of proapoptotic Bcl-2 family members in parthenolide-induced mitochondrial dysfunction and apoptosis.

scientific article published on August 2004

Involvement of reactive oxygen species in aflatoxin B1-induced cell injury in cultured rat hepatocytes

scientific article published on 01 May 1995

Is correction for protein concentration appropriate for protein adduct dosimetry? Hypothesis and clues from an aflatoxin B1-exposed population

scientific article published on 01 February 2007

Isorhynchophylline, a natural alkaloid, promotes the degradation of alpha-synuclein in neuronal cells via inducing autophagy.

scientific article

Knowledge and beliefs on corneal donation in Singapore adults.

scientific article published on July 2005

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p

scientific article

Luteolin induces G1 arrest in human nasopharyngeal carcinoma cells via the Akt-GSK-3β-Cyclin D1 pathway.

scientific article published on 23 July 2010

Luteolin sensitizes the anticancer effect of cisplatin via c-Jun NH2-terminal kinase-mediated p53 phosphorylation and stabilization.

scientific article published on April 2007

Luteolin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells.

scientific article published on October 2004

Luteolin, a flavonoid with potential for cancer prevention and therapy

scientific article

Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels

scientific article published on 28 April 2019

Mapping sites of aspirin-induced acetylations in live cells by quantitative acid-cleavable activity-based protein profiling (QA-ABPP).

scientific article published on 20 January 2015

Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity

scientific article published on 6 October 2016

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

scientific article

Metabolic signatures of four major histological types of lung cancer cells

scientific article published on 31 August 2018

Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway.

scientific article published on December 2006

Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis.

scientific article published on October 1996

Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination

scientific article published on 27 December 2018

Nonradioactive quantification of autophagic protein degradation with L-azidohomoalanine labeling.

scientific article published on 12 January 2017

Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation.

scientific article

Novel synthetic luteolin analogue-caused sensitization of tumor necrosis factor-alpha-induced apoptosis in human tumor cells

scientific article published on 9 October 2008

Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation

scientific article published on 17 October 2018

PRL-3 activates mTORC1 in Cancer Progression

scientific article

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy.

scientific article published on 22 June 2018

PTEN-L puts a brake on mitophagy

scientific article published on 02 September 2018

Parthenolide sensitizes ultraviolet (UV)-B-induced apoptosis via protein kinase C-dependent pathways. ⬇️

scientific article published on 28 July 2005

Pharmacological inhibitors of autophagy as novel cancer therapeutic agents.

scientific article published on 27 January 2016

Pivotal role of mitochondrial Ca(2+) in microcystin-induced mitochondrial permeability transition in rat hepatocytes

scientific article published in August 2001

Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels

scientific article published on 02 January 2017

Post-translational Modifications of Key Machinery in the Control of Mitophagy

scientific article published on 09 October 2019

Protection of salvia miltiorrhiza against aflatoxin-B1-induced hepatocarcinogenesis in Fischer 344 rats dual mechanisms involved

scientific article published in June 2001

Protective effect of ebselen against hydrogen peroxide-induced cytotoxicity and DNA damage in HepG2 cells

scientific article published on February 1999

Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells

scientific article published on September 2005

Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration.

scientific article published on 16 April 2009

Proteomic Profiling of De Novo Protein Synthesis in Starvation-Induced Autophagy Using Bioorthogonal Noncanonical Amino Acid Tagging.

scientific article published on 16 November 2016

Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways: mechanism of tumorigenesis.

scientific article

Quantitative chemical proteomics profiling of de novo protein synthesis during starvation-mediated autophagy.

scientific article published on 27 July 2016

Recent advances in quantitative and chemical proteomics for autophagy studies

scientific article published on 18 August 2017

Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells

scientific article published in September 2001

SAHA and cisplatin sensitize gastric cancer cells to doxorubicin by induction of DNA damage, apoptosis and perturbation of AMPK-mTOR signalling

scientific article published on 28 June 2018

STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

scientific article published on 03 May 2019

Salvia miltiorrhiza inhibits cell growth and induces apoptosis in human hepatoma HepG(2) cells

scientific article

Selenite-induced toxicity in cancer cells is mediated by metabolic generation of endogenous selenium nanoparticles

scientific article

Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death

scientific journal article

Sodium selenite-induced oxidative stress and apoptosis in human hepatoma HepG2 cells

scientific article published on May 1999

Studies on oxidative damage induced by cyanobacteria extract in primary cultured rat hepatocytes

scientific article published in July 1998

Suppressed NF-kB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-a induced apoptosis in human cancer cells

journal article published in 2004

Suppression of autophagy during mitosis via CUL4-RING ubiquitin ligases-mediated WIPI2 polyubiquitination and proteasomal degradation

scientific article published on 30 March 2019

TNF receptor superfamily-induced cell death: redox-dependent execution

scientific article published on August 2006

Target identification with quantitative activity based protein profiling (ABPP).

scientific article

Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells

scientific article published on 24 July 2019

Targeting p53 as a therapeutic strategy in sensitizing TRAIL-induced apoptosis in cancer cells

scientific article published on 07 October 2011

Targeting the potent Beclin 1-UVRAG coiled-coil interaction with designed peptides enhances autophagy and endolysosomal trafficking.

scientific article

Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation

scientific article

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

article

The Long and the Short of PTEN in the Regulation of Mitophagy

scientific article published on 13 May 2020

The associations among semen quality, oxidative DNA damage in human spermatozoa and concentrations of cadmium, lead and selenium in seminal plasma

scientific article

The atherogenic effects of serum amyloid A are potentially mediated via inflammation and apoptosis

scientific article published on 01 May 2014

The emerging mechanisms and functions of microautophagy

scientific article published in 2022

The role of autophagy in liver diseases: mechanisms and potential therapeutic targets.

scientific article

To die or to live: the dual role of poly(ADP-ribose) polymerase-1 in autophagy and necrosis under oxidative stress and DNA damage

scientific article published on 17 February 2009

Tumor necrosis factor-induced nonapoptotic cell death requires receptor-interacting protein-mediated cellular reactive oxygen species accumulation

scientific article

Use of inducible Atg5 deletion and expression cell lines in study of the pro-survival function of autophagy under starvation.

scientific article

c-Jun N-terminal kinase mediates hydrogen peroxide-induced cell death via sustained poly(ADP-ribose) polymerase-1 activation

scientific article published on 12 January 2007

mTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif.

scientific article

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC-MAPKs-AP-1 pathway.

scientific article

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