List of works - Vladimír Kryštof

2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.

scientific article published in September 2003

2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro

scientific article published on 16 April 2015

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

scientific article published on 17 April 2019

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

scientific article published on 08 October 2019

4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

scientific article published on November 2006

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.

scientific article published on 18 January 2016

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

scientific article published on 06 June 2019

8-Azapurines as new inhibitors of cyclin-dependent kinases

scientific article published on September 2005

A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors

scientific article published on 24 November 2017

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors

scientific article published on 24 July 2013

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

scientific article published on 12 January 2017

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

scientific article published on 31 August 2019

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold.

scientific article published on 7 July 2016

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

scientific article published on 13 April 2011

Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines.

scientific article published on 27 May 2011

Anticancer activity of natural cytokinins: a structure-activity relationship study

scientific article published in June 2010

Antifungal activity of silver nanoparticles against Candida spp.

scientific article

Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.

scientific article published on August 2005

Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves.

scientific article published on 12 June 2012

Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.

scientific article

Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation.

scientific article

Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties.

scientific article

Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

scientific article published on 04 September 2012

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

scientific article published on 15 September 2020

Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells.

scientific article

Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro

scientific article published on 22 July 2015

Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases.

scientific article published on 5 March 2007

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

scientific article published on 5 February 2018

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis

scientific article (publication date: 2012)

Cyclin-dependent kinase inhibitors as anticancer drugs.

scientific article published on March 2010

Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).

scientific article published on 10 July 2015

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

scientific article published on 23 November 2015

Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes

scientific article

Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.

scientific article published on 19 April 2018

Discovery of nitroaryl urea derivatives with antiproliferative properties

scientific article

Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2

article

Dose and drug changes in chronic lymphocytic leukemia cell response in vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors

scientific article published on 05 March 2019

Effects of BP-14, a novel cyclin-dependent kinase inhibitor, on anaplastic thyroid cancer cells

scientific article published on 05 February 2016

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.

scientific article published on 11 December 2016

Exploitation of new structurally diverse d-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential.

scientific article published on 18 May 2017

How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

scientific article published on 05 October 2018

How selective are clinical CDK4/6 inhibitors?

scientific article published on 10 December 2020

Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring.

scientific article published on 23 April 2018

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy

scientific article

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

scientific article

New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity

scientific article published on 21 February 2015

Novel arylazopyrazole inhibitors of cyclin-dependent kinases.

scientific article

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

scientific article published on 12 August 2013

Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells

scientific article published on 07 January 2020

Novel potent pharmacological cyclin-dependent kinase inhibitors

scientific article published on December 2009

Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

scientific article published in April 2009

Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.

scientific article published on January 2012

Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens

scientific article published on 25 June 2015

Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells

scientific article published on 7 October 2005

Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

scientific article published on 16 March 2007

Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of.

scientific article published on March 2001

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

scientific article published on 25 December 2019

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity

scientific article

Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.

scientific article published in September 2003

Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells

scientific article published on December 2008

Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81.

scientific article

Semisynthetic Esters of 17-Hydroxycativic Acid with in Vitro Cytotoxic Activity against Leukemia Cell Lines.

scientific article published in January 2017

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

scientific article published on 01 January 2019

Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.

scientific article published on 27 January 2017

Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux

scientific article published on 06 September 2016

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.

scientific article published on 14 August 2013

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

scientific article published on 16 March 2018

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine

scientific article published on 15 April 2017

Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin

scientific article published on 22 September 2006

Synthesis and biological activity of olomoucine II.

scientific article published in November 2002

Synthesis and biological evaluation of guanidino analogues of roscovitine.

scientific article published on 22 January 2013

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.

scientific article published on 23 June 2012

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

scientific article published on 18 March 2014

Synthesis of Novel N9-Substituted Purine Derivatives from Polymer Supported α-Amino Acids.

scientific article published on 25 June 2015

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

scientific article published on 27 August 2018

Synthesis, anticancer evaluation, and molecular docking studies of some novel 4,6-disubstituted pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 (CDK2) inhibitors.

scientific article

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

scientific article published on 19 December 2015

Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

scientific article

The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, (57)Fe Mössbauer), theoretical, and biological activity studies.

scientific article

The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.

scientific article published on 5 January 2010

The selective P-TEFb inhibitor CAN508 targets angiogenesis.

scientific article

Trisubstituted purine inhibitors of PDGFRα and their antileukemic activity in the human eosinophilic cell line EOL-1.

scientific article published on 21 October 2017

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors

scientific article

Tumour suppressor PTEN regulates cell cycle and protein kinase B/Akt pathway in breast cancer cells.

scientific article published on March 2006

Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity

scientific article published on 4 January 2006

List of works by Vladimír Kryštof

2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.

2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases.

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

8-Azapurines as new inhibitors of cyclin-dependent kinases

A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors

A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold.

Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases

Anti-leishmanial activity of disubstituted purines and related pyrazolo[4,3-d]pyrimidines.

Anticancer activity of natural cytokinins: a structure-activity relationship study

Antifungal activity of silver nanoparticles against Candida spp.

Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor.

Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves.

Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase.

Arylazopyrazole AAP1742 inhibits CDKs and induces apoptosis in multiple myeloma cells via Mcl-1 downregulation.

Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties.

Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

Cdk2 inhibition prolongs G1 phase progression in mouse embryonic stem cells.

Characterization of a Pyrazolo[4,3-d]pyrimidine Inhibitor of Cyclin-Dependent Kinases 2 and 5 and Aurora A With Pro-Apoptotic and Anti-Angiogenic Activity In Vitro

Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases.

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

Cyclin-dependent kinase 9 activity regulates neutrophil spontaneous apoptosis

Cyclin-dependent kinase inhibitors as anticancer drugs.

Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).

Design, Synthesis and In Vitro Activity of Anticancer Styrylquinolines. The p53 Independent Mechanism of Action

Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes

Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations.

Discovery of nitroaryl urea derivatives with antiproliferative properties

Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2

Dose and drug changes in chronic lymphocytic leukemia cell response in vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors

Effects of BP-14, a novel cyclin-dependent kinase inhibitor, on anaplastic thyroid cancer cells

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines.

Exploitation of new structurally diverse d-glucuronamide-containing N-glycosyl compounds: synthesis and anticancer potential.

How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

How selective are clinical CDK4/6 inhibitors?

Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring.

Inhibition of post-transcriptional RNA processing by CDK inhibitors and its implication in anti-viral therapy

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat.

New approaches to the synthesis of sildenafil analogues and their enzyme inhibitory activity

Novel arylazopyrazole inhibitors of cyclin-dependent kinases.

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells

Novel potent pharmacological cyclin-dependent kinase inhibitors

Outcome of treatment of human HeLa cervical cancer cells with roscovitine strongly depends on the dosage and cell cycle status prior to the treatment

Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.

Potential Clinical Uses of CDK Inhibitors: Lessons from Synthetic Lethality Screens

Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells

Preparation, biological activity and endogenous occurrence of N6-benzyladenosines

Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of.

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

Pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine: evaluation of a novel selective inhibitor of cyclin-dependent kinases with antiproliferative activity

Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.

Roscovitine up-regulates p53 protein and induces apoptosis in human HeLaS(3) cervix carcinoma cells

Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81.

Semisynthetic Esters of 17-Hydroxycativic Acid with in Vitro Cytotoxic Activity against Leukemia Cell Lines.

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles.

Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux

Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines.

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine

Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin

Synthesis and biological activity of olomoucine II.

Synthesis and biological evaluation of guanidino analogues of roscovitine.

Synthesis and in vitro biological evaluation of 2,6,9-trisubstituted purines targeting multiple cyclin-dependent kinases.

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines

Synthesis of Novel N9-Substituted Purine Derivatives from Polymer Supported α-Amino Acids.

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[c]phenanthridine Alkaloids

Synthesis, anticancer evaluation, and molecular docking studies of some novel 4,6-disubstituted pyrazolo[3,4-d]pyrimidines as cyclin-dependent kinase 2 (CDK2) inhibitors.

Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors

Synthesis, characterization and biological activity of ring-substituted 6-benzylamino-9-tetrahydropyran-2-yl and 9-tetrahydrofuran-2-ylpurine derivatives

The first iron(III) complexes with cyclin-dependent kinase inhibitors: Magnetic, spectroscopic (IR, ES+ MS, NMR, (57)Fe Mössbauer), theoretical, and biological activity studies.