Search filters

List of works by Juan Segura-Aguilar

A new direct method for determining superoxide dismutase activity by measuring hydrogen peroxide formation

scientific article published on 01 January 1993

A new mechanism for protection of dopaminergic neurons mediated by astrocytes

scientific article published on August 2015

Activity and immunohistochemistry of DT-diaphorase in hamster and human kidney tumours.

scientific article published in August 1994

Altered Voltage Dependent Calcium Currents in a Neuronal Cell Line Derived From the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Down Syndrome ⬇️

scientific article published on December 28, 2011

Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease.

scientific article

Aminochrome Toxicity is Mediated by Inhibition of Microtubules Polymerization Through the Formation of Adducts with Tubulin

scientific article published on 7 September 2015

Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease.

scientific article published on 22 December 2015

Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's disease

scientific article published on September 2007

Aminochrome as preclinical model for Parkinson's disease

scientific article published on 2 June 2017

Aminochrome decreases NGF, GDNF and induces neuroinflammation in organotypic midbrain slice cultures.

scientific article published on 24 March 2018

Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson's disease.

scientific article

Aminochrome induces microglia and astrocyte activation.

scientific article

Angiotensin receptor II is present in dopaminergic cell line of rat substantia nigra and it is down regulated by aminochrome

scientific article

Antioxidant and glutathione-related enzymatic activities in rat sciatic nerve

scientific article published in November 1990

Association of GST M1 null polymorphism with Parkinson's disease in a Chilean population with a strong Amerindian genetic component

scientific article published on 14 March 2007

Association of Parkinson disease to PARK16 in a Chilean sample

scientific article published on 8 October 2010

Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line

scientific article

Autophagy protects against neural cell death induced by piperidine alkaloids present in Prosopis juliflora (Mesquite).

scientific article published in January 2017

Availability of genetic diagnosis of Huntington disease in Chile

scientific article published in August 2009

Behavioral effects of aminochrome and dopachrome injected in the rat substantia nigra.

scientific article

Behavioral effects of manganese injected in the rat substantia nigra are potentiated by dicumarol, a DT-diaphorase inhibitor

scientific article published in February 2004

Botulinum neurotoxin: evolution from poison, to research tool--onto medicinal therapeutic and future pharmaceutical panacea.

scientific article published on December 2007

Can we conclude a potential therapeutic action for Parkinson's disease by using postmortem tissue and a preclinical model based on an exogenous neurotoxin?

scientific article

Comment on: "Activating Autophagy as a Therapeutic Strategy for Parkinson's Disease"

scientific article published on 01 July 2018

Commentary: A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson's Disease

scientific article published on 20 June 2016

Commentary: Evaluation of Models of Parkinson's Disease

scientific article published on 19 April 2016

Commentary: Gene Therapy: A Promising Approach for Neuroprotection in Parkinson's Disease?

scientific article published on 19 May 2017

Copper dopamine complex induces mitochondrial autophagy preceding caspase-independent apoptotic cell death

scientific article

Copper neurotoxicity in rat substantia nigra and striatum is dependent on DT-diaphorase inhibition

scientific article

Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line

scientific article published on April 2001

Corrigendum: Commentary: Evaluation of Models of Parkinson's Disease

scientific article published on 7 July 2016

DT-Diaphorase Prevents Aminochrome-Induced Alpha-Synuclein Oligomer Formation and Neurotoxicity

scientific article published on 28 January 2015

DT-Diaphorase maintains the reduced state of ubiquinones in lipid vesicles thereby promoting their antioxidant function

scientific article published on 01 January 1997

DT-diaphorase Protects Against Autophagy Induced by Aminochrome-Dependent Alpha-Synuclein Oligomers.

scientific article

DT-diaphorase catalyzes N-denitration and redox cycling of tetryl

scientific article published on 01 October 1998

DT-diaphorase protects astrocytes from aminochrome-induced toxicity.

scientific article

DT-diaphorase-catalyzed two-electron reduction of quinone epoxides

scientific article published on January 1987

DT-diaphorase-catalyzed two-electron reduction of various p-benzoquinone- and 1,4-naphthoquinone epoxides

scientific article published on 01 January 1988

Dicoumarol-sensitive glucuronidation of benzo(a)pyrene metabolites in rat liver microsomes

scientific article published on 01 November 1986

Distribution of DT diaphorase in the rat brain: biochemical and immunohistochemical studies

scientific article published on 01 December 1988

Dopamine oxidation and autophagy

scientific article published on 26 August 2012

Dopamine-dependent iron toxicity in cells derived from rat hypothalamus

scientific article

Effect of superoxide dismutase on the autoxidation of various hydroquinones--a possible role of superoxide dismutase as a superoxide:semiquinone oxidoreductase

scientific article published on 01 January 1988

Effects of four organohalogen environmental contaminants on cytochrome P450 forms that catalyze 4- and 2-hydroxylation of estradiol in the rat liver

scientific article published on 01 April 1997

Effects of superoxide dismutase and catalase during reduction of adrenochrome by DT-diaphorase and NADPH-cytochrome P450 reductase

scientific article published on 01 October 1995

Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome

scientific article published on April 2002

Frequency of the D620N mutation in VPS35 in Parkinson disease

scientific article published in October 2012

Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones.

scientific article

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction

scientific article published on 14 January 2014

Glutathione transferase-M2-2 secreted from glioblastoma cell protects SH-SY5Y cells from aminochrome neurotoxicity

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Human class Mu glutathione transferases, in particular isoenzyme M2-2, catalyze detoxication of the dopamine metabolite aminochrome

scientific article published on 01 February 1997

Impact of Plant-Derived Flavonoids on Neurodegenerative Diseases.

scientific article published on 7 March 2016

Inhibition of DT-diaphorase is a requirement for Mn(III) to produce a 6-OH-dopamine like rotational behaviour

scientific article published on 01 March 2002

Inhibition of VMAT-2 and DT-diaphorase induce cell death in a substantia nigra-derived cell line--an experimental cell model for dopamine toxicity studies

scientific article published on 11 April 2007

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

scientific article

Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers

scientific article

KM-34, a Novel Antioxidant Compound, Protects against 6-Hydroxydopamine-Induced Mitochondrial Damage and Neurotoxicity.

scientific article published on 2 January 2018

Knockdown of Myo-Inositol Transporter SMIT1 Normalizes Cholinergic and Glutamatergic Function in an Immortalized Cell Line Established from the Cerebral Cortex of a Trisomy 16 Fetal Mouse, an Animal Model of Human Trisomy 21 (Down Syndrome).

scientific article

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

scientific article published on November 2006

Metabolic activation of dopamine o-quinones to o-semiquinones by NADPH cytochrome P450 reductase may play an important role in oxidative stress and apoptotic effects

scientific article published on 01 June 1998

Molecular and neurochemical mechanisms in PD pathogenesis.

scientific article

Monoamine transporter inhibitors and norepinephrine reduce dopamine-dependent iron toxicity in cells derived from the substantia nigra

scientific article published in March 2005

Neurotoxicity of some MAO inhibitors in adult rat hypothalamic cell culture.

scientific article published in March 2002

Neurotoxicological and neuroprotective elements in Parkinson's disease

scientific article published on 01 March 2002

Neurotoxin mechanisms and processes relevant to Parkinson's disease: an update

scientific article published on 29 January 2015

Neurotoxins and neurotoxic species implicated in neurodegeneration.

scientific article

Neurotoxins and neurotoxicity mechanisms. An overview.

scientific article published on December 2006

Neurotoxins as Preclinical Models for Parkinson's Disease

scientific article

New preclinical model are required to discover neuroprotective compound in Parkinson's disease.

scientific article published on 25 November 2016

Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity.

scientific article published on October 1997

Novel mechanisms and approaches in the study of neurodegeneration and neuroprotection. a review.

scientific article published on January 2003

On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo

scientific article published on 11 March 2017

On the Role of Mining Exposure in Epigenetic Effects in Parkinson's Disease

scientific article published on 29 April 2017

On the mechanism of the Mn3(+)-induced neurotoxicity of dopamine:prevention of quinone-derived oxygen toxicity by DT diaphorase and superoxide dismutase

scientific article published on 01 January 1989

On the neurotoxicity mechanism of leukoaminochrome o-semiquinone radical derived from dopamine oxidation: mitochondria damage, necrosis, and hydroxyl radical formation

scientific article published on July 2004

On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease

scientific article published on June 2017

One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity

scientific article published on 6 February 2013

Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity

scientific article

Peroxidase activity of liver microsomal vitamin D 25-hydroxylase and cytochrome P450 1A2 catalyzes 25-hydroxylation of vitamin D3 and oxidation of dopamine to aminochrome

scientific article published on 01 June 1996

Possible role of salsolinol quinone methide in the decrease of RCSN-3 cell survival

scientific article published on May 2001

Protective and toxic roles of dopamine in Parkinson's disease

scientific article published on 18 March 2014

Protective effects of nicotine against aminochrome-induced toxicity in substantia nigra derived cells: implications for Parkinson's disease

scientific article

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

scientific article published on 01 May 1998

Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product

scientific article published on 01 January 1999

Reduction of brain antioxidant defense upon treatment with butylated hydroxyanisole (BHA) and Sudan III in Syrian golden hamster

scientific article

Regioselectivity and reversibility of the glutathione conjugation of quercetin quinone methide

scientific article

Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs

scientific article published on 01 November 1999

Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol

scientific article published on 01 March 1992

Stable expression of short interfering RNA for DT-diaphorase induces neurotoxicity.

scientific article published on September 2010

Superoxide dismutase and catalase enhance autoxidation during one-electron reduction of aminochrome by NADPH-cytochrome P-450 reductase

scientific article published on 01 February 1995

Superoxide dismutase and catalase prevent the formation of reactive oxygen species during reduction of cyclized dopa ortho-quinone by DT-diaphorase

scientific article published on 01 November 1994

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

scientific article published on 14 February 2012

The Effect of 5OH-1,4-Naphthoquinone on Norway Spruce Seeds during Germination

scientific article published on 01 December 1992

The Importance of Mitophagy in Maintaining Mitochondrial Function in U373MG Cells. Bafilomycin A1 Restores Aminochrome-Induced Mitochondrial Damage

scientific article published in August 2017

The anticancer enzyme DT diaphorase is induced selectively in liver during ascites hepatoma growth

scientific article published on 01 March 1988

The catecholaminergic RCSN-3 cell line: a model to study dopamine metabolism

scientific article

The cytotoxic effects of 5-OH-1,4-naphthoquinone and 5,8-diOH-1,4-naphthoquinone on doxorubicin-resistant human leukemia cells (HL-60) ⬇️

scientific article published on June 1, 1992

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.

scientific article published on August 2012

The levels of quinone reductases, superoxide dismutase and glutathione-related enzymatic activities in diethylstilbestrol-induced carcinogenesis in the kidney of male Syrian golden hamsters.

scientific article published in October 1990

The need of a new and more physiological preclinical model for Parkinson's disease

scientific article published on 23 January 2016

The possible role of one-electron reduction of aminochrome in the neurodegenerative process of the dopaminergic system.

scientific article

The protective effect of superoxide dismutase and catalase against formation of reactive oxygen species during reduction of cyclized norepinephrine ortho-quinone by DT-diaphorase

scientific article published on 01 July 1994

The two-electron quinone reductase DT-diaphorase generates and maintains the antioxidant (reduced) form of coenzyme Q in membranes

scientific article published on 01 January 1997

Paulina is supported by:

About Paulina

Help