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List of works by Esteban Ballestar

A DNA methylation fingerprint of 1628 human samples

scientific article

A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer

scientific article published on 13 January 2012

A Drosophila MBD family member is a transcriptional corepressor associated with specific genes

scientific article published in October 2001

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors

scientific article

A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer

scientific article published on September 2006

A robust and highly efficient immune cell reprogramming system

scientific article

A role for methyl-CpG binding domain protein 2 in the modulation of the estrogen response of pS2/TFF1 gene

scientific article

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition

scientific article

Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites

scientific article published on 8 August 2017

Allele-specific histone lysine methylation marks regulatory regions at imprinted mouse genes

scientific article

Amino acid substitutions enhancing thermostability of Bacillus polymyxa beta-glucosidase A

scientific article published on March 1996

An introduction to epigenetics.

scientific article published on January 2011

Autophagy maintains stemness by preventing senescence

scientific article published on January 2016

Autophagy maintains stemness by preventing senescence

scientific article published in Nature

BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia

scientific article

C/EBPa-mediated activation of microRNAs 34a and 223 inhibits Lef1 expression to achieve efficient reprogramming into macrophages

scientific article

CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia

scientific article published on 06 April 2009

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia.

scientific article

Capillary electrophoresis-based method to quantitate DNA–protein interactions ⬇️

scientific article published on June 15, 2003

Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus

scientific article

Chromatin immunoprecipitation.

scientific article published on January 2014

Chromatin-wide and transcriptome profiling integration uncovers p38α MAPK as a global regulator of skeletal muscle differentiation

scientific article

Clinical value of DNA methylation markers in autoimmune rheumatic diseases

scientific article published on 05 August 2020

Combinatorial effects of splice variants modulate function of Aiolos

scientific article

Conformational changes in the nucleosome followed by the selective accessibility of histone glutamines in the transglutaminase reaction: effects of ionic strength

scientific article published in February 2001

Coordinated glucocorticoid receptor and MAFB action induces tolerogenesis and epigenome remodeling in dendritic cells

scientific article published on 01 January 2022

Core histones are glutaminyl substrates for tissue transglutaminase

scientific article published in August 1996

DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes.

scientific article published on 6 July 2016

DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E.

scientific article

Data integration in the era of omics: current and future challenges

scientific article

Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch.

scientific article

Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells

scientific article published on December 2007

Dissecting Epigenetic Dysregulation of Primary Antibody Deficiencies

scientific article published on 17 March 2016

E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription

scientific article

Effects of Rett syndrome mutations of the methyl-CpG binding domain of the transcriptional repressor MeCP2 on selectivity for association with methylated DNA

scientific article published on 01 June 2000

Environmental triggers and epigenetic deregulation in autoimmune disease

scientific article

Epigenetic alterations in autoimmune disease

scientific article published on 23 November 2011

Epigenetic alterations in autoimmune rheumatic diseases ⬇️

scientific article published on February 22, 2011

Epigenetic connections between autoimmune disorders and haematological malignancies

scientific article published on 24 October 2008

Epigenetic contributions in autoimmune disease. Preface

scientific article published on 01 January 2011

Epigenetic control of myeloid cell differentiation, identity and function.

scientific article published on January 2015

Epigenetic differences arise during the lifetime of monozygotic twins

scientific article

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

scientific article published on 13 March 2007

Epigenetic gene regulation in cancer

scientific article published on January 2008

Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies

scientific article

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

scientific article

Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies

scientific article published on 27 October 2009

Epigenetic interplay between immune, stromal and cancer cells in the tumor microenvironment

scientific article published on 06 March 2018

Epigenetic mechanisms of myeloid differentiation in the tumor microenvironment.

scientific article published on 25 May 2017

Epigenetic regulation of PRAME in acute myeloid leukemia is different compared to CD34+ cells from healthy donors: Effect of 5-AZA treatment

scientific article published on 13 April 2012

Epigenetic regulation of myogenesis

scientific article

Epigenetic signatures associated with different levels of differentiation potential in human stem cells

scientific article

Epigenetics lessons from twins: prospects for autoimmune disease.

scientific article

Epigenetics: DNA methylation signatures in Sjögren syndrome

scientific article published on 09 September 2016

Epigenome-Wide Comparative Study Reveals Key Differences Between Mixed Connective Tissue Disease and Related Systemic Autoimmune Diseases

Epigenomic deregulation in the immune system.

scientific article published on December 2011

Epigenomics and transcriptomics of systemic sclerosis CD4+ T cells reveal long-range dysregulation of key inflammatory pathways mediated by disease-associated susceptibility loci

scientific article published on 25 September 2020

Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation

scientific article published on 3 October 2013

Gains of DNA methylation in myeloid terminal differentiation are dispensable for gene silencing but influence the differentiated phenotype

scientific article published on 07 October 2014

Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation

scientific article published on 15 February 2007

Genetic and Epigenetic Determinants in Autoinflammatory Diseases.

scientific article published on 22 March 2017

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells

scientific article

Genetics: Insights into RA pathogenesis from DNA methylome analysis

scientific article published on 19 May 2015

Geriatric muscle stem cells switch reversible quiescence into senescence.

scientific article

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

scientific article published on 25 June 2004

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

scientific article

Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.

scientific article

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

scientific article published on 8 January 2013

Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting.

scientific article published on 3 November 2009

Impaired CpG Demethylation in Common Variable Immunodeficiency Associates With B Cell Phenotype and Proliferation Rate

scientific article published on 24 April 2019

Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation

scientific article

In vivo analysis of DNA methylation patterns recognized by specific proteins: coupling CHIP and bisulfite analysis

scientific article published in October 2004

In vivo conditional deletion of HDAC7 reveals its requirement to establish proper B lymphocyte identity and development.

scientific article published on 17 October 2016

Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

scientific article published on 29 October 2019

Inflammatory cytokines shape a changing DNA methylome in monocytes mirroring disease activity in rheumatoid arthritis

scientific article published on 01 August 2019

JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis

scientific article published on 17 November 2021

Long-range epigenetic silencing associates with deregulation of Ikaros targets in colorectal cancer cells

scientific article published on 7 July 2011

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

scientific article

Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.

scientific article

Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

scientific article

Methyl-CpG-binding proteins. Targeting specific gene repression.

scientific article

Methyl-DNA immunoprecipitation (MeDIP): hunting down the DNA methylome.

scientific article

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

scientific article (publication date: September 1999)

Microglial Innate Memory and Epigenetic Reprogramming in Neurological Disorders

scientific article published on 09 December 2020

Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition

scientific article

Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events

scientific article published on March 2007

NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas.

scientific article

NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation

scientific article

New insights into the biology and origin of mature aggressive B-cell lymphomas by combined epigenomic, genomic, and transcriptional profiling

scientific article

New insights into the epigenetics of inflammatory rheumatic diseases.

scientific article published on 14 September 2017

Notch signaling is essential for ventricular chamber development

scientific article

Nucleosome structure completely inhibits in vitro cleavage by the V(D)J recombinase

scientific article published on July 1999

PU.1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation

scientific article published on January 2013

Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes

scientific article published on 15 November 2011

Promoter DNA hypermethylation and gene repression in undifferentiated Arabidopsis cells

scientific article

Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.

scientific article published in October 2017

Recruitment of CREB1 and histone deacetylase 2 (HDAC2) to the mouse Ltbp-1 promoter regulates its constitutive expression in a dioxin receptor-dependent manner

scientific article published on 30 April 2008

Release of Hypoacetylated and Trimethylated Histone H4 Is an Epigenetic Marker of Early Apoptosis

scientific article published in Journal of Biological Chemistry

SIRT1/2 orchestrate acquisition of DNA methylation and loss of histone H3 activating marks to prevent premature activation of inflammatory genes in macrophages

scientific article published on 01 January 2020

STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse

scientific article published on 31 October 2019

Sampling artifacts in single-cell genomics cohort studies ⬇️

journal article from 'bioRxiv' published in 2020

Sampling time-dependent artifacts in single-cell genomics studies

scientific article published on 11 May 2020

Single-cell Atlas of common variable immunodeficiency shows germinal center-associated epigenetic dysregulation in B-cell responses

scientific article published on 01 April 2022

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

scientific article

SnapShot: The Human DNA Methylome in Health and Disease

article

Specific hypermethylation of LINE-1 elements during abnormal overgrowth and differentiation of human placenta

scientific article published on 9 October 2006

Stage-specific chromosomal association of Drosophila dMBD2/3 during genome activation

scientific article published in March 2002

TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.

scientific article published on September 2017

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease

scientific article published on 18 January 2021

Tet2 facilitates the derepression of myeloid target genes during CEBPα-induced transdifferentiation of pre-B cells

scientific article published on 13 September 2012

The B cell transcription program mediates hypomethylation and overexpression of key genes in Epstein-Barr virus-associated proliferative conversion.

scientific article published on 15 January 2013

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis

scientific article

The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells.

scientific article published on 21 April 2007

The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

scientific article published in March 2003

The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding.

scientific article published on 12 January 2006

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer

scientific article published on 10 February 2009

The epigenetic breakdown of cancer cells: from DNA methylation to histone modifications

scientific article

The epigenetic face of systemic lupus erythematosus

scientific article

The impact of MECP2 mutations in the expression patterns of Rett syndrome patients

scientific article published on 11 November 2004

The impact of chromatin in human cancer: linking DNA methylation to gene silencing

scientific article

The p38 SAPK is recruited to chromatin via its interaction with transcription factors

scientific article published on 3 August 2010

Tolerogenic Dendritic Cells in Autoimmunity and Inflammatory Diseases

scientific article published on 05 December 2020

Towards defining the lymphoma methylome

scientific article published on 01 October 2006

Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53.

scientific article published on September 2006

Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells.

scientific article

Transforming pathways unleashed by a HDAC2 mutation in human cancer.

scientific article published on 11 February 2008

Understanding the Relevance of DNA Methylation Changes in Immune Differentiation and Disease

scientific article published on 18 January 2020

Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins

scientific article published on 28 January 2008

Use of the transglutaminase reaction to study the dissociation of histone N-terminal tails from DNA in nucleosome core particles

scientific article published on 01 May 1997

miRNAs as Therapeutic Targets in Inflammatory Disease

scientific article published on 29 October 2019

shinyÉPICo: A graphical pipeline to analyze Illumina DNA methylation arrays

scientific article published on 08 January 2021

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