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List of works by Ian J Frew

A binding motif for Siah ubiquitin ligase.

scholarly article

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours

scientific article

A clearer view of the molecular complexity of clear cell renal cell carcinoma.

scientific article

A versatile modular vector system for rapid combinatorial mammalian genetics

scientific article

Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation

scientific article published on 15 February 2016

Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation

scientific article

Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.

scientific article published on 12 May 2008

Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions

scientific article published on 30 May 2016

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice

scientific article published on 29 May 2017

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice

scientific article published on 22 April 2013

Competition by second messenger systems for receptor interaction and activation: implications for tissue-specific responses and disease therapy

scientific article published on August 1997

Detecting circulating tumor DNA in renal cancer: An open challenge.

scientific article published on 15 February 2017

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells

scientific article published on 13 November 2017

Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α.

scientific article published on 12 January 2016

Generation and analysis of Siah2 mutant mice.

scientific article

Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics

scientific article published on 27 March 2013

HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

scientific article published on 17 August 2020

Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma.

scientific article published on 15 January 2015

IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer

scientific article published on 11 April 2019

Induction of long noncoding RNA MALAT1 in hypoxic mice

scientific article published on 08 October 2015

KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation.

scientific article

Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma.

scientific article

Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in Swiss 3T3 cells

scientific article published on December 1999

Normal p53 function in primary cells deficient for Siah genes.

scientific article

Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma

scientific article published on 5 October 2017

Osteopenia in Siah1a mutant mice.

scientific article

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

scientific article

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia.

scientific article

Stress-induced decrease in TRAF2 stability is mediated by Siah2

scientific article

The VHL tumor suppressor: riding tandem with GSK3beta in primary cilium maintenance

scientific article published on 25 May 2007

The complex genetics of epigenetics in urothelial carcinomas

scientific article published on 09 October 2020

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice

scientific journal article

Tumour modelling using viral vectors

scientific article

VHL loss causes spindle misorientation and chromosome instability.

scientific article

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis

scientific article published on 12 August 2016

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans ⬇️

scientific article published on June 8, 2012

pVHL and GSK3beta are components of a primary cilium-maintenance signalling network

scientific article published on 22 April 2007

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation

scientific article published on 22 May 2008

pVHL: a multipurpose adaptor protein

scientific article published on 17 June 2008

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