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List of works by Simon S. McDade

A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence

scientific article

A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis

scientific article published on 03 February 2020

A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers

scientific article published on 23 February 2012

ACE: A Workbench Using Evolutionary Genetic Algorithms for Analyzing Association in TCGA

scientific article published on 13 February 2019

AKT in Stromal Fibroblasts Controls Invasion of Epithelial Cells ⬇️

scientific article published on July 1, 2013

Androgens and estrogens stimulate ribosome biogenesis in prostate and breast cancer cells in receptor dependent manner.

scientific article published on 19 April 2013

BRCA1 deficiency exacerbates estrogen-induced DNA damage and genomic instability

scientific article

Cancer-cell intrinsic gene expression signatures overcome intratumoural heterogeneity bias in colorectal cancer patient classification ⬇️

scientific article published on 31 May 2017

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer.

scientific article published on 5 May 2016

Comparison of Molecular Assays for HPV Testing in Oropharyngeal Squamous Cell Carcinomas: A Population-Based Study in Northern Ireland

scientific article published on 30 October 2019

Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists

scientific article published on 22 October 2018

Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs

scientific article published on 26 January 2012

Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists

scientific article published on 01 April 2022

Functional and genetic analysis of the colon cancer network

scientific article

Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation

scientific article

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

scientific article

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

scientific article published on 13 May 2014

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

scientific article published on 24 June 2015

Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability

scientific article

Immune-Derived PD-L1 Gene Expression Defines a Subgroup of Stage II/III Colorectal Cancer Patients with Favorable Prognosis Who May Be Harmed by Adjuvant Chemotherapy.

scientific article published on 13 May 2016

Investigating Radiotherapy Response in a Novel Syngeneic Model of Prostate Cancer

scientific article published on 29 September 2020

MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 levels by E6

scientific article

Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology.

scientific article published on 10 April 2017

Pevonedistat (MLN4924): mechanism of cell death induction and therapeutic potential in colorectal cancer

scientific article published on 21 July 2020

Profiling of the BRCA1 transcriptome through microarray and ChIP-chip analysis.

scientific article

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

scientific article published on 20 March 2019

Role of DeltaNp63gamma in epithelial to mesenchymal transition

scientific article

SEPT9_v4 expression induces morphological change, increased motility and disturbed polarity

scientific article

Synthetic Lethal Targeting of ARID1A-Mutant Ovarian Clear Cell Tumors with Dasatinib

scientific article

TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells

scientific article published on 23 September 2021

The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer

scientific article published on March 2011

The pseudo-caspase FLIP(L) regulates cell fate following p53 activation

scientific article published on 13 July 2020

The role of p63 in epidermal morphogenesis and neoplasia

scientific article published on 01 February 2010

Transcription factor activities enhance markers of drug sensitivity in cancer.

scientific article published on 11 December 2017

Transcriptional subtyping and CD8 immunohistochemistry identifies poor prognosis stage II/III colorectal cancer patients who benefit from adjuvant chemotherapy

scientific article published on 01 June 2018

Translational control of SEPT9 isoforms is perturbed in disease

scientific article published on April 2007

Tumor suppressor p53: from engaging DNA to target gene regulation

scientific article published on 14 August 2020

VPRBP Functions Downstream of the Androgen Receptor and OGT to Restrict p53 Activation in Prostate Cancer

scientific article published in 2022

Validation of a Metastatic Assay using biopsies to improve risk stratification in patients with prostate cancer treated with radical radiation therapy.

scientific article

p63 drives invasion in keratinocytes expressing HPV16 E6/E7 genes through regulation of Src-FAK signalling.

scientific article

p63 maintains keratinocyte proliferative capacity through regulation of Skp2-p130 levels

scientific article

ΔNp63γ/SRC/Slug signalling axis promotes epithelial-to-mesenchymal transition in squamous cancers.

scientific article

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