List of works - José R Tormo

10-Oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex I

scientific article published on 01 August 1998

A deficiency in respiratory complex I in heart mitochondria from vitamin A-deficient rats is counteracted by an increase in coenzyme Q

scientific article published on 01 April 1997

A method for the selection of production media for actinomycete strains based on their metabolite HPLC profiles.

scientific article published on 9 September 2003

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin

scientific article

A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors.

scientific article published on 15 June 2012

Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

scientific article published in 2021

Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.

scientific article published on 21 November 2012

Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites

scientific article published in March 2009

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

scientific article published on 31 January 2021

Characterization of Actinomycetes Strains Isolated from the Intestinal Tract and Feces of the Larvae of the Longhorn Beetle <i>Cerambyx welensii</i>

scientific article published on 16 December 2020

Chemical and Physical Modulation of Antibiotic Activity in Emericella Species

article

Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I).

scientific article published in November 1997

Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants

scientific article published on 31 January 2022

Current approaches to exploit actinomycetes as a source of novel natural products.

scientific article

Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola

scientific article published on 30 January 2015

Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes

scientific article published on 4 August 2023

Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1.

scientific article published on 19 September 2014

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

scientific article

Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.

scientific article

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

scientific article published on July 2009

Distribution of the antifungal agents sordarins across filamentous fungi

scientific article

Enantiospecific semisynthesis of (+)-almuheptolide-A, a novel natural heptolide inhibitor of the mammalian mitochondrial respiratory chain.

scientific article

Epoxy-acetogenins and other polyketide epoxy derivatives as inhibitors of the mitochondrial respiratory chain complex I

scientific article published on 01 May 2000

Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani

scientific article published on 21 September 2019

Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.

scientific article

Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp.

scientific article published on 17 May 2022

Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors

scientific article published on 18 October 2005

High-content screening of natural products reveals novel nuclear export inhibitors

scientific article published on 17 September 2013

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

scientific article

Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). ⬇️

scientific article published on 8 June 2015

Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives

scientific article published in November 2003

Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica

scientific article published on 13 June 2012

Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins

scientific article published on 01 September 1999

Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris. ⬇️

scientific article published on 4 February 2013

Manipulating filamentous fungus chemical phenotypes by growth on nutritional arrays.

scientific article published in January 2012

Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway.

scientific article published on 21 November 2012

New antitumoral acetogenin 'Guanacone type' derivatives: isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone

scientific article published on 25 April 2007

New evidence for the multiplicity of ubiquinone- and inhibitor-binding sites in the mitochondrial complex I

scientific article published on 01 September 2000

Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening.

scientific article

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

scientific article published on May 2006

Polyalthidin: new prenylated benzopyran inhibitor of the mammalian mitochondrial respiratory chain

scientific article published on 01 October 1996

Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I.

scientific article

Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.

scientific article

Sponge-derived Kocuria and Micrococcus spp. as sources of the new thiazolyl peptide antibiotic kocurin

scientific article published on 28 March 2013

Studies on Morinia: recognition of Morinia longiappendiculata sp. nov. as a new endophytic fungus, and a new circumscription of Morinia pestalozzioides.

scientific article

Synthesis of N-diisopropyl phosphoryl benzyl-tetrahydroisoquinoline, a new class of mitochondrial complexes I and III inhibitors

scientific article published on 01 July 2000

The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides.

scientific article published on 23 September 2005

List of works by José R Tormo

10-Oximeguanacone, the first nitrogenated acetogenin derivative found to be a potent inhibitor of mitochondrial complex I

A deficiency in respiratory complex I in heart mitochondria from vitamin A-deficient rats is counteracted by an increase in coenzyme Q

A method for the selection of production media for actinomycete strains based on their metabolite HPLC profiles.

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin

A yeast-based in vivo bioassay to screen for class I phosphatidylinositol 3-kinase specific inhibitors.

Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

Analysis of cytotoxic activity at short incubation times reveals profound differences among Annonaceus acetogenins, inhibitors of mitochondrial Complex I.

Bacterial diversity from benthic mats of Antarctic lakes as a source of new bioactive metabolites

Bioactivity Screening and Gene-Trait Matching across Marine Sponge-Associated Bacteria

Characterization of Actinomycetes Strains Isolated from the Intestinal Tract and Feces of the Larvae of the Longhorn Beetle <i>Cerambyx welensii</i>

Chemical and Physical Modulation of Antibiotic Activity in Emericella Species

Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I).

Comoclathrin, a novel potent skin-whitening agent produced by endophytic Comoclathris strains associated with Andalusia desert plants

Current approaches to exploit actinomycetes as a source of novel natural products.

Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola

Delftia tsuruhatensis TC1 symbiont suppresses malaria transmission by anopheline mosquitoes

Development of a Drosophila melanogaster spliceosensor system for in vivo high-throughput screening in myotonic dystrophy type 1.

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

Discovery of bacterial fatty acid synthase inhibitors from a Phoma species as antimicrobial agents using a new antisense-based strategy.

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

Distribution of the antifungal agents sordarins across filamentous fungi

Enantiospecific semisynthesis of (+)-almuheptolide-A, a novel natural heptolide inhibitor of the mammalian mitochondrial respiratory chain.

Epoxy-acetogenins and other polyketide epoxy derivatives as inhibitors of the mitochondrial respiratory chain complex I

Extending the Metabolite Diversity of the Endophyte Dimorphosporicola tragani

Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.

Grapevine Xylem Sap Is a Potent Elicitor of Antibiotic Production in Streptomyces spp.

Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors

High-content screening of natural products reveals novel nuclear export inhibitors

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010). ⬇️

Inhibitory effects on mitochondrial complex I of semisynthetic mono-tetrahydrofuran acetogenin derivatives

Isolation and Structural Elucidation of Cyclic Tetrapeptides from Onychocola sclerotica

Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins

Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustris. ⬇️

Manipulating filamentous fungus chemical phenotypes by growth on nutritional arrays.

Mitochondrial complex I inhibitors, acetogenins, induce HepG2 cell death through the induction of the complete apoptotic mitochondrial pathway.

New antitumoral acetogenin 'Guanacone type' derivatives: isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone

New evidence for the multiplicity of ubiquinone- and inhibitor-binding sites in the mitochondrial complex I

Occurrence, distribution, dereplication and efficient discovery of thiazolyl peptides by sensitive-resistant pair screening.

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Polyalthidin: new prenylated benzopyran inhibitor of the mammalian mitochondrial respiratory chain

Semisynthesis of antitumoral acetogenins: SAR of functionalized alkyl-chain bis-tetrahydrofuranic acetogenins, specific inhibitors of mitochondrial complex I.

Specific interactions of monotetrahydrofuranic annonaceous acetogenins as inhibitors of mitochondrial complex I.

Sponge-derived Kocuria and Micrococcus spp. as sources of the new thiazolyl peptide antibiotic kocurin

Studies on Morinia: recognition of Morinia longiappendiculata sp. nov. as a new endophytic fungus, and a new circumscription of Morinia pestalozzioides.

Synthesis of N-diisopropyl phosphoryl benzyl-tetrahydroisoquinoline, a new class of mitochondrial complexes I and III inhibitors

The discovery of moriniafungin, a novel sordarin derivative produced by Morinia pestalozzioides.