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List of works by Anders A Jensen

11-Aminostrychnine and N-(Strychnine-11-yl)propionamide: Synthesis, Configuration, and Pharmacological Evaluation at Glycine Receptors

scientific article published on 06 August 2019

18F-Labelling of electron rich iodonium ylides: application to the radiosynthesis of potential 5-HT2A receptor PET ligands

scientific article published on 5 May 2017

3B but which 3B and that's just one of the questions: the heterogeneity of human 5-HT3 receptors.

scientific article

4,4-Dimethyl- and diastereomeric 4-hydroxy-4-methyl- (2S)-glutamate analogues display distinct pharmacological profiles at ionotropic glutamate receptors and excitatory amino acid transporters

scientific article published in November 2009

5-(Piperidin-4-yl)-3-Hydroxypyrazole: A Novel Scaffold for Probing the Orthosteric γ-Aminobutyric Acid Type A Receptor Binding Site

scientific article published on 26 August 2014

5-HT2A/5-HT2C Receptor Pharmacology and Intrinsic Clearance of N-Benzylphenethylamines Modified at the Primary Site of Metabolism.

scientific article published on September 2016

5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.

scientific article published on 19 January 2018

5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.

scientific article

A Multifaceted GABAA Receptor Modulator: Functional Properties and Mechanism of Action of the Sedative-Hypnotic and Recreational Drug Methaqualone (Quaalude)

scientific article

A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

scientific article

A strategic approach to [6,6]-bicyclic lactones: application towards the CD fragment of DHβE

scientific article

A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists

scientific article

Allosteric modulation of G-protein coupled receptors.

scientific article published on March 2004

Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain.

scientific article published in January 2013

Allosteric modulation of the calcium-sensing receptor

scientific article published on September 2007

Azetidinic amino acids: stereocontrolled synthesis and pharmacological characterization as ligands for glutamate receptors and transporters.

scientific article published on 29 September 2005

Bioavailability Studies and in vitro Profiling of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitor UCPH-102.

scientific article published on 21 January 2016

Carbamoylcholine analogs as nicotinic acetylcholine receptor agonists--structural modifications of 3-(dimethylamino)butyl dimethylcarbamate (DMABC).

scientific article published on 7 November 2008

Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors

scientific article published on October 2003

Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.

scientific article published on August 2004

Characteristics of stably expressed human dopamine D1a and D1b receptors: atypical behavior of the dopamine D1b receptor.

scientific article published on March 1994

Characterization of AN317, a novel selective agonist of α6β2-containing nicotinic acetylcholine receptors

scientific article published on 27 December 2019

Characterization of AN6001, a positive allosteric modulator of α6β2-containing nicotinic acetylcholine receptors

scientific article published on 27 December 2019

Characterization of the effects of four HTR3B polymorphisms on human 5-HT3AB receptor expression and signalling.

scientific article

Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2.

scientific article

Chemoenzymatic Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter Inhibitors.

scientific article published on 15 August 2018

Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3.

scientific article published on December 2005

Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

scientific article

Cloning and characterization of a functional human gamma-aminobutyric acid (GABA) transporter, human GAT-2.

scientific article published on 14 May 2007

Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D

scientific article

Comparison of biophysical properties of α1β2 and α3β2 GABAA receptors in whole-cell patch-clamp electrophysiological recordings

scientific article published on 01 June 2020

Conformational transitions of the serotonin 5-HT3 receptor

scientific article published in Nature

Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations

scientific article published in September 2015

Copper and protons directly activate the zinc-activated channel

scientific article published on 09 February 2016

DARK Classics in Chemical Neuroscience: NBOMes

scientific article published on 12 November 2019

Delineation of the functional properties and the mechanism of action of AA29504, an allosteric agonist and positive allosteric modulator of GABAA receptors.

scientific article published on 15 February 2018

Delineation of the functional properties and the mechanism of action of TMPPAA, an allosteric agonist and positive allosteric modulator of 5-HT3 receptors

scientific article published on 13 April 2016

Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters

scientific article published on 24 May 2019

Design, Synthesis, and Pharmacological Characterization of Heterobivalent Ligands for the Putative 5-HT2A/mGlu2 Receptor Complex

scientific article published on 20 August 2020

Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102 ⬇️

scientific article published on October 2, 2012

Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists.

scientific article

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties

scientific article

Detailed Characterization of the In Vitro Pharmacological and Pharmacokinetic Properties of N-(2-Hydroxybenzyl)-2,5-Dimethoxy-4-Cyanophenylethylamine (25CN-NBOH), a Highly Selective and Brain-Penetrant 5-HT2A Receptor Agonist

scientific article published on 30 March 2017

Developing New 4-PIOL and 4-PHP Analogues for Photoinactivation of γ-Aminobutyric Acid Type A Receptors

scientific article published on 21 October 2019

Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site

scientific article published on 15 May 2012

Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile.

scientific article

Discovery of benzamide analogues as a novel class of 5-HT₃ receptor agonists.

scientific article

Discovery of the first selective inhibitor of excitatory amino acid transporter subtype 1

scientific article

Discovery of α-Substituted Imidazole-4-acetic Acid Analogues as a Novel Class of ρ1 γ-Aminobutyric Acid Type A Receptor Antagonists with Effect on Retinal Vascular Tone

scientific article published on 13 September 2016

Dual Nicotinic Acetylcholine Receptors α4β2 Antagonists/α7 Agonists: Synthesis, Docking Studies and Pharmacological Evaluation of Tetrahydroisoquinolines and Tetrahydroisoquinolinium Salts.

scientific article published on 31 January 2018

Excitatory amino acid transporters as potential drug targets.

scientific article published on June 2009

Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities.

scientific article

Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane

scientific article published on 17 July 2015

Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters

scientific article published on 05 June 2019

From Methaqualone and Beyond: Structure-Activity Relationship of 6-, 7-, and 8-Substituted 2,3-Diphenyl-quinazolin-4(3H)-ones and in Silico Prediction of Putative Binding Modes of Quinazolin-4(3H)-ones as Positive Allosteric Modulators of GABAA Rece

scientific article published on 10 November 2020

Functional characterisation of homomeric ionotropic glutamate receptors GluR1-GluR6 in a fluorescence-based high throughput screening assay

scientific article published in February 2006

Functional characterisation of human glycine receptors in a fluorescence-based high throughput screening assay

scientific article published on 21 September 2005

Functional characterisation of the human alpha1 glycine receptor in a fluorescence-based membrane potential assay

scientific article published on May 2004

Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay

scientific article published on 21 February 2020

Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings

scientific article published on 13 October 2017

Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.

scientific article published on 2 August 2007

Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes

scientific article published on 23 March 2015

Functional characterization of α7 nicotinic acetylcholine and NMDA receptor signaling in SH-SY5Y neuroblastoma cells in an ERK phosphorylation assay

scientific article

Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor

scientific article published on September 2000

Functional importance of the carboxyl tail cysteine residues in the human D1 dopamine receptor

scientific article

Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors.

scientific article published on 15 November 2017

GABAB receptor phosphorylation regulates KCTD12-induced K⁺ current desensitization

scientific article

Ginkgolide X is a potent antagonist of anionic Cys-loop receptors with a unique selectivity profile at glycine receptors.

scientific article

Ginkgolides and glycine receptors: a structure-activity relationship study

scientific article published in March 2004

Identification and Structure-Activity Relationship Study of Imidazo[1,2-a]pyridine-3-amines as First Selective Inhibitors of Excitatory Amino Acid Transporter Subtype 3 (EAAT3)

scientific article published on 01 October 2019

Identification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity Relationship Study

scientific article

Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3.

scientific article

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor

scientific article

Investigation of the 2,5-dimethoxy motif in phenethylamine Serotonin 2A receptor agonists

scientific article published on 26 March 2020

Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism

scientific article

Modulation of thalamo-cortical activity by the NMDA receptor antagonists ketamine and phencyclidine in the awake freely-moving rat

scientific article published on 21 August 2019

Naturally occurring variations in the human 5-HT3A gene profoundly impact 5-HT3 receptor function and expression

scientific article published on 01 April 2007

Neuroprotective effects of the novel glutamate transporter inhibitor (-)-3-hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]-isoxazole-4-carboxylic acid, which preferentially inhibits reverse transport (glutamate release) compared with glutamate reupta

scientific article

New Insight into the Structure-Activity Relationships of the Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors UCPH-101 and UCPH-102

scientific article published on 12 January 2016

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

scientific article

Novel 4-(piperidin-4-yl)-1-hydroxypyrazoles as gamma-aminobutyric acid(A) receptor ligands: synthesis, pharmacology, and structure-activity relationships.

scientific article published on April 2010

Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.

scientific article

Novel aza-analogous ergoline derived scaffolds as potent serotonin 5-HT₆ and dopamine D₂ receptor ligands

scientific article published on 18 June 2014

Oxime Ethers of (E)-11-Isonitrosostrychnine as Highly Potent Glycine Receptor Antagonists.

scientific article

Pharmacological characterisation of strychnine and brucine analogues at glycine and alpha7 nicotinic acetylcholine receptors.

scientific article published on 9 May 2006

Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.

scientific article published on 28 August 2007

Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor

scientific article published on April 2001

Probing for improved potency and in vivo bioavailability of excitatory amino acid transporter subtype 1 inhibitors UCPH-101 and UCPH-102: design, synthesis and pharmacological evaluation of substituted 7-biphenyl analogs

scientific article

Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET).

scientific article published on October 2002

Probing the molecular basis for affinity/potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors

scientific article published on 17 August 2018

Probing the pharmacophore of ginkgolides as glycine receptor antagonists

scientific article published on 13 March 2007

Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue

scientific article

Probing α4βδ GABAA receptor heterogeneity: differential regional effects of a functionally selective α4β1δ/α4β3δ receptor agonist on tonic and phasic inhibition in rat brain.

scientific article published in December 2014

Profiling of GABA and GABA receptor expression in the myometrium of the human uterus

scientific article published on 19 October 2018

Rational design and enantioselective synthesis of (1R,4S,5R,6S)-3-azabicyclo[3.3.0]octane-4,6-dicarboxylic acid - a novel inhibitor at human glutamate transporter subtypes 1, 2, and 3.

scientific article published on January 2006

Rational design of alpha-conotoxin analogues targeting alpha7 nicotinic acetylcholine receptors: improved antagonistic activity by incorporation of proline derivatives

scientific article

Selective potentiation of (α4)3(β2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats

scientific article published on 16 September 2013

Semisynthetic analogues of toxiferine I and their pharmacological properties at α7 nAChRs, muscle-type nAChRs, and the allosteric binding site of muscarinic M2 receptors

scientific article

Site-specific incorporation of unnatural amino acids into proteins.

scientific article published in July 2004

Stereoselective chemoenzymatic synthesis of the four stereoisomers of l-2-(2-carboxycyclobutyl)glycine and pharmacological characterization at human excitatory amino acid transporter subtypes 1, 2, and 3.

scientific article published in November 2006

Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors

scientific article

Structure-activity relationship study of first selective inhibitor of excitatory amino acid transporter subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101).

scientific article published on October 2010

Structure-activity relationship study of selective excitatory amino acid transporter subtype 1 (EAAT1) inhibitor 2-amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101) and absolute configuratio

scientific article published on 17 May 2012

Structure-activity relationships of strychnine analogs at glycine receptors

scientific article

Structure-activity-relationship study of N-acyl-N-phenylpiperazines as potential inhibitors of the Excitatory Amino Acid Transporters (EAATs): improving the potency of a micromolar screening Hit is not truism

scientific article published on 14 March 2013

Synthesis and Biological Evaluation of 4-(Aminomethyl)-1-hydroxypyrazole Analogues of Muscimol as γ-Aminobutyric AcidA Receptor Agonists

scientific article published on 23 January 2013

Synthesis and Pharmacological Evaluation of DHβE Analogues as Neuronal Nicotinic Acetylcholine Receptor Antagonists.

scientific article published on 20 May 2014

Synthesis and biological activity of novel alpha-conotoxin analogues incorporating substituted proline derivatives.

scientific article published in January 2009

Synthesis and evaluation of (18)F-labeled 5-HT2A receptor agonists as PET ligands

scientific article published on 19 April 2016

Synthesis and nicotinic receptor activity of a hydroxylated tropane

scientific article published in January 2004

Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABAA receptor agonists

scientific article published in September 2014

Synthesis of (3-hydroxy-pyrazolin-5-yl)glycine based ligands interacting with ionotropic glutamate receptors

scientific article published on 25 January 2014

Synthesis, pharmacology, and biostructural characterization of novel α4β2 nicotinic acetylcholine receptor agonists

scientific article

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Targeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach

scientific article

Temporally dissociable effects of ketamine on neuronal discharge and gamma oscillations in rat thalamo-cortical networks

scientific article published on 24 April 2018

The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain

scientific article published on June 1999

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

scientific article published in June 2002

The dance of the clams: twists and turns in the family C GPCR homodimer

scientific article published on 01 November 2002

The dopamine D1 receptor family: structural and functional aspects

scientific article published on February 1996

The four human gamma-aminobutyric acid (GABA) transporters: pharmacological characterization and validation of a highly efficient screening assay

scientific article

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization

scientific article

The metabolic impact of β-hydroxybutyrate on neurotransmission: Reduced glycolysis mediates changes in calcium responses and KATP channel receptor sensitivity.

scientific article

The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.

scientific article

The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity

scientific article

The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

scientific article published on 13 April 2020

Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues

scientific article

Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors.

scientific article published on 4 March 2015

Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors ⬇️

scientific article published on April 1, 2013

Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands

scientific article published on 18 April 2019

α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors

scientific article published on 28 June 2019

β-Sulfonamido Functionalized Aspartate Analogues as Excitatory Amino Acid Transporter Inhibitors: Distinct Subtype Selectivity Profiles Arising from Subtle Structural Differences.

scientific article published on 16 September 2016

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