List of works - Andrew R. Tee

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

scientific article published on 18 August 2013

Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

scientific article

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

scientific article

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

scientific article

Bidirectional regulation of nuclear factor-κB and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes

scientific article published on 8 February 2013

Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin

scientific article

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

scientific article

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

scientific article published on 19 January 2005

Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.

scientific article

Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock.

scientific article published on 9 July 2010

Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy

scientific article published on 30 November 2020

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.

scientific article

Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment

scientific article published on 10 October 2018

Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours

scientific article

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

scientific article

Fundamental for life: mTOR orchestrates developing biological systems.

scientific article published on 24 October 2014

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

scientific article published on 14 May 2007

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

scientific journal article

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

scientific article published on 16 July 2003

Leucine and mTORC1: a complex relationship

scientific article

Localisation and regulation of the eIF4E-binding protein 4E-BP3.

scientific article

Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.

scientific article published on 08 January 2009

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting.

scientific article published on 30 May 2018

Metastatic castration-resistant prostate cancer hungers for leucine

scientific article published on 19 September 2013

Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.

scientific article published on 06 February 2016

Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression

scientific article published on 3 January 2018

Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy.

scientific article published on 23 April 2014

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

scientific article published on 13 March 2020

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

scientific article published on June 2003

STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.

scientific article

STAT3 and mTOR: co-operating to drive HIF and angiogenesis

scientific article published on 23 November 2015

Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.

scientific article published on August 2001

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

scientific article

Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes.

scientific article published on 21 July 2009

The Target of Rapamycin and Mechanisms of Cell Growth

scientific article published on 16 March 2018

The benefits of exploiting rare genetic disorders to better understand human health and disease

scientific article published in April 2016

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

scientific article published on 17 January 2002

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

scientific article published on August 2013

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex.

scientific article published on 2 February 2016

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

scientific article (publication date: 13 May 2005)

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

scientific article

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

scientific journal article

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

scientific article published on July 2011

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

scientific article

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

scientific article

mTOR, translational control and human disease.

scientific article

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

scientific article

List of works by Andrew R. Tee

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.

Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility

Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

Bidirectional regulation of nuclear factor-κB and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes

Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation

Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1.

Control of HIF-1{alpha} and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock.

Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy

Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine.

Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment

Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

Fundamental for life: mTOR orchestrates developing biological systems.

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

Leucine and mTORC1: a complex relationship

Localisation and regulation of the eIF4E-binding protein 4E-BP3.

Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting.

Metastatic castration-resistant prostate cancer hungers for leucine

Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer.

Oncogenic Signalling through Mechanistic Target of Rapamycin (mTOR): A Driver of Metabolic Transformation and Cancer Progression

Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy.

Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis

Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

STAT3 and HIF1α Signaling Drives Oncogenic Cellular Phenotypes in Malignant Peripheral Nerve Sheath Tumors.

STAT3 and mTOR: co-operating to drive HIF and angiogenesis

Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes.

The Target of Rapamycin and Mechanisms of Cell Growth

The benefits of exploiting rare genetic disorders to better understand human health and disease

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

The kinase triad, AMPK, mTORC1 and ULK1, maintains energy and nutrient homoeostasis

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex.

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity.

mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E

mTOR, translational control and human disease.

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3