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List of works by Christopher J. Moody

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity

scientific article

5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo

scientific article published on 01 July 2006

7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine

scientific article published on 07 February 2011

A Concise Route to Pyridines from Hydrazides by Metal Carbene N−H Insertion, 1,2,4-Triazine Formation, and Diels−Alder Reaction

scientific article (publication date: 20 August 2009)

A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity

scientific article

A new protecting-group strategy for indoles

A new route to α-carbolines based on 6π-electrocyclization of indole-3-alkenyl oximes

scientific article

A short synthesis of the triazolopyrimidine antibiotic essramycin

scientific article published on 13 September 2010

A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis ⬇️

scientific article published on November 22, 2010

Alkyl Halide-Free Heteroatom Alkylation and Epoxidation Facilitated by a Recyclable Polymer-Supported Oxidant for the In-Flow Preparation of Diazo Compounds

scientific article published on 11 February 2015

Amination of heteroaryl chlorides: palladium catalysis or SN Ar in green solvents?

scientific article

Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.

scientific article published on 10 April 2013

An Exploration of Ferrocenyl Ureas as Enantioselective Electrochemical Sensors for Chiral Carboxylate Anions

scientific article published on 19 January 2008

An Improved Synthesis of Resorcylic Acid Macrolactone Inhibitors of Hsp90

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration

scientific article published on October 2013

Antitumor indolequinones induced apoptosis in human pancreatic cancer cells via inhibition of thioredoxin reductase and activation of redox signaling

scientific article published on 6 December 2011

Antitumour indolequinones: synthesis and activity against human pancreatic cancer cells

scientific article published in July 2014

Asymmetric Synthesis of 2-Substituted Piperidines. Synthesis of the Alkaloids (−)-Coniine and (+)-Pseudoconhydrine

scientific article published on 01 February 1997

Asymmetric Synthesis of Chiral α-Ferrocenylalkylamines and Their Use in the Preparation of Chiral Redox-Active Receptors

scientific article published on 01 November 2002

Asymmetric synthesis of N-protected amino acids by the addition of organolithium carboxyl synthons to ROPHy/SOPHy-derived aldoximes and ketoximes

scientific article

Asymmetric synthesis of the central tryptophan residue of stephanotic acid

scientific article published on 3 November 2004

Benzimidazole- and benzothiazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.

scientific article published on 8 October 2007

Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1

scientific article published on 6 April 2013

Benzofuranquinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis and biological evaluation

scientific article published in May 2014

Biochemical, cytotoxic, and genotoxic effects of ES936, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, in cellular systems

scientific article published in September 2003

Biomimetic Synthesis of the Apoptosis-Inducing Thiazinoquinone Thiaplidiaquinone A

scientific article published on 08 October 2012

Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide

scientific article published on 09 May 2006

C-H Insertion as a Key Step to Spiro-Oxetanes, Scaffolds for Drug Discovery

scientific article

Carbene reactivity of 4-diazo-4H-imidazoles toward nucleophiles and aromatic compounds

scientific article published in December 2009

Characterization of a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches

scientific article

Chiral oxime ethers in asymmetric synthesis. O-(1-Phenylbutyl)benzyloxyacetaldoxime, a versatile reagent for the asymmetric synthesis of protected 1,2-aminoalcohols, alpha-amino acid derivatives, and 2-hydroxymethyl nitrogen heterocycles including i

scientific article published on 28 February 2005

Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents

scientific article

Competition between planar and central chiral control elements in nucleophilic addition to ferrocenyl imine derivatives

scientific article

Construction of macrocyclic thiodepsipeptides: synthesis of a nosiheptide 'southern hemisphere' model system

scientific article published on 23 November 2007

Control of competing N-H insertion and Wolff rearrangement in dirhodium(II)-catalyzed reactions of 3-indolyl diazoketoesters. synthesis of a potential precursor to the marine 5-(3-indolyl)oxazole martefragin A.

scientific article published in July 2005

Copper(II)‐Mediated Synthesis of Indolequinones from Bromoquinones and Enamines ⬇️

scientific article published on February 20, 2013

Cyclopropamitosenes, Novel Bioreductive Anticancer Agents. Synthesis, Electrochemistry, and Biological Activity of 7-Substituted Cyclopropamitosenes and Related Indolequinones

scientific article published on 01 October 1994

Delivery of Temozolomide and N3-Propargyl Analog to Brain Tumors Using an Apoferritin Nanocage

scientific article published on 04 March 2020

Development of indolequinone mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1): NQO1 inhibition and growth inhibitory activity in human pancreatic MIA PaCa-2 cancer cells

scientific article published on 25 April 2007

Diastereoselective Synthesis of Highly Substituted, Amino- and Pyrrolidino-Tetrahydrofurans as Lead-like Molecular Scaffolds

scientific article published on 14 April 2018

Dirhodium(II) carboxylate-catalysed oxidation of allylic and benzylic alcohols

Dirhodium(II) tetraacetate catalysed reactions of diazo thioamides: isolation and cycloaddition of anhydro-4-hydroxy-1,3-thiazolium hydroxides (thioisomünchnones), an approach to analogues of dehydrogliotoxin

scientific article published in August 2003

Diverse Trifluoromethyl Heterocycles from a Single Precursor

scientific article published on 20 January 2012

Enantioselective insertion of metal carbenes into N-H bonds: a potentially versatile route to chiral amine derivatives

scientific article published in January 2007

Experimental Organic Chemistry: Principles and Practice ⬇️

Book

First Synthesis of the Naturally Occurring Diazocarbonyl Compound Cremeomycin

article published in 2008

First syntheses of 2,2-dimethyl-7-(2'-methylbut-3'-en-2'-yl)-2H-chromen-6-ol and 2-(3'-methylbut-2'-enyl)-5-(2'-methylbut-3'-en-2'-yl)-1,4-benzoquinone, novel prenylated quinone derivatives from the New Zealand brown alga Perithalia capillaris

scientific article

First synthesis of N-(3-carboxylpropyl)-5-amino-2-hydroxy-3- tridecyl-1,4-benzoquinone, an unusual quinone isolated from Embelia ribes.

scientific article published on 14 November 2007

Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement

scientific article published on 27 June 2016

From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides

scientific article published on January 2007

Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines

scientific article published on April 2016

Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.

scientific article published on January 2004

Heat shock protein 90 controls HIV-1 reactivation from latency

scientific article published on 31 March 2014

Indolequinone Antitumor Agents: Correlation between Quinone Structure, Rate of Metabolism by Recombinant Human NAD(P)H:Quinone Oxidoreductase, and in Vitro Cytotoxicity1

scientific article published on 01 November 1998

Indolequinone Antitumor Agents: Reductive Activation and Elimination from (5-Methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl Derivatives and Hypoxia-Selective Cytotoxicity in Vitro

scientific article published on 01 July 1998

Indolequinone antitumor agents: Relationship between quinone structure and rate of metabolism by recombinant human NQO1

scientific article published on 01 March 1998

Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2.

scientific article published in September 2001

Indolequinone antitumour agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase.

scientific article

Indolequinone inhibitors of NRH:quinone oxidoreductase 2. Characterization of the mechanism of inhibition in both cell-free and cellular systems

scientific article published on 19 July 2011

Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies

scientific article

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol

scientific article published on November 2006

Keap calm, and carry on covalently

scientific article published on 25 July 2013

Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.

scientific article

Ligand effects in the metal catalysed reactions of N-aryldiazoamides: Ylide formation vs. insertion reactions

Mechanism-Based Inhibition of Quinone Reductase 2 (NQO2): Selectivity for NQO2 over NQO1 and Structural Basis for Flavoprotein Inhibition

scientific article

Microwave-mediated Claisen rearrangement followed by phenol oxidation: a simple route to naturally occurring 1,4-benzoquinones. The first syntheses of verapliquinones A and B and panicein A.

scientific article published in May 2005

Modifying rates of reductive elimination of leaving groups from indolequinone prodrugs: a key factor in controlling hypoxia-selective drug release

scientific article

Natural and synthetic quinones and their reduction by the quinone reductase enzyme NQO1: from synthetic organic chemistry to compounds with anticancer potential

scientific article published on 13 December 2007

Natural products containing a diazo group

scientific article published on 18 May 2011

Novel quinolinequinone antitumor agents: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

scientific article published on 01 August 1999

Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1).

scientific article published on April 2004

Nucleophilic fluorination of β-ketoester derivatives with HBF4

scientific article published on 12 November 2012

N–H Insertion reactions of rhodium carbenoids. Part 5: A convenient route to 1,3-azoles

Origin of the Thiopyrone CTP-431 “Unexpectedly” Isolated from the Marine Sponge Cacospongia mycofijiensis

scientific article published on 02 August 2018

Oxidative Rearrangement of Indoles: A New Approach to the EFHG-Tetracyclic Core of Diazonamide A

scientific article published on 17 March 2007

Oxidative Routes to the Heterocyclic Cores of Benzothiazole Natural Products

Oxidative activation of antioxidant defence

scientific article

Potassium N-iodo p-toluenesulfonamide (TsNIK, Iodamine-T): a new reagent for the oxidation of hydrazones to diazo compounds

scientific article published on 11 March 2014

Potent activity of indolequinones against human pancreatic cancer: identification of thioredoxin reductase as a potential target

scientific article published on 13 April 2009

Preparation of tetrahydrobenz[cd]indoles from 1-tetralones

article

Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.

scientific article published in November 2003

Quinones as dienophiles in the Diels-Alder reaction: history and applications in total synthesis

scientific article published on 20 January 2014

Rapid access to α-alkoxy and α-amino acid derivatives through safe continuous-flow generation of diazoesters

scientific article published on 27 July 2011

Regioselectivity of the Claisen rearrangement in meta-allyloxy aryl ketones: an experimental and computational study, and application in the synthesis of (R)-(-)-pestalotheol D.

scientific article published on 10 January 2011

Relationship between NAD(P)H:quinone oxidoreductase 1 (NQO1) levels in a series of stably transfected cell lines and susceptibility to antitumor quinones

scientific article

Rhodium carbene routes to oxazoles and thiazoles. Catalyst effects in the synthesis of oxazole and thiazole carboxylates, phosphonates, and sulfones

scientific article published in January 2010

Rhodium carbenoid mediated cyclisations. Part 6. Synthesis of cyclic sulphoxonium ylides

scholarly article by Christopher J. Moody & Roger J. Taylor published January 1990 in Tetrahedron

Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry

scientific article published on 13 January 2015

Solar photochemical oxidation of alcohols using catalytic hydroquinone and copper nanoparticles under oxygen: oxidative cleavage of lignin models

scientific article

Solar photochemical oxidations of benzylic and allylic alcohols using catalytic organo-oxidation with DDQ: application to lignin models

scientific article published on 24 September 2014

Solution structures of thiopeptide antibiotics

scientific article published on 24 August 2006

Stereoselective Synthesis of Functionalized Pyrrolidines by the Diverted N-H Insertion Reaction of Metallocarbenes with β-Aminoketone Derivatives

scientific article published on 5 February 2016

Stereoselective Synthesis of Highly Substituted Tetrahydrofurans through Diverted Carbene O-H Insertion Reaction

scientific article published on 9 June 2015

Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity

scientific article

Synthesis and evaluation of 3-aryloxymethyl-1,2-dimethylindole-4,7-diones as mechanism-based inhibitors of NAD(P)H:quinone oxidoreductase 1 (NQO1) activity

scientific article published on 18 October 2007

Synthesis and evaluation of prodrugs for anti-angiogenic pyrrolylmethylidenyl oxindoles

scientific article published on 08 January 2007

Synthesis and growth-inhibitory activities of imidazo[5,1-]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

article

Synthesis and solid state structures of N,N′-linked carbazoles and indoles

Synthesis of (+/-)-likonide B (smenochromene D) using a regioselective Claisen rearrangement, separation of the enantiomers and stereochemical assignment.

scientific article published on 27 March 2009

Synthesis of (±)-Smenochromene D (Likonide B) Using a Regioselective Claisen Rearrangement

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90

scientific article

Synthesis of 3-(carboxyarylalkyl)imidazo[2,1-f][1,2,4]triazines as potential inhibitors of AMP deaminase.

scientific article

Synthesis of Indolequinones from Bromoquinones and Enamines Mediated by Cu(OAc)2·H2O

scientific article published on 01 September 2010

Synthesis of Ptaeroxylin (Desoxykarenin): An Unusual Chromone from the Sneezewood TreePtaeroxylon obliquum

Synthesis of Spirotetramates via a Diels−Alder Approach

scientific article published on 06 April 2011

Synthesis of amino-1,4-benzoquinones and their use in Diels-Alder approaches to the aminonaphthoquinone antibiotics

scientific article

Synthesis of an achiral isomer of lipoic acid as an anchor group for SAM formation on gold surfaces

scientific article published in April 2010

Synthesis of balsaminone A, a naturally occurring pentacyclic dinaphthofuran quinone

scientific article

Synthesis of cyclic ethers by rhodium carbenoid cyclisation

scholarly article by Julie C Heslin et al published January 1986 in Tetrahedron Letters

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery.

scientific article published on 31 March 2018

Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90

scientific article

Synthesis of parvistemin A via biomimetic oxidative dimerization

scientific article published on 6 June 2011

Synthesis of the 2,3,4-trisubstituted indole fragments of nosiheptide and glycothiohexide

scientific article published on 29 January 2004

Synthesis of the Reported Structure of Crassiflorone, a Pentacyclic Naphthoquinone Isolated from the African Ebony Diospyros crassiflora

Synthesis of the Reported Structure of the Bisbenzoquinone Lanciaquinone, Isolated from Maesa lanceolata

scientific article published on 12 September 2008

Synthesis of the combined centre- and right-hand section of the antitumour agent CC-1065

Synthesis of the oxepinochromone natural products ptaeroxylin (desoxykarenin), ptaeroxylinol, and eranthin

scientific article published in January 2010

Synthesis of the reported structure of crassiflorone, a naturally occurring quinone isolated from the African ebony Diospyros crassiflora, and regioisomeric pentacyclic furocoumarin naphthoquinones

scientific article published on 16 March 2011

Synthesis of the ‘Northern-Hemisphere’ Fragments of the Thiopeptide Antibiotic Nosiheptide

Synthesis of β-keto esters in-flow and rapid access to substituted pyrimidines

scientific article published on 17 November 2010

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin

scientific article published on 04 January 2007

Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.

scientific article published in March 2010

Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies

scientific article

Telomestatin: formal total synthesis and cation-mediated interaction of its seco-derivatives with G-quadruplexes.

scientific article published on 16 December 2010

The design of a new group of angiotensin-converting enzyme inhibitors

scientific article published on 01 October 1982

The diazo route to diazonamide A. Studies on the indole bis-oxazole fragment

scientific article published in September 2005

The diazo route to diazonamide A: studies on the tyrosine-derived fragment

scientific article

The effect of central and planar chirality on the electrochemical and chiral sensing properties of ferrocenyl urea H-bonding receptors

scientific article published on 01 April 2015

The remarkable effect of the 7-substituent in the diastereoselective oxidative rearrangement of indoles: Asymmetric synthesis of 3,3-disubstituted oxindoles

scientific article published on 26 October 2006

The rhodium carbene route to oxazoles: a remarkable catalyst effect

scientific article

The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product

scientific article published on 11 January 2008

The total synthesis of siphonazole, a structurally unusual bis-oxazole natural product

scientific article published on 2 February 2007

Total Synthesis of (±)-Distomadines A and B

scientific article published on 08 February 2014

Total Synthesis of Stephanotic Acid Methyl Ester

scientific article published on 01 May 2006

Total Synthesis of the Cyclic Dodecapeptides Wewakazole and Wewakazole B.

scientific article published on 15 June 2017

Total Synthesis of the Post-translationally Modified Polyazole Peptide Antibiotic Goadsporin

scientific article

Total Synthesis of the Posttranslationally Modified Polyazole Peptide Antibiotic Plantazolicin A.

scientific article

Total synthesis of mevashuntin

scientific article published on 27 February 2012

Total synthesis of siphonazole and its O-methyl derivative, structurally unusual bis-oxazole natural products

scientific article

Total synthesis of the thiopeptide antibiotic amythiamicin D.

scientific article published in November 2005

Toward the Total Synthesis of Hygrocin B and Divergolide C: Construction of the Naphthoquinone–Azepinone Core

scientific article published on 25 March 2014

Two approaches to the aromatic core of the aminonaphthoquinone antibiotics

scientific article published on 23 May 2013

Two-step route to indoles and analogues from haloarenes: a variation on the Fischer indole synthesis

scientific article published on 14 October 2011

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