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List of works by Stuart J. Conway

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

scientific article

A Single-Stranded DNA-Encoded Chemical Library Based on a Stereoisomeric Scaffold Enables Ligand Discovery by Modular Assembly of Building Blocks

scientific article published on 14 October 2020

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

scientific article published on 12 May 2014

Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System. ⬇️

scientific article published on 28 June 2017

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

scientific article published on 15 May 2018

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

scientific article

Bifunctional Molecules beyond PROTACs

scientific article published on 11 March 2020

Biology-enabling inositol phosphates, phosphatidylinositol phosphates and derivatives

scientific article (publication date: August 2007)

Bromodomains: are readers right for epigenetic therapy?

scientific article

Bürgenstock 2012: Reflections on stereochemistry

scientific article published on 01 February 2013

CH-01 is a hypoxia-activated prodrug that sensitizes cells to hypoxia/reoxygenation through inhibition of Chk1 and Aurora A.

scientific article published on 10 May 2013

CYP450 Enzymes Effect Oxygen-Dependent Reduction of Azide-Based Fluorogenic Dyes

scientific article (publication date: 25 January 2017)

Caged AG10: new tools for spatially predefined mitochondrial uncoupling

scientific article

Chemical Epigenetics: The Impact of Chemical and Chemical Biology Techniques on Bromodomain Target Validation

scientific article published on 14 November 2019

Co-incident signalling between mu-opioid and M3 muscarinic receptors at the level of Ca2+ release from intracellular stores: lack of evidence for Ins(1,4,5)P3 receptor sensitization

scientific article published on November 2003

Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions.

scientific article published on 12 January 2016

Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils

scientific article published on 30 June 2006

Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs.

scientific article published on 24 March 2016

Development of inositol-based antagonists for thed-myo-inositol 1,4,5-trisphosphate receptor

scientific article published in 2011

Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

scientific article (publication date: 2 July 2014)

Engineering transkingdom signalling in plants to control gene expression in rhizosphere bacteria

scientific article published on 31 July 2019

Epigenetics 2.0: Special Issue on Epigenetics-Call for Papers

scientific article published on 22 October 2020

Epigenetics: Novel Therapeutics Targeting Epigenetics

scientific article published on 29 January 2016

Epigenetics: novel therapeutics targeting epigenetics

scientific article published on 22 December 2014

Facile one-pot synthesis of 5-substituted hydantoins

scientific article published on 14 February 2008

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi

scientific article published on 17 November 2020

Hypoxia-Activated, Small-Molecule-Induced Gene Expression

scientific article published on 07 December 2018

In vitro photo-release of a TRPV1 agonist

scientific article

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

scientific article published on 01 August 2006

Isoxazole-Derived Amino Acids are Bromodomain-Binding Acetyl-Lysine Mimics: Incorporation into Histone H4 Peptides and Histone H3.

scientific article published on 6 June 2016

KefF, the regulatory subunit of the potassium efflux system KefC, shows quinone oxidoreductase activity.

scientific article published on 08 July 2011

Mechanism of ligand-gated potassium efflux in bacterial pathogens

scientific article published on 16 November 2010

Mitochondrial β-amyloid in Alzheimer's disease.

scientific article published in August 2011

NAADP activates two-pore channels on T cell cytolytic granules to stimulate exocytosis and killing

scientific article published on 21 November 2012

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

scientific article

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

scientific article published on February 2014

Phenylglycine derivatives as antagonists of group III metabotropic glutamate receptors expressed on neonatal rat primary afferent terminals.

scientific article

Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).

scientific article published on February 2004

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

scientific article published on 27 September 2012

Purinergic receptor-stimulated IP3-mediated Ca2+ release enhances neuroprotection by increasing astrocyte mitochondrial metabolism during aging.

scientific article published in June 2007

Pyocyanin degradation by a tautomerizing demethylase inhibits Pseudomonas aeruginosa biofilms

scientific article published on 8 December 2016

Quantitative hopanoid analysis enables robust pattern detection and comparison between laboratories

scientific article published in July 2015

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

scientific article

Selective fragments for the CREBBP bromodomain identified from an Encoded Self-Assembly Chemical Library

scientific article published on 19 July 2020

Small molecule inhibitors of bromodomain-acetyl-lysine interactions

scientific article published on January 2015

Small molecules as tools to study the chemical epigenetics of lysine acetylation

scientific article published on 27 June 2018

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

scientific article

Synthesis and biological evaluation of a novel cardiolipin affinity matrix

scientific article published on 14 July 2009

Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes

scientific article

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors

scientific article

Synthesis, photolysis studies and in vitro photorelease of caged TRPV1 agonists and antagonists

scientific article

TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.

scientific article published on 20 June 2008

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1

scientific article published on 14 June 2007

The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET bromodomains

scientific article published on January 2013

The photochemical thiol-ene reaction as a versatile method for the synthesis of glutathione S-conjugates targeting the bacterial potassium efflux system Kef.

scientific article

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

scientific article published on 09 August 2007

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction

scientific article published on 23 November 2004

Understanding the structural requirements for activators of the Kef bacterial potassium efflux system.

scientific article

Wavelength-orthogonal photolysis of neurotransmitters in vitro

scientific article published on 7 October 2011

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