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List of works by H Llewelyn Roderick

2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels

scientific article published in July 2003

Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate.

scientific article

Activin A Modulates CRIPTO-1/HNF4α+ Cells to Guide Cardiac Differentiation from Human Embryonic Stem Cells.

scientific article

Altered adrenergic response in myocytes bordering a chronic myocardial infarction underlies in vivo triggered activity and repolarization instability

scientific article published on 03 January 2020

Alzheimer's disease-associated peptide Aβ42 mobilizes ER Ca(2+) via InsP3R-dependent and -independent mechanisms.

scientific article

An update on nuclear calcium signalling.

scientific article published on July 2009

Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release

scientific article published on 02 October 2019

Atrial cardiomyocyte calcium signalling.

scientific article published on 03 February 2011

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

scientific article

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

scientific article

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

scientific article published on 14 April 2008

Bi-directional signalling from the InsP3 receptor: regulation by calcium and accessory factors ⬇️

scientific article published on October 1, 2003

CREB-dependent Nur77 induction following depolarization in PC12 cells and neurons is modulated by MEF2 transcription factors.

scientific article published on 3 December 2009

Calcium Signaling in Cardiomyocyte Function

scientific article published on 02 March 2020

Calcium in the heart: when it's good, it's very very good, but when it's bad, it's horrid.

scientific article published on November 2007

Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization

scientific article published on 31 July 2008

Calcium signaling in cardiac myocytes.

scientific article

Calcium signalling: dynamics, homeostasis and remodelling

scientific article (publication date: July 2003)

Calcium signalling: more messengers, more channels, more complexity

scientific article published in August 2002

Calcium/calmodulin-dependent kinase II and nitric oxide synthase 1-dependent modulation of ryanodine receptors during β-adrenergic stimulation is restricted to the dyadic cleft

scientific article published on 28 April 2016

Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells

scientific article published on August 2004

Cell signalling: IP3 receptors channel calcium into cell death.

scientific article

Comparison of the T-tubule system in adult rat ventricular and atrial myocytes, and its role in excitation–contraction coupling and inotropic stimulation

scientific article published on 27 January 2010

Contractile responses to endothelin-1 are regulated by PKC phosphorylation of cardiac myosin binding protein-C in rat ventricular myocytes.

scientific article

Cytosolic phosphorylation of calnexin controls intracellular Ca(2+) oscillations via an interaction with SERCA2b

scientific article

Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils

scientific article published on 30 June 2006

ER Ca2+ release and store-operated Ca2+ entry - partners in crime or independent actors in oncogenic transformation?

scientific article published on 27 July 2019

Elevated InsP3R expression underlies enhanced calcium fluxes and spontaneous extra-systolic calcium release events in hypertrophic cardiac myocytes.

scientific article published on 17 January 2010

Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes

scientific article published on 15 June 2008

Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors

scientific article published on 13 April 2017

Endothelin-1-stimulated InsP3-induced Ca2+ release is a nexus for hypertrophic signaling in cardiac myocytes.

scientific article

Epigenetics in the heart: the role of histone modifications in cardiac remodelling

scientific article published on June 2013

Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B

article

Exposure to GSM RF fields does not affect calcium homeostasis in human endothelial cells, rat pheocromocytoma cells or rat hippocampal neurons

scientific article

Global fibroblast activation throughout the left ventricle but localized fibrosis after myocardial infarction.

scientific article published on 7 September 2017

Glucocorticoid-mediated inhibition of Lck modulates the pattern of T cell receptor-induced calcium signals by down-regulating inositol 1,4,5-trisphosphate receptors

scientific article published on 23 September 2009

Hyperactive ryanodine receptors in human heart failure and ischemic cardiomyopathy reside outside of couplons.

scientific article published on 14 April 2018

Identification and characterization of an amino acid transporter expressed differentially in liver

scholarly article

Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide

scientific article published on 01 October 2020

Inositol 1,4,5-trisphosphate receptors in the heart.

scientific article published in January 2004

Inositol 1,4,5-trisphosphate receptors: "exciting" players in cardiac excitation-contraction coupling?

scientific article published on 27 August 2013

Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes

scientific article published on 01 August 2006

Ins(1,4,5)P3-mediated calcium signals and apoptosis: is there a role for Bcl-2? ⬇️

scientific article published on October 1, 2003

Interaction between store-operated and arachidonate-activated calcium entry

scientific article published on 12 June 2006

Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons

scientific article published on 7 September 2012

KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells

scientific article published in November 1997

Lnc'ing Ca2+, SERCA and cardiac disease

scientific article published on 17 May 2018

Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels

scientific article

Mitochondrial Ca2+ laMety directs fibrosis

scientific article published on 23 December 2019

Myofibroblast Phenotype and Reversibility of Fibrosis in Patients With End-Stage Heart Failure

scientific article published on 01 May 2019

New Ca2+ indicator has freedom to express

scientific article published in May 2006

Nuclear localisation of calreticulin in vivo is enhanced by its interaction with glucocorticoid receptors

scientific article published on 01 March 1997

Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodelling of the isoform composition of IP₃Rs and ER luminal Ca²⁺ levels in colorectal cancer cell lines.

scientific article published on 12 February 2014

Oncogenic KRAS suppresses store-operated Ca 2+ entry and I CRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines

scientific article published on 14 March 2018

Overexpression of calreticulin fails to abolish its induction by perturbation of normal ER function

scientific article published on January 1998

Pacemaking, arrhythmias, inotropy and hypertrophy: the many possible facets of IP3 signalling in cardiac myocytes

scientific article published on 19 April 2007

Quantitative proteomics and systems analysis of cultured H9C2 cardiomyoblasts during differentiation over time supports a ‘function follows form’ model of differentiation

scientific article published on 01 June 2018

Redoxing calcium from the ER.

scientific article

Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins

scientific article

Subcellular calcium dynamics in a whole-cell model of an atrial myocyte

scientific article

Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate.

scientific article

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

scientific article

Temporal changes in atrial EC-coupling during prolonged stimulation with endothelin-1

scientific article published on 14 June 2007

The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy

scientific article

The JAK3 inhibitor WHI-P154 prevents PDGF-evoked process outgrowth in human neural precursor cells

scientific article

The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect

scientific article published on 22 January 2008

The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis

scientific article published on 09 August 2007

The role of the paracrine/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth.

scientific article published on January 2013

The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction

scientific article published on 23 November 2004

Using Calcium Imaging as a Readout of GPCR Activation

scientific article published on 01 January 2011

Why, where, and when do cardiac myocytes express inositol 1,4,5-trisphosphate receptors?

scientific article published on 7 December 2007

XTRPC1-dependent chemotropic guidance of neuronal growth cones

scientific article published on 08 May 2005

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