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List of works by Kai Breuhahn

A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes

scientific article published on 31 December 2012

A cellular view of Nf2 in liver homeostasis and tumorigenesis

scientific article published on 01 September 2010

AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor

scientific article

Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes-Associated Protein 1 Activation and Transient Expansion of Stem-Like Cancer Cells

scientific article published on 24 November 2021

Analysis of UVB‐modulated Gene Expression in Human Keratinocytes by mRNA Differential Display Polymerase Chain Reaction ⬇️

scientific article published on September 1, 1997

Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesis

scientific article published in July 2008

Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes.

scientific article

Cellular apoptosis susceptibility (CAS) is linked to integrin β1 and required for tumor cell migration and invasion in hepatocellular carcinoma (HCC).

scientific article published on 23 March 2016

Cellular apoptosis susceptibility (CAS) is overexpressed in thyroid carcinoma and maintains tumor cell growth: A potential link to the BRAFV600E mutation

scientific article published on 09 February 2016

Chromosome 8p tumor suppressor genes SH2D4A and SORBS3 cooperate to inhibit interleukin-6 signaling in hepatocellular carcinoma

scientific article published on 16 June 2016

Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysis

scientific article published on March 2005

Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines

scientific article

Concomitant expression of far upstream element (FUSE) binding protein (FBP) interacting repressor (FIR) and its splice variants induce migration and invasion of non-small cell lung cancer (NSCLC) cells

scientific article published on 14 July 2015

Coordinated expression of stathmin family members by far upstream sequence element-binding protein-1 increases motility in non-small cell lung cancer

scientific article published on 3 March 2009

Correction: Stathmin Regulates Keratinocyte Proliferation and Migration during Cutaneous Regeneration

scientific article published on 13 December 2013

Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer

scientific article

Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma

scientific article published on July 2006

Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice

scientific article published on 12 February 2004

Cytoplasmic localization of the cell polarity factor Scribble supports liver tumor formation and tumor cell invasiveness.

scientific article published on 20 November 2017

Cytosolic and nuclear caspase-8 have opposite impact on survival after liver resection for hepatocellular carcinoma

scientific article

Directed random walks and constraint programming reveal active pathways in hepatocyte growth factor signaling.

scientific article published on 31 October 2015

Down-regulation of tumor suppressor A kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms

scientific article

Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells

scientific article published on 25 June 2013

Dysregulation of growth factor signaling in human hepatocellular carcinoma.

scientific article published on June 2006

Elevated expression of c-kit in small venous malformations of blue rubber bleb nevus syndrome ⬇️

scientific article published on 30 June 2010

Endothelial plasticity governs the site-specific leukocyte recruitment in hepatocellular cancer

scientific article published on 10 June 2013

Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival.

scientific article published on 21 July 2013

Epidermal overexpression of granulocyte-macrophage colony-stimulating factor induces both keratinocyte proliferation and apoptosis

scientific article published on 01 February 2000

Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.

scientific article

Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma

scientific article

Expression of cyclooxygenase-2 (COX-2) in an advanced metastasized hypopharyngeal carcinoma and cultured tumor cells.

scientific article published in March 2010

Expression of epithelial cellular adhesion molecule (Ep-CAM) in chronic (necro-)inflammatory liver diseases and hepatocellular carcinoma

scientific article published on 20 December 2005

Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma

scientific article published on 29 September 2004

Gene network dynamics controlling keratinocyte migration

scientific article published on July 2008

Global alterations of DNA methylation in cholangiocarcinoma target the Wnt signaling pathway

scientific article published on 24 December 2013

High-fat intake during pregnancy and lactation exacerbates high-fat diet-induced complications in male offspring in mice.

scientific article published on 16 July 2013

Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.

scientific article published on 31 March 2014

Imbalance of DNA-dependent protein kinase subunits in polycythemia vera peripheral blood stem cells.

scientific article

Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma

scientific article published on 3 August 2016

Induction of Chromosome Instability by Activation of Yes-Associated Protein and Forkhead Box M1 in Liver Cancer.

scientific article

Insulin-like growth factor (IGF)-signalling pathway components are potential therapeutic targets in the treatment of human hepatocellular carcinoma

scientific article published in January 2007

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

article

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression in hepatocellular carcinoma. A clinicopathological analysis with emphasis on diagnostic value.

scientific article published in January 2012

Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP.

scientific article published on 16 May 2012

Kallikrein 6 induces E-cadherin shedding and promotes cell proliferation, migration, and invasion

scientific article published on 01 September 2007

Keratinocyte-derived granulocyte-macrophage colony stimulating factor accelerates wound healing: Stimulation of keratinocyte proliferation, granulation tissue formation, and vascularization

scientific article

Large-scale N-terminal deletions but not point mutations stabilize beta-catenin in small bowel carcinomas, suggesting divergent molecular pathways of small and large intestinal carcinogenesis.

scientific article published in July 2008

Lipid droplet-associated PAT-proteins show frequent and differential expression in neoplastic steatogenesis.

scientific article published on 15 January 2010

MicroRNAs are key regulators of hepatocellular carcinoma (HCC) cell dissemination-what we learned from microRNA-494.

scientific article published on August 2016

Molecular mechanisms of progression in human hepatocarcinogenesis

scientific article published on October 2010

Molecular pathogenesis of human hepatocellular carcinoma

scientific article published on 01 January 2002

Molecular profiling of human hepatocellular carcinoma defines mutually exclusive interferon regulation and insulin-like growth factor II overexpression

scientific article published on 01 September 2004

Non-specific effects of siRNAs on tumor cells with implications on therapeutic applicability using RNA interference

scientific article

Nuclear accumulation of seven in absentia homologue-2 supports motility and proliferation of liver cancer cells.

scientific article published on 27 March 2012

Nuclear expression of the deubiquitinase CYLD is associated with improved survival in human hepatocellular carcinoma

scientific article

Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells

scientific article published on 26 February 2011

Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes

scientific article published on 24 October 2012

Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases

scientific article published on September 2006

On the ontology based representation of cell lines

scientific article

Oncogenetic tree modeling of human hepatocarcinogenesis

scientific article published on 9 May 2011

Overexpression of far upstream element (FUSE) binding protein (FBP)-interacting repressor (FIR) supports growth of hepatocellular carcinoma.

scientific article published on 31 July 2014

PI3K/AKT/mTOR-dependent stabilization of oncogenic far-upstream element binding proteins in hepatocellular carcinoma cells.

scientific article published on 14 January 2016

Patch-Based Nonlinear Image Registration for Gigapixel Whole Slide Images

scientific article published on 23 November 2015

Podocalyxin-like protein 1 expression in primary hepatic tumours and tumour-like lesions

scientific article published on 01 September 2006

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1).

scientific article

Proapoptotic and antiproliferative potential of selective cyclooxygenase-2 inhibitors in human liver tumor cells

scientific article published in October 2002

Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon

scientific article published on 23 June 2008

Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer

scientific article published on 17 July 2014

Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer

scientific article published on 07 December 2016

Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis.

scientific article

Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCycler instrument and a SYBR GreenI-based assay: determining FAT10 mRNA levels in hepatocellular carcinoma

scientific article published in January 2008

Quantitative and integrative analysis of paracrine hepatocyte activation by nonparenchymal cells upon lipopolysaccharide induction

scientific article published on 21 January 2017

Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage.

scientific article published in August 2009

Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma.

scientific article published on March 2008

S100A8 and S100A9 are novel nuclear factor kappa B target genes during malignant progression of murine and human liver carcinogenesis.

scientific article published in October 2009

SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice

scientific article

Signaling Networks in Human Hepatocarcinogenesis—Novel Aspects and Therapeutic Options

scientific article published on January 1, 2010

Stathmin regulates keratinocyte proliferation and migration during cutaneous regeneration

scientific article

Strategies for hepatocellular carcinoma therapy and diagnostics: lessons learned from high throughput and profiling approaches.

scientific article published on June 2011

TTCA: an R package for the identification of differentially expressed genes in time course microarray data

scientific article

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

scientific article published on 11 October 2010

The designer cytokine hyper-IL-6 mediates growth inhibition and GM-CSF-dependent rejection of B16 melanoma cells

scientific article published on February 2001

The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells.

scientific article

The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1.

scientific article

Transcriptional regulators in hepatocarcinogenesis--key integrators of malignant transformation.

scientific article published on 21 March 2012

Tumor cell load and heterogeneity estimation from diffusion-weighted MRI calibrated with histological data: an example from lung cancer.

scientific article

UVB-regulated gene expression in human keratinocytes. Analysis by differential display.

scientific article published in January 2000

Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.

scientific article

Wound healing revised: a novel reepithelialization mechanism revealed by in vitro and in silico models.

scientific article

Yes-associated protein (YAP) induces a secretome phenotype and transcriptionally regulates plasminogen activator Inhibitor-1 (PAI-1) expression in hepatocarcinogenesis

scientific article published on 23 October 2020

[Insulin-like growth factor (IGF)-II in human hepatocarcinogenesis--a potential therapeutic target?]

scientific article published on 01 January 2005

[Molecular pathogenesis of hepatocellular carcinoma: new therapeutic approaches and predictive pathology]

scientific article published on 01 July 2007

[Reduced expression of the E3-ubiquitin ligase seven in absentia homologue (SIAH)-1 in human hepatocellular carcinoma]

scientific article published on 01 January 2007

miR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma.

scientific article

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